WO2016168806A1

WO2016168806A1 - Fluid transfer device

Info

Publication number: WO2016168806A1
Application number: PCT/US2016/028062
Authority: WO
Inventors: Grant BELTON; Caroline BRIGHAM; Anjali Kumar; Meera NAMIREDDY
Original assignee: Becton Dickinson and Company Limited
Priority date: 2015-04-16
Filing date: 2016-04-18
Publication date: 2016-10-20

Abstract

A fluid transfer includes a first portion including a first connector configured to be connected to a first container, and a second portion having a body and a connection member rotatable relative to the body, with the connection member including a second connector configured to be connected to a second container and a third connector spaced apart from the second connector. The second and third connectors are rotatable relative to the first connector. The connection member has a first position in which the first connector is aligned with the second connector and a second position in which the first connector is aligned with the third connector. At least a portion of the first portion is axially movable with respect to at least a portion of the second portion.

Description

FLUID TRANSFER DEVICE

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 62/148,336, filed April 16, 2015, the disclosure of which is incorporated herein by reference.

BACKGROUND OF THE INVENTION

Field of the Invention

[0002] The present invention relates to a device for transferring fluid from a container to another container or device. More particularly, the present invention relates to a device that provides a closed environment for transferring fluid from a container to another container.

Description of Related Art

[0003] Health care providers reconstituting, transporting, and administering hazardous drugs, such as cancer treatments, can put health care providers at risk of exposure to these medications and present a major hazard in the health care environment. For example, nurses treating cancer patients risk being exposed to chemotherapy drugs and their toxic effects. Unintentional chemotherapy exposure can affect the nervous system, impair the reproductive system, and bring an increased risk of developing blood cancers in the future. In order to reduce the risk of health care providers being exposed to toxic drugs, the closed transfer of these drugs becomes important.

[0004] Some drugs must be dissolved or diluted before they are administered, which involves transferring a solvent from one container to a sealed vial containing the drug in powder or liquid form, by means of a needle. Closed-system transfer devices (CSTDs) are used to prevent such hazardous exposure. However, currently available CSTDs are often complicated and/or costly to manufacture and may be complicated for the healthcare workers to operate. Therefore, there is a need for a CSTD that is easier and more economical to manufacture and easier for healthcare workers to use.

SUMMARY OF THE INVENTION

[0005] hi accordance with an aspect of the present invention, a fluid transfer device includes a first portion having a first connector configured to be connected to a first container and a second portion having a body including a connection member. The connection member includes a second connector configured to be connected to a second container and a third connector configured to be connected to a third container. The third connector is spaced apart from the second connector and the second and third connectors are rotatable relative to the first connector. The connection member has a first position in which the first connector is permitted to be in fluid communication with the second connector and a second position in which the first connector is permitted to be in fluid communication with the third connector and isolated from the second connector. At least a portion of the first portion is axially movable with respect to at least a portion of the second portion. The connection member transitions from the first position to the second position upon rotational movement of at least a portion of the second portion with respect to at least a portion of the first portion.

[0006] The connection member may define an opening that receives a body of the first portion for guiding rotational movement of the connection member between the first position and the second position.

[0007] The first portion of the fluid transfer device includes a body and an actuating member received by the body. The actuating member is axially movable within the body of the first portion and within the body of the second portion between a non-actuated position and an actuated position. Axial movement of the actuating member from the non-actuated position to the actuated position establishes fluid communication between the first connector and the second connector when the connection member is in the first position. Axial movement of the actuating member from the non-actuated position to the actuated position establishes fluid communication between the first connector and the third connector when the connection member is in the second position.

[0008] The body of the first portion and the actuating member may define cooperating threads such that rotation of the actuating member causes axial displacement of the actuating member. The actuating member may be configured to receive a syringe. The actuating member may further comprise a sealing member such that the body of the second portion is configured to receive the sealing member when the actuating member is in the actuated position.

[0009] At least one of the first connector, the second connector, and the third connector, may be a luer connector. The first connector, the second connector and the third connector may be configured to receive containers of different sizes. At least one of the second connector and the third connector is configured to receive a medical vial and at least one of the second connector and the third connector is configured to be connected to an IV line.

[0010] In a further aspect, a fluid transfer system includes a fluid transfer device, a first container configured to be connected to the first connector, a second container configured to be connected to the second connector; and a third container configured to be connected to the third connector. The fluid transfer device includes a first portion having a body for receiving an actuation member and a first connector and a second portion having a body and a connection member. The connection member includes a second connector and a third connector. The third connector spaced apart from the second connector and the second and third connectors are rotatable relative to the first connector. The connection member has a first position in which the first connector is permitted to be in fluid communication with the second connector and a second position in which the first connector is permitted to be in fluid communication with the third connector and isolated from the second connector. At least a portion of the first portion is axially movable with respect to at least a portion of the second portion. The connection member transitions from the first position to the second position upon rotational movement of at least a portion of the second portion with respect to at least a portion of the first portion.

[0011] The body of the first portion and the actuating member may define cooperating threads. The threads facilitate the actuating member being movable axially and rotationally within the body of the first portion and within the body of the second portion between a non-actuated position and an actuated position. Axial movement of the actuating member from the non-actuated position to the actuated position establishes fluid communication between the first connector and the second connector when the connection member is in the first position. Axial movement of the actuating member from the non-actuated position to the actuated position establishes fluid communication between the first connector and the third connector when the connection member is in the second position.

[0012] An opening may be defined in the connection member for guiding the rotational movement of the connection member between the first position and the second position.

[0013] The second container of the fluid transfer system may be a medical vial and the third container may be an IV line.

[0014] In a further aspect, a method of transferring a fluid includes providing a fluid transfer device including a first portion having a first connector and a second portion having a body and a connection member including a second connector and a third connector. The third connector is spaced apart from the second connector and at least a portion of the first portion is movable axially and rotationallv with respect to at least a portion of the second portion. The first connector of the fluid transfer device is engaged with a first container, the second connector of the fluid transfer device is engaged with a second container, and the third connector of the fluid transfer device is engaged with the third container. A portion of the first portion is advanced into a portion of the second portion until fluid communication is established between the first container and the second container. A portion of the first portion is then withdrawn from a portion of the second portion and the connection member is rotated with respect to the first portion from a first position to a second position. Fluid communication is then established between the first container and the third container by advancing a portion of the first portion into a portion of the second portion.

[0015] The first container may be a syringe. The second container may be a medical vial. The third container may be an IV line.

BRIEF DESCRIPTION OF THE DRAWINGS

[0016] FIG. 1 is a side view of a fluid transfer device according to one aspect of the present invention.

[0017] FIG. 2 is an exploded perspective view of the fluid transfer device of FIG. 1 according to one aspect of the present invention.

[0018] FIG. 3 is a side view of the fluid transfer device of FIG. 1 in an initial position according to one aspect of the present invention.

[0019] FIG. 4 is a side view of the fluid transfer device of FIG. 3 after the first portion has been pushed into the second portion to establish fluid communication between the syringe and the medicament container according to one aspect of the present invention.

[0020] FIG. 5 is a side view of the fluid transfer device of FIG. 4 after the first portion has been withdrawn from the second portion to disengage fluid communication between the syringe and the medicament container according to one aspect of the present invention.

[0021] FIG. 6 is a side view of the fluid transfer device of FIG. 5 after the first portion has been rotated with respect to the second portion to align the syringe with the IV adapter according to one aspect of the present invention. [0022] FIG. 7 is a side view of the fluid transfer device of FIG. 6 after the first portion has been pushed into the second portion to establish fluid communication between the swinge and the IV adapter according to one aspect of the present invention.

[0023] FIG. 8 is a top perspective view of a fluid transfer device according to a further aspect of the present invention.

[0024] FIG. 9 is front perspective view^r of the fluid transfer device of FIG. 8 according to one aspect of the present invention.

[0025] FIG. 10 is a front perspective view^r of the fluid transfer device of FIG. 8 showing a first portion in an initial position and a vial attached to a second portion according to one aspect of the present invention.

[0026] FIG. 11 is a front perspective view of the fluid transfer device of FIG. 8 showing a first portion in an initial position and a vial aligned with the first portion according to one aspect of the present invention.

[0027] FIG. 12 is a front perspective view of the fluid transfer device of FIG. 8 showing a first portion in an actuated position and a vial aligned with the first portion according to one aspect of the present invention.

[0028] FIG. 13 is a front perspective view of the fluid transfer device of FIG. 8 showing a first portion in an actuated position and a syringe aspirating fluid from a vial according to one aspect of the present invention.

[0029] FIG. 14 is a front perspective view of the fluid transfer device of FIG. 8 showing a first portion returned to an initial position and a third connector aligned with the first portion according to one aspect of the present invention.

[0030] FIG. 15 is a front perspective view of the fluid transfer device of FIG. 8 showing a first portion in an actuated position and an IV line connected to a third connector according to one aspect of the present invention.

DESCRIPTION OF THE INVENTION

[0031] For purposes of the description hereinafter, the words "upper", "lower", "right", "left", "vertical", "horizontal", "top", "bottom", "lateral", "longitudinal", and like spatial terms, if used, shall relate to the described aspects as oriented in the drawing figures. However, it is to be understood that many alternative variations and aspects may be assumed except where expressly specified to the contrary. It is also to be understood that the specific devices and aspects illustrated in the accompanying drawings and described herein are simply exemplary aspects of the invention.

[0032] A fluid transfer device of the present invention is used to provide transfer, including reconstitution if necessary, of a fluid medicament from a first container to a patient in a completely closed system such that the medicament is never released into the atmosphere. As used herein, a container refers to any object that can be used to hold or transport fluid. A vial refers to a small container, typically cylindrical in shape. A medical vial refers to a vial made of glass or a medical grade plastic that can be used to safely store or transfer a medicament. An IV line as used herein refers to a tubing, typically a flexible tubing, for transferring a liquid medicament from a container directly into a vein of a patient.

[0033] As shown in FIGS. 1-7, the fluid transfer device 10 has a first cylindrical portion 12, a second cylindrical portion 14, and at least one sealing member 16 provided between the first cylindrical portion 12 and the second cylindrical portion 14.

[0034] The first cylindrical portion 12 has an open end 18 and a closed end 20. A first connector 22 including a central passageway therethrough extends from the closed end 20 of the first cylindrical portion 12. A needle cannula 24 is provided in fluid communication with the central passageway of the first connector 22 and may extend into the interior of the first cylindrical portion 12. The first cylindrical portion 12 may also include a handle 23 extending from the first cylindrical portion 12, such as from the closed end 20, which is shown in FIGS. 2-7, but not FIG. 1

[0035] The first connector 22 may be configured to connect to a syringe 26 and may be a standard male luer fitting that can cooperate with a corresponding female luer fitting on the syringe 26 to attach the syringe 26 to the first cylindrical portion 12 as shown in FIG. 1, or may be a standard female luer fitting that can cooperate with a corresponding male luer fitting on the syringe 26, although other suitable connectors may be utilized. The needle cannula 24 is connected to the first connector 22 such that the central passageway of the first connector 22 is sealingly engaged with the needle cannula 24 to provide an air-tight and fluid-tight connection therebetween.

[0036] The second cylindrical portion 14 has an open end 28 and a closed end 30. A second connector 32 including a central passageway therethrough extends from the second cylindrical portion 14, such as the closed end 30 of the second cylindrical portion 14. A third connector 34 including a central passageway therethrough also extends from the closed end 30 of the second cylindrical portion 14 and is spaced apart from the second connector 32.

[0037] The second connector 32 may be adapted for connection to a medicament container 36 that contains a medicament. The container 36 may be a vial having a pierceable septum, as shown in FIGS. 2-7. The second connector 32 may be a threaded connector as shown in FIGS. 3-7 or, as shown in FIG. 1, may be a snap-fit connector having vial grip members, hook protrusions, and angled walls, or other suitable connectors. The second connector 32 may include a seal 38, such as an O-ring, to provide a sealing engagement between the container 36 and the second connector 32.

[0038] The third connector 34 may be adapted for connection to an IV adapter 40 through which the medicament will be administered to the patient. Such a connector may be any standard connector known in the art including, but not limited to, a connector having a groove including a locking portion wherein the IV adapter 40 has protrusions for engagement with the groove or a connector having protrusions wherein the IV adapter 40 has a groove including a locking portion for engagement with the protrusions. The third connector 34 may further include a seal 42, such as an elastomeric seal or the like. The seal 42 may be air-tight and fluid-tight and adapted to seal the central passageway of the third connector 34. Such a seal may also be adapted to allow the passage of the needle cannula 24 through the seal 42 in a manner in which the seal 42 provides an air-tight and fluid-tight seal around the needle cannula 24 and, on removal of the needle cannula 24 from the seal 42, reseals to provide an air-tight and fluid-tight seal for the central passageway of the third connector 34.

[0039] The first cylindrical portion 12 and/or the second cylindrical portion 14 may each be formed of a single piece or may comprise a sidewall portion 44 and a closure portion 46 as shown in FIGS. 1-7. The sidew^rall portion 44 and closure portion 46 may be connected using a suitable means that provides an air-tight and fluid-tight seal including, but not limited to, welding or adhesive.

[0040] The outer diameter of the first cylindrical portion 12 is slightly less than the inner diameter of the second cylindrical portion 14 such that a portion of the open end 18 of the first cylindrical portion 12 extends into a portion of the open end 28 of the second cylindrical portion 14. In this manner, the first cylindrical portion 12 and the second cylindrical portion 14 define an internal chamber. The needle cannula 24 is contained within this chamber. [0041] The first connector 22, the second connector 32, and the third connector 34 are positioned such that the first connector 22 can be axially aligned with either the second connector 32 or the third connector 34 when the first cylindrical portion 12 is mated with the second cylindrical portion 14 and rotated with respect to the second cylindrical portion 14.

[0042] The first cylindrical portion 12 is movable axially and rotationally with respect to the second cylindrical portion 14. The first cylindrical portion 12 is axially movable with respect to the second cylindrical portion 14 from a first position (shown in FIGS. 3, 5, and 6) to a second position (shown in FIGS. 1, 4, and 7) witere the volume of the chamber in the first position is greater than the volume of the chamber in the second position. In addition, the first cylindrical portion 12 is rotatable with respect to the second cylindrical portion 14 from a first position (shown in FIGS. 1 and 3-5) where the first connector 22 is aligned with the second connector 32 to a second position (shown in FIGS. 6 and 7) where the first connector 22 is aligned with the third connector 34.

[0043] The sealing member 16 is provided between an outer sidewall surface 48 of the first cylindrical portion 12 and an inner sidewall surface of the second cylindrical portion 14. As shown in FIG. 2, the sealing member 16 may be an O-ring and may sit in a groove 52 in the outer sidewall surface 48 of the first cylindrical portion 12 or the inner sidewall surface of the second cylindrical portion 14. A second sealing member 16 may also be provided. The sealing member 16 is adapted to provide an air-tight and fluid-tight seal between the first cylindrical portion 12 and the second cylindrical portion 14 yet still allow for the axial and rotational movement of the first cylindrical portion 12 with respect to the second cylindrical portion 14.

[0044] A container 54 having an open end 56 and a closed end 58 may also be provided. The open end 56 of the container 54 is sealably connected around the second connector 32. The connection between the second connector 32 and the open end 56 of the container 54 may be a threaded connection or may utilize an elastic band that stretches over the container 54 and fits into a groove in the second connector 32, although any suitable connection that provides an air-tight and fluid- tight seal may be used.

[0045] The container 54 may be flexible and may be made of plastic or any suitable material that allows it to be fit over the medicament container 36 that contains the medicament and sealed to the second connector 32. The container 54 may be a plastic bag. [0046] The fluid transfer device 10 may also include a third cylindrical portion 60 having a first open end 62 and a second open end 64. The third cylindrical portion 60 has an outer diameter that is smaller than the inner diameter of the first cylindrical portion 12 and the second cylindrical portion 14. The first open end 62 of the third cylindrical portion 60 abuts the closed end 20 of the first cylindrical member 12 and the second open end 64 of the third cylindrical portion 60 abuts the closed end 30 of the second cylindrical member 14 when the first cylindrical portion 12 is advanced into the second cylindrical portion 14 as shown in FIGS. 1, 4, and 7. This results in a more equal distribution of force during this operation. In addition, the third cylindrical portion 60 stabilizes the device during rotation of the first cylindrical portion 12 with respect to the second cylindrical portion 14 as shown in FIG. 6. All of the components including the first cylindrical portion 12, the second cylindrical portion 14, the first connector 22, the second connector 32, the third connector 34, and the container 54 may be made from any suitable material having the necessary chemical resistance and strength including, but not limited to, polypropylene (PP) and polyvinyl chloride (PVC).

[0047] In use, as shown in FIG. 3, the fluid transfer device 10 is placed in a first position where the first connector 22 is axially aligned with the second connector 32 and the first cylindrical portion 12 extends from the second cylindrical portion 14. A first device, such as a syringe 26 having a diluent, is connected to the first connector 22. A second device, such as a medicament container 36, is connected to the second connector 32. A third device, such as IV adapter 40 or other device for delivery of the medicament to the patient, is connected to the third connector 34. The container 54 may then be placed over the medicament container 36 and sealingly secured to the second connector 32.

[0048] As shown in FIG. 4, by actuating the handle 23, the first cylindrical portion 12 is at least partially advanced into the second cylindrical portion 14 reducing the volume of the chamber and causing the needle cannula 24 to enter the medicament container 36 creating a fluid passageway between the syringe 26, connected to the first connector 22, and the medicament container 36, connected to the second connector 32. The needle cannula 24 may enter the medicament container 36 by piercing a septum on the top of the medicament container 36 or any other arrangement as long as a fluid passageway is provided between the syringe 26 and the medicament container 36. At this point, if the medicament is ready for administration to the patient, it can be drawn into the syringe 26. If the medicament is a powder or liquid that needs to be reconstituted, the necessary fluid/solvent can be injected into the medicament container 36 from the syringe 26 and, upon completion of the reconstitution, the medicament can be drawn into the syringe 26.

[0049] As shown in FIG. 5, after the medicament has been drawn into the syringe 26, the first cylindrical portion 12 is at least partially withdrawn from the second cylindrical portion 14, such as by actuating the handle 23, thus increasing the volume of the chamber defined between the first cylindrical portion 12 and the second cylindrical portion 14. As the first cylindrical portion 12 is partially displaced from the second cylindrical portion 14, the needle cannula 24 is removed from the medicament container 36. Then, as shown in FIG. 6, the first cylindrical portion 12 is rotated with respect to the second cylindrical portion 14 until the first connector 22 is axially aligned with the third connector 34. After rotation of the first cylindrical portion 12, as shown in FIG. 7, a portion of the first cylindrical portion 12 is again pushed into the second cylindrical portion 14 reducing the volume of the chamber defined between the first cylindrical portion 12 and the second cylindrical portion 14, thereby causing the needle cannula 24 to enter the IV adapter 40 creating a fluid passageway between the syringe 26 connected to the first connector 22 and the IV adapter 40 connected to the third connector 34. At this point, the medicament can be injected from the syringe 26 into the IV tube for delivery to the patient. This procedure may be repeated until all the medicament has been delivered to the patient.

[0050] The fluid transfer device 10 has at least two advantages over prior closed system transfer devices. First, the number of components is reduced resulting in a corresponding reduction in manufacturing costs. Second, the entire drug reconstitution process and transfer of the drug to the rV bag is contained within one component, so the number of different devices that the user must use to complete this process and the number of actions the user must perform is reduced as compared to prior art transfer devices.

[0051] Referring to FIGS. 8-15, a fluid transfer device 100 according to a further aspect of the present invention is shown. The fluid transfer device 100 is similar to the fluid transfer device 10 shown in FIGS. 1-7 and described above, hi particular, similar to device 10, the fluid transfer device 100 includes a first portion 102 having a first connector 104 and a second portion 106 having second and third connectors 108, 110 with the first portion 102 and the second portion 106 being rotatable relative to each other between a first position (FIG. 11) witere the second connector 108 is aligned with the first connector 104 and a second position (FIG. 15) where the third connector 110 is aligned with the first connector 104. Also similar to device 10, the first portion 102 of device 100 is movable axially relative to the second portion 106 to place the first connector 104 in fluid communication with the second or third connectors 108, 110 depending on the relative rotational position of the first and second portions 102, 106.

[0052] Referring still to FIGS. 8-15, the second portion 106 includes body 124 having a central passageway that receives at least a portion of the first portion 102. In particular, the body 124 of the second portion 106 receives the seal member 122 and actuating member 114 of the first portion 102 during axial displacement of the actuating member 114. The seal member 122 may form a seal with a portion of the body 124 of the second portion 106. For instance, the seal member 122 may engage a cylinder-shaped portion of the body 124 that defines the central passageway. The second portion 106 includes a connection member 126 that includes the second and third connectors 108, 110. The body 124 of the second portion 106 may be cylindrical and the connection member 126 may be annular. The connection member 126 is rotatable about the body 124 of the second portion 106 and relative to the first portion 102. The connection member 126 defines an opening 128 that receives the body 112 of the first portion 102 and guides the rotational movement of the connection member 126 between the first (FIG. 11) and second (FIG. 15) positions of the fluid transfer device 100. The opening 128 of the connection member 126 may act as a stop such that the connection member 126 abuts one side of the body 112 of the first portion 102 in the first position (FIG. 11) and abuts an opposite side of the body 112 of the first portion 102 in the second position (FIG. 15). The second connector 108 is configured to be secured to a second container 130, such as a medical vial. The third connector 110 is configured to be connected to tubing 132, such as an IV line.

[0053] Referring to FIGS. 8-15, the first portion 102 includes a body 112 that receives an actuating member 114 that is movable axially and rotationally relative to the body 112. hi particular, the body 112 and the actuating member 114 each include cooperating threads 116 such that rotation of the actuating member by a user will cause axial displacement of the actuating member 114 within the body 112 and into the second portion 106 as discussed in more detail below. The actuating member 114 may have a flange 118 extending radially outward to provide a gripping surface for the user. The actuating member 114 defines the first connector 104 that is configured to receive a first container 120, such as a syringe. The first connector 104 may be a luer connector, although any other suitable connection arrangement may be utilized. The actuating member 114 also includes a seal member 122 that is movable along with the actuating member 114. Although not shown, the first portion 102 may include a cannula extending from the actuating member 114 that is configured to be placed in fluid communication with the second and third connectors 108, 110 depending on the relative rotational position of the first and second portions 102, 106.

[0054] Referring to FIG. 9, the fluid transfer device 100 is in the second position with the third connector 110 aligned with the first connector 104. The actuating member 114 of the first portion 102 is in a non-actuated or retracted position. The syringe 120 is secured to and in fluid communication with the first connector 104. Referring to FIG. 10, the vial 130 is connected to the second connector 108 of the second portion 106. Referring to FIG. 11, the connection member 126 of the second portion 106 is rotated such that the fluid transfer device 100 is in the first position with the second connector 108 is aligned with the first connector 104. Referring to FIG. 12, the actuating member 114 of the first portion 102 is then rotated to axially displace the actuating member 114 into the body 124 of the second portion 106 and to place the second connector 108 in fluid communication with the first connector 104. As shown in FIG. 13, the syringe 120 may then be used to aspirate fluid from the vial 130 into the syringe 120. Alternatively, the syringe 120 may^¬ be used to inject a diluent into the vial 130 to reconstitute a medicament contained within the vial 130 and with the reconstituted medicament subsequently aspirated into the syringe 120.

[0055] Referring to FIG. 14, the actuating member 114 is returned to the retracted or non- actuated position and the connection member 126 of the second portion 106 may then be rotated such that the third connector 110 is aligned with the first connector 104 to place the fluid transfer device 100 in the second position. As shown in FIG. 15, the actuating member 114 of the first portion 102 is then rotated to axially displace the actuating member 114 into the body 124 of the second portion 106 and to place the third connector 110 in fluid communication with the first connector 104. The medicament contained within the syringe 120 may then be administered to a patient or IV set via the first and third connectors 104, 110 and into the IV line 132 connected to the third connector 110.

[0056] While the present invention is described with reference to several distinct aspects of a fluid transfer device and method of use, those skilled in the art may make modifications and alterations without departing from the scope and spirit. Accordingly, the above detailed description is intended to be illustrative rather than restrictive.

Claims

THE INVENTION CLAIMED IS

1. A fluid transfer device comprising:

a first portion including a first connector configured to be connected to a first container; and

a second portion having a body including a connection member, the connection member including a second connector configured to be connected to a second container and a third connector configured to be connected to a third container, the third connector spaced apart from the second connector, and the second and third connectors rotatable relative to the first connector, wherein the connection member has a first position in which the first connector is permitted to be in fluid communication with the second connector and a second position in which the first connector is permitted to be in fluid communication with the third connector and isolated from the second connector, at least a portion of the first portion is axially movable with respect to at least a portion of the second portion, and wherein rotational movement of at least a portion of the second portion with respect to at least a portion of the first portion transitions the connection member from the first position to the second position.

2. The fluid transfer device of claim 1, wherein the connection member defines an opening that receives a body of the first portion.

3. The fluid transfer device of claim 1, wherein the first portion includes a body and an actuating member received by the body of the first portion, the actuating member is movable axially within the body of the first portion and within the body of the second portion between a non-actuated position and an actuated position.

4. The fluid transfer device of claim 3, wherein the body of the first portion and the actuating member define cooperating threads such that rotation of the actuating member causes axial displacement of the actuating member.

5. The fluid transfer device of claim 3, wherein the actuating member is configured to receive a syringe.

6. The fluid transfer device of claim 3, wherein axial movement of the actuating member from the non-actuated position to the actuated position establishes fluid communication between the first connector and the second connector when the connection member is in the first position and wherein axial movement of the actuating member from the non-actuated position to the actuated position establishes fluid communication between the first connector and the third connector witen the connection member is in the second position.

7. The fluid transfer device of claim 3, wherein the actuating member further comprises a sealing member and wherein the body of the second portion is configured to receive the sealing member when the actuating member is in the actuated position.

8. The fluid transfer device of claim 1, wherein at least one of the first connector, the second connector, and the third connector, is a luer connector.

9. The fluid transfer device of claim 2, wherein the opening guides rotational movement of the connection member between the first position and the second position.

10. The fluid transfer device of claim 1 , wherein the first connector, the second connector and the third connector are configured to receive containers of different sizes.

1 1. The fluid transfer device of claim 10, wherein at least one of the second connector and the third connector is configured to receive a medical vial.

12. The fluid transfer device of claim 11, wherein at least one of the second connector and the third connector is configured to be connected to an IV line.

13. A fluid transfer system comprising:

a fluid transfer device comprising:

a first portion having a body for receiving an actuating member and a first connector; and a second portion having a body and a connection member, the connection member including a second connector and a third connector, the third connector spaced apart from the second connector, and the second and third connectors rotatable relative to the first connector, a first container configured to be connected to the first connector; a second container configured to be connected to the second connector; and a third container configured to be connected to the third connector, wherein the connection member has a first position in which the first connector is permitted to be in fluid communication with the second connector and a second position in which the first connector is permitted to be in fluid communication with the third connector and isolated from the second connector, at least a portion of the first portion is axially movable with respect to at least a portion of the second portion, and wherein rotational movement of at least a portion of the second portion with respect to at least a portion of the first portion transitions the connection member from the first position to the second position.

14. The fluid transfer system of claim 13, wherein the body of the first portion and the actuating member define cooperating threads.

15. The fluid transfer system of claim 13 , wherein the actuating member is movable axially and rotationally within the body of the first portion and within the body of the second portion between a non-actuated position and an actuated position.

16. The fluid transfer system of claim 15, wherein axial movement of the actuating member from the non-actuated position to the actuated position establishes fluid communication between the first connector and the second connector when the connection member is in the first position and wherein axial movement of the actuating member from the non-actuated position to the actuated position establishes fluid communication between the first connector and the third connector when the connection member is in the second position.

17. The fluid transfer system of claim 13, wherein the connection member defines an opening for guiding the rotational movement of the connection member between the first position and the second position.

18. The fluid transfer system of claim 13, wherein the second container is a medical vial and the third container is an IV line.

19. A method of transferring a fluid comprising:

providing a fluid transfer device including a first portion having a first connector and a second portion having a body and a connection member including a second connector and a third connector, the third connector spaced apart from the second connector, wherein at least a portion of the first portion is movable axially and rotationally with respect to at least a portion of the second portion;

engaging a first container with the first connector, engaging a second container with the second connector, and engaging a third container with the third connector;

advancing a portion of the first portion into a portion of the second portion until fluid communication is established between the first container and the second container;

withdrawing a portion of the first portion from a portion of the second portion; rotating the connection member with respect to the first portion from a first position to a second position; and

advancing a portion of the first portion into a portion of the second portion until fluid communication is established between the first container and the third container.

20. The method of claim 19, wherein the first container is a syringe, the second container is a medical vial, and the third container is an IV line.