EP2742154A4 - Biomarker compositions and methods - Google Patents
Biomarker compositions and methodsInfo
- Publication number
- EP2742154A4 EP2742154A4 EP12821745.2A EP12821745A EP2742154A4 EP 2742154 A4 EP2742154 A4 EP 2742154A4 EP 12821745 A EP12821745 A EP 12821745A EP 2742154 A4 EP2742154 A4 EP 2742154A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- biomarker compositions
- biomarker
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000090 biomarker Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161521333P | 2011-08-08 | 2011-08-08 | |
US201161523763P | 2011-08-15 | 2011-08-15 | |
US201161526623P | 2011-08-23 | 2011-08-23 | |
US201161529762P | 2011-08-31 | 2011-08-31 | |
US201161534352P | 2011-09-13 | 2011-09-13 | |
US201161537462P | 2011-09-21 | 2011-09-21 | |
US201161542639P | 2011-10-03 | 2011-10-03 | |
US201161551674P | 2011-10-26 | 2011-10-26 | |
US201161559676P | 2011-11-14 | 2011-11-14 | |
US201261612111P | 2012-03-16 | 2012-03-16 | |
US201261619803P | 2012-04-03 | 2012-04-03 | |
PCT/US2012/050030 WO2013022995A2 (en) | 2011-08-08 | 2012-08-08 | Biomarker compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2742154A2 EP2742154A2 (en) | 2014-06-18 |
EP2742154A4 true EP2742154A4 (en) | 2015-08-12 |
Family
ID=47669214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12821745.2A Withdrawn EP2742154A4 (en) | 2011-08-08 | 2012-08-08 | Biomarker compositions and methods |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2742154A4 (en) |
JP (1) | JP2014522993A (en) |
KR (1) | KR20140067001A (en) |
CN (1) | CN103874770A (en) |
AU (1) | AU2012294458A1 (en) |
BR (1) | BR112014002975A2 (en) |
CA (1) | CA2844671A1 (en) |
WO (1) | WO2013022995A2 (en) |
Families Citing this family (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009246180B2 (en) | 2008-05-14 | 2015-11-05 | Dermtech International | Diagnosis of melanoma and solar lentigo by nucleic acid analysis |
AU2011223789A1 (en) | 2010-03-01 | 2012-09-20 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
NZ703411A (en) | 2012-06-27 | 2017-09-29 | Berg Llc | Use of markers in the diagnosis and treatment of prostate cancer |
US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
CN103160509B (en) * | 2013-03-07 | 2015-02-18 | 新乡医学院第一附属医院 | miRNA marker relative to esophagus cancer postoperative early relapse and prognosis and application |
EP2971162B1 (en) | 2013-03-15 | 2019-05-08 | Board Of Regents, The University Of Texas System | Mirna biogenesis in exosomes for diagnosis and therapy |
CN104076151B (en) * | 2013-03-29 | 2017-04-12 | 复旦大学附属华山医院 | Kit for early diagnosis of glioma |
EP2992330B1 (en) * | 2013-04-29 | 2018-04-18 | Apogenix AG | Method of diagnosing cancer |
EP2994545B1 (en) * | 2013-05-10 | 2019-03-20 | University Of Southern California | Dna methylation biomarkers for bladder cancer |
EP3030675B1 (en) * | 2013-08-06 | 2018-10-03 | Exosome Diagnostics Inc. | Urine biomarker cohorts, gene expression signatures, and methods of use thereof |
WO2015031694A2 (en) * | 2013-08-28 | 2015-03-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
WO2015031604A1 (en) * | 2013-08-28 | 2015-03-05 | Crown Bioscience, Inc. | Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same |
US10139402B2 (en) | 2013-11-06 | 2018-11-27 | Jsr Corporation | Separation method, detection method, signal measurement method, method for determining disease, method for evaluating drug efficacy of disease treatment drug, kit, and liquid composition |
FR3014198B1 (en) * | 2013-12-03 | 2017-03-03 | Biomerieux Sa | METHOD FOR ISOLATING EXOSOMES |
EP3078889B1 (en) * | 2013-12-06 | 2019-09-18 | The University of Tokyo | Valve, fluid-controlling structure, fluid device, and method for manufacturing valve |
JP2017509351A (en) * | 2013-12-30 | 2017-04-06 | ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | Prostate cancer gene profile and method of use thereof |
WO2015101988A1 (en) | 2013-12-31 | 2015-07-09 | Yeda Research And Development Co. Ltd. | Diagnosis of systemic lupus erythematosus using oligonucleotides antigens |
WO2015117164A1 (en) * | 2014-02-03 | 2015-08-06 | Memorial Sloan-Kettering Cancer Center | Tumor-associated macrophages and methods and compositions for targeting cancer therapy and identifying potential responders |
EP3137909B1 (en) | 2014-04-29 | 2018-06-06 | Apogenix AG | Diagnostic anti-cd95l antibody |
EP3137626B1 (en) * | 2014-05-01 | 2020-12-02 | Stichting VUmc | Small ncrnas as biomarkers |
ES2481819B1 (en) * | 2014-06-12 | 2015-04-01 | Sistemas Genómicos, S.L. | ASSESSMENT METHOD TO EVALUATE A POSSIBILITY OF BREAST CANCER |
RU2017100253A (en) | 2014-06-12 | 2018-07-17 | Торэй Индастриз, Инк. | KIT OR DEVICE FOR DETECTING PROSTATE CANCER AND DETECTION METHOD |
US20160038608A1 (en) * | 2014-08-07 | 2016-02-11 | National Taiwan University | Silica-based mesoporous carrier and delivery method of using the same |
US10670611B2 (en) * | 2014-09-26 | 2020-06-02 | Somalogic, Inc. | Cardiovascular risk event prediction and uses thereof |
KR101596166B1 (en) | 2014-10-07 | 2016-02-19 | 가톨릭대학교 산학협력단 | A Use of microRNA for Ddiagnosing and Treating Brest Cancer |
CN104313171A (en) * | 2014-11-06 | 2015-01-28 | 南京大学 | MicroRNA molecular marker for diagnosing glioma and application of microRNA molecular marker |
AU2015360694B2 (en) * | 2014-12-08 | 2021-10-14 | Berg Llc | Use of markers including filamin a in the diagnosis and treatment of prostate cancer |
CN105807063B (en) * | 2014-12-29 | 2018-02-06 | 中国人民解放军第二军医大学 | Applications of the CD63 in preparing diagnosis for liver disease kit or preparing prevention or treatment liver diseases medicine |
CN104548134A (en) * | 2015-01-04 | 2015-04-29 | 中国人民解放军第二军医大学 | Application of miR-144 and inhibitor thereof |
US20180148783A1 (en) * | 2015-01-05 | 2018-05-31 | The Johns Hopkins University | Method of epigenetic analysis for determining clinical genetic risk |
WO2016121821A1 (en) * | 2015-01-27 | 2016-08-04 | Jsr株式会社 | Separation method, detection method, signal measurement method, method for determining disease, method for evaluating drug efficacy, kit, liquid composition, and analyte diluent |
US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
IL303543A (en) | 2015-02-18 | 2023-08-01 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
WO2016139659A1 (en) | 2015-03-01 | 2016-09-09 | Immunarray Ltd. | Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens |
CA2979361A1 (en) | 2015-03-09 | 2016-09-15 | Caris Science, Inc. | Method of preparing oligonucleotide libraries |
CN104714032B (en) * | 2015-04-02 | 2015-09-16 | 闫星宇 | For mark and the detection reagent thereof of postpartum eclampsia diagnosis |
JP6803339B2 (en) | 2015-04-21 | 2020-12-23 | エンリヴェックス セラピューティクス リミテッド | Therapeutic pooled blood apoptotic cell preparations and their use |
WO2016186215A1 (en) * | 2015-05-20 | 2016-11-24 | Jsr株式会社 | Separation method, detection method, signal measurement method, disease determination method, drug efficacy assessment method, kit, liquid composition, and specimen diluent |
EP3307890A1 (en) | 2015-06-10 | 2018-04-18 | Board of Regents, The University of Texas System | Use of exosomes for the treatment of disease |
CN104992058B (en) * | 2015-06-25 | 2017-08-01 | 成都厚立信息技术有限公司 | Disease risks adjust method for establishing model |
EP3314027A4 (en) | 2015-06-29 | 2019-07-03 | Caris Science, Inc. | Therapeutic oligonucleotides |
CN105177117A (en) * | 2015-07-03 | 2015-12-23 | 张理义 | Major depressive disorder biomarker, screening method and kit |
CN106350578A (en) * | 2015-07-13 | 2017-01-25 | 中国人民解放军第二军医大学 | Application of NY-ESO-1 in diagnosis and treatment of microsatellite instability intestinal cancer |
WO2017019918A1 (en) | 2015-07-28 | 2017-02-02 | Caris Science, Inc. | Targeted oligonucleotides |
CN105039342B (en) * | 2015-08-06 | 2017-12-01 | 李家平 | SiRNA and its application of MAT2A gene expressions can be suppressed |
WO2017025954A1 (en) * | 2015-08-09 | 2017-02-16 | Immunarray Ltd | Methods for determining the risk of a systemic lupus erythematosus (sle) patient to develop neuropsychiatric syndromes |
CN105067822B (en) * | 2015-08-12 | 2017-05-24 | 中山大学附属肿瘤医院 | Marker for diagnosing esophagus cancer |
JP6583817B2 (en) * | 2015-09-04 | 2019-10-02 | 国立大学法人山口大学 | Diagnostic markers for tumors in uterine smooth muscle |
KR102078310B1 (en) * | 2015-09-11 | 2020-02-19 | 주식회사 압타머사이언스 | Protein biomarker panel for diagnosing non-small cell lung cancer and method for diagnosing non-small cell lung cancer using the same |
KR20180063127A (en) | 2015-09-17 | 2018-06-11 | 암젠 인크 | Prediction of Clinical Response to IL23-Antagonists Using IL23 Pathway Biomarkers |
EP3165926A1 (en) * | 2015-11-06 | 2017-05-10 | Humanitas Mirasole S.p.A. | Method for characterization of cell specific microvesicles |
US11230735B2 (en) | 2015-12-24 | 2022-01-25 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems and methods for characterizing sepsis |
WO2017113565A1 (en) * | 2015-12-29 | 2017-07-06 | 中国医学科学院肿瘤医院 | Kit for auxiliary diagnosis of patient with liver cancer or digestive tract cancer based on protein marker psg3 |
KR20180110141A (en) | 2016-02-18 | 2018-10-08 | 엔리벡스 테라퓨틱스 리미티드 | Combination of immunotherapy and cytokine regulating therapy to treat cancer |
IL303936A (en) | 2016-03-18 | 2023-08-01 | Caris Science Inc | Oligonucleotide probes and uses thereof |
CN105842461A (en) * | 2016-04-30 | 2016-08-10 | 广州恒泰生物科技有限公司 | Rapid diagnostic kit for uterine sarcoma in early and middle stages and preparation method of kit |
US11293017B2 (en) | 2016-05-25 | 2022-04-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
CN107475356A (en) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | Osteosarcoma circulating tumor cell identification kit |
CN105907875A (en) * | 2016-06-13 | 2016-08-31 | 武汉泰安康生物科技有限公司 | Method for screening kidney cancer peripheral blood miRNA marker and kidney cancer marker miR-378 |
JP6980219B2 (en) * | 2016-08-22 | 2021-12-15 | いであ株式会社 | How to detect cancer or determine the stage of cancer staging |
EP3541958A1 (en) * | 2016-11-15 | 2019-09-25 | Ventana Medical Systems, Inc. | Compositions and methods for prognosing and treating colorectal cancer |
CN108165635B (en) * | 2016-12-07 | 2021-07-13 | 南京农业大学 | KIAA1462 gene promoter region variant site and application thereof in improving egg laying performance of geese |
PL3554681T3 (en) * | 2016-12-16 | 2022-05-16 | The Brigham And Women's Hospital, Inc. | Method for protein corona sensor array for early detection of diseases |
US20210072255A1 (en) | 2016-12-16 | 2021-03-11 | The Brigham And Women's Hospital, Inc. | System and method for protein corona sensor array for early detection of diseases |
CN106636296A (en) * | 2016-12-22 | 2017-05-10 | 广州医科大学附属肿瘤医院 | Application of Hsp27 in tolerance diagnosis and treatment for tongue cancer chemotherapy |
CN106501517B (en) * | 2016-12-27 | 2018-05-08 | 北京蛋白质组研究中心 | Detect application of the material of SPARC protein in serum in examination hepatocellular carcinoma kit is prepared |
CN106939340A (en) * | 2017-03-31 | 2017-07-11 | 哈尔滨医科大学 | A kind of molecular marked compound related to adenocarcinoma of lung transfer and prognosis and its application |
CN106947820B (en) * | 2017-04-11 | 2020-09-29 | 成都望路医药技术有限公司 | Application of VCAN in diagnosis and treatment of colon adenocarcinoma |
AU2018265421B2 (en) * | 2017-05-12 | 2024-03-07 | The Regents Of The University Of Michigan | Individual and cohort pharmacological phenotype prediction platform |
CN106987649A (en) * | 2017-05-31 | 2017-07-28 | 上海博慷生物科技有限公司 | A kind of primer sets and detection method for being used to detect glioma |
CN109085355A (en) * | 2017-06-13 | 2018-12-25 | 中国医学科学院肿瘤医院 | Serum protein markers combine the application in screening lung cancer and diagnosis and treatment |
CN107273718A (en) * | 2017-06-27 | 2017-10-20 | 电子科技大学 | A kind of Analysis of Survival Time method of fusion dna methylation characteristic |
JP7029719B2 (en) * | 2017-08-31 | 2022-03-04 | 静岡県 | Biomarker |
CN107630092B (en) * | 2017-10-23 | 2020-03-31 | 广州医科大学附属第二医院 | Application of miR-505-3p in diagnosis, prognosis and treatment of bone metastasis of prostate cancer |
US11971414B2 (en) * | 2017-12-22 | 2024-04-30 | Wisconsin Alumni Research Foundation | Nanoengineered surfaces for cancer biomarker capture |
CN107868829B (en) * | 2017-12-26 | 2021-05-18 | 浙江自贸区锐赛生物医药科技有限公司 | Combined reagent and kit for evaluating postoperative recurrence risk of chordoma and application of combined reagent and kit |
CN107937621A (en) * | 2018-01-12 | 2018-04-20 | 南方医科大学皮肤病医院(广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心) | The application of miRNA, product and detection method using it |
CN108192970A (en) * | 2018-01-24 | 2018-06-22 | 苏州大学 | A kind of diagnosing cancer of liver marker and its application |
CN108048460B (en) * | 2018-02-01 | 2021-04-09 | 浙江大学 | Novel molecular marker and application thereof in preparation of kit for head and neck cancer diagnosis and prognosis |
US11976332B2 (en) | 2018-02-14 | 2024-05-07 | Dermtech, Inc. | Gene classifiers and uses thereof in non-melanoma skin cancers |
EP3776381A4 (en) * | 2018-04-13 | 2022-01-05 | Freenome Holdings, Inc. | Machine learning implementation for multi-analyte assay of biological samples |
FR3080185A1 (en) * | 2018-04-16 | 2019-10-18 | Biomerieux | EVALUATION OF THE RISK OF COMPLICATION IN A PATIENT SUSPECTED TO HAVE AN INFECTION HAVING A SOFA SCORE LESS THAN TWO |
CN108559778B (en) * | 2018-04-28 | 2020-06-12 | 北京师范大学 | Multiple myeloma molecular typing and application thereof in medication guidance |
CN108570501B (en) * | 2018-04-28 | 2020-06-12 | 北京师范大学 | Multiple myeloma molecular typing and application |
CN108586579B (en) * | 2018-05-11 | 2021-11-30 | 京东方科技集团股份有限公司 | Quasi-peptide, derivative, salt, preparation method and application thereof |
CN113855675A (en) * | 2018-05-22 | 2021-12-31 | 郑州大学第一附属医院 | Kit and medicine based on gallbladder cancer marker |
CN108841962B (en) * | 2018-08-01 | 2021-11-19 | 博奥生物集团有限公司 | Non-small cell lung cancer detection kit and application thereof |
KR102094608B1 (en) * | 2018-08-08 | 2020-04-23 | 고려대학교 산학협력단 | Method for Providing Information on Classification and Prognosis of Hematologic Malignancy |
JP7378739B2 (en) | 2018-08-10 | 2023-11-14 | 東レ株式会社 | Kits, devices and methods for the detection of prostate cancer |
CN109321656B (en) * | 2018-10-22 | 2021-10-01 | 上海交通大学医学院附属仁济医院 | Use of protein DEPDC1 as marker for diagnosing triple-negative breast cancer |
WO2020091044A1 (en) * | 2018-11-01 | 2020-05-07 | 花王株式会社 | Method for preparing nucleic acid derived from skin cell of subject |
CN109507425A (en) * | 2018-11-07 | 2019-03-22 | 国家纳米科学中心 | Carcinoma of prostate based on the extracellular vesica of thermophoresis recurs monitoring system and method |
EP3877400A4 (en) | 2018-11-07 | 2022-09-07 | Seer, Inc. | Compositions, methods and systems for protein corona analysis and uses thereof |
WO2020104588A1 (en) * | 2018-11-22 | 2020-05-28 | Institut D'investigació Sanitària Pere Virgili | Biomarkers of prostate cancer aggressiveness |
CN109609630B (en) * | 2018-12-03 | 2023-01-13 | 哈尔滨医科大学 | Molecular marker for early gastric cancer diagnosis and application thereof |
CN109439757A (en) * | 2018-12-18 | 2019-03-08 | 首都医科大学附属北京佑安医院 | Application of the blood plasma excretion body miR-455-3p as early liver cancer diagnosis marker |
CN109652504B (en) * | 2018-12-27 | 2021-03-16 | 杭州迪相实业有限公司 | Method for simultaneously detecting exosome membrane protein and mRNA |
WO2020140927A1 (en) * | 2019-01-02 | 2020-07-09 | Crownmab Biotech Inc. | Cancer treatment using multi-targeted kinase inhibitor in combination of protein kinase biomarkers |
CN109609653B (en) * | 2019-02-12 | 2019-07-19 | 山东大学齐鲁医院 | The molecular marked compound and its application of diagnosis or treatment glioma |
EP3699300A1 (en) * | 2019-02-22 | 2020-08-26 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Seminal mirnas as non-invasive biomarkers for the diagnosis and/or prognosis of prostate cancer |
US11578373B2 (en) | 2019-03-26 | 2023-02-14 | Dermtech, Inc. | Gene classifiers and uses thereof in skin cancers |
CN110196329A (en) * | 2019-05-31 | 2019-09-03 | 郑州大学第一附属医院 | A kind of cancer of the esophagus early stage combined detection kit |
JP7562523B2 (en) | 2019-06-27 | 2024-10-07 | 大塚製薬株式会社 | Exosome measurement method and exosome measurement kit |
CN110279707A (en) * | 2019-07-05 | 2019-09-27 | 深圳市康宁医院(深圳市精神卫生研究所深圳市精神卫生中心) | MiR-212 is preparing the application in the drug for treating habituation |
EP3999096A1 (en) * | 2019-07-19 | 2022-05-25 | Universiteit Antwerpen | Mucin isoforms in diseases characterized by barrier dysfunction |
KR102346864B1 (en) * | 2019-07-24 | 2022-01-04 | 한국전자기술연구원 | Biomarker composition for diagnosing or prognostic analysis of bladder cancer, kit comprising the same and method for diagnosing bladder cancer using the same |
CA3146525A1 (en) | 2019-08-05 | 2021-02-11 | William Manning | Systems and methods for sample preparation, data generation, and protein corona analysis |
CN110295228A (en) * | 2019-08-05 | 2019-10-01 | 中国人民解放军总医院第八医学中心 | Detect application of the substance of GATA2 in preparation diagnostic activities kit lungy |
CN110551809A (en) * | 2019-08-21 | 2019-12-10 | 昆明医科大学第一附属医院 | Application of miR-124 in spinal cord injury repair |
CN110564867B (en) * | 2019-10-10 | 2022-06-24 | 扬州大学 | SNP molecular marker of Qinchuan cattle CFL1 gene and detection method thereof |
CN110643672A (en) * | 2019-10-15 | 2020-01-03 | 西安交通大学 | Medical application of high-expression TrkB as novel target point in inhibiting pancreatic cancer metastasis |
CN115244149B (en) * | 2019-12-27 | 2023-09-15 | 关西涂料株式会社 | Paint manufacturing method, color data prediction method and computer color matching system |
US20230142955A1 (en) * | 2020-02-27 | 2023-05-11 | The Trustees Of The University Of Pennsylvania | Methods of using a multi-analyte approach for diagnosis and staging a disease |
CN111647658B (en) * | 2020-06-05 | 2022-09-27 | 上海市第一人民医院 | Application of LINC00963 related oncogenic axis in early diagnosis and treatment of prostate cancer distant metastasis |
CN111690746A (en) * | 2020-06-30 | 2020-09-22 | 镇江维思生物科技有限责任公司 | Platelet RNA marker related to lung cancer and application thereof |
CN113940999B (en) * | 2020-07-15 | 2022-11-29 | 中国农业大学 | Application of target point for treating non-alcoholic fatty liver disease |
WO2022054976A1 (en) * | 2020-09-08 | 2022-03-17 | (주)유로테크 | Method for calculating prostate cancer diagnostic score, and uses thereof |
CN112180100A (en) * | 2020-09-27 | 2021-01-05 | 西安交通大学 | Application of TWEAK as molecular marker for identifying different types of psoriasis |
CN112255408B (en) * | 2020-10-16 | 2023-04-14 | 牡丹江医学院 | Tumor biomarker and tumor detection kit |
CN112285195B (en) * | 2020-10-27 | 2021-08-10 | 江南大学 | Characteristic glycoprotein marker of milk exosome and characteristic marker separation method of milk exosome |
CN112433053A (en) * | 2020-11-20 | 2021-03-02 | 四川大学华西医院 | Application of Tetraspin-14 protein detection reagent in preparation of lung cancer screening kit |
CN112301133B (en) * | 2020-12-01 | 2021-07-27 | 江门市中心医院 | Application of cholesterol generation gene label in prognosis prediction of young breast cancer patient |
KR102427057B1 (en) * | 2020-12-04 | 2022-07-29 | 전남대학교산학협력단 | Biomaker for metastasis prediction or prognosis analysis of Solitary fibrous tumor/hemangiopericytoma and diagnosis method using there of |
EP4269613A1 (en) | 2020-12-24 | 2023-11-01 | Pontificia Universidad Católica De Chile | In-vitro method for diagnosing and predicting the aggressiveness of thyroid cancer, and the precision surgery options and type to be used to remove a tumour from a patient; kit; reagents forming the kit; and use of the reagents and use of molecular markers as part of the method |
CN113151460B (en) * | 2021-01-29 | 2022-10-18 | 复旦大学附属中山医院 | Gene marker for identifying lung adenocarcinoma tumor cells and application thereof |
CN115166245A (en) * | 2021-04-04 | 2022-10-11 | 兰州大学第一医院 | Application of CLU (CLU) and composition thereof in diagnosis of bile duct cancer and bile duct cancer diagnosis kit |
KR102540416B1 (en) * | 2021-04-09 | 2023-06-12 | 주식회사 애티스랩 | Composition or kit for diagnosing cancer and method for diagnosis cancer |
CN113125757B (en) * | 2021-04-22 | 2022-10-28 | 石河子大学 | Protein biomarker for early pregnancy diagnosis of sows and method for detecting early pregnancy of sows by using protein biomarker |
CN113122544A (en) * | 2021-04-25 | 2021-07-16 | 杭州广科安德生物科技有限公司 | Aptamer specifically binding with TIMP1 protein and application thereof |
CN113311166B (en) * | 2021-04-28 | 2022-10-28 | 新疆农垦科学院 | Protein biomarker for diagnosing early pregnancy of sheep and method for detecting early pregnancy of sheep |
CN113186267A (en) * | 2021-06-07 | 2021-07-30 | 上海康黎诊断技术有限公司 | Primer-probe combination, kit and method for detecting human CYP2D6 copy number variation and genotyping |
CN113687076B (en) * | 2021-07-14 | 2024-03-01 | 郑州大学 | Combined detection serum marker for early diagnosis of lung adenocarcinoma and application thereof |
GB202111635D0 (en) * | 2021-08-13 | 2021-09-29 | Randox Laboratories | Risk prediction model for prostate cancer |
JPWO2023054436A1 (en) * | 2021-09-29 | 2023-04-06 | ||
WO2023064883A1 (en) * | 2021-10-14 | 2023-04-20 | The University Of Chicago | Immunotherapeutic methods for treating cancer |
WO2023140658A1 (en) * | 2022-01-24 | 2023-07-27 | 고려대학교 산학협력단 | Pharmaceutical composition for diagnosing, preventing or treating sepsis by using brain-derived neurotrophic factor |
AU2022445159A1 (en) * | 2022-03-10 | 2024-09-26 | Buzzard Pharmaceuticals AB | Inhibitor of interleukin-1 receptor type 1 for use in the treatment of cancer |
WO2024050856A1 (en) * | 2022-09-06 | 2024-03-14 | 南京市第一医院 | Method and system for assisting blood cell analyzer in determining abnormal platelet aggregation |
KR20240058548A (en) * | 2022-10-26 | 2024-05-07 | 연세대학교 산학협력단 | Extracellular vesicles-derived miRNA gene biomarkders for diagnosis or prediction of recurrence of breast cancer and use thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008092153A2 (en) * | 2007-01-26 | 2008-07-31 | University Of Louisville Research Foundation, Inc. | Modification of exosomal components for use as a vaccine |
WO2009015357A1 (en) * | 2007-07-25 | 2009-01-29 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
WO2010056337A2 (en) * | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
WO2011127219A1 (en) * | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3316600A (en) * | 1999-02-22 | 2000-09-21 | Torben F. Orntoft | Gene expression in bladder tumors |
EP1697497A4 (en) * | 2003-11-03 | 2008-04-23 | Gene News Inc | Liver cancer biomarkers |
WO2007006408A2 (en) * | 2005-07-08 | 2007-01-18 | Bayer Healthcare Ag | Methods and kits for predicting and monitoring direct response to cancer therapy |
US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
US20100248225A1 (en) * | 2006-11-06 | 2010-09-30 | Bankaitis-Davis Danute M | Gene expression profiling for identification, monitoring and treatment of melanoma |
WO2009065230A1 (en) * | 2007-11-23 | 2009-05-28 | British Columbia Cancer Agency Branch | Methods for detecting lung cancer and monitoring treatment response |
US8617806B2 (en) * | 2008-01-25 | 2013-12-31 | Hansabiomed Ou | Method to measure and characterize microvesicles in the human body fluids |
US20110177054A1 (en) * | 2008-06-06 | 2011-07-21 | Derrick Gibbings | Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna |
JP2012507300A (en) * | 2008-10-30 | 2012-03-29 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | Method for evaluating RNA patterns |
GB0822836D0 (en) * | 2008-12-15 | 2009-01-21 | Oxford Biomedica Ltd | Method |
EP2475989A4 (en) * | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | Use of microvesicles in analyzing kras mutations |
US20110166030A1 (en) * | 2009-09-30 | 2011-07-07 | Yixin Wang | Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells |
US20130203061A1 (en) * | 2009-11-30 | 2013-08-08 | Michael KLASS | Methods and systems for isolating, storing, and analyzing vesicles |
-
2012
- 2012-08-08 CN CN201280049340.2A patent/CN103874770A/en active Pending
- 2012-08-08 AU AU2012294458A patent/AU2012294458A1/en not_active Abandoned
- 2012-08-08 JP JP2014525128A patent/JP2014522993A/en active Pending
- 2012-08-08 CA CA2844671A patent/CA2844671A1/en not_active Abandoned
- 2012-08-08 BR BR112014002975A patent/BR112014002975A2/en not_active IP Right Cessation
- 2012-08-08 EP EP12821745.2A patent/EP2742154A4/en not_active Withdrawn
- 2012-08-08 KR KR1020147004204A patent/KR20140067001A/en not_active Application Discontinuation
- 2012-08-08 WO PCT/US2012/050030 patent/WO2013022995A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008092153A2 (en) * | 2007-01-26 | 2008-07-31 | University Of Louisville Research Foundation, Inc. | Modification of exosomal components for use as a vaccine |
WO2009015357A1 (en) * | 2007-07-25 | 2009-01-29 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
WO2010056337A2 (en) * | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
WO2011127219A1 (en) * | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
Non-Patent Citations (3)
Title |
---|
T. DENG ET AL: "Abstract 444: Subpopulations of circulating microvesicles have different microRNA profiles", CANCER RESEARCH, vol. 71, no. 8 Supplement, 15 April 2011 (2011-04-15), pages 444 - 444, XP055168378, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2011-444 * |
TA DENG ET AL: "Subpopulations of Circulating Microvesicles Have Different MicroRNA Profiles", 7 April 2011 (2011-04-07), XP055168385, Retrieved from the Internet <URL:http://www.carislifesciences.com/media/pdf/Spetzler-sorted-MiRs-AACR-poster-2011.pdf> [retrieved on 20150209] * |
TRACI PAWLOWSKI ET AL: "Circulating exosomes may provide an alternate platform to monitor disease progression compared to circulating tumor cells CD-81 Labeled Exosome Level vs CTCs in Plasma Derived Exosomes miR-21 Copy Number vs CTCs in EpCAM+ Plasma Derived Exosomes", 5 July 2010 (2010-07-05), XP055168408, Retrieved from the Internet <URL:http://www.carislifesciences.com/media/pdf/ASCO_Pawlowski2010.pdf> [retrieved on 20150209] * |
Also Published As
Publication number | Publication date |
---|---|
BR112014002975A2 (en) | 2017-03-01 |
JP2014522993A (en) | 2014-09-08 |
AU2012294458A1 (en) | 2014-02-27 |
WO2013022995A2 (en) | 2013-02-14 |
WO2013022995A3 (en) | 2013-04-04 |
EP2742154A2 (en) | 2014-06-18 |
KR20140067001A (en) | 2014-06-03 |
CA2844671A1 (en) | 2013-02-14 |
CN103874770A (en) | 2014-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUS2100012I1 (en) | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk-inhibitors | |
EP2742154A4 (en) | Biomarker compositions and methods | |
EP2721179A4 (en) | Biomarker compositions and methods | |
EP2922861A4 (en) | Biomarker compositions and methods | |
EP2823306A4 (en) | Biomarker compositions and methods | |
SI2791160T1 (en) | Modified mrna compositions | |
HK1202625A1 (en) | Compositions and methods for assessing appendicitis | |
ZA201408594B (en) | Xylitol-based anti-mucosal compositions and related methods and compositions | |
GB201122195D0 (en) | Composition and method | |
GB201408236D0 (en) | Composition and method | |
EP2672822A4 (en) | Methods and compositions for improving cognitive function | |
GB201411762D0 (en) | Precoating methods and compositions | |
ZA201308892B (en) | Compositions and methods | |
EP2734646A4 (en) | Compositions and methods for selecting aptamers | |
EP2667710A4 (en) | Insescticidal composition and processes related thereto | |
GB201106433D0 (en) | Composition and method | |
EP2766357A4 (en) | Meso-biliverdin compositions and methods | |
IL227384A0 (en) | Metal-passivating cmp compositions and methods | |
IL239426A0 (en) | Biomarker methods and compositions | |
HK1203232A1 (en) | Biomarker and use thereof | |
IL231798A0 (en) | Method and composition | |
IL230868A0 (en) | Biomarker compositions and methods | |
GB201116340D0 (en) | Compositions and methods | |
GB201117620D0 (en) | Method and composition | |
GB201116421D0 (en) | Composition and method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20140226 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: CARIS LIFE SCIENCES SWITZERLAND HOLDINGS GMBH |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/50 20060101ALI20150217BHEP Ipc: G01N 33/68 20060101ALI20150217BHEP Ipc: G01N 33/53 20060101ALI20150217BHEP Ipc: G01N 33/566 20060101ALI20150217BHEP Ipc: C12Q 1/68 20060101AFI20150217BHEP Ipc: G01N 33/574 20060101ALI20150217BHEP |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: BROWN, KIRK Inventor name: SPETZLER, DAVID Inventor name: PAWLOWSKI, TRACI |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: PAWLOWSKI, TRACI Inventor name: BROWN, KIRK Inventor name: SPETZLER, DAVID |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20150713 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/50 20060101ALI20150707BHEP Ipc: G01N 33/53 20060101ALI20150707BHEP Ipc: G01N 33/574 20060101ALI20150707BHEP Ipc: G01N 33/566 20060101ALI20150707BHEP Ipc: C12Q 1/68 20060101AFI20150707BHEP Ipc: G01N 33/68 20060101ALI20150707BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20170516 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20170927 |