EP2742154A4 - Biomarker compositions and methods - Google Patents

Biomarker compositions and methods

Info

Publication number
EP2742154A4
EP2742154A4 EP12821745.2A EP12821745A EP2742154A4 EP 2742154 A4 EP2742154 A4 EP 2742154A4 EP 12821745 A EP12821745 A EP 12821745A EP 2742154 A4 EP2742154 A4 EP 2742154A4
Authority
EP
European Patent Office
Prior art keywords
methods
biomarker compositions
biomarker
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12821745.2A
Other languages
German (de)
French (fr)
Other versions
EP2742154A2 (en
Inventor
Kirk Brown
Traci Pawlowski
David Spetzler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caris Life Sciences Switzerland Holdings GmbH
Original Assignee
Caris Life Sciences Switzerland Holdings GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caris Life Sciences Switzerland Holdings GmbH filed Critical Caris Life Sciences Switzerland Holdings GmbH
Publication of EP2742154A2 publication Critical patent/EP2742154A2/en
Publication of EP2742154A4 publication Critical patent/EP2742154A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57434Specifically defined cancers of prostate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
EP12821745.2A 2011-08-08 2012-08-08 Biomarker compositions and methods Withdrawn EP2742154A4 (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201161521333P 2011-08-08 2011-08-08
US201161523763P 2011-08-15 2011-08-15
US201161526623P 2011-08-23 2011-08-23
US201161529762P 2011-08-31 2011-08-31
US201161534352P 2011-09-13 2011-09-13
US201161537462P 2011-09-21 2011-09-21
US201161542639P 2011-10-03 2011-10-03
US201161551674P 2011-10-26 2011-10-26
US201161559676P 2011-11-14 2011-11-14
US201261612111P 2012-03-16 2012-03-16
US201261619803P 2012-04-03 2012-04-03
PCT/US2012/050030 WO2013022995A2 (en) 2011-08-08 2012-08-08 Biomarker compositions and methods

Publications (2)

Publication Number Publication Date
EP2742154A2 EP2742154A2 (en) 2014-06-18
EP2742154A4 true EP2742154A4 (en) 2015-08-12

Family

ID=47669214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12821745.2A Withdrawn EP2742154A4 (en) 2011-08-08 2012-08-08 Biomarker compositions and methods

Country Status (8)

Country Link
EP (1) EP2742154A4 (en)
JP (1) JP2014522993A (en)
KR (1) KR20140067001A (en)
CN (1) CN103874770A (en)
AU (1) AU2012294458A1 (en)
BR (1) BR112014002975A2 (en)
CA (1) CA2844671A1 (en)
WO (1) WO2013022995A2 (en)

Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009246180B2 (en) 2008-05-14 2015-11-05 Dermtech International Diagnosis of melanoma and solar lentigo by nucleic acid analysis
AU2011223789A1 (en) 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
NZ703411A (en) 2012-06-27 2017-09-29 Berg Llc Use of markers in the diagnosis and treatment of prostate cancer
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
CN103160509B (en) * 2013-03-07 2015-02-18 新乡医学院第一附属医院 miRNA marker relative to esophagus cancer postoperative early relapse and prognosis and application
EP2971162B1 (en) 2013-03-15 2019-05-08 Board Of Regents, The University Of Texas System Mirna biogenesis in exosomes for diagnosis and therapy
CN104076151B (en) * 2013-03-29 2017-04-12 复旦大学附属华山医院 Kit for early diagnosis of glioma
EP2992330B1 (en) * 2013-04-29 2018-04-18 Apogenix AG Method of diagnosing cancer
EP2994545B1 (en) * 2013-05-10 2019-03-20 University Of Southern California Dna methylation biomarkers for bladder cancer
EP3030675B1 (en) * 2013-08-06 2018-10-03 Exosome Diagnostics Inc. Urine biomarker cohorts, gene expression signatures, and methods of use thereof
WO2015031694A2 (en) * 2013-08-28 2015-03-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2015031604A1 (en) * 2013-08-28 2015-03-05 Crown Bioscience, Inc. Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same
US10139402B2 (en) 2013-11-06 2018-11-27 Jsr Corporation Separation method, detection method, signal measurement method, method for determining disease, method for evaluating drug efficacy of disease treatment drug, kit, and liquid composition
FR3014198B1 (en) * 2013-12-03 2017-03-03 Biomerieux Sa METHOD FOR ISOLATING EXOSOMES
EP3078889B1 (en) * 2013-12-06 2019-09-18 The University of Tokyo Valve, fluid-controlling structure, fluid device, and method for manufacturing valve
JP2017509351A (en) * 2013-12-30 2017-04-06 ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド Prostate cancer gene profile and method of use thereof
WO2015101988A1 (en) 2013-12-31 2015-07-09 Yeda Research And Development Co. Ltd. Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
WO2015117164A1 (en) * 2014-02-03 2015-08-06 Memorial Sloan-Kettering Cancer Center Tumor-associated macrophages and methods and compositions for targeting cancer therapy and identifying potential responders
EP3137909B1 (en) 2014-04-29 2018-06-06 Apogenix AG Diagnostic anti-cd95l antibody
EP3137626B1 (en) * 2014-05-01 2020-12-02 Stichting VUmc Small ncrnas as biomarkers
ES2481819B1 (en) * 2014-06-12 2015-04-01 Sistemas Genómicos, S.L. ASSESSMENT METHOD TO EVALUATE A POSSIBILITY OF BREAST CANCER
RU2017100253A (en) 2014-06-12 2018-07-17 Торэй Индастриз, Инк. KIT OR DEVICE FOR DETECTING PROSTATE CANCER AND DETECTION METHOD
US20160038608A1 (en) * 2014-08-07 2016-02-11 National Taiwan University Silica-based mesoporous carrier and delivery method of using the same
US10670611B2 (en) * 2014-09-26 2020-06-02 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
KR101596166B1 (en) 2014-10-07 2016-02-19 가톨릭대학교 산학협력단 A Use of microRNA for Ddiagnosing and Treating Brest Cancer
CN104313171A (en) * 2014-11-06 2015-01-28 南京大学 MicroRNA molecular marker for diagnosing glioma and application of microRNA molecular marker
AU2015360694B2 (en) * 2014-12-08 2021-10-14 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
CN105807063B (en) * 2014-12-29 2018-02-06 中国人民解放军第二军医大学 Applications of the CD63 in preparing diagnosis for liver disease kit or preparing prevention or treatment liver diseases medicine
CN104548134A (en) * 2015-01-04 2015-04-29 中国人民解放军第二军医大学 Application of miR-144 and inhibitor thereof
US20180148783A1 (en) * 2015-01-05 2018-05-31 The Johns Hopkins University Method of epigenetic analysis for determining clinical genetic risk
WO2016121821A1 (en) * 2015-01-27 2016-08-04 Jsr株式会社 Separation method, detection method, signal measurement method, method for determining disease, method for evaluating drug efficacy, kit, liquid composition, and analyte diluent
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
IL303543A (en) 2015-02-18 2023-08-01 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
WO2016139659A1 (en) 2015-03-01 2016-09-09 Immunarray Ltd. Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
CA2979361A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Method of preparing oligonucleotide libraries
CN104714032B (en) * 2015-04-02 2015-09-16 闫星宇 For mark and the detection reagent thereof of postpartum eclampsia diagnosis
JP6803339B2 (en) 2015-04-21 2020-12-23 エンリヴェックス セラピューティクス リミテッド Therapeutic pooled blood apoptotic cell preparations and their use
WO2016186215A1 (en) * 2015-05-20 2016-11-24 Jsr株式会社 Separation method, detection method, signal measurement method, disease determination method, drug efficacy assessment method, kit, liquid composition, and specimen diluent
EP3307890A1 (en) 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Use of exosomes for the treatment of disease
CN104992058B (en) * 2015-06-25 2017-08-01 成都厚立信息技术有限公司 Disease risks adjust method for establishing model
EP3314027A4 (en) 2015-06-29 2019-07-03 Caris Science, Inc. Therapeutic oligonucleotides
CN105177117A (en) * 2015-07-03 2015-12-23 张理义 Major depressive disorder biomarker, screening method and kit
CN106350578A (en) * 2015-07-13 2017-01-25 中国人民解放军第二军医大学 Application of NY-ESO-1 in diagnosis and treatment of microsatellite instability intestinal cancer
WO2017019918A1 (en) 2015-07-28 2017-02-02 Caris Science, Inc. Targeted oligonucleotides
CN105039342B (en) * 2015-08-06 2017-12-01 李家平 SiRNA and its application of MAT2A gene expressions can be suppressed
WO2017025954A1 (en) * 2015-08-09 2017-02-16 Immunarray Ltd Methods for determining the risk of a systemic lupus erythematosus (sle) patient to develop neuropsychiatric syndromes
CN105067822B (en) * 2015-08-12 2017-05-24 中山大学附属肿瘤医院 Marker for diagnosing esophagus cancer
JP6583817B2 (en) * 2015-09-04 2019-10-02 国立大学法人山口大学 Diagnostic markers for tumors in uterine smooth muscle
KR102078310B1 (en) * 2015-09-11 2020-02-19 주식회사 압타머사이언스 Protein biomarker panel for diagnosing non-small cell lung cancer and method for diagnosing non-small cell lung cancer using the same
KR20180063127A (en) 2015-09-17 2018-06-11 암젠 인크 Prediction of Clinical Response to IL23-Antagonists Using IL23 Pathway Biomarkers
EP3165926A1 (en) * 2015-11-06 2017-05-10 Humanitas Mirasole S.p.A. Method for characterization of cell specific microvesicles
US11230735B2 (en) 2015-12-24 2022-01-25 Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for characterizing sepsis
WO2017113565A1 (en) * 2015-12-29 2017-07-06 中国医学科学院肿瘤医院 Kit for auxiliary diagnosis of patient with liver cancer or digestive tract cancer based on protein marker psg3
KR20180110141A (en) 2016-02-18 2018-10-08 엔리벡스 테라퓨틱스 리미티드 Combination of immunotherapy and cytokine regulating therapy to treat cancer
IL303936A (en) 2016-03-18 2023-08-01 Caris Science Inc Oligonucleotide probes and uses thereof
CN105842461A (en) * 2016-04-30 2016-08-10 广州恒泰生物科技有限公司 Rapid diagnostic kit for uterine sarcoma in early and middle stages and preparation method of kit
US11293017B2 (en) 2016-05-25 2022-04-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
CN107475356A (en) * 2016-06-08 2017-12-15 益善生物技术股份有限公司 Osteosarcoma circulating tumor cell identification kit
CN105907875A (en) * 2016-06-13 2016-08-31 武汉泰安康生物科技有限公司 Method for screening kidney cancer peripheral blood miRNA marker and kidney cancer marker miR-378
JP6980219B2 (en) * 2016-08-22 2021-12-15 いであ株式会社 How to detect cancer or determine the stage of cancer staging
EP3541958A1 (en) * 2016-11-15 2019-09-25 Ventana Medical Systems, Inc. Compositions and methods for prognosing and treating colorectal cancer
CN108165635B (en) * 2016-12-07 2021-07-13 南京农业大学 KIAA1462 gene promoter region variant site and application thereof in improving egg laying performance of geese
PL3554681T3 (en) * 2016-12-16 2022-05-16 The Brigham And Women's Hospital, Inc. Method for protein corona sensor array for early detection of diseases
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
CN106636296A (en) * 2016-12-22 2017-05-10 广州医科大学附属肿瘤医院 Application of Hsp27 in tolerance diagnosis and treatment for tongue cancer chemotherapy
CN106501517B (en) * 2016-12-27 2018-05-08 北京蛋白质组研究中心 Detect application of the material of SPARC protein in serum in examination hepatocellular carcinoma kit is prepared
CN106939340A (en) * 2017-03-31 2017-07-11 哈尔滨医科大学 A kind of molecular marked compound related to adenocarcinoma of lung transfer and prognosis and its application
CN106947820B (en) * 2017-04-11 2020-09-29 成都望路医药技术有限公司 Application of VCAN in diagnosis and treatment of colon adenocarcinoma
AU2018265421B2 (en) * 2017-05-12 2024-03-07 The Regents Of The University Of Michigan Individual and cohort pharmacological phenotype prediction platform
CN106987649A (en) * 2017-05-31 2017-07-28 上海博慷生物科技有限公司 A kind of primer sets and detection method for being used to detect glioma
CN109085355A (en) * 2017-06-13 2018-12-25 中国医学科学院肿瘤医院 Serum protein markers combine the application in screening lung cancer and diagnosis and treatment
CN107273718A (en) * 2017-06-27 2017-10-20 电子科技大学 A kind of Analysis of Survival Time method of fusion dna methylation characteristic
JP7029719B2 (en) * 2017-08-31 2022-03-04 静岡県 Biomarker
CN107630092B (en) * 2017-10-23 2020-03-31 广州医科大学附属第二医院 Application of miR-505-3p in diagnosis, prognosis and treatment of bone metastasis of prostate cancer
US11971414B2 (en) * 2017-12-22 2024-04-30 Wisconsin Alumni Research Foundation Nanoengineered surfaces for cancer biomarker capture
CN107868829B (en) * 2017-12-26 2021-05-18 浙江自贸区锐赛生物医药科技有限公司 Combined reagent and kit for evaluating postoperative recurrence risk of chordoma and application of combined reagent and kit
CN107937621A (en) * 2018-01-12 2018-04-20 南方医科大学皮肤病医院(广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心) The application of miRNA, product and detection method using it
CN108192970A (en) * 2018-01-24 2018-06-22 苏州大学 A kind of diagnosing cancer of liver marker and its application
CN108048460B (en) * 2018-02-01 2021-04-09 浙江大学 Novel molecular marker and application thereof in preparation of kit for head and neck cancer diagnosis and prognosis
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
EP3776381A4 (en) * 2018-04-13 2022-01-05 Freenome Holdings, Inc. Machine learning implementation for multi-analyte assay of biological samples
FR3080185A1 (en) * 2018-04-16 2019-10-18 Biomerieux EVALUATION OF THE RISK OF COMPLICATION IN A PATIENT SUSPECTED TO HAVE AN INFECTION HAVING A SOFA SCORE LESS THAN TWO
CN108559778B (en) * 2018-04-28 2020-06-12 北京师范大学 Multiple myeloma molecular typing and application thereof in medication guidance
CN108570501B (en) * 2018-04-28 2020-06-12 北京师范大学 Multiple myeloma molecular typing and application
CN108586579B (en) * 2018-05-11 2021-11-30 京东方科技集团股份有限公司 Quasi-peptide, derivative, salt, preparation method and application thereof
CN113855675A (en) * 2018-05-22 2021-12-31 郑州大学第一附属医院 Kit and medicine based on gallbladder cancer marker
CN108841962B (en) * 2018-08-01 2021-11-19 博奥生物集团有限公司 Non-small cell lung cancer detection kit and application thereof
KR102094608B1 (en) * 2018-08-08 2020-04-23 고려대학교 산학협력단 Method for Providing Information on Classification and Prognosis of Hematologic Malignancy
JP7378739B2 (en) 2018-08-10 2023-11-14 東レ株式会社 Kits, devices and methods for the detection of prostate cancer
CN109321656B (en) * 2018-10-22 2021-10-01 上海交通大学医学院附属仁济医院 Use of protein DEPDC1 as marker for diagnosing triple-negative breast cancer
WO2020091044A1 (en) * 2018-11-01 2020-05-07 花王株式会社 Method for preparing nucleic acid derived from skin cell of subject
CN109507425A (en) * 2018-11-07 2019-03-22 国家纳米科学中心 Carcinoma of prostate based on the extracellular vesica of thermophoresis recurs monitoring system and method
EP3877400A4 (en) 2018-11-07 2022-09-07 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof
WO2020104588A1 (en) * 2018-11-22 2020-05-28 Institut D'investigació Sanitària Pere Virgili Biomarkers of prostate cancer aggressiveness
CN109609630B (en) * 2018-12-03 2023-01-13 哈尔滨医科大学 Molecular marker for early gastric cancer diagnosis and application thereof
CN109439757A (en) * 2018-12-18 2019-03-08 首都医科大学附属北京佑安医院 Application of the blood plasma excretion body miR-455-3p as early liver cancer diagnosis marker
CN109652504B (en) * 2018-12-27 2021-03-16 杭州迪相实业有限公司 Method for simultaneously detecting exosome membrane protein and mRNA
WO2020140927A1 (en) * 2019-01-02 2020-07-09 Crownmab Biotech Inc. Cancer treatment using multi-targeted kinase inhibitor in combination of protein kinase biomarkers
CN109609653B (en) * 2019-02-12 2019-07-19 山东大学齐鲁医院 The molecular marked compound and its application of diagnosis or treatment glioma
EP3699300A1 (en) * 2019-02-22 2020-08-26 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Seminal mirnas as non-invasive biomarkers for the diagnosis and/or prognosis of prostate cancer
US11578373B2 (en) 2019-03-26 2023-02-14 Dermtech, Inc. Gene classifiers and uses thereof in skin cancers
CN110196329A (en) * 2019-05-31 2019-09-03 郑州大学第一附属医院 A kind of cancer of the esophagus early stage combined detection kit
JP7562523B2 (en) 2019-06-27 2024-10-07 大塚製薬株式会社 Exosome measurement method and exosome measurement kit
CN110279707A (en) * 2019-07-05 2019-09-27 深圳市康宁医院(深圳市精神卫生研究所深圳市精神卫生中心) MiR-212 is preparing the application in the drug for treating habituation
EP3999096A1 (en) * 2019-07-19 2022-05-25 Universiteit Antwerpen Mucin isoforms in diseases characterized by barrier dysfunction
KR102346864B1 (en) * 2019-07-24 2022-01-04 한국전자기술연구원 Biomarker composition for diagnosing or prognostic analysis of bladder cancer, kit comprising the same and method for diagnosing bladder cancer using the same
CA3146525A1 (en) 2019-08-05 2021-02-11 William Manning Systems and methods for sample preparation, data generation, and protein corona analysis
CN110295228A (en) * 2019-08-05 2019-10-01 中国人民解放军总医院第八医学中心 Detect application of the substance of GATA2 in preparation diagnostic activities kit lungy
CN110551809A (en) * 2019-08-21 2019-12-10 昆明医科大学第一附属医院 Application of miR-124 in spinal cord injury repair
CN110564867B (en) * 2019-10-10 2022-06-24 扬州大学 SNP molecular marker of Qinchuan cattle CFL1 gene and detection method thereof
CN110643672A (en) * 2019-10-15 2020-01-03 西安交通大学 Medical application of high-expression TrkB as novel target point in inhibiting pancreatic cancer metastasis
CN115244149B (en) * 2019-12-27 2023-09-15 关西涂料株式会社 Paint manufacturing method, color data prediction method and computer color matching system
US20230142955A1 (en) * 2020-02-27 2023-05-11 The Trustees Of The University Of Pennsylvania Methods of using a multi-analyte approach for diagnosis and staging a disease
CN111647658B (en) * 2020-06-05 2022-09-27 上海市第一人民医院 Application of LINC00963 related oncogenic axis in early diagnosis and treatment of prostate cancer distant metastasis
CN111690746A (en) * 2020-06-30 2020-09-22 镇江维思生物科技有限责任公司 Platelet RNA marker related to lung cancer and application thereof
CN113940999B (en) * 2020-07-15 2022-11-29 中国农业大学 Application of target point for treating non-alcoholic fatty liver disease
WO2022054976A1 (en) * 2020-09-08 2022-03-17 (주)유로테크 Method for calculating prostate cancer diagnostic score, and uses thereof
CN112180100A (en) * 2020-09-27 2021-01-05 西安交通大学 Application of TWEAK as molecular marker for identifying different types of psoriasis
CN112255408B (en) * 2020-10-16 2023-04-14 牡丹江医学院 Tumor biomarker and tumor detection kit
CN112285195B (en) * 2020-10-27 2021-08-10 江南大学 Characteristic glycoprotein marker of milk exosome and characteristic marker separation method of milk exosome
CN112433053A (en) * 2020-11-20 2021-03-02 四川大学华西医院 Application of Tetraspin-14 protein detection reagent in preparation of lung cancer screening kit
CN112301133B (en) * 2020-12-01 2021-07-27 江门市中心医院 Application of cholesterol generation gene label in prognosis prediction of young breast cancer patient
KR102427057B1 (en) * 2020-12-04 2022-07-29 전남대학교산학협력단 Biomaker for metastasis prediction or prognosis analysis of Solitary fibrous tumor/hemangiopericytoma and diagnosis method using there of
EP4269613A1 (en) 2020-12-24 2023-11-01 Pontificia Universidad Católica De Chile In-vitro method for diagnosing and predicting the aggressiveness of thyroid cancer, and the precision surgery options and type to be used to remove a tumour from a patient; kit; reagents forming the kit; and use of the reagents and use of molecular markers as part of the method
CN113151460B (en) * 2021-01-29 2022-10-18 复旦大学附属中山医院 Gene marker for identifying lung adenocarcinoma tumor cells and application thereof
CN115166245A (en) * 2021-04-04 2022-10-11 兰州大学第一医院 Application of CLU (CLU) and composition thereof in diagnosis of bile duct cancer and bile duct cancer diagnosis kit
KR102540416B1 (en) * 2021-04-09 2023-06-12 주식회사 애티스랩 Composition or kit for diagnosing cancer and method for diagnosis cancer
CN113125757B (en) * 2021-04-22 2022-10-28 石河子大学 Protein biomarker for early pregnancy diagnosis of sows and method for detecting early pregnancy of sows by using protein biomarker
CN113122544A (en) * 2021-04-25 2021-07-16 杭州广科安德生物科技有限公司 Aptamer specifically binding with TIMP1 protein and application thereof
CN113311166B (en) * 2021-04-28 2022-10-28 新疆农垦科学院 Protein biomarker for diagnosing early pregnancy of sheep and method for detecting early pregnancy of sheep
CN113186267A (en) * 2021-06-07 2021-07-30 上海康黎诊断技术有限公司 Primer-probe combination, kit and method for detecting human CYP2D6 copy number variation and genotyping
CN113687076B (en) * 2021-07-14 2024-03-01 郑州大学 Combined detection serum marker for early diagnosis of lung adenocarcinoma and application thereof
GB202111635D0 (en) * 2021-08-13 2021-09-29 Randox Laboratories Risk prediction model for prostate cancer
JPWO2023054436A1 (en) * 2021-09-29 2023-04-06
WO2023064883A1 (en) * 2021-10-14 2023-04-20 The University Of Chicago Immunotherapeutic methods for treating cancer
WO2023140658A1 (en) * 2022-01-24 2023-07-27 고려대학교 산학협력단 Pharmaceutical composition for diagnosing, preventing or treating sepsis by using brain-derived neurotrophic factor
AU2022445159A1 (en) * 2022-03-10 2024-09-26 Buzzard Pharmaceuticals AB Inhibitor of interleukin-1 receptor type 1 for use in the treatment of cancer
WO2024050856A1 (en) * 2022-09-06 2024-03-14 南京市第一医院 Method and system for assisting blood cell analyzer in determining abnormal platelet aggregation
KR20240058548A (en) * 2022-10-26 2024-05-07 연세대학교 산학협력단 Extracellular vesicles-derived miRNA gene biomarkders for diagnosis or prediction of recurrence of breast cancer and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008092153A2 (en) * 2007-01-26 2008-07-31 University Of Louisville Research Foundation, Inc. Modification of exosomal components for use as a vaccine
WO2009015357A1 (en) * 2007-07-25 2009-01-29 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
WO2010056337A2 (en) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
WO2011127219A1 (en) * 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3316600A (en) * 1999-02-22 2000-09-21 Torben F. Orntoft Gene expression in bladder tumors
EP1697497A4 (en) * 2003-11-03 2008-04-23 Gene News Inc Liver cancer biomarkers
WO2007006408A2 (en) * 2005-07-08 2007-01-18 Bayer Healthcare Ag Methods and kits for predicting and monitoring direct response to cancer therapy
US20080085524A1 (en) * 2006-08-15 2008-04-10 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
US20100248225A1 (en) * 2006-11-06 2010-09-30 Bankaitis-Davis Danute M Gene expression profiling for identification, monitoring and treatment of melanoma
WO2009065230A1 (en) * 2007-11-23 2009-05-28 British Columbia Cancer Agency Branch Methods for detecting lung cancer and monitoring treatment response
US8617806B2 (en) * 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
US20110177054A1 (en) * 2008-06-06 2011-07-21 Derrick Gibbings Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
JP2012507300A (en) * 2008-10-30 2012-03-29 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Method for evaluating RNA patterns
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
EP2475989A4 (en) * 2009-09-09 2013-02-27 Gen Hospital Corp Use of microvesicles in analyzing kras mutations
US20110166030A1 (en) * 2009-09-30 2011-07-07 Yixin Wang Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells
US20130203061A1 (en) * 2009-11-30 2013-08-08 Michael KLASS Methods and systems for isolating, storing, and analyzing vesicles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008092153A2 (en) * 2007-01-26 2008-07-31 University Of Louisville Research Foundation, Inc. Modification of exosomal components for use as a vaccine
WO2009015357A1 (en) * 2007-07-25 2009-01-29 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
WO2010056337A2 (en) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
WO2011127219A1 (en) * 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
T. DENG ET AL: "Abstract 444: Subpopulations of circulating microvesicles have different microRNA profiles", CANCER RESEARCH, vol. 71, no. 8 Supplement, 15 April 2011 (2011-04-15), pages 444 - 444, XP055168378, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2011-444 *
TA DENG ET AL: "Subpopulations of Circulating Microvesicles Have Different MicroRNA Profiles", 7 April 2011 (2011-04-07), XP055168385, Retrieved from the Internet <URL:http://www.carislifesciences.com/media/pdf/Spetzler-sorted-MiRs-AACR-poster-2011.pdf> [retrieved on 20150209] *
TRACI PAWLOWSKI ET AL: "Circulating exosomes may provide an alternate platform to monitor disease progression compared to circulating tumor cells CD-81 Labeled Exosome Level vs CTCs in Plasma Derived Exosomes miR-21 Copy Number vs CTCs in EpCAM+ Plasma Derived Exosomes", 5 July 2010 (2010-07-05), XP055168408, Retrieved from the Internet <URL:http://www.carislifesciences.com/media/pdf/ASCO_Pawlowski2010.pdf> [retrieved on 20150209] *

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