EP2729211A1 - Device for aseptic connection and separation of connections between containers - Google Patents
Device for aseptic connection and separation of connections between containersInfo
- Publication number
- EP2729211A1 EP2729211A1 EP12722299.0A EP12722299A EP2729211A1 EP 2729211 A1 EP2729211 A1 EP 2729211A1 EP 12722299 A EP12722299 A EP 12722299A EP 2729211 A1 EP2729211 A1 EP 2729211A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- parts
- connector
- containers
- coupling
- sterile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/16—Tube connectors; Tube couplings having provision for disinfection or sterilisation
- A61M39/18—Methods or apparatus for making the connection under sterile conditions, i.e. sterile docking
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/74—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by welding and severing, or by joining and severing, the severing being performed in the area to be joined, next to the area to be joined, in the joint area or next to the joint area
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/05—Particular design of joint configurations
- B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
- B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
- B29C66/112—Single lapped joints
- B29C66/1122—Single lap to lap joints, i.e. overlap joints
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
- B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
- B29C66/43—Joining a relatively small portion of the surface of said articles
- B29C66/431—Joining the articles to themselves
- B29C66/4312—Joining the articles to themselves for making flat seams in tubular or hollow articles, e.g. transversal seams
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
- B29C66/832—Reciprocating joining or pressing tools
- B29C66/8322—Joining or pressing tools reciprocating along one axis
- B29C66/83221—Joining or pressing tools reciprocating along one axis cooperating reciprocating tools, each tool reciprocating along one axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/84—Specific machine types or machines suitable for specific applications
- B29C66/857—Medical tube welding machines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2023/00—Tubular articles
- B29L2023/005—Hoses, i.e. flexible
- B29L2023/007—Medical tubes other than catheters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/04—Seals
Definitions
- the invention relates to a device for aseptically connecting and disconnecting connections between two
- the invention further relates to a method for
- the transfer tubes should be separated in such a way that on the one hand the sterility of media is preserved and on the other hand the environment is not contaminated.
- a disadvantage of such a squeezing and separating system is that with increasing hose diameter, the dimensions of the tools increase accordingly and relatively large forces are required to operate the tools.
- such a device is only for separating and not for
- AI is a device for
- the free hose ends each have one
- Cap made of a thermoplastic material, which is connected at one end tightly connected to the hose.
- the two ends to be joined together are squeezed together by pressing from opposite sides so that the lumen of the respective
- a disadvantage is that on the one hand, the process is relatively expensive and on the other hand, aseptic separation of the tubes with this method is not possible. Another disadvantage is that this method is only suitable for thermoplastic tubes.
- Hose ends parallel side by side introduced into a device the adjacent ends are on both sides of a designated interface by
- tube sections to be joined together have an insert made of a material that melts at a higher level in this area than the tube wall.
- the tube sections are placed against each other and pressed together with heating to a temperature which is lower than the melting temperature of the deposits to make a connection, so that the material of the
- Hose sections in the deposits is pressed away and creates a passage between the two hose sections.
- Manufacture of the containers must be planned and pre-assembled, with a subsequent contribution is either not possible or associated with greater effort and risk, and that on the other devices can indeed be used for connecting and transferring dangerous fluids, a separation after the transfer but relatively risky is. After separation, parts of the hazardous fluid may come into contact with the environment and, for example, contamination of employees and work areas
- Object of the present invention is therefore, a
- a coupling connector has a first and a second connector part, which are verkuppelbar via corresponding coupling parts with each other, that the connector parts at their the
- Dome-facing ends are each in communication with a first part of a sterile connector and that the connector parts in the coupled state of a
- Tubular film are surrounded by theirs
- Connector parts or opposite to the connector parts connected connecting tubes or against the parts of the sterile connectors is sealed and at the
- junction of the dome parts forms a circumferential fold, which allows a seal of the coupling connector with uncoupled and spaced connector parts.
- the device consisting essentially of the
- the sterile connectors or their first parts and surrounding the connector parts tubular film can be delivered sterile packaged and connected without tools with corresponding to the containers associated second parts of sterile connectors. Due to the circumferential fold of the tubular film of the coupling connector or
- Tubular film reliably prevents the environment from being contaminated with undesirable substances.
- the tubular film can be folded, welded and separated between the dome parts, so that the separate dome parts or connector parts are each reliably sealed from the environment by the welding of the tubular film. This is a connection device available, the simple and at any time for aseptic
- Transferring liquids can be used. After transferring the liquid, a simple and completely aseptic separation without environmental contamination is made possible.
- the connector parts are connected via hoses to the first parts of the sterile connectors.
- Coupling connectors and sterile connectors are used with appropriate hose connections.
- sterile connectors are associated with the first parts of the second parts of the sterile connectors via hoses with them associated containers in connection.
- the sterile connectors or their second parts can be arranged directly on the associated containers.
- Invention is one of the containers as a bioreactor
- the aseptic compound of the invention proves to be advantageous.
- a welding and cutting device for welding and cutting through the tubular film in the space formed by the decoupled connector parts.
- a simple welding and cutting device known per se to the person skilled in the art can be used.
- a welding tool or welding device and a separate cutting tool or cutting device can also be used.
- the welding temperature which is for example about 160 ° C, under the weld or between them
- the tubular film is formed as a multi-layer film.
- Invention is the inner layer of the tubular film
- Inner layers of these materials also contribute to better protection and weldability.
- the coupling connector is designed as a quick coupling
- Coupling connector which has at opposite ends in each case a first part of a sterile connector and that of a sealed at their ends tubular film. surrounded, which has a circumferential fold, for connecting the
- Container over the first parts of the sterile connectors with second parts of the sterile connectors, which are in communication with the containers, and that for separating the connection between the containers in a first step
- Connector parts are separated and pulled apart, in a second step, the tubular film in the space between the connector parts juxtaposed and welded, and in a third step, the tubular film is severed in the welded area.
- the method has the advantages described with respect to the device. Both the connection and the disconnection between two containers is relatively simple, inexpensive and also safe.
- the connections associated with the containers are interrupted by means of clamping valves.
- Figure 1 a side view of a device with a
- Coupling connector with sterile connectors and with a tubular film partially in section;
- Figure 2 the device of Figure 1 as a connection
- FIG. 3 shows a side view of the device of FIG. 1 in the decoupled state
- FIG. 4 shows a side view of the device of FIG. 3 with the tubular film juxtaposed between the connector parts with the welding tool in the unwelded state;
- Figure 5 is a side view of the device of Figure 4 with welded between the connector parts foil with welding tool;
- FIG. 6 shows a side view of the device of FIG. 5 with a severed weld
- FIG. 7 shows a second part of a first connector part in FIG.
- FIG. 8 shows a first part of a second connector part in FIG.
- a device 1 for the aseptic connection and disconnection of connections between containers 2, 3 consists essentially of a coupling connector 4, two first parts 5 of sterile connectors 6 and a tubular film 7.
- the coupling connector 4 consists of a first
- the connector parts 8, 9 are at their the dome parts 10, 11 facing away from each one ends Hose 12 with the first part 5 of a sterile connector 6 in conjunction.
- the coupling connector 4 is in the embodiment of
- Figures 1 to 6 surrounded by the tubular film, which is sealed at the first parts 5 of the sterile connectors 6 adjacent ends 13 of the tubes 12.
- the seal can be done via cable ties, not shown, by welding, by gluing or by jamming.
- the tubular film 7 has a circumferential fold 15 which, even with uncoupled connector parts 8, 9 den
- Clutch connector 4 seals against the environment.
- the first parts 5 of the Sterilkonnektoren 6 are with
- the coupling connector 4 is referred to as a so-called
- the coupling connector 4 consists of the first connector part 8, which has a first coupling part 10 and is formed, for example, as a male dome part.
- the second dome part 11 of the second connector part 9 corresponding to the first dome part 10 is correspondingly designed as a female dome part which receives the first dome part 10.
- coupling connectors 4 for example, NS6 couplings can be used, as described by the company Colder
- the device 1 has at its two free ends connected to the hoses 12 first parts 5 of
- Corresponding second parts 16 of the sterile connectors 6 are arranged at the free ends of the tubes 17, 18, which in turn are connected to the containers 2, 3. While the first parts 5 are formed, for example, as a male receiving part, the second parts 16 as
- the device 1 may also have at one end a first part 5 designed as a female part and at the other end have a first part 5 designed as a male part.
- Sterilkonnektoren 6 can, for example
- connections designed as tubes 17, 18 belong to the connections designed as tubes 17, 18
- Containers 2, 3 each have a pinch valve 22.
- the first parts 5 of the sterile connectors 6 are connected to the second parts 16 of the sterile connectors 6, which are connected to the tubes 17, 18 associated with them container 2, 3.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011106852.3A DE102011106852B4 (en) | 2011-07-05 | 2011-07-05 | Device for aseptically connecting and disconnecting connections between containers |
PCT/EP2012/002095 WO2013004322A1 (en) | 2011-07-05 | 2012-05-16 | Device for aseptic connection and separation of connections between containers |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2729211A1 true EP2729211A1 (en) | 2014-05-14 |
Family
ID=46146815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12722299.0A Withdrawn EP2729211A1 (en) | 2011-07-05 | 2012-05-16 | Device for aseptic connection and separation of connections between containers |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2729211A1 (en) |
DE (1) | DE102011106852B4 (en) |
WO (1) | WO2013004322A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2420286A1 (en) | 2010-08-18 | 2012-02-22 | Fresenius Kabi Deutschland GmbH | Method and device for sterile connection of hoses |
US9533135B2 (en) | 2014-06-19 | 2017-01-03 | Fenwal, Inc. | Method for forming, opening and/or evaluating a connection site |
CA2914298C (en) | 2015-12-07 | 2021-06-08 | Ingenyewity Inc. | Medical torsion tool |
CA172988S (en) | 2017-02-09 | 2017-09-14 | Ingenyewity Inc | Medical torsion tool |
US10919235B2 (en) | 2017-06-07 | 2021-02-16 | Fenwal, Inc. | Apparatus and method for mechanically opening a connection site |
GB201808826D0 (en) * | 2018-05-30 | 2018-07-11 | Ge Healthcare Bio Sciences Ab | Connector for aseptic connection, and method for connecting and disconnecting such connectors |
WO2019243258A1 (en) * | 2018-06-19 | 2019-12-26 | Sartorius Stedim Biotech Gmbh | Sales unit for a fluid processing system and method for preparing said system to be put into use |
DE102019108664A1 (en) * | 2019-04-03 | 2020-10-08 | Sartorius Stedim Biotech Gmbh | Sterile connector for the sterile transfer of a liquid medium |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209013A (en) * | 1979-04-05 | 1980-06-24 | Baxter Travenol Laboratories, Inc. | Sterile connection system using flexible container |
GB2060399A (en) * | 1979-09-25 | 1981-05-07 | Avon Medicals | Peritoneal dialysis equipment |
WO1983003538A1 (en) * | 1982-04-19 | 1983-10-27 | Baxter Travenol Lab | Shield for connectors |
DE3519128A1 (en) * | 1985-05-28 | 1986-12-04 | Yen-Cheng Dr.med. 6650 Homburg Wu | Device for the aseptic handling of the connectors of transfer devices on exchange of bags during continuous ambulatory peritoneal dialysis (CAPD), and plastic bag filled with dialysate |
FR2764809A1 (en) * | 1997-06-18 | 1998-12-24 | Marie Anne Raybaut | DEVICE FOR STERILE HOLDING A CONNECTION MEANS BETWEEN A PIPE UPSTREAM AND AT LEAST ONE PIPE DOWNSTREAM |
FR2820325A1 (en) * | 2001-02-05 | 2002-08-09 | Medex Sa | Coupling for tubes in medical use has male and female connectors with lateral protection in form of bellows |
US20030030272A1 (en) * | 2001-08-06 | 2003-02-13 | Johnson Theodore D. | Connection system |
WO2010119476A2 (en) * | 2009-04-17 | 2010-10-21 | Abc Pharmatech S.R.L. | Apparatus for transferring incoherent or liquid material |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4022256A (en) | 1975-08-06 | 1977-05-10 | California Institute Of Technology | Aseptic fluid transfer system |
DE3043333A1 (en) | 1980-11-17 | 1982-06-24 | Klaus-Werner Dipl.-Volksw. Dr. 2300 Altenholz Schatz | Sterile connections of ducts esp. for kidney dialysis - are made in pref. transparent plastics bag suitable for use by patient |
GB8314189D0 (en) | 1983-05-23 | 1983-06-29 | Clark R D | Technique and equipment for dialysis treatment |
DE19717765C1 (en) | 1997-04-26 | 1999-02-25 | Fresenius Ag | Sterile connector and foil pouch with a sterile connector |
ATE485075T1 (en) | 2006-07-07 | 2010-11-15 | Caridianbct Inc | METHOD FOR CONNECTING THERMOPLASTIC HOSES |
US7398813B2 (en) | 2006-07-31 | 2008-07-15 | Denco Inc. | Device for welding plastic tubes |
US7926856B2 (en) | 2007-03-02 | 2011-04-19 | Smith & Nephew, Inc. | Fluid conduit connection |
-
2011
- 2011-07-05 DE DE102011106852.3A patent/DE102011106852B4/en active Active
-
2012
- 2012-05-16 EP EP12722299.0A patent/EP2729211A1/en not_active Withdrawn
- 2012-05-16 WO PCT/EP2012/002095 patent/WO2013004322A1/en active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209013A (en) * | 1979-04-05 | 1980-06-24 | Baxter Travenol Laboratories, Inc. | Sterile connection system using flexible container |
GB2060399A (en) * | 1979-09-25 | 1981-05-07 | Avon Medicals | Peritoneal dialysis equipment |
WO1983003538A1 (en) * | 1982-04-19 | 1983-10-27 | Baxter Travenol Lab | Shield for connectors |
DE3519128A1 (en) * | 1985-05-28 | 1986-12-04 | Yen-Cheng Dr.med. 6650 Homburg Wu | Device for the aseptic handling of the connectors of transfer devices on exchange of bags during continuous ambulatory peritoneal dialysis (CAPD), and plastic bag filled with dialysate |
FR2764809A1 (en) * | 1997-06-18 | 1998-12-24 | Marie Anne Raybaut | DEVICE FOR STERILE HOLDING A CONNECTION MEANS BETWEEN A PIPE UPSTREAM AND AT LEAST ONE PIPE DOWNSTREAM |
FR2820325A1 (en) * | 2001-02-05 | 2002-08-09 | Medex Sa | Coupling for tubes in medical use has male and female connectors with lateral protection in form of bellows |
US20030030272A1 (en) * | 2001-08-06 | 2003-02-13 | Johnson Theodore D. | Connection system |
WO2010119476A2 (en) * | 2009-04-17 | 2010-10-21 | Abc Pharmatech S.R.L. | Apparatus for transferring incoherent or liquid material |
Non-Patent Citations (1)
Title |
---|
See also references of WO2013004322A1 * |
Also Published As
Publication number | Publication date |
---|---|
DE102011106852B4 (en) | 2019-02-14 |
DE102011106852A1 (en) | 2013-01-10 |
WO2013004322A1 (en) | 2013-01-10 |
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