EP2670344A1 - Dispositif pour proceder a une inoculation d'un produit veterinaire dans l'aile d'une volaille - Google Patents

Dispositif pour proceder a une inoculation d'un produit veterinaire dans l'aile d'une volaille

Info

Publication number
EP2670344A1
EP2670344A1 EP12703031.0A EP12703031A EP2670344A1 EP 2670344 A1 EP2670344 A1 EP 2670344A1 EP 12703031 A EP12703031 A EP 12703031A EP 2670344 A1 EP2670344 A1 EP 2670344A1
Authority
EP
European Patent Office
Prior art keywords
jaw
wing
support member
scarification
veterinary product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12703031.0A
Other languages
German (de)
English (en)
French (fr)
Inventor
Karl GROSBOIS
Ludovic BRAUD
Anno Jorna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Desvac SAS
Original Assignee
Desvac SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Desvac SAS filed Critical Desvac SAS
Publication of EP2670344A1 publication Critical patent/EP2670344A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00Surgical instruments for veterinary use
    • A61D1/02Trocars or cannulas for teats; Vaccination appliances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00Surgical instruments for veterinary use
    • A61D1/02Trocars or cannulas for teats; Vaccination appliances
    • A61D1/025Vaccination appliances

Definitions

  • the field of the invention is that of the design and manufacture of devices for assisting veterinary practices. More specifically, the invention relates to a device for inoculating veterinary products with birds, and more particularly with poultry, according to a technique for inoculating the veterinary product or products at the level of the wing of the poultry.
  • an inoculation method consists of depositing the veterinary product at the level of the membrane situated in front part of the wing and extending between the radius and the humerus of the so-called wing-membrane wing . It should be noted that at this point, the wing membrane has a relatively small thickness, of the order of 1 mm thick.
  • transfixion also called transfixion or "wing-web”
  • wing-web This method of inoculation, also called transfixion or "wing-web”
  • Avian pox is a worldwide disease caused by a DNA virus belonging to the genus Avipoxvirus of the poxviridae family. Antigenically different species are distinguished: chicken poxvirus (Avipoxvirus galli), turkey (Avipoxvirus meleagridis), pigeon (Avipoxvirus columbae), canary (Avipoxvirus serini).
  • Avian pox is a poorly contagious disease, affecting among other things hens and turkeys, which is characterized by the presence of diphtheritic lesions on the digestive and upper respiratory mucosa. Vaccination against this disease is very important in the farms because it has a heavy economic impact. Indeed, the fowl pox is at the origin of a fall of egg laying and affects the growth performances of the birds.
  • smallpox viruses and in particular fowl pox, have emerged as induction of immunity against foreign antigens for which they code.
  • These vectors are also used to vaccinate poultry against several other diseases and there may be mentioned, for example, Vectormune® FP-LT Ceva Animal Health which contains a live chicken poxvirus used as a vector to express in vivo antigens of avian infectious laryngotracheitis.
  • the method of transfixion is widely used in poultry farms and is an integral part of vaccination campaigns, whether to vaccinate poultry against smallpox or against other infectious diseases.
  • the operator seizes the poultry and unfolds a wing so as to reveal the wing membrane;
  • the operator is dipping a needle into a vaccine reservoir, which has provided a longitudinally extending wound and forming a kind of reserve for a dose of veterinary product;
  • the operator stitches and passes through the wing of the poultry at the level of said wing membrane, on one point or two points (transfixion).
  • the veterinary product present in the reserve of the needle is deposited on either side of the needle, in the wound made by the needle.
  • a method of vaccination, more generally of veterinary product administration, thus carried out has several drawbacks among which:
  • the needle used for the inoculation of veterinary products is successively in contact with the poultry and with the veterinary product contained in the tank in which the needle is soaked, at the risk of polluting the reservoir of veterinary product;
  • the invention particularly aims to overcome these disadvantages of the prior art.
  • the invention aims to provide a device for assisting the inoculation of a veterinary product in the wing membrane of a poultry that allows to deliver a precise and constant dose of veterinary products.
  • the invention also aims to provide such a device that allows to administer a veterinary product to a poultry more efficiently and faster than with the solutions of the prior art.
  • Another object of the invention is to provide such a device which allows the operator to proceed to the administration of veterinary product in a secure and ergonomic manner.
  • the invention which relates to a device for inoculating at least one veterinary product with at least one poultry, said inoculation being intended for to be performed at the level of the wing membrane located at the front of the wing and extending between the radius and the humerus of the wing, characterized in that it comprises: - A jaw comprising an upper portion and a lower portion defining between them a receiving space for receiving said wing membrane;
  • a scarification tool carried by a support element, said scarification tool having a channel intended to deliver a dose of veterinary product
  • said jaw and / or said support member being movable towards each other and provided to enable said scarification tool to be brought into said reception space.
  • the circuit through which the veterinary product is conveyed into the device is isolated from any external environment (with the exception, of course, of the passage through which it is delivered).
  • a device according to the invention comprises a scarification tool having a channel for delivering a dose of product veterinary clinic, its implementation allows the vaccination of poultry by scarification.
  • vaccination by scarification is a process that involves scarification on the skin of the subject to be vaccinated, that is to say to achieve a slight injury by a superficial incision of the dermal surface.
  • the product to be inoculated with the subject is then brought into contact with this superficial injury of the dermis.
  • the superficial injury of the dermis may be provided after the product to be inoculated has been deposited on the dermis.
  • Scarification vaccination is therefore different from vaccination with a syringe.
  • the product to be inoculated is injected under the epidermis after the tip of the syringe has been planted there.
  • the device comprises a tongue external to the jaw capable of cooperating with one of the lower and upper parts of the jaw to tension the membrane and / or repel the feathers of the wing.
  • the wing membrane, in the scarification zone is stretched, which is intended to guarantee that the scarification tool will cut the wing membrane in the desired manner (unlike the situation in which the membrane is relaxed, it can then deform under the pressure of the scarification tool at the risk that the notch is only partially executed);
  • the feathers are removed from the scarification zone, which tends to limit the risk that the veterinary product is deposited on the feathers and not on the wound itself.
  • said tongue is deformable between a position outside the jaw and a position inside the jaw against one of the lower and upper parts thereof.
  • the tongue has a resting position out of the jaw and, when the wing of a bird is introduced into the jaw and a relative movement between the jaw and the scarification tool is imposed by the operator, the tongue will engage inside the jaw, this engaging in the space between the wing of the poultry and the corresponding part of the jaw, which causes the deformation of the tongue.
  • said tongue has a passage through which said scarification tool is intended to be engaged.
  • said support member extends under said jaw and at least the lower part of said jaw has a passage through which said scarification tool is intended to be engaged.
  • the treatment of the poultry is effected by a downward movement of the jaw towards the scarification tool, the latter passing through the lower part of the jaw.
  • said upper portion has an orifice extending in alignment with the passage of said lower part of the jaw, this orifice being preferably provided with an insert forming a stop for said scarification tool.
  • said scarification tool bears against the insert, the latter being designed to avoid providing premature wear of the protruding parts of the scarification tool.
  • said scarification tool has a tubular shape extending between a base carried by said support member and a scarification end having at least one point.
  • the tubular shape combined with the presence of a point on this tool allows it to have a dual function: that of allowing scarification and that of allowing the delivery of the veterinary product or products, being connected to a circuit including the dosing means.
  • said scarification end has four tips.
  • the device comprises a frame, said support member being fixedly mounted on said frame while said jaw is mounted movably on said frame so as to be moved towards or away from said support member.
  • said drive means can be actuated manually and / or assisted by means known to those skilled in the art such as for example a pneumatic pump controlled by a control actuated by the foot.
  • a lever intended to be actuated manually is mounted on a secondary arm movable integrally with said jaw in a direction of displacement, said support member extending in said direction of movement between the arm and the jaw. Such a lever can then be maneuvered by a thrust exerted directly by the operator.
  • said jaw is carried by a primary arm and said support member has a gutter-shaped portion in which said primary arm is guided.
  • said lever has an end provided with a plate intended to form a bearing surface.
  • the upper and lower parts of the jaw are spaced from each other by a height designed for a radius and / or a humerus of a bird's wing to abut against them.
  • said metering means comprise a micro pump mounted on said support member.
  • said reservoir is mounted on said support element.
  • the reservoir can thus be mounted on an area of the device in which it is easy to control the level of veterinary product contained in the reservoir and in which the reservoir can easily be replaced or filled.
  • the device comprises a set of at least two jaws, each being appropriate, in terms of dimensions of the receiving space, to a wing morphology, which changes with the age of the poultry, the receiving space of one of the jaws being for example greater, at least in height, to the receiving space of the other jaw.
  • the device according to the invention is used for poultry chosen from hens, ducks or turkeys.
  • a device according to the invention is used for the vaccination of poultry against smallpox and all types of vaccines adapted for application by transfixion or scarification.
  • the invention discussed therefore relates to the use of a device in any of the variants described above for the vaccination of poultry against fowl pox.
  • a device according to the invention is used for the administration to poultry of a vaccine comprising a smallpox virus used as a vector for expressing in vivo antigens of one or more infectious diseases.
  • the invention thus discussed relates to the use of a device in any of the above-described variants for administering to poultry a vaccine comprising a smallpox virus used as a vector for expressing antigens in vivo. one or more infectious diseases.
  • the infectious diseases are selected from the group consisting of Newcastle disease, infectious laryngotracheitis, avian encephalomyelitis and avian mycoplasmas.
  • Figures 1 and 2 are each a perspective and overall view of a device according to the invention
  • Figures 3 and 4 are each a partial perspective view of a device according to the invention.
  • FIG. 5 is another partial perspective view of a device according to the invention, in operation;
  • FIGS. 6 and 7 illustrate two different jaws capable of equipping a device according to the invention;
  • Figure 8 is an anatomical representation of a poultry wing. As indicated above, the principle of the invention consists in proposing a device for inoculating at least one veterinary product with a poultry.
  • such an inoculation is carried out in the context of the invention at the level of the wing membrane M situated in front part AV of the wing A and extending between the radius R and the humerus H of the wing.
  • a device comprises:
  • a frame 1 encompassing the present embodiment a streamlined assembly and provided with several accessories described in more detail later;
  • a scarification tool 30 carried by a support element 3; dosing means 4 of the veterinary product, and a reservoir 40 attached to the device (removably, for replacement) and connected (also removably) to the dosing means.
  • the jaw 2 and / or the support member 3 are movable towards each other and are provided to enable the scarification tool 30 to be brought into contact with the wing of a poultry placed in the jaw 2 to cut the membrane indicated above.
  • the jaw 2 has a receiving space 22 intended to receive the wing membrane located in front of the wing extending between the radius and the humerus of the wing, this space of receiving being defined between an upper portion 20 and a lower portion 21 of the jaw.
  • the upper and lower portions of the jaw 2 are positioned relative to one another so as to have a spacing therebetween so that the receiving space is adjusted in height approximately to the thickness of the membrane wing intended to be introduced into the jaw.
  • the upper and lower parts 20, 21 of the jaw are spaced from each other by a height less than the height of the radius and / or the humerus of the wing of the bird.
  • reception space thus produced is limited in height to the point of not allowing the operator to introduce a finger into the reception space.
  • the depth of the receiving space is dimensioned in a particular way.
  • the reception space is provided so that the entire wing membrane of the bird, in its dimension from front to back, comes to take place in the reception space. Therefore, the radius and / or the humerus abut the jaw entrance against the upper and lower portions of the jaw, once the membrane is properly positioned within the jaw or other words, completely engaged back and forth between the upper and lower parts of the jaw.
  • the end shape of the upper and lower parts of the jaw may vary: they may have a rounded shape at their free end, as shown in Figure 2, or a more angular shape (although made of curves) as illustrated in Figures 6 and 7, adapted to the angle formed by the radius and the humerus of the wing, which allows to better center the wing membrane in the jaw.
  • a device according to the invention may be provided with a set of several jaws whose spacings E between the upper and lower parts 21 differ from one another and whose the angle may vary from one to the other.
  • the operator can choose one or the other jaw according to the age of the poultry and its morphology so as to make the receiving space most suitable for the thickness of the wing membrane.
  • the use of the most appropriate jaw provides the best possible wedging of the bones of the wing (radius and humerus) against the upper and lower parts of the jaw.
  • the scarification tool 30 has a tubular shape extending between a base 31 carried by the support element 3 and a scarification end having at least one point, scarification tool according to the present embodiment having four tips 301.
  • the scarification tool 30 has a channel 302, in the form of an axial recess opening at each end of the scarification tool.
  • This channel 302 is intended, once the scarification tool has notched the wing membrane placed in the jaw, and while the scarification tool is held between the upper portion 20 and the lower portion 21 of the jaw, to deliver a dose of veterinary product on and / or under the wing membrane.
  • the delivery of the dose of veterinary product can be caused just before, during or just after scarification of the membrane by the tool of the device.
  • the dosing means 4 consist of a micro-pump mounted on the support member 3.
  • a micro-pump is an organ known to those skilled in the art.
  • the micro-pump used is sized to deliver doses of 0.01 ml.
  • the tank 40 of veterinary product is also mounted on the support member 3, on one side of the support member opposite to that carrying the dosing means.
  • the reservoir 40 is connected to the dosing means by a flexible conduit 41.
  • Another conduit 42 connects the dosing means 4 to the scarification tool 30, this conduit 42 communicating with the channel 302 of the scarification tool, passing through through the support member 3 via a passage 310 ( Figure 4) provided for this purpose.
  • the device has a configuration according to which:
  • the support element 3 extends under the jaw 2;
  • the support element is fixedly mounted on the frame 1 while the jaw is carried by a primary arm 23 mounted movably on the frame 1, so that the jaw 2 can be near or away from the scarification tool (whose tips are therefore directed upwards).
  • the lower part 21 of the jaw has an orifice 210 dimensioned and positioned to allow the passage of the scarification tool 30 to bring it into the receiving space 22 delimited between the lower part and the part upper jaw;
  • the upper part 20 of the jaw has an orifice 200, coaxial with the orifice 210 of the lower part, and making it possible to bring the scarification tool beyond the receiving space 22, this penetrating the inside the upper part.
  • the orifice 200 is provided with an insert 201 (shown in broken lines in Figure 4) forming a stop for the scarification tool.
  • This insert here takes the form of a washer, deformable or not, against which the tips of the scarification tool are intended to bear.
  • the insert may also take the form of a frustoconical piece against which the scarification tool comes into abutment while being coaxial with the frustoconical piece, the latter being provided for its smaller diameter end to come into contact with the frustoconical piece. place, at the end of the race, between the tips of the scarification tool while the tips come into abutment against the outer surface of the frustoconical piece.
  • the device comprises drive means intended to be actuated in this case manually to move the jaw 2 towards the support member 3.
  • these drive means comprise: a secondary arm 60, solidly movable with the jaw 2 in the direction of displacement D (shown in dashed lines in FIG. 4) and corresponding according to the present embodiment to a curve passing through the center of the orifice 200 of the upper part 20 of the jaw, by the center 210 of the lower part 21 of the jaw and by the central point between the four points of the scarification tool) of the jaw towards the scarification tool, the secondary arm 60 extending below the support member 3 such that, in the present embodiment, the support member 3 extends between the secondary arm and the jaw in the direction of travel;
  • the lever 6 can be mounted indifferently on one side or the other of the secondary arm, depending on the lateralization of the operator, allowing in other words to place the lever on the left or right of the device.
  • the primary arm carrying the jaw and the secondary arm carrying the lever are both fixedly mounted on a common arm (not shown) pivoting on a fixed part of the frame.
  • a return spring 32 is connected at one of its ends to the primary arm 23 and at the other end to the support element 3.
  • Such a spring is intended to work in compression: when the primary arm is driven down (this under the action of a downward thrust exerted on the lever 6), the spring 32 is compressed. As a result, when the thrust on the lever is released, the spring tends to return the primary arm to a rest position away from the support member.
  • the support element 3 has, over a portion of its length, a gutter shape 33 in which the primary arm 23 is guided laterally. Indeed, in the lower position of the primary arm, it is enrolled in the gutter 33.
  • the jaw 2 is made in the form of a tip attached to the end of the primary arm 23, this tip forming a protrusion.
  • the gutter 33 terminates in an area coinciding with the start of the protrusion formed by the jaw 2 when the arm 23 is in the lower position.
  • the device comprises a tongue 5, external to the jaw 2, and capable of cooperating with one of the lower and upper parts of the jaw.
  • the tongue is mounted at the end of the support element 3 and extends upwards, in an oblique direction, towards the jaw 2.
  • This tongue 5 is made of a deformable material, and has a thickness allowing it to bend from a position such as that illustrated in FIGS. 3 and 4, in which it extends out of the receiving space 22 of the jaw at a position in which it extends partly inside the receiving space 22, between the lower part of the jaw 2 and the wing A of a poultry (as illustrated in FIG. ).
  • the lower portion 21 of the jaw 2 has at its free end a cavity 211, a slot 212 passing through the lower part of the jaw opening on the one hand in the cavity 211 and on the other hand, in the reception space 22. This slot is adapted and provided to allow the passage of the tongue 5 through the lower part of the jaw.
  • the support member 3 has a length from the upper frame to that of the assembly formed by the primary arm and the jaw 2.
  • the tongue 5 is mounted by its base at the end of the support member and extends obliquely towards the slot 212 which is at a distance less than the frame at the distance between the base of the tongue and the frame.
  • the slot 212 is made to pass through the lower part of the jaw in a direction almost coincident with that corresponding to the inclination of the tongue 5.
  • the tongue 5 has a recess 50 forming a passage through which the scarification tool 30 is intended to be engaged when the jaw is in a position close to the support member 3.
  • This recess 50 has an oblong shape that makes it possible to place recess in correspondence with the orifice 210 of the lower part 21 of the jaw, without requiring to precisely position the tongue relative to the lower part of the jaw.
  • the operator seizes a poultry and spreads one of the wings of it so as to reveal the wing membrane located in front of the wing and extending between the radius and the humerus of the wing.
  • This portion of the disengaged membrane is introduced into the jaw 2, between the lower part and the upper part of the jaw which defines the receiving space.
  • the body of the bird is presented so that the underside of the wing is directed downwards.
  • the descent of the lever is accompanied simultaneously by the descent of the primary arm 23 and, consequently, the jaw 2 towards the support member 3.
  • the scarification tool engages in the orifice 210 of the lower part of the jaw.
  • the tongue 5 engages in the slot 212 of the lower part of the jaw.
  • the reception space is dimensioned in height so that the tongue 5 is placed in contact with the lower part on the one hand and, in contact with the wing of the poultry on the other hand, so as to:
  • the length of the tongue 5 and the height of the scarification tool are provided relative to each other so that the tongue is in place in the receiving space (i.e. the recess 50 brought into coincidence with the orifice 210 of the lower part of the jaw) before the scarification tool 30 opens from the lower part into the receiving space.
  • a dose of veterinary product is sucked into the reservoir 40 by the micro pump 4, this dose of veterinary product being sent, via the conduit 42, to the inside of the scarification tool until be placed on the wing and / or under the wing (the membrane being very thin at this point of the wing). It is recalled that the delivery of the dose of veterinary product can be carried out indifferently just before, or during or just after the incision of the wing by the scarification tool.
  • the micro-pump comprises a chamber 44 and a piston 43 arranged in a manner known per se, such that a partial withdrawal of the piston from the chamber causes product suction while a Piston thrust into the chamber causes an expulsion of the product present in the chamber out of the chamber.
  • the primary arm 23 carries a finger 230 coupled to a rod 231 (surrounded by a spring assisting the return to the upper position of the rod) which extends in a passage through the wall of the support member 3 until to a second finger 232 secured to the piston 43 of the micro-pump.
  • the frame carries several functional organs, namely:
  • the two leds 1 0 may, for example, be simultaneously green when the device is at rest while they are simultaneously red when the downward movement of the jaw is properly performed to proceed with the inoculation of the veterinary product;
  • a counter 12 intended to display the number of doses of veterinary product delivered.
  • the device according to the invention is used to carry out vaccinations of poultry against smallpox.
  • the device is used to carry out the vaccination of poultry by inoculating avian pox viruses used as vectors for expressing in vivo antigens of one or more infectious diseases (vector vaccines).
  • the smallpox viruses used as vectors express in vivo antigens of Newcastle disease, infectious laryngotracheitis, avian encephalomyelitis or avian mycoplasmas.
  • the device according to the invention is used to carry out the vaccination of poultry and more particularly hens, ducks and turkeys.
  • Tests have been carried out in order to verify that the use of a device according to the invention makes it possible to vaccinate poultry properly, in particular against smallpox.
  • a vaccination campaign was carried out for this purpose on a batch of 2182 brown and white pullets aged six to seven weeks.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Processing Of Meat And Fish (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP12703031.0A 2011-02-01 2012-01-30 Dispositif pour proceder a une inoculation d'un produit veterinaire dans l'aile d'une volaille Withdrawn EP2670344A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1100298A FR2970863B1 (fr) 2011-02-01 2011-02-01 Dispositif pour proceder a une inoculation d'un produit veterinaire dans l'aile d'une volaille
US13/185,335 US20120197181A1 (en) 2011-02-01 2011-07-18 Device for inoculating a veterinary product into a poultry bird's wing
PCT/EP2012/051470 WO2012104259A1 (fr) 2011-02-01 2012-01-30 Dispositif pour proceder a une inoculation d'un produit veterinaire dans l'aile d'une volaille

Publications (1)

Publication Number Publication Date
EP2670344A1 true EP2670344A1 (fr) 2013-12-11

Family

ID=44549495

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12703031.0A Withdrawn EP2670344A1 (fr) 2011-02-01 2012-01-30 Dispositif pour proceder a une inoculation d'un produit veterinaire dans l'aile d'une volaille

Country Status (8)

Country Link
US (1) US20120197181A1 (ru)
EP (1) EP2670344A1 (ru)
JP (1) JP2014511212A (ru)
CN (1) CN103379878A (ru)
BR (1) BR112013018038A2 (ru)
FR (1) FR2970863B1 (ru)
RU (1) RU2592852C2 (ru)
WO (1) WO2012104259A1 (ru)

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Publication number Priority date Publication date Assignee Title
EP2777601A1 (en) * 2013-03-12 2014-09-17 Desvac Device for inoculating a veterinary product into a poultry bird's wing
US10350041B2 (en) 2013-11-25 2019-07-16 Zoetis Services Llc Vaccination system for delivering vaccine to avian pullets, and associated methods, devices, and assemblies
US9763428B2 (en) 2013-11-25 2017-09-19 Zoetis Services Llc Holder apparatus for avian birds, and associated method
EP3192364A1 (en) * 2016-01-18 2017-07-19 Agri Advanced Technologies GmbH Method, device and system for handling, grading and vaccinating living birds
IL263034B (en) * 2016-05-16 2022-09-01 Nova Tech Engineering Llc Poultry injection apparatus with rotating capture units and methods of use

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FR2920295B1 (fr) * 2007-09-05 2009-12-11 Desvac Dispositif d'injection de produits veterinaires a des volailles, comprenant un element de contention presentant une forme anatomique incluant des moyens de calage d'un os reperable

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Also Published As

Publication number Publication date
RU2013134703A (ru) 2015-03-10
CN103379878A (zh) 2013-10-30
JP2014511212A (ja) 2014-05-15
US20120197181A1 (en) 2012-08-02
BR112013018038A2 (pt) 2019-09-24
FR2970863B1 (fr) 2014-01-17
FR2970863A1 (fr) 2012-08-03
WO2012104259A1 (fr) 2012-08-09
RU2592852C2 (ru) 2016-07-27

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