EP2652653B1 - Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données - Google Patents

Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données Download PDF

Info

Publication number
EP2652653B1
EP2652653B1 EP11804812.3A EP11804812A EP2652653B1 EP 2652653 B1 EP2652653 B1 EP 2652653B1 EP 11804812 A EP11804812 A EP 11804812A EP 2652653 B1 EP2652653 B1 EP 2652653B1
Authority
EP
European Patent Office
Prior art keywords
scan
imaging
parameters
imaging protocol
user interface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP11804812.3A
Other languages
German (de)
English (en)
Other versions
EP2652653A1 (fr
Inventor
Julien Senegas
Jens Von Berg
Eric Cohen-Solal
Sebastian Peter Michael Dries
Michael Chun-Chieh Lee
Tim Nielsen
Stefanie Remmele
Torbjørn VIK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philips Intellectual Property and Standards GmbH
Koninklijke Philips NV
Original Assignee
Philips Intellectual Property and Standards GmbH
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Intellectual Property and Standards GmbH, Koninklijke Philips NV filed Critical Philips Intellectual Property and Standards GmbH
Priority to EP11804812.3A priority Critical patent/EP2652653B1/fr
Publication of EP2652653A1 publication Critical patent/EP2652653A1/fr
Application granted granted Critical
Publication of EP2652653B1 publication Critical patent/EP2652653B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/543—Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/546—Interface between the MR system and the user, e.g. for controlling the operation of the MR system or for the design of pulse sequences
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/20—ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00—Subject matter not provided for in other main groups of this subclass

Definitions

  • the invention relates to a method of performing a magnetic resonance imaging scan using an MR scanner, a method of providing statistical information to a magnetic resonance imaging scanner, a computer program product, a magnetic resonance imaging scanner for performing a magnetic resonance imaging scan and a database system.
  • Image-forming MR methods which utilize the interaction between magnetic field and nuclear spins in order to form two-dimensional or three-dimensional images are widely used nowadays, notably in the field of medical diagnostics, because for the imaging of soft tissue they are superior to other imaging methods in many respects, they do not require ionizing radiation, and they are usually not invasive.
  • the body of a patient or in general an object to be examined is arranged in a strong, uniform magnetic field B0 whose direction at the same time defines an axis, normally the z-axis, of the coordinate system on which the measurement is based.
  • the magnetic field produces different energy levels for the individual nuclear spins in dependence on the applied magnetic field strength which spins can be excited (spin resonance) by application of an alternating electromagnetic field (RF field) of defined frequency, the so called Larmor frequency or MR frequency.
  • RF field alternating electromagnetic field
  • Larmor frequency or MR frequency the so called Larmor frequency or MR frequency.
  • the distribution of the individual nuclear spins produces an overall magnetization which can be deflected out of the state of equilibrium by application of an electromagnetic pulse of appropriate frequency (RF pulse) while the magnetic field extends perpendicularly to the z-axis, so that the magnetization performs a precessional motion about the z-axis.
  • Any variation of the magnetization can be detected by means of receiving RF antennas, which are arranged and oriented within an examination volume of the MR device in such a manner that the variation of the magnetization is measured in the direction perpendicularly to the z-axis.
  • the signal picked up in the receiving antennas then contains components of different frequencies which can be associated with different locations in the body.
  • the signal data obtained via the receiving antennas corresponds to the spatial frequency domain and is called k-space data.
  • the k-space data usually includes multiple lines acquired with different phase encoding. Each line is digitized by collecting a number of samples. A set of samples of k-space data is converted to an MR image, e.g. by means of Fourier transformation.
  • an MR scan protocol used for adjustment of the conditions to be used when performing a magnetic resonance imaging scan can consist of more than 150 adjustable parameters.
  • US 7,315,755 discloses a system and method for communicating a protocol over a network. More specifically, this document relates to a protocol/medical image registration method that permits centralized management of pairs of protocol and a medical image, wherein numerous user terminals are permitted to share protocols as common resources. Consequently, this method permits to make imaging protocols available, however with the drawback that only 'prefabricated' protocols are provided, such that with respect to the individual circumstances with respect to an imaging procedure a user is still required to adapt the scan parameters of the selected MR scan protocol in an individual manner. Consequently, the optimal choice of scan parameters is still difficult even for expert users.
  • EP 1 354 554 A2 refers to a networked scanner environment wherein each scanner is communicable with one or more databases configured to store data associated with previously executed imaging sessions.
  • the databases may be queried by a user to determine, based on a set of user inputs, an historical evaluation of the prior imaging sessions conducted in accordance with scan parameters similar to the scan parameters of an imminent imaging session.
  • Included is a global database that is accessible by a series of remotely located imaging systems as well as one or more databases particular to a specific treatment facility housing one or more imaging scanners.
  • US 2008/130972 A1 refers to a method of imaging.
  • the method includes determining imaging parameters. Further, the method includes acquiring image data from a patient. Additionally, the method includes storing the imaging parameters with the acquired image data. The method also includes retrieving the stored imaging parameters for use in a subsequent examination. Systems and computer-readable medium that afford functionality of the type defined by this method are also contemplated in conjunction with the present technique.
  • US 2004/148403 A1 provides a technique for sharing clinical protocols for diagnostic imaging systems.
  • the clinical protocols generally represent operational parameters, such as configuration data and procedures, which are clinically developed for a particular imaging diagnosis.
  • An interface or access point such as a network accessible database or website, is provided to facilitate the exchange of these clinical protocols between clinicians.
  • the present technique also may facilitate the formation of new clinical protocols and/or the integration of new clinical protocols into various diagnostic imaging systems. Accordingly, clinicians can electronically exchange and configure a variety of imaging protocols for potentially greater quality in the particular imaging diagnosis.
  • EP 1 229 472 A1 describes an MRI system center connected to a plurality of MRI systems for visualizing the interior of a subject to be examined using a magnetic resonance phenomenon through an electronic communication line.
  • the MRI system center receives data of a log file on which a use state of the MRI systems is recorded or use-state data extracted from the log file, from the MRI systems through a communication control unit.
  • a database unit stores the data of the log file or the use-state data.
  • An analysis unit analyzes the data of the log file or the use-state data received within a given period of time.
  • a method of performing a magnetic resonance imaging scan using an MR scanner comprising the steps of receiving an MR imaging protocol via a user interface, the MR imaging protocol being categorizable into an MR scan type of a predefined set of MR scan types, wherein the MR scan type is a generic term which permits to describe a set of specific imaging sequences which can be classified with said generic term, and the MR imaging protocol includes adjustable parameters of the MR scanner for performing the MR imaging scan using the MR scan type employed at the MR scanner for performing the MR imaging scan, querying a database by providing scan information to the database, the scan information permitting the database to identify the MR scan type of the MR imaging protocol, and providing statistical information on the MR scan type, wherein the statistical information is obtained by analysis of previous MR scans, receiving in response to said querying from the database the statistical information on the MR scan type, said statistical information comprising statistics on modifications of individual scan parameters of the adjustable parameters of the MR scan type
  • an 'MR scan type' is understood as for example a generic term which permits to describe a set of specific imaging sequences which can be classified with said generic term.
  • the generic term or MR scan type 'gradient echo' covers the pulse sequences coherent gradient echo (FFE), incoherent gradient echo (T1 FFE), incoherent gradient echo, steady-state free precession (T2 FFE), balanced sequence (balanced FFE), and double echo steady-state.
  • the MR scan type inversion recovery' covers short T1 inversion recovery (STIR), long Tau inversion recovery (FLAIR) and true inversion recovery (Real IR).
  • an MR scan type may also categorize an MR imaging protocol with respect to different scan options used when performing an MR imaging scan.
  • Options comprise for example the provision of saturation pulses for water and/or fat saturation, multislice imaging, single-slice imaging, three-dimensional imaging, bandwidth, magnetization transfer contrast, the application of partial echoes, as well as patient-specific protocols used for ECG synchronization, respiratory compensation and automatic bolus detection.
  • any MR imaging protocol received via the user interface can be categorized into a certain MR scan type which in turn permits to provide an elegant possibility to provide statistical information with respect to this MR scan type, wherein the statistical information was obtained by analysis of previous MR scans.
  • the present invention provides a possibility to support for example a technician at a user interface with information on parameters which may require adaption when using the selected MR imaging protocol and which parameter values are typically used, i.e. are appropriate.
  • the statistical information is based on information about previously performed MR imaging scans employing said MR scan type. More specifically, providing said statistical information to the user interface comprises indicating individual scan parameters for which the statistics on modification frequency is above a predefined threshold.
  • the invention proposes to compute statistics on scan parameters which are most frequently adapted for a given MR scan type or protocol, wherein preferably the statistics are computed together with statistical descriptors of the parameter values, such as the modes (most frequent values), or the range. This information may then be provided to the user interface, i.e. for example displayed to the user in a suitable manner, for example while adjusting a given parameter.
  • the statistical information comprises statistics on ranges of modifications of individual scan parameters of the scan type.
  • the statistics on ranges of modifications of individual scan parameters of the MR scan type further comprise threshold ranges for said scan parameters.
  • the method further comprises receiving a modification of a scan parameter of the MR imaging protocol via the user interface, determining if the received modification of the scan parameter is outside a threshold range for said scan parameter and providing an indication to the user interface in case the received modification if outside the threshold range.
  • threshold ranges may be provided to the user interface which has the advantage that the user is assisted in choosing the most appropriate parameters since he will intuitively select the parameters to be within the threshold range.
  • the method further comprises providing information about the MR imaging protocol used in the imaging procedure to the database.
  • the database provides information about the MR imaging protocol used in the imaging procedure to the database.
  • the method further comprises categorizing the MR imaging protocol for obtaining an MR scan type of the imaging protocol, wherein the scan information comprises the obtained MR scan type.
  • the MR scanner itself performs the categorization and only provides the resulting MR scan type to the database, or the MR scanner provides for example the MR imaging protocol itself to the database, wherein in turn the database performs the categorization of the MR imaging protocol to determine the MR scan type associated with said MR imaging protocol.
  • the scan information comprises parameters of the MR imaging protocol and/or information on the MR scanner hardware and/or information on the MR scanner software. Consequently, this permits to identify the MR scan type more precisely adapted to the actual requirements with respect to hardware and software.
  • scan protocol parameters information on hardware and software configuration for each scan protocol like scanner type, applied magnetic field strengths, gradient type or software release number may be used to categorize in a highly precise manner the correct MR scan type.
  • the invention in another aspect, relates to a computer program product comprising computer executable instructions to perform the method steps as described above.
  • the invention relates to the magnetic resonance imaging scanner for performing the magnetic resonance imaging scan, as defined in independent claim 10.
  • an MR imaging system 1 comprises superconducting or resistive main magnet coils 2 such that a substantially uniform, temporarily constant main magnetic field B0 is created along a z-axis through an examination volume.
  • the magnetic resonance system applies a series of RF pulses and switched magnetic field gradients to invert or excite nuclear magnetic spins, induce magnetic resonance, refocus magnetic resonance, manipulate magnetic resonance, spatially or otherwise encode the magnetic resonance, saturate spins and the like to perform MR imaging.
  • a gradient pulse amplifier 3 applies current pulses to selected ones of whole body gradient coils 4, 5 and 6 along x, y and z-axes of the examination volume.
  • An RF transmitter 7 transmits RF pulses or pulse packets, via a send/receive switch 8 to an RF antenna 9 to transmit RF pulses into the examination volume.
  • a typical MR imaging sequence is composed of a packet of RF pulse sequences of short duration which taken together with each other and any applied magnetic field gradients achieve a selected manipulation of nuclear magnetic resonance.
  • the RF pulses are used to saturate, excite resonance, invert magnetization, refocus resonance, or manipulate resonance and select a portion of a body 10 positioned in the examination volume.
  • the MR signals may also be picked up by the RF antenna 9.
  • a set of local array RF coils 11, 12 and 13 are placed contiguous to the region selected for imaging.
  • the array coils 11, 12 and 13 can be used to receive MR signals induced by RF transmissions effected via the RF antenna.
  • the resultant MR signals are picked up by the RF antenna 9 and/or by the array of RF coils 11, 12 and 13 and are demodulated by a receiver 14 preferably including a pre-amplifier (not shown).
  • the receiver 14 is connected to the RF coils 9, 11, 12 and 13 via a send/receive switch 8.
  • a host computer 15 controls the gradient pulse amplifier 3 and the transmitter 7 to generate any of a plurality of imaging sequences, such as echo planar imaging (EPI), echo volume imaging, gradient and spin echo imaging, fast spin echo imaging and the like.
  • EPI echo planar imaging
  • echo volume imaging gradient and spin echo imaging
  • fast spin echo imaging fast spin echo imaging
  • the receiver 14 receives a single or a plurality of MR data lines in a rapid succession following each RF excitation pulse.
  • a data acquisition system 16 performs analogue to digital conversion of the received signals and converts each MR data line to a digital format suitable for further processing.
  • the data acquisition system 16 is a separate computer which is specialized in acquisition of raw image data.
  • the digital raw image data is reconstructed into an image representation by a reconstruction processor 17 which applies a Fourier transform or other appropriate reconstruction algorithms.
  • the MR image may represent a planar slice through the patient, an array of parallel planar slices, a three-dimensional volume or the like.
  • the image is then stored in an image memory where it may be accessed for converting slices or other portions of the image representation into appropriate formats for visualization, for example via a video monitor 18 which provides a man readable display of the resultant MR image.
  • Fig. 1 Further shown in Fig. 1 is an interface 21 connected to for example the host computer 15.
  • the interface 21 serves for providing a communication with an external database 30.
  • the host computer 15 may either provide directly this MR imaging protocol via the interface 21 to the database 30, wherein in response to the provision of said protocol the database 30 returns statistical information comprising statistics on modification of individual scan parameters with respect to said provided MR imaging protocol.
  • the host computer 15 may provide the MR imaging protocol to the categorizing component 20, which categorizes the MR imaging protocol into an MR scan type of a predefined set of MR scan types, wherein this identified MR scan type is then provided via the interface 21 to the database 30.
  • Shown in Fig. 2 is for example a user interface, for example a graphical user interface 18, which displays various parameters of a selected MR imaging protocol.
  • an MR imaging protocol may be stored in a database (not shown in Fig. 2 ) comprising so called 'ExamCards', where scan protocols are optimized and stored according to the most often performed examinations with respect to the scanner 1 shown in Fig. 2 .
  • scan protocols require adaption of a certain number of parameters to comply with patient-specific constraints. In the state of the art this is generally done by a radiology technician during the examination, while the patient is on the scan table, wherein the technician often has to cope with patient-specific problems such as motion or breathe hold length. It turned out that not only geometry parameters are routinely adapted by the technician but also parameters having an influence on image quality, scan time or contrast. The degree to which scan parameters are optimized by the user greatly varies within institutions or technicians.
  • Examples of user interface parameters requiring more or less frequent adaption by a technician include for example the field of view, resolution, number of slices, slice gap, fold over direction, SENSE mode, SENSE reduction factor, number of averages, echo time and repetition time.
  • the present invention uses for example data-mining techniques to find out which parameters of a given scan protocol require adaption and to provide statistical information on the values they are typically used with.
  • the database system 30 uses log files 104 that are systematically for example stored on the MR system and sent to the database system 30 via a remote service network. These log files 104 contain the values of all user interface parameters for previously executed MR scans.
  • the main advantage of using the log files as an information source is that parameter settings often encountered in practice are taken as a basis, as opposed to rule-based mechanisms.
  • the invention exploits the log files stemming from the MR system under consideration. However, generally it is preferred to use log files from a multitude of different MR systems and to build up a database which offers multi-site information.
  • a preprocessing step 106 the values of the scan parameters are extracted from the log files 104 and are organized in a database table 100 at the database system 30.
  • the present invention can also be carried out by using for example only a local database system 30 associated with the MR scanner shown in Fig. 2 .
  • the database table 100 is a local database table and not a global one as discussed above.
  • the values of the scan parameters may be extracted and stored in a local database table 100 of the MR system 1, possibly as a compliment to the ExamCard database.
  • the database system 30 is a global database system at a remote site compared to the MR scanner used in Fig. 2 .
  • Data transmission between the MR scanner 1 and the database system 30 may be performed via a network like the internet.
  • the database system 30 For each scan protocol contained in the database table 100, the database system 30 computes statistics on the scan parameters which are most frequently adapted for this particular protocol, together with statistical descriptors of the parameter values such as the modes (most frequent values) or the range.
  • the information comprised in the log files 104 may be parsed in a suitable data structure, containing only the relevant parameters.
  • this data structure may be an XML data structure.
  • the results of the parsing operation are then stored into the database table 100.
  • the database system 30 collects information gathered over multiple days or weeks, and possibly from different installed scanners.
  • the database may also store information on hardware and software configuration for each scan protocol like the scanner type, hardware configuration such as gradient type and software release number.
  • the search for optimized protocol settings becomes active on the MR scanner 1 when an MR user loads a protocol from the ExamCard database into the scan lists and starts editing the protocol in the for example graphical user interface 18.
  • the database system 30 which in turn provides statistical information 102 on this specific MR scan type to the scanner.
  • the data-mining performed by the database system 30 on the database table 100 may be either performed 'on the fly' when receiving the MR scan type or the MR imaging protocol.
  • the data-mining may be performed in a preprocessing step such that the database system 30 only has to access the readily computed statistical information on the MR scan type. In the latter case, the statistical information is precomputed.
  • step 108 the statistical information is provided in step 108 to the graphical user interface 18.
  • different functionalities may be provided at the graphical user interface 18:
  • a set of scan parameters which often require adaptation i.e. for which the statistics on modification frequency is above a predefined threshold
  • These parameters may be grouped into a single parameter group or just highlighted in the whole parameter list on the graphical user interface. Further, it is possible to display statistics showing the typical values (mode or range) for a selected parameter. This functionality could become active for example only upon request by the user. Alternatively, this functionality may become active automatically in case a user starts editing a selected parameter.
  • the statistics can be derived from the pre-computed statistics, or they may be computed on the fly, taking into account the values of all other scan parameters currently chosen.
  • a further functionality may be displaying of a warning (or request for confirmation) for parameters being out of the typical range of utilization, once the protocol has been finalized.
  • the invention provides a method which permits the technician to identify in an easy and reliable manner which parameters of a given MR scan protocol may require adaption and which parameter values may be appropriate for that purpose.
  • categorizing of an MR imaging protocol into an MR scan type may be performed at different levels of complexity: categorization may be either performed, as described above, only with respect to a given type of imaging sequence which describes in a generic term different sub-groups of specialized imaging pulse sequences. However, it is additionally or alternatively possible to perform a categorization with respect to desired imaging contrast types or even with respect to specific applications.
  • the logfile 104 generated by the MR system 1 upon execution of the MR scan is provided to the database system 30 for further analysis, i.e. for enabling updating the database table 100 and optionally the statistical information 102.

Landscapes

  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Signal Processing (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Pathology (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • Bioethics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Claims (10)

  1. Procédé de réalisation d'un balayage d'imagerie par résonance magnétique (RM) à l'aide d'un balayeur RM (1), ledit procédé comprenant les étapes suivantes :
    - la réception d'un protocole d'imagerie RM par l'intermédiaire d'une interface utilisateur (18), ledit protocole d'imagerie RM pouvant être catégorisé en un type de balayage RM d'un ensemble prédéfini de types de balayage RM, dans lequel le type de balayage RM est un terme générique, lequel permet de décrire un ensemble de séquences d'imagerie spécifiques, lesquelles peuvent être classées selon ledit terme générique, et ledit protocole d'imagerie RM comprend des paramètres réglables du balayeur RM (1) pour réaliser le balayage d'imagerie RM à l'aide du type de balayage RM utilisé au niveau du balayeur IRM (1) pour réaliser le balayage d'imagerie RM,
    - l'interrogation d'une base de données (30) par fourniture des informations de balayage à la base de données (30), les informations de balayage permettant à la base de données (30) d'identifier le type de balayage RM du protocole d'imagerie RM et de fournir des informations statistiques (102) sur le type de balayage RM, dans lequel les informations statistiques (102) sont obtenues par analyse des balayages RM précédents,
    - la réception (108) en réponse à ladite interrogation de la base de données (30) des informations statistiques (102) sur le type de balayage RM, lesdites informations statistiques (102) comprenant des statistiques sur les modifications des paramètres de balayage individuels des paramètres réglables du type de balayage RM,
    - la fourniture desdites informations statistiques (102) à l'interface utilisateur (18) pour fournir un support au niveau de l'interface utilisateur (18) comportant des informations sur les paramètres, lesquelles peuvent nécessiter une adaptation lors de l'utilisation du protocole d'imagerie RM sélectionné et/ou sur les valeurs de paramètres généralement utilisées, dans lequel l'étape de fourniture desdites informations statistiques (102) à l'interface utilisateur (18) comprend l'étape consistant à indiquer des paramètres de balayage individuels pour lesquels les statistiques sur la fréquence de modification sont supérieures à un seuil prédéfini,
    - la réception des modifications dudit protocole d'imagerie RM de l'interface utilisateur (18), lesdites modifications résultant en un protocole d'imagerie RM modifié,
    - la réalisation du balayage d'imagerie RM à l'aide dudit protocole d'imagerie RM modifié.
  2. Procédé selon la revendication 1, dans lequel les informations statistiques (102) comprennent des statistiques sur des plages de modifications des paramètres de balayage individuels du type de balayage RM.
  3. Procédé selon la revendication 2, dans lequel les statistiques sur les plages de modifications des paramètres de balayage individuels du type de balayage RM comprennent en outre des plages seuils pour lesdits paramètres de balayage, les plages seuils définissant des plages typiques des paramètres de balayage.
  4. Procédé selon la revendication 3, comprenant en outre les étapes suivantes :
    - la réception d'une modification d'un paramètre de balayage du protocole d'imagerie RM par l'intermédiaire de l'interface utilisateur (18),
    - la détermination si la modification reçue du paramètre de balayage est en dehors de la plage seuil pour ledit paramètre de balayage, et
    - la fourniture d'une indication à l'interface utilisateur (18) lorsque la modification reçue est en dehors de la plage seuil.
  5. Procédé selon la revendication 3, comprenant en outre l'étape consistant à fournir lesdites plages seuils à l'interface utilisateur (18).
  6. Procédé selon la revendication 1, comprenant en outre l'étape consistant à fournir des informations sur ledit protocole d'imagerie RM modifié à la base de données (30).
  7. Procédé selon la revendication 1, comprenant en outre l'étape consistant à catégoriser le protocole d'imagerie RM pour obtenir un type de balayage RM du protocole d'imagerie, dans lequel les informations de balayage comprennent le type de balayage RM obtenu.
  8. Procédé selon la revendication 1, dans lequel les informations de balayage comprennent des paramètres du protocole d'imagerie RM et/ou des informations sur le matériel du balayeur RM (1) et/ou des informations sur le logiciel du balayeur RM (1).
  9. Produit de programme informatique comprenant des instructions exécutables par ordinateur, lesquelles, lorsqu'elles sont exécutées par un ordinateur connecté à un balayeur d'imagerie par résonance magnétique (RM) (1), configurent l'ordinateur pour mettre en œuvre ledit procédé selon l'une quelconque des revendications précédentes.
  10. Balayeur d'imagerie par résonance magnétique (RM) (1) permettant de réaliser un balayage d'imagerie par résonance magnétique, le système étant conçu pour réaliser les étapes suivantes :
    - la réception d'un protocole d'imagerie RM par l'intermédiaire d'une interface utilisateur (18), ledit protocole d'imagerie RM pouvant être catégorisé en un type de balayage RM d'un ensemble prédéfini de types de balayage RM, dans lequel le type de balayage RM est un terme générique, lequel permet de décrire un ensemble de séquences d'imagerie spécifiques, lesquelles peuvent être classées selon ledit terme générique, et ledit protocole d'imagerie RM comprend des paramètres réglables du balayeur RM (1) pour réaliser le balayage d'imagerie RM à l'aide du type de balayage RM utilisé au niveau du balayeur RM (1) pour réaliser le balayage d'imagerie RM,
    - l'interrogation d'une base de données (30) par fourniture des informations de balayage à la base de données (30), les informations de balayage permettant à la base de données (30) d'identifier le type de balayage RM du protocole d'imagerie RM et de fournir des informations statistiques (102) sur le type de balayage IRM, dans lequel les informations statistiques (102) sont obtenues par analyse des balayages RM précédents,
    - la réception en réponse à ladite interrogation de la base de données (30) des informations statistiques (102) sur le type de balayage RM, lesdites informations statistiques (102) comprenant des statistiques sur les modifications des paramètres de balayage individuels des paramètres réglables du type de balayage RM,
    - la fourniture desdites informations statistiques (102) à l'interface utilisateur (18) pour fournir un support au niveau de l'interface utilisateur (18) comportant des informations sur les paramètres, lesquels peuvent nécessiter une adaptation lors de l'utilisation du protocole d'imagerie RM sélectionné et/ou sur les valeurs de paramètres généralement utilisées, dans lequel l'étape de fourniture desdites informations statistiques (102) à l'interface utilisateur (18) comprend l'étape consistant à indiquer des paramètres de balayage individuels pour lesquels les statistiques sur la fréquence de modification sont supérieures à un seuil prédéfini,
    - la réception des modifications dudit protocole d'imagerie RM de l'interface utilisateur (18), lesdites modifications résultant en un protocole d'imagerie RM modifié, et
    - la réalisation du balayage d'imagerie RM à l'aide dudit protocole d'imagerie RM modifié.
EP11804812.3A 2010-12-13 2011-12-07 Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données Active EP2652653B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11804812.3A EP2652653B1 (fr) 2010-12-13 2011-12-07 Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10194733 2010-12-13
PCT/IB2011/055511 WO2012080904A1 (fr) 2010-12-13 2011-12-07 Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données
EP11804812.3A EP2652653B1 (fr) 2010-12-13 2011-12-07 Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données

Publications (2)

Publication Number Publication Date
EP2652653A1 EP2652653A1 (fr) 2013-10-23
EP2652653B1 true EP2652653B1 (fr) 2021-02-17

Family

ID=45444668

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11804812.3A Active EP2652653B1 (fr) 2010-12-13 2011-12-07 Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données

Country Status (5)

Country Link
US (1) US9568578B2 (fr)
EP (1) EP2652653B1 (fr)
CN (1) CN103262082B (fr)
RU (1) RU2633283C2 (fr)
WO (1) WO2012080904A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2652653B1 (fr) * 2010-12-13 2021-02-17 Koninklijke Philips N.V. Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données
KR20140040419A (ko) 2012-09-26 2014-04-03 삼성전자주식회사 의료영상장치 및 그 제어방법
JP5752738B2 (ja) * 2013-04-25 2015-07-22 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー スキャン条件決定装置、磁気共鳴イメージング装置、スキャン条件決定方法、およびプログラム
KR20160020897A (ko) * 2014-08-14 2016-02-24 삼성전자주식회사 자기 공명 영상 장치의 펄스 시퀀스 검증 방법 및 이를 위한 장치
DE102014226053A1 (de) * 2014-12-16 2016-06-16 Siemens Healthcare Gmbh Verfahren zum Betrieb einer Magnetresonanzeinrichtung und Magnetresonanzeinrichtung
US20180045800A1 (en) * 2015-02-24 2018-02-15 Koninklijke Philips N.V. Scan geometry planning method for mri or ct
JP6833311B2 (ja) * 2015-08-12 2021-02-24 キヤノンメディカルシステムズ株式会社 核医学診断装置及び制御プログラム
JP6790119B2 (ja) * 2016-04-21 2020-11-25 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 磁気共鳴イメージングのためのパルスシーケンスパラメータの変更
DE102016207645A1 (de) 2016-05-03 2017-11-09 Siemens Healthcare Gmbh Rechnergestütztes Verfahren zum Bearbeiten eines Untersuchungsschritts
EP3544492A4 (fr) * 2016-11-23 2020-05-27 General Electric Company Gestionnaire de protocoles d'imagerie
RU2019122820A (ru) 2016-12-20 2021-01-22 Конинклейке Филипс Н.В. Способ конфигурирования медицинского устройства
US10325409B2 (en) * 2017-06-16 2019-06-18 Microsoft Technology Licensing, Llc Object holographic augmentation
EP3451344A1 (fr) 2017-09-01 2019-03-06 Koninklijke Philips N.V. Vérification de cohérence automatisée pour l'imagerie médicale
EP3503113B1 (fr) * 2017-12-22 2024-02-21 Siemens Healthineers AG Imagerie mr en nuage
US10878561B2 (en) * 2018-05-31 2020-12-29 General Electric Company Automated scanning workflow
US11574728B2 (en) 2018-06-22 2023-02-07 Koninklijke Philips N.V. Method for enabling magnetic resonance imaging of a subject
CN111768843A (zh) * 2019-04-02 2020-10-13 上海西门子医疗器械有限公司 医学成像装置的控制方法和装置、医学成像装置及方法
EP4020166A1 (fr) * 2020-12-22 2022-06-29 Siemens Healthcare GmbH Procédé de mise en uvre d'au moins une application sur un dispositif de résonance magnétique

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020080918A1 (en) * 2000-12-27 2002-06-27 Tsukasa Sako Radiographic apparatus and method, and control apparatus and method upon radiography
US20090006131A1 (en) * 2007-06-29 2009-01-01 General Electric Company Electronic medical record-influenced data acquisition, processing, and display system and method

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001069474A1 (fr) * 2000-03-14 2001-09-20 Kabushiki Kaisha Toshiba Centre de systemes d'irm et systeme d'irm
US7081750B1 (en) * 2000-05-11 2006-07-25 Fonar Corporation Dynamic real-time magnetic resonance imaging sequence designer
US20020186818A1 (en) * 2000-08-29 2002-12-12 Osteonet, Inc. System and method for building and manipulating a centralized measurement value database
JP2003052660A (ja) * 2001-07-25 2003-02-25 Ge Medical Systems Global Technology Co Llc プロトコル・医用画像登録方法、医用画像提供方法、プロトコル利用方法、プロトコル・医用画像登録システム、医用画像提供システム、プロトコル利用システム、ベンダー端末、利用者端末、およびプロトコル管理サーバ装置
US6687527B1 (en) 2001-08-28 2004-02-03 Koninklijke Philips Electronics, N.V. System and method of user guidance in magnetic resonance imaging including operating curve feedback and multi-dimensional parameter optimization
US7254623B1 (en) 2002-04-16 2007-08-07 General Electric Company Method and apparatus for reducing x-ray dosage in CT imaging prescription
US7685262B2 (en) * 2003-01-24 2010-03-23 General Electric Company Method and system for transfer of imaging protocols and procedures
US7218107B2 (en) * 2003-09-04 2007-05-15 Koninklijke Philips Electronics N.V. Adaptive image homogeneity correction for high field magnetic resonance imaging
US7152785B2 (en) 2003-12-09 2006-12-26 Ge Medical Systems Global Technology Company, Llc Patient-centric data acquisition protocol selection and identification tags therefor
US7430313B2 (en) * 2004-05-04 2008-09-30 Zbilut Joseph P Methods using recurrence quantification analysis to analyze and generate images
US7542792B2 (en) 2004-06-01 2009-06-02 General Electric Company Methods for automatic protocol selection
RU2007124523A (ru) * 2004-12-30 2009-02-10 ПРОВЕНТИС, Инк., (US) Способы, системы и компьютерные программные продукты для разработки и использования прогнозных моделей для прогнозирования большинства медицинских случаев, оценки стратегий вмешательства и для одновременной оценки нерегулярности биологических маркеров
DE102005028873B4 (de) 2005-06-22 2014-07-24 Siemens Aktiengesellschaft Verfahren zur Durchführung einer Untersuchung und Diagnosevorrichtung hierfür
US20080130972A1 (en) 2006-11-30 2008-06-05 General Electric Company Storing imaging parameters
US8468244B2 (en) * 2007-01-05 2013-06-18 Digital Doors, Inc. Digital information infrastructure and method for security designated data and with granular data stores
EP2652653B1 (fr) * 2010-12-13 2021-02-17 Koninklijke Philips N.V. Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données
US10429535B2 (en) * 2011-10-31 2019-10-01 Schlumberger Technology Corporation Statistical analysis of combined log data
US8975892B2 (en) * 2011-12-02 2015-03-10 Siemens Corporation Method of optimizing magnetic resonance image contrast with MRI relaxation time scanning parameters correlated to age of a subject

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020080918A1 (en) * 2000-12-27 2002-06-27 Tsukasa Sako Radiographic apparatus and method, and control apparatus and method upon radiography
US20090006131A1 (en) * 2007-06-29 2009-01-01 General Electric Company Electronic medical record-influenced data acquisition, processing, and display system and method

Also Published As

Publication number Publication date
RU2013132201A (ru) 2015-01-20
CN103262082B (zh) 2017-02-15
WO2012080904A1 (fr) 2012-06-21
CN103262082A (zh) 2013-08-21
EP2652653A1 (fr) 2013-10-23
US9568578B2 (en) 2017-02-14
RU2633283C2 (ru) 2017-10-11
US20130265044A1 (en) 2013-10-10

Similar Documents

Publication Publication Date Title
EP2652653B1 (fr) Système d'examen par résonance magnétique avec des paramètres préférés basés sur l'exploration de données
US10444315B2 (en) MRI with motion correction using navigators acquired using a dixon technique
JP4736184B2 (ja) Ｍｒジオメトリー規定制御を備えたｍｒイメージング・システム
US9733328B2 (en) Compressed sensing MR image reconstruction using constraint from prior acquisition
US6687527B1 (en) System and method of user guidance in magnetic resonance imaging including operating curve feedback and multi-dimensional parameter optimization
EP2628016B1 (fr) Acquisition de données de résonance magnétique (mr) à l'aide d'une surveillance physiologique
US9103898B2 (en) Motion correction in accelerated T1-weighted magnetic resonance imaging
US10241175B2 (en) Medical imaging apparatus having multiple subsystems, and operating method therefor
US10191131B2 (en) Medical imaging apparatus having multiple subsystems, and operating method therefor
EP2539729B1 (fr) Imagerie par résonance magnétique d'espèces chimiques au moyen d'un modèle spectral
KR101453297B1 (ko) 복수 타입의 자기 공명 영상들을 동시에 생성하는 장치 및 방법
JP5914488B2 (ja) 化学種の磁気共鳴撮像
EP3278130B1 (fr) Appareil à bobines rf de type sans fil comprenant un réseau de transducteurs rf et un réseau de sondes de champ magnétique
US20130088230A1 (en) Method of reconstructing a magnetic resonance image of an object considering higher-order dynamic fields
US10168407B2 (en) Medical imaging apparatus having multiple subsystems, and operating method therefor
EP3191862B1 (fr) Imagerie par résonance magnétique à temps d'écho nul
JP2012503517A (ja) 画像診断システム及び方法
CN101322647B (zh) 磁共振成像设备和射频发射增益设置方法
US7642776B2 (en) Method to determine an acquisition sequence in an imaging method for generation of 2D slice images
EP4224193A1 (fr) Optimisation automatique des protocoles d'examen par résonance magnétique
EP4239356A1 (fr) Soutien à la planification d'examens par rm après des examens antérieurs par rayons x ou ct
WO2023148091A1 (fr) Optimisation automatique de protocoles d'examen par résonance magnétique
JP3743734B2 (ja) 磁気共鳴映像装置
WO2022171608A1 (fr) Imagerie par résonance magnétique à séparation eau/graisse de type dixon
KR20030034849A (ko) 촬상 대상의 촬상 체적의 배열 위치 규정 방법 및 그 검색방법, 및 자기 공명 촬상 시스템

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20130715

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20140331

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: KONINKLIJKE PHILIPS N.V.

Owner name: PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602011070154

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: G06F0019000000

Ipc: G01R0033540000

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RIC1 Information provided on ipc code assigned before grant

Ipc: G01R 33/54 20060101AFI20200825BHEP

INTG Intention to grant announced

Effective date: 20200916

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602011070154

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1362161

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210315

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602011070154

Country of ref document: DE

Owner name: PHILIPS GMBH, DE

Free format text: FORMER OWNER: PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH, 20099 HAMBURG, DE

REG Reference to a national code

Ref country code: DE

Ref legal event code: R084

Ref document number: 602011070154

Country of ref document: DE

REG Reference to a national code

Ref country code: GB

Ref legal event code: 746

Effective date: 20210422

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20210217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210517

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210517

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210617

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210518

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1362161

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210617

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602011070154

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20211118

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210617

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20211231

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20211207

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20211207

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20211231

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20211231

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20211231

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20211231

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20111207

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20231219

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20231221

Year of fee payment: 13

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210217

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20231227

Year of fee payment: 13