EP2651500B1 - Zylindrische mehrkanalelektrode für nervenstimulation und -aufzeichnung - Google Patents

Zylindrische mehrkanalelektrode für nervenstimulation und -aufzeichnung Download PDF

Info

Publication number
EP2651500B1
EP2651500B1 EP11808038.1A EP11808038A EP2651500B1 EP 2651500 B1 EP2651500 B1 EP 2651500B1 EP 11808038 A EP11808038 A EP 11808038A EP 2651500 B1 EP2651500 B1 EP 2651500B1
Authority
EP
European Patent Office
Prior art keywords
electrode
electrode body
end surface
bottom end
electrode according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP11808038.1A
Other languages
English (en)
French (fr)
Other versions
EP2651500A1 (de
Inventor
Claude Jolly
Anandhan Dhanasingh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MED EL Elektromedizinische Geraete GmbH
Original Assignee
MED EL Elektromedizinische Geraete GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MED EL Elektromedizinische Geraete GmbH filed Critical MED EL Elektromedizinische Geraete GmbH
Publication of EP2651500A1 publication Critical patent/EP2651500A1/de
Application granted granted Critical
Publication of EP2651500B1 publication Critical patent/EP2651500B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes

Definitions

  • the present invention relates to an implantable electrode for biomedical devices.
  • a normal ear directs sounds as shown in Figure 1 from the outer ear pinna 101 through the generally cylindrical ear canal 110 to vibrate the tympanic membrane 102 (eardrum).
  • the tympanic membrane 102 moves the bones of the middle ear 103 that vibrate the cochlea 104, which in turn functions as a transducer to generate electric pulses to the brain that are interpreted as sounds.
  • the inner ear also includes a balance sensing vestibular system which involves the vestibular labyrinth 105, its three interconnected and mutually orthogonal semi-circular canals: the superior canal 106, posterior canal 107, and horizontal canal 108 (as well as the otolith organs, the utricle and saccule - not shown).
  • the canals and spaces of the vestibular labyrinth 105 are filled with endolymph fluid which moves relative to head movements, thereby activating hair cells that send an electrical balance signal to the brain via the vestibular nerve 111.
  • the vestibular system is damaged or impaired, causing balance problems such as unsteadiness, vertigo and unsteady vision.
  • Vestibular implants are currently under development, with one of the challenges being to stimulate the fibers of the vestibular nerve 111, which lie embedded in a plane in a bony channel surrounding the vestibular labyrinth 105. These nerve fibers need to be stimulated at several different specific locations, suggesting use of a multi channel electrode.
  • the electrode contacts of such a multi channel electrode need to be as close as possible to the nerve fiber, but yet still some distance away, for example, a few microns up to some tens of microns away from the nerve fibers.
  • some of the surrounding bone may be drilled away until a membranous periosteum is exposed, thereby creating an electrode well just above the plane of the nerve fibers.
  • the electrode well may be conical in shape due to the spherical drill burr, 100 microns to 1 mm or more in depth. Or the electrode well may be extended in some lateral direction creating a shoe box-shape well.
  • a planar shape electrode could be used, but it would need to be extremely flexible and yet robust enough to adapt to the shape of the electrode well. And the connection between the electrode contacts and the bottom of the electrode well may be less than optimum with a planar electrode. The placement of a planar electrode in the electrode well also may be hindered by the electrode lead that connects the electrode contacts to the implanted stimulator device.
  • Embodiments of the present invention are directed to an implantable multi-channel electrode.
  • An ear implant electrode with a cylinder shaped electrode body has opposing top and bottom end surfaces. Electrode contacts are dispersed across the bottom end surface to provide electrical interaction with nearby auditory nerve tissue.
  • An insertion limiter may be located on an outer circumference of the electrode body limiting how closely the electrode body may be positioned with respect to the nerve tissue.
  • the insertion limiter may be multiple insertion protrusions disposed around at least a portion of the outer circumference.
  • the insertion limiter may be a skirt protrusion structure extending around at least a portion of the outer circumference.
  • the electrode lead may be connected to the top end surface of the electrode body.
  • the electrode body may include a cylindrical side surface where the electrode lead is connected.
  • the cylinder shape may specifically be a circular cylinder, an elliptic cylinder, or a multi-lobe cylinder shape.
  • the electrode body may be adapted to fit into a prepared electrode holding recess adjacent to the nerve tissue.
  • the bottom end surface may be planar or curved.
  • the electrode body may be made of a resilient silicone material.
  • Embodiments of the present invention also include a biomedical implant system such as a vestibular implant system having an implantable multi-channel electrode according to any of the foregoing.
  • a biomedical implant system such as a vestibular implant system having an implantable multi-channel electrode according to any of the foregoing.
  • US 2008/077174 discloses a device according to the preambule of claim 1.
  • Embodiments of the present invention are directed to an implantable multi-channel electrode in the form of an ear implant electrode with a cylinder shaped electrode body having opposing top and bottom end surfaces.
  • the electrode contacts are dispersed across the bottom end surface of the electrode body to provide electrical interaction with nearby nerve tissue.
  • Such a small cylindrical multi-channel electrode is useful to stimulate small nerve fibers which lie very close together.
  • a multi-channel ear implant electrode can also allow choosing the best electrode contacts closest to the nerve cells for use in stimulation. In the past, this has proven to be quite difficult with the small vestibular nerve and a single channel electrode where interaction of the electrode with the nerve is hit or miss based on its proximity to the nerve, where a miss means no stimulation is possible.
  • FIG. 2 shows an example of a multi-channel ear implant electrode 200 according to one embodiment of the present invention when positioned for use in a vestibular implant system.
  • the cylinder shaped electrode body 201 is implanted so that the electrode contacts 204 on its bottom end surface 203 are positioned adjacent to the nerve fibers of the vestibular nerve 111 where they connect to the vestibular labyrinth.
  • the electrode body 201 may be made of resilient silicone material of a size and shape specifically adapted to fit properly in the drilled electrode well.
  • An electrode lead 202 much smaller in diameter than the electrode body 201 is connected to the top end surface 205 of the electrode body 201 and provides electrical connection of the electrode contacts 204 to an implant stimulator device. This arrangement results in low drag forces on the electrode body 201. Locating the connection of the electrode lead 202 at the top end surface 205 of the electrode body 201 on the opposite end from the bottom end surface 203 of the electrode contacts 204 minimizes its effect on the interaction of the electrode contacts 204 with the nerve fibers. By contrast, placing the electrode lead 202 on the side of the electrode body 201 as with a conventional flat planar electrode would require additional insertion space and be destabilizing for the implanted placement of the electrode body 201.
  • Figure 6 shows an embodiment of a cylinder shaped electrode body 201 with an electrode lead 202 that enters the side of the electrode body 201.
  • Such an embodiment might be especially useful, for example, in an application as a transcranial plug that penetrates through the skull bone with electrode contacts 204 that lie against target tissue on the surface of the brain.
  • Fig. 7A shows the bottom end surface 203 of a specific embodiment of an ear implant electrode 200 where the electrode body 201 is a circular cylinder where the electrode contacts 204 are distributed towards the outer circumference.
  • Fig. 7B shows the bottom end surface 203 where the electrode body 201 is an elliptic cylinder and the electrode contacts 204 are distributed in a straight line along the length of the elliptical axis. Such a shape may allow less bone to be removed at the insertion point.
  • Fig. 7C shows the bottom end surface 203 where the electrode body 201 is a multi-lobed cylinder with an electrode contact 204 in each lobe.
  • the bottom end surface 203 may be planar, curved, etc.
  • Figure 3A shows a bottom perspective view of an ear implant electrode 200 having a ground electrode 301 around the outer circumference of the electrode body 201 some distance above the bottom end surface 203.
  • the ground electrode 301 provides an electrical circuit reference for the electrode contacts 204 on the bottom surface 203. Locating a ground electrode 301 this way helps confine the electrical field from the stimulation signals to the region around the cylinder of the electrode body 201 and reduces current dispersion and unwanted stimulation of nearby nerve cells.
  • Figure 3B shows an example of an arrangement wherein there is a ground electrode 301 around the outer circumference of the bottom end surface 203.
  • Figure 3C shows an arrangement having a separate common ground electrode 301.
  • Figure 3D shows an arrangement where there is an individual ground electrode 301 for each stimulating electrode contact 204. Such an arrangement of adjacent contact pairs helps minimize channel cross-talk-in applications such as vestibular implants this is an important consideration to preserve proper functionality of nearby systems such as the eye.
  • Figure 4 shows an electrode body 201 implanted in an electrode well 401 in a prepared bone location.
  • the bottom end surface 203 of the electrode body 201 fits snuggly against the well bottom 403 of the electrode well 401 so that the electrode contacts 204 are adjacent to the plane of the nerve fibers 402.
  • the electrode body 201 may just fit within the electrode well 401, or there may be some compression of the electrode body 201 to fit it more snuggly.
  • the electrode contacts 204 are spherical shaped, whereas in the embodiments shown in Figs. 3 A-D they are flat circles. In other specific embodiments, the electrode contacts 204 may have other specific shapes, for example linear line segments, wire ends, etc.
  • ear implant electrodes 200 may also include one or more insertion limiter structures for limiting how closely the electrode body may be positioned with respect to the nerve tissue.
  • Figure 5A shows an embodiment of an ear implant electrode 200 having a skirt limiter 501 extending around the outer circumference of the electrode body 201 some height above the bottom end surface 203.
  • the insertion skirt 501 limits how closely the electrode body 201 may be positioned with respect to the nerve tissue.
  • the insertion skirt 501 also provides anchoring stabilization around the cylindrical electrode body 201.
  • Figure 5B shows an embodiment where there are a plurality of limiter protrusions 502 disposed around at least a portion of an outer circumference of the electrode body 201.
  • Figure 5C shows an embodiment of a cylindrical multi-channel ear implant electrode having a partial limiting insertion skirt 503 extending part way around the outer circumference of the electrode body 201. Such an embodiment may provide a better field of view during surgical insertion.
  • Embodiments of a multi-channel cylindrical electrode such as those described above may be very useful when implemented as a small structure for stimulating nerve fibers that are hidden in or shielded by bone, such as is the case with vestibular nerves.
  • the superior and lateral ampullar nerve can be independently stimulated with an optimum contact closest to each nerve.
  • an arrangement of multiple cylindrical multi-channel electrodes may also be useful when connected to one or more stimulation devices to approach a single larger nerve such as in some spinal cord applications, especially to avoid damaging the dura and/or for localized stimulation from the true scope of the invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)
  • Prostheses (AREA)

Claims (13)

  1. Implantierbare Mehrkanalelektrode, umfassend:
    eine Ohrimplantat-Elektrode (200) mit einem zylinderförmigen Elektrodenkörper (201) mit gegenüberliegenden oberen und unteren Endoberflächen (205, 203); und
    eine Vielzahl von Elektrodenkontakten (204) zum Bereitstellen von elektrischer Wechselwirkung mit benachbartem vestibulärem Nervengewebe,
    dadurch gekennzeichnet, dass die Elektrodenkontakte (204) über die untere Endoberfläche (203) verteilt sind und dass wenigstens eine Masseelektrode (301) zum Bereitstellen einer elektrischen Schaltkreisreferenz für die Elektrodenkontakte (204) vorhanden ist, wobei die Masseelektrode um einen Außenumfang des Elektrodenkörpers (201) angeordnet ist.
  2. Elektrode gemäß Anspruch 1, ferner umfassend:
    einen Einführbegrenzer, der an einem Außenumfang des Elektrodenkörpers (201) angeordnet ist, um zu begrenzen, wie eng der Elektrodenkörper (201) an dem Nervengewebe positioniert werden kann.
  3. Elektrode gemäß Anspruch 2, wobei der Einführbegrenzer eine Schürzenvorsprungsstruktur (501) ist, die um wenigstens einen Teil eines Außenumfangs des Elektrodenkörpers (201) verläuft.
  4. Elektrode gemäß Anspruch 2, wobei es sich bei dem Einführbegrenzer um eine Vielzahl von Begrenzervorsprüngen (502) handelt, die um wenigstens einen Teil eines Außenumfangs des Elektrodenkörpers (201) angeordnet sind.
  5. Elektrode gemäß Anspruch 1, ferner umfassend:
    eine Elektrodenleitung (202), die mit dem Elektrodenkörper (201) verbunden und viel kleiner als dieser ist und eine elektrische Verbindung der Elektrodenkontakte mit einer Implantat-Stimulationsvorrichtung bereitstellt.
  6. Elektrode gemäß Anspruch 5, wobei die Elektrodenleitung (202) an der oberen Endoberfläche (205) des Elektrodenkörpers (201) angeschlossen ist.
  7. Elektrode gemäß Anspruch 1, wobei der Elektrodenkörper (201) dafür ausgelegt ist, in eine vorbereitete Elektrodenhaltevertiefung (401) nahe dem Nervengewebe zu passen.
  8. Elektrode gemäß Anspruch 1, wobei der Elektrodenkörper (201) aus einem nachgiebigen Siliconmaterial besteht.
  9. Elektrode gemäß Anspruch 1, wobei der Elektrodenkörper (201) eine kreiszylindrische Form aufweist.
  10. Elektrode gemäß Anspruch 1, wobei der Elektrodenkörper (201) eine elliptischzylindrische Form aufweist.
  11. Elektrode gemäß Anspruch 1, wobei der Elektrodenkörper (201) eine mehrkeulige Zylinderform aufweist.
  12. Elektrode gemäß Anspruch 1, wobei die untere Endoberfläche (203) planar ist.
  13. Elektrode gemäß Anspruch 1, wobei die untere Endoberfläche (203) gekrümmt ist.
EP11808038.1A 2010-12-15 2011-12-14 Zylindrische mehrkanalelektrode für nervenstimulation und -aufzeichnung Active EP2651500B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42318110P 2010-12-15 2010-12-15
PCT/US2011/064779 WO2012082822A1 (en) 2010-12-15 2011-12-14 Multichannel cylindrical electrode for nerve stimulation and recording

Publications (2)

Publication Number Publication Date
EP2651500A1 EP2651500A1 (de) 2013-10-23
EP2651500B1 true EP2651500B1 (de) 2016-07-20

Family

ID=45476610

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11808038.1A Active EP2651500B1 (de) 2010-12-15 2011-12-14 Zylindrische mehrkanalelektrode für nervenstimulation und -aufzeichnung

Country Status (5)

Country Link
US (1) US8423158B2 (de)
EP (1) EP2651500B1 (de)
CN (1) CN103269745B (de)
AU (1) AU2011343868B2 (de)
WO (1) WO2012082822A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903017C (en) * 2013-03-01 2023-10-17 The Regents Of The University Of California Method and system for altering body mass composition using galvanic vestibular stimulation
DE102016116871A1 (de) * 2016-09-08 2018-03-08 Phenox Gmbh Vorrichtung und Verfahren zur Vorbeugung und Behandlung eines Vasospasmus
WO2018080955A1 (en) * 2016-10-24 2018-05-03 Med-El Elektromedizinische Geraete Gmbh A fixation component for insertion tools for minimally invasive cochlear implants
US11806530B2 (en) 2020-04-21 2023-11-07 Cochlear Limited Balance compensation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7300449B2 (en) * 1999-12-09 2007-11-27 Mische Hans A Methods and devices for the treatment of neurological and physiological disorders
US7442164B2 (en) * 2003-07-23 2008-10-28 Med-El Elektro-Medizinische Gerate Gesellschaft M.B.H. Totally implantable hearing prosthesis
US7580754B2 (en) * 2003-11-14 2009-08-25 Cochlear Limited Implantable acoustic sensor
US7894910B2 (en) * 2006-06-20 2011-02-22 Ebr Systems, Inc. Systems and methods for implantable leadless cochlear stimulation

Also Published As

Publication number Publication date
AU2011343868B2 (en) 2015-03-12
CN103269745B (zh) 2015-11-25
US8423158B2 (en) 2013-04-16
WO2012082822A1 (en) 2012-06-21
US20120158112A1 (en) 2012-06-21
AU2011343868A1 (en) 2013-05-02
EP2651500A1 (de) 2013-10-23
CN103269745A (zh) 2013-08-28

Similar Documents

Publication Publication Date Title
US20230173256A1 (en) Vestibular stimulation device
US7962226B2 (en) Cochlear endosteal electrode carrier member
US20110029031A1 (en) Bimodal hearing prosthesis
US20080154339A1 (en) Electrically Nonconductive Occludent For Tissue Openings
CA2464453A1 (en) Auditory midbrain implant
US20240017060A1 (en) Neural stimulator with flying lead electrode
EP2651500B1 (de) Zylindrische mehrkanalelektrode für nervenstimulation und -aufzeichnung
WO2008031144A1 (en) Implantable electrode array
CN104159542B (zh) 组织刺激电极配件
EP3265027B1 (de) Atraumatische vorhofstimulation und messelektrode
US20090143840A1 (en) Auditory prosthesis utilizing intra-neural stimulation of the auditory nerve
EP3769809B1 (de) Prothese zur vestibulären stimulation
US20230355962A1 (en) Advanced surgically implantable technologies
CN111344040A (zh) 可导航的可植入电极和塌陷的润滑剂储器

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20130422

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20140319

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602011028422

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: A61N0001050000

Ipc: A61N0001360000

RIC1 Information provided on ipc code assigned before grant

Ipc: A61N 1/36 20060101AFI20160316BHEP

Ipc: A61N 1/05 20060101ALI20160316BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20160506

RIN1 Information on inventor provided before grant (corrected)

Inventor name: JOLLY, CLAUDE

Inventor name: DHANASINGH, ANANDHAN

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 813547

Country of ref document: AT

Kind code of ref document: T

Effective date: 20160815

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602011028422

Country of ref document: DE

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20160720

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 813547

Country of ref document: AT

Kind code of ref document: T

Effective date: 20160720

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 6

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161120

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161020

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161121

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161021

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602011028422

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161020

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

26N No opposition filed

Effective date: 20170421

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20161214

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20161214

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20161231

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20161231

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20161214

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20161214

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 7

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20111214

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20161214

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160720

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20231226

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20231227

Year of fee payment: 13