EP2639216A4 - Halogenated indenones and method for producing optically active indanones or optically active indanols by using same - Google Patents

Halogenated indenones and method for producing optically active indanones or optically active indanols by using same

Info

Publication number
EP2639216A4
EP2639216A4 EP11839101.0A EP11839101A EP2639216A4 EP 2639216 A4 EP2639216 A4 EP 2639216A4 EP 11839101 A EP11839101 A EP 11839101A EP 2639216 A4 EP2639216 A4 EP 2639216A4
Authority
EP
European Patent Office
Prior art keywords
optically active
indenones
indanols
indanones
halogenated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11839101.0A
Other languages
German (de)
French (fr)
Other versions
EP2639216B1 (en
EP2639216A1 (en
Inventor
Shohei Yamamoto
Masakatsu Nishihachijo
Rie Tanaka
Shigeru Kawano
Akio Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of EP2639216A1 publication Critical patent/EP2639216A1/en
Publication of EP2639216A4 publication Critical patent/EP2639216A4/en
Application granted granted Critical
Publication of EP2639216B1 publication Critical patent/EP2639216B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C07C29/175—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds with simultaneous reduction of an oxo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/38—Cyclopentanone- or cyclopentadione-containing products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP11839101.0A 2010-11-09 2011-11-08 Halogenated indenones and method for producing optically active indanones or optically active indanols by using same Not-in-force EP2639216B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010251095 2010-11-09
PCT/JP2011/075767 WO2012063843A1 (en) 2010-11-09 2011-11-08 Halogenated indenones and method for producing optically active indanones or optically active indanols by using same

Publications (3)

Publication Number Publication Date
EP2639216A1 EP2639216A1 (en) 2013-09-18
EP2639216A4 true EP2639216A4 (en) 2014-12-10
EP2639216B1 EP2639216B1 (en) 2018-07-11

Family

ID=46050984

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11839101.0A Not-in-force EP2639216B1 (en) 2010-11-09 2011-11-08 Halogenated indenones and method for producing optically active indanones or optically active indanols by using same

Country Status (5)

Country Link
EP (1) EP2639216B1 (en)
JP (2) JP5941410B2 (en)
CN (2) CN103209949B (en)
DK (1) DK2639216T3 (en)
WO (1) WO2012063843A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR094054A1 (en) 2012-12-19 2015-07-08 H Lundbeck As 6-CHLORINE-3- (FENIL-D₅) -INDEN-1-ONA AND USE OF THE SAME
CN106011094B (en) * 2016-07-27 2020-11-03 苏州汉酶生物技术有限公司 Engineered ketoreductase polypeptide and method for preparing (3R,5S) -6-chloro-3, 5-dyhydroxyl hexanoic acid tert-butyl ester by using same
WO2020114853A1 (en) 2018-12-03 2020-06-11 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine
CN111261786B (en) * 2020-01-19 2023-07-28 浙江大学 Efficient organic solar cell based on asymmetric end-capped electron acceptor

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55192D0 (en) 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindene derivatives
KR100266920B1 (en) 1992-08-10 2003-12-31 가네가후치 가가쿠고교 가부시키가이샤 DNA encoding decarbamylase with improved heat resistance and use thereof
JP4753273B2 (en) 1999-07-21 2011-08-24 株式会社カネカ Method for producing optically active pyridine ethanol derivative
CZ20012792A3 (en) 1999-12-03 2002-03-13 Kaneka Corporation Polypeptide, polynucleotide encoding polypeptide, expression vector, transformant and preparation process
SE9904850D0 (en) * 1999-12-30 1999-12-30 Pharmacia & Upjohn Ab Novel process and intermediates
AU2003264502A1 (en) 2002-09-19 2004-04-08 Kaneka Corporation Novel carbonyl reductase, gene thereof and method of using the same
BRPI0413595B8 (en) * 2003-08-18 2021-05-25 H Lundbeck As malonate salt, pharmaceutical composition, use of a malonate salt, and method of manufacturing a compound
ME00154B (en) * 2003-08-18 2010-10-10 H Lundbeck As Succinate and malonate salt of trans-4-(ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament
CN1993464B (en) 2004-08-06 2011-12-28 株式会社钟化 Novel carbonyl reductase, gene thereof and method of using the same
WO2006033333A1 (en) 2004-09-24 2006-03-30 Kaneka Corporation Method of producing aldonic acids and aldose dehydrogenase
EP1811021A4 (en) 2004-10-27 2008-05-28 Kaneka Corp Novel carbonyl reductase, gene therefor and use thereof
TWI453198B (en) 2005-02-16 2014-09-21 Lundbeck & Co As H Process for making the trans-1-( (1r , 3s)- 6-chloro - 3 -phenylindan-1- yl ) - 3 , 3 - dimethylpiperazine and salts thereof and for making 4 -((1r , 3s )-6- chloro- 3- phenylindan -1- yl )-1, 2 , 2 -trimethylpiperazine and salts thereof
JP2006262767A (en) 2005-03-24 2006-10-05 Kaneka Corp New glucose dehydrogenase
US20100003732A1 (en) * 2005-05-31 2010-01-07 Kaneka Corporation Process for production of optically active 2-substituted propanal derivative
JP5005672B2 (en) 2006-02-28 2012-08-22 株式会社カネカ Novel carbonyl reductase, gene thereof, and method for producing optically active alcohol using them
WO2007099994A1 (en) 2006-03-02 2007-09-07 Kaneka Corporation Novel carbonyl reductase, gene for the reductase, vector, transformant, and method for production of optically active alcohol utilizing these materials
JP5261172B2 (en) 2006-03-31 2013-08-14 株式会社カネカ Method for producing erythro or threo-2-amino-3-hydroxypropionic ester, novel carbonyl reductase, gene, vector, transformant thereof, and method for producing optically active alcohol using them
JP5308163B2 (en) 2006-11-29 2013-10-09 株式会社カネカ Novel alcohol dehydrogenase, its gene, vector, transformant, and method for producing optically active alcohol using them
US20100292292A1 (en) * 2007-09-13 2010-11-18 Link Medicine Corporation Treatment of Neurodegenerative Diseases Using Indatraline Analogs
EP2202303B1 (en) 2007-09-26 2016-10-26 Kaneka Corporation Novel glucose dehydrogenase
JP2010130912A (en) 2008-12-02 2010-06-17 Kaneka Corp Method for producing optically active 3-quinuclidinol

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JAMES F. FREEMAN ET AL.: "3-Phenylindones. I. The synthesis of 6-chloro-3-(p-chlorophenyl)-1-indenone and some related compounds", J. AM. CHEM. SOC., vol. 72, 1950, pages 1522 - 1526, XP002721657 *
S.C. PAKRASHI ET AL.: "The Reformatsky reaction on 1-naphthyl-2-bromophenyl ketone", TETRAHEDRON, vol. 18, 1962, pages 1243 - 1249, XP002721656 *
See also references of WO2012063843A1 *

Also Published As

Publication number Publication date
WO2012063843A1 (en) 2012-05-18
CN104496780A (en) 2015-04-08
JPWO2012063843A1 (en) 2014-05-12
JP6093427B2 (en) 2017-03-08
JP5941410B2 (en) 2016-06-29
DK2639216T3 (en) 2018-09-24
EP2639216B1 (en) 2018-07-11
JP2016074712A (en) 2016-05-12
CN103209949B (en) 2016-08-10
EP2639216A1 (en) 2013-09-18
CN103209949A (en) 2013-07-17

Similar Documents

Publication Publication Date Title
IL252687B (en) Database management system
EP2670469A4 (en) Snap-seal sterile intravascular catheter-dressing system
SG10201510576WA (en) Optically active diazabicyclooctane derivative and process for preparing the same
EP2661752A4 (en) Wireless in-core neutron monitor
PL2639207T3 (en) Granular pumice and method for producing granular pumice
EP2716662A4 (en) Hydrogel and method for producing same
GB201012605D0 (en) Method & system
GB201006682D0 (en) Co-9x optical alarm
EP2567259A4 (en) Q tomography method
EP2556479A4 (en) Techniques for monetizing anonymized context
EP2798792B8 (en) Distributed system management
EP2730959A4 (en) Optical connection member, optical connection structure, and method for producing optical connection member
HK1167971A1 (en) Optical network unit and method thereof
HK1187157A1 (en) Spherical liquid-crystal laser
PT2627629T (en) Method for producing isocyanates
IL222607A0 (en) Method for disinfecting surfaces
EP2558083A4 (en) Methods for providing enhanced resveratrol activity using 4-acetoxy-resveratrol
EP2677525A4 (en) Reactor
PL2547652T3 (en) Method for producing isocyanates
EP2639216A4 (en) Halogenated indenones and method for producing optically active indanones or optically active indanols by using same
EP2660232A4 (en) Novel alicyclic alcohol
EP2660233A4 (en) Novel alicyclic alcohol
EP2634701A4 (en) Database management method
EP2706063A4 (en) Ruthenium-diamine complex and method for producing optically active compound
GB201216821D0 (en) Decontamination method

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20130607

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 49/697 20060101ALI20141021BHEP

Ipc: C07C 29/143 20060101ALI20141021BHEP

Ipc: C07D 241/04 20060101ALI20141021BHEP

Ipc: C07B 53/00 20060101ALI20141021BHEP

Ipc: C07B 61/00 20060101ALI20141021BHEP

Ipc: C12P 7/26 20060101ALI20141021BHEP

Ipc: C07C 35/52 20060101ALI20141021BHEP

Ipc: C07C 45/62 20060101AFI20141021BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20141110

17Q First examination report despatched

Effective date: 20160822

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602011050044

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: C07C0045620000

Ipc: C07C0029170000

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 45/62 20060101ALI20180205BHEP

Ipc: C12P 7/22 20060101ALI20180205BHEP

Ipc: C07C 45/65 20060101ALI20180205BHEP

Ipc: C12P 7/38 20060101ALI20180205BHEP

Ipc: C07D 241/04 20060101ALI20180205BHEP

Ipc: C07C 29/17 20060101AFI20180205BHEP

Ipc: C07C 45/63 20060101ALI20180205BHEP

Ipc: C07B 53/00 20060101ALI20180205BHEP

INTG Intention to grant announced

Effective date: 20180219

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1016712

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180715

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602011050044

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: VOSSIUS AND PARTNER PATENTANWAELTE RECHTSANWAE, CH

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20180919

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 8

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20180711

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181012

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181011

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181011

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181111

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602011050044

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

26N No opposition filed

Effective date: 20190412

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181108

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181108

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20191111

Year of fee payment: 9

Ref country code: DE

Payment date: 20191029

Year of fee payment: 9

REG Reference to a national code

Ref country code: AT

Ref legal event code: UEP

Ref document number: 1016712

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180711

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20191017

Year of fee payment: 9

Ref country code: IT

Payment date: 20191108

Year of fee payment: 9

Ref country code: DK

Payment date: 20191112

Year of fee payment: 9

Ref country code: FR

Payment date: 20191014

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20191116

Year of fee payment: 9

Ref country code: AT

Payment date: 20191025

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20191107

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: MK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180711

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20111108

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602011050044

Country of ref document: DE

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20201130

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 1016712

Country of ref document: AT

Kind code of ref document: T

Effective date: 20201108

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20201108

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20201130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201130

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201108

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201130

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201108

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201108

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201130

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201108

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210601

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20201130