EP2574326B1 - Flacon filtrant doté d'un piston tubulaire, d'une coupelle de retenue et d'un filtre - Google Patents

Flacon filtrant doté d'un piston tubulaire, d'une coupelle de retenue et d'un filtre Download PDF

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Publication number
EP2574326B1
EP2574326B1 EP12199346.3A EP12199346A EP2574326B1 EP 2574326 B1 EP2574326 B1 EP 2574326B1 EP 12199346 A EP12199346 A EP 12199346A EP 2574326 B1 EP2574326 B1 EP 2574326B1
Authority
EP
European Patent Office
Prior art keywords
piston
cup
filter
vial
flange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12199346.3A
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German (de)
English (en)
Other versions
EP2574326A3 (fr
EP2574326A2 (fr
Inventor
Samuel A. Ellis
Kishan G. Hingorani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scientific Plastic Products Inc
Securus Inc
Original Assignee
Scientific Plastic Products Inc
Securus Inc
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Publication date
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Publication of EP2574326A2 publication Critical patent/EP2574326A2/fr
Publication of EP2574326A3 publication Critical patent/EP2574326A3/fr
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Publication of EP2574326B1 publication Critical patent/EP2574326B1/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D33/00—Filters with filtering elements which move during the filtering operation
    • B01D33/01—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons
    • B01D33/0108—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with bag, cage, hose, tube, sleeve or the like filtering elements
    • B01D33/0116—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with bag, cage, hose, tube, sleeve or the like filtering elements arranged for inward flow filtration
    • B01D33/0125—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with bag, cage, hose, tube, sleeve or the like filtering elements arranged for inward flow filtration open ended
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D33/00—Filters with filtering elements which move during the filtering operation
    • B01D33/01—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons
    • B01D33/015—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with flat filtering elements
    • B01D33/0183—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with flat filtering elements supported
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/30—Filter housing constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
    • B23P11/00—Connecting or disconnecting metal parts or objects by metal-working techniques not otherwise provided for 
    • B23P11/02—Connecting or disconnecting metal parts or objects by metal-working techniques not otherwise provided for  by first expanding and then shrinking or vice versa, e.g. by using pressure fluids; by making force fits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining
    • Y10T29/49908—Joining by deforming
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/53—Means to assemble or disassemble
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Definitions

  • Filter vials have a tubular piston with a filter at the distal end of the piston.
  • the piston fits into a mating vial containing a fluid and things suspended in the fluid.
  • When the piston is inserted into the vial fluid passes through the filter and into the piston in order to separate the fluid from particles or molecules too large to pass through the filter in the bottom of the piston.
  • the filtered fluid can be extracted from the piston for further use.
  • the diameter and thickness of the filters can vary greatly from filter to filter and the thickness of the filter can vary greatly even across one filter. These variations make it difficult to seal the filters so all the fluid being filtered passes through the filter, and so that fluid does not wick around the peripheral edge of the filter to contaminate the filtered fluid in the piston. Further, as fluid is forced through the filters the filters can bow or otherwise deform and allow fluid to bypass the filter as it enters the body of the piston.
  • Current assemblies use ultrasonically welded assemblies. Even if the filters are ultrasonically welded to the adjacent walls that leaves plasticizers that contaminate the fluids placed in the vials during use.
  • US5833860 discloses an adsorptive sample preparation device and method for concentrating, desalting and/or purifying biomolecules.
  • DE9013914 discloses a device for separating liquid, in particular blood fractions.
  • US3512940 discloses a pressure or vacuum filter device to be used in a test tube.
  • US4990253 discloses a sample filtration device employing differential pressure.
  • US4734262 discloses a reaction mixture handling device comprising a chamber for containing a reaction mixture with an open upper end and an outlet at its lower end.
  • US5998214 discloses an apparatus for collecting fluids and holding samples taken from the fluid for qualitative and quantitative testing.
  • a filter vial and piston are provided that has a cup which holds a filter in position on the piston during use so that all the fluid passes through the filter and none passes around the edges of the filter.
  • the parts are integrally molded so there is no contamination from ultrasonic welding.
  • the parts snap-fit together, but appropriates seals are provided to prevent wicking or leakage at the location of the snap-locks.
  • the filter vial assembly has a longitudinal axis along which the piston moves during use.
  • the assembly includes a tubular vial having a closed bottom and an open top with walls defining a cylindrical interior having a diameter D.
  • a tubular piston is provided having opposing distal and proximal ends with at least the distal end being open.
  • the piston has walls defining a cylindrical interior with an exterior facing recessed portion adjacent the distal end the piston.
  • the piston further has a distal piston flange at or adjacent to the distal end of the piston and extending outward from piston.
  • a filter support is located inside the piston at the distal end of the piston.
  • a retainer cup having a sidewall extending between a proximal and distal ends of the cup with an interior diameter smaller than the distal seal on the piston.
  • the cup has a lip extending inward toward the longitudinal axis at the distal end of the retainer cup, and further has a cup seal extending outward from the proximal end of the cup a distance greater than the diameter D.
  • the sidewall of the cup are sufficiently flexible to deform outward as the cup passes over the distal seal on the piston so the sidewalls assume an outer dimension larger than diameter D at the location of the piston flange when the retainer cup passes over the piston distal seal.
  • a filter is interposed between the retaining cup's lip and the distal end of the piston when the proximal end of the retainer cup is placed over the distal end of the piston.
  • the piston and retainer cup are placed through the open end of the filter vial so the filter cup abuts and forms a fluid seal with the inside of the vial at the location of the cup seal and at the location of the distal piston flange.
  • the recessed area extends entirely around a circumference of the piston.
  • the lip preferably extends continuously around an inner circumference of the retainer cup, it could be intermittent.
  • the piston, vial and retaining cup are made of plastic, and preferably each part is separately formed.
  • a cap is provided where the cap is sized to releasably but snugly fit over the proximal end of the piston.
  • Such caps are commonly used, and typically have a flexible membrane through which a needle can be inserted to withdraw filter fluid from inside the piston.
  • the proximal cup seal abuts an end of the recess in the piston during use.
  • there is an additional seal extending outward from the piston adjacent the proximal end of the piston and located to engage and form a fluid tight seal against the vial when the distal end of the piston is adjacent the bottom of the vial.
  • the piston flange has a generally triangular cross sectional shape which is larger at the proximal end and smaller at the distal end of the seal.
  • a method of forming a piston for a filter vial where the piston has a cylindrical tube with opposing proximal and distal ends.
  • the method includes forming an outwardly extending piston flange at the distal end of the piston.
  • a cylindrical recess is formed around a periphery of the distal end of the piston at the distal end of the piston and adjacent to the piston flange and on the proximal side of the piston flange.
  • a filter is placed in the bottom of a retaining cup which cup is sized to fit over the distal end of the piston.
  • the retaining cup is provided with an open proximal end and an inward extending lip at an opposing distal end which lip abuts a periphery of the filter.
  • the method also includes placing the open proximal end of the cup over the distal end of the piston and piston flange to form a snap fit between the proximal end of the cup and the recess on the piston and advancing the retaining cup along the piston until the distal end of the piston abuts the filter.
  • the retaining cup is provided with an outwardly extending seal at the proximal end sized to sealingly engage the inside of the filter vial during use.
  • the retaining cup is made of sufficiently flexible material to bulge outward at the piston flange with the piston flange and retaining cup being dimensioned to extend outward a distance sufficient to form a fluid tight seal with walls of the filter vial during use.
  • the method includes providing a filter support on the distal end of the retaining cup, the cup filter support located to abut the filter during use.
  • the method can also include providing a piston filter support on the distal end of the piston, with the piston filter support located to abut the filter during use.
  • the method also includes providing a piston filter support on the distal end of the piston, the piston filter support located to abut the filter during use.
  • the method includes placing a rib on a distal edge of the piston located to form an axial facing seal around a periphery of the filter.
  • a tubular piston 10 with a circular cross-section has proximal and distal ends 12, 14, respectively, with a porous piston support 16 located at the distal end 14.
  • the support 16 advantageously takes the form of radial arms intersecting at a central location on the longitudinal axis 18 of the piston 10.
  • distal and proximal refer to relative locations of parts along the longitudinal axis 18, and the terms inward and outward refer to relative directions toward and away from the longitudinal axis 18.
  • One or more flanges 20 extend radially from the proximal end 12.
  • a first, proximal seal 22 is located adjacent to but inward from the proximal end 12 and extends outward, away from longitudinal axis 18.
  • a vent hole 24 is adjacent the seal 22 but located slightly toward the distal end 14.
  • Adjacent to and preferably extending to the distal end 14 is a recessed area 26 having a smaller diameter than that of the body of piston 10 forming a shoulder 27 at the location of the larger diameter portion of the piston body.
  • An outward extending distal piston flange 28 is located adjacent the distal end 14 in this recessed area.
  • An axially extending tip 31 ( Fig. 2 ) is preferably, but optionally provided that encircles the distal end of the piston 10.
  • the tip 31 preferably has a triangular cross section and is very small.
  • a retainer cup 30 has an inner diameter sized to fit snugly against the piston recess 26.
  • the retainer cup 30 has proximal and distal ends 32, 34, respectively, with a porous cup support 36 over the distal end 34 and a third, cup seal 38 at the proximal end, extending outward, away from the axis 18.
  • the support 36 is like the support 16.
  • a membrane filter 40 fits inside the retainer cup 30 and abuts the cup support 36.
  • the membrane filter 40 is disc shaped, usually with an axial thickness that is several times smaller than its diameter. In some situations multiple filters 40 can be stacked.
  • An inward extending lip 41 at the distal end 34 of the cup 30 provides an axial support around the periphery of the filter 40.
  • the tip 31 ( Fig. 2 ) on the distal end of the piston 10 presses the filter 40 against this lip 41 when the parts are assembled.
  • the supports 16, 36 preferably take the form of radial struts or spokes extending from the walls of piston 10 or cup 30, respectively. But the supports 16, 36 could take other forms, such a rectangular or square grid work, or a plate with drain holes therein.
  • a spoke with a triangular cross-section is believed suitable, with the apex of the triangle abutting the filter 40 in order to reduce blockage of the filter. Since supports 16, 36 abut opposing sides of the filter 40, a spoke with a triangular cross section will require orientating the apexes so they are toward each other. While four spokes are shown, six equally spaced spokes are believed preferable.
  • the intersection of the spokes at the center is preferably small so as not to block fluid flow through the filter, with a center obstruction of about .1 inches for a piston 10 with an inner diameter of about .3 inches.
  • the dimensions will vary with the sizes and with the strength of the materials used.
  • a tubular vial 42 has an open proximal end 44 and a closed distal end 46.
  • the vial 42 is sized and shaped so the retainer cup 30 and piston 10 fit within the vial.
  • the vial 42, cup 30 and piston 10 are preferably all cylindrical with a circular cross section, but other shapes could be used.
  • the retaining cup 30 fits over piston flange 28 and abuts the recessed portion 26 on distal end 14 of piston 10 so the piston support 16 abuts membrane filter 40 and preferably presses the filter 40 against lip 41 and against cup support 36.
  • the circular tip 31 provides a concentrated force around the periphery of the filter 40 to clamp the filter against the lip.
  • the filter 40 is thus held in position by the lip 41 and tip 31, and further supported by the supports 16, 36.
  • the tip 31 and lip 41 hold the periphery of the filter 40 in position with the tip 31 providing an axial compression seal against the filter 40. Movement, such as bowing or twisting of the body of the filter 40, is restrained by the supports 16, 36.
  • the combination of supports 16, 36, lip 41 and tip 31 are sufficient so that the seal between the periphery of the filter 40 and lip 41 does not leak as filtrate fluid 50 is forced through the filter 40.
  • the flange 28 forces the sidewall 29 of the cup 30 outward to form a fluid tight seal and the proximal end 32 preferably abuts or comes close to shoulder 27.
  • the piston flange 28 is preferably at or very close to the distal end 14 of piston 10, and is interposed between the outer wall of piston 10 and the inner wall of the cup 30 to form a fluid tight seal.
  • the piston support 16 presses the filter 40 against the lip 41 enough to prevent any leakage past the end of the filter 30, and preferably the filter is compressed by the circular periphery of distal end 14 of piston 10, or compressed by the circular periphery of the support 16, so that any fluid wicking between the outer periphery of the filter 10 and the wall 29 of the cup 30, does not enter the cup.
  • the location of the shoulder 27 and the axial length of the sidewall 29 of cup 30 can be selected to achieve a desired amount of compression.
  • the sidewall 29of the cup 30 is deformed outward so the outer diameter of the assembled cup 30 and piston 10 is slightly larger than the diameter of the piston body 10.
  • the assembled cup 30 and piston 10 are then fit into vial 42 to force fluid or filtrate 50 through the filter 40 and into the hollow interior of the tubular piston 10.
  • the piston flange 28 bulges the sidewall 29 of cup 30 outward enough to form a fluid tight seal with the inner walls of vial 42.
  • the seal 38 is also sized relative to the inner walls of vial 42 to form a fluid tight seal with the vial.
  • there are thus two outward facing seals adjacent the distal end 14 of the piston 10 which seal against the interior walls of vial 42.
  • the cap 52 forms a snap fit with the proximal end of the piston 10, and more preferably has an inwardly extending rim or lip that forms a snap-fit over flange(s) 20 on the piston 10.
  • the amount of deformation or bulging caused by forcing the cup 30 over the flange 28 affects the quality of the fluid tight seal formed between the sidewall 29 of the cup 30 and the inner wall of vial 42 at the location of the flange 28.
  • the deformation is affected mostly by the stiffness of the sidewall 29 on cup 30, the thickness of the wall on cup 30, the stiffness of the flange 28, the shape and size of the flange 28.
  • the flange 28 is stiff enough that it does not loose its circular shape and forms a fluid tight seal around the entire circumference of the abutting inner side of sidewall 29 of cup 30.
  • the walls of the vial 42 are shown as slightly deforming at the two seal locations, but such deformation is optional and will vary with the thickness and material used for the vial 42.
  • the flange 28 has an inclined surface angled outward and inclining from the distal toward the proximal end of the piston.
  • the seal 38 also preferably has an inclined surface angled outward and inclining from the distal toward the proximal end of the piston.
  • the seal 22 also preferably has an inclined surface angled outward and inclining from the distal toward the proximal end of the piston.
  • the seals 22, 28 and flange 38 preferably have a generally triangular cross-section, and are integrally molded with the piston 10, or cup 30. This construction allows the walls of piston 10 and vial 42 to be thin while the seals 22, 28 and flange 38 are strong and maintain their circular shape and sealing uniformity during use. Different cross-sectional shapes could be used. Likewise, the supports 16, 36 are integrally molded during formation of the piston 10 and cup 30, respectively.
  • the plug inserted into the hollow body of piston 10 and the hollow cup portion of cup 30 passes along the longitudinal axis 18.
  • the supports 16, 36 each have a triangular cross-section with the apexes of the triangles facing opposing sides of the filter 40 during use, then a mating plug must be used to form the distal end of the piston 10 to form the triangular cross-section of the supports.
  • the cross-section of the struts could be generally square or rectangular n which case the reverse shapes could be formed in the molding plug with only sufficient taper to allow withdrawal of the plug after molding.
  • the formation of supports 36 with a triangular cross section on the cup is not difficult as the triangular shape can be formed in the end of the molding plug and the angles facilitate withdrawal of the plug.
  • seals 28, 22, 38 could also be used for seals 28, 22, 38, but are believed much less desirable.
  • O-ring seals set in rectangular or semi-circular recesses could be used. But the recesses used to position such seals reduce the wall thickness and strength of the walls, making them undesirable.
  • the seals 28, 22, 38 are preferably integrally molded or cast with the parts from which they extend.
  • the preferred piston 10, cup 30 and vial 42 are molded out of various plastics and that makes forming suitable recesses to hold the O-ring or even D-ring seals difficult because the recesses reduce the strength of the parts.
  • the piston 10, cup 30 and vial 42 are preferably molded of a suitable plastic, preferably one that does not contaminate samples placed in the vial 42.
  • the vial is preferably made of polyolefin, preferably polypropylene, or other suitable polymer.
  • the filter 40 is preferably, but optionally made of Teflon, nylon, glass fiber or other filter materials such as PVDF (polyvinyldifloride) or PES (polyethersulphone), etc.
  • the filter 40 is placed inside the retaining cup 30.
  • the cup 30 is then snap fit over piston flange 28 and onto the distal end of the piston 10, and preferably (but optionally) pushed along the piston until the cup seal 38 abuts the shoulder 27 on the piston.
  • the filter 40 is held between the distal end of the piston 10 and lip 41, and preferably held between the piston support 16 and cup support 36 and lip 41.
  • the tip 31 pressing the filter 40 against lip 41 advantageously forms an axial seal encircling the filter 40 near the periphery of the filter, and further helps prevent the periphery of the filter from deforming between the spaces in the supports 16, 36 and thus helps provide a good seal at the periphery of the filter.
  • the supports 16, 36 prevent the filter 40 from bending along axis 18 and breaking the seal at the periphery of the filter.
  • the tip 31 preferably has a triangular cross-section with the apex abutting the filter 40. During assembly, the tip 31 is preferably small enough that it deforms when it presses the filter 40 against the lip 41.
  • a tip 31 having a height of about .01 inches is believed suitable when used on a piston 10 with an inner diameter of about .3 inches so the diameter of the tip 31 is slightly smaller.
  • the tip 31 may be viewed as a rib on the circular distal edge of the tubular piston 10.
  • This assembly also forms two outwardly extending portions, one at the location where the piston flange 28 forces the sidewall 29 of cup 30 outward, and the other at the location of cup seal 38. Both of these seal locations are larger than the inside of tubular vial 42 and form two seals with the vial. Both of these seal locations are preferably separated by a distance sufficient that the wall of the vial 42 extends inward toward longitudinal axis 18 a slight distance in order to ensure a good fluidtight seal at both locations.
  • the distal piston flange 28 is located slightly before the end of the piston 10, so that there is a short cylindrical section before the inclined flange 28 begins.
  • This cylindrical section is optional.
  • This cylindrical section could be formed by ultrasonically welding a disc-shaped filter support 16 having a cylindrical periphery onto the distal edge of the piston 10. But such ultrasonic welding leaves contaminants, as do adhesives.
  • the filter support 16 is preferably integrally molded simultaneously with the formation of the piston 10 and thus made of the same material as the piston 10. This integral molding is usually difficult because of the length of the piston 10 is typically several times longer than the diameters of the piston so it is difficult to mold interior parts.
  • the flange 28 also cooperates with the deformable wall 29 of the retainer cup 30 to bulge the sidewall 29 outward and form a sealing location at the distal end of the cup 30 and at the distal end of the piston 10.
  • a fill line 54 is optionally placed on the outside of the vial 42 to indicate a maximum level of fluid placed inside the vial.
  • the walls of the vial are preferably sufficiently transparent or translucent so the placement of fluid inside the vial 42 can be seen from outside the vial to allow use of the fill line 54.
  • the fill line 54 can be molded into the vial as an outwardly extending flange or inwardly extending recess, or the fill line can be marked by paint, marker, abrasion, laser etching, chemical etching, or other process leaving a visible indicia.
  • the distal end 14 of the piston 10 could hold the filter against the inwardly extending lip 41 on the cup. But preferably one, and optimally both supports 16, 36 are also used to hold the filter in place and to support the middle of the filter during use.
  • the piston support 16 restrains the filter from bowing and leaking around the periphery as the piston advances into the vial and fluid is forced through the filter.
  • the piston support 16 is thus preferably stronger than the cup support 36.
  • the piston 10 can be made of an equal or stronger and harder material than the retaining cup 30, especially since the retaining cup 30 must have a sidewall 29 flexible enough to slide over the piston flange 28 and form a snap fit with the piston recess 26.
  • the piston 10 is of the same material as the retaining cup 30, but the cup is slightly thinner and thus more flexible.

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Claims (11)

  1. Ensemble flacon filtrant, comprenant : un flacon à parois cylindriques (42) avec un fond fermé (46) et un dessus ouvert (44) avec des parois définissant un intérieur cylindrique présentant un diamètre D, le flacon présentant un piston tubulaire creux (10) dans celui-ci, le piston présentant une extrémité distale (14) recouverte par une coupelle (30) présentant un joint de coupelle étanche proximal (38) s'étendant vers l'extérieur depuis l'extrémité proximale de la coupelle (32) sur une distance supérieure au diamètre D, le joint de coupelle étanche étant dimensionné par rapport aux parois internes du flacon (42) pour former un joint étanche aux fluides lorsque le piston est avancé dans le flacon sur une distance suffisante pour mettre en prise le joint de coupelle étanche proximal avec les parois de flacon, l'extrémité distale du piston présentant une bride de piston (28) s'étendant vers l'extérieur et située adjacente à un évidement tourné vers l'extérieur (26) dans le piston de sorte que la coupelle forme un emboîtement par pression sur la bride de piston et s'étende dans l'évidement, la bride de piston amenant la coupelle à se bomber suffisamment vers l'extérieur pour former un joint de coupelle étanche aux fluides distal avec le flacon lorsque la bride et la coupelle sont insérées dans le flacon ; et un filtre (40) présentant une périphérie venant en butée contre une lèvre (41) sur la coupelle qui s'étend vers l'intérieur en direction de l'axe longitudinal (18) et maintenu entre un support de piston (16) à l'extrémité distale du piston et de la lèvre ;
    dans lequel la coupelle présente une paroi latérale s'étendant entre des extrémités proximale (32) et distale (34) de la coupelle avec un diamètre interne plus petit que la bride de piston distale, et la paroi latérale de la coupelle est suffisamment flexible pour se déformer vers l'extérieur lorsque la coupelle passe sur la bride de piston de sorte que les parois latérales assument une dimension externe plus grande qu'un diamètre D à l'emplacement de la bride de piston lorsque la coupelle de retenue passe sur la bride de piston ;
    dans lequel un fluide ou filtrat (50) est poussé à travers le filtre et dans l'intérieur creux du piston tubulaire lorsque la coupelle et le piston assemblés sont emboîtés dans le flacon ; caractérisé en ce que :
    lorsque la coupelle (30) est emboîtée sur la portion évidée (26) et la bride de piston (28), la paroi latérale de la coupelle est déformée vers l'extérieur de sorte que le diamètre externe de la coupelle et du piston assemblés (10) soit plus grand que le diamètre du corps de piston, et dans lequel la bride de piston fait bomber la paroi latérale de la coupelle vers l'extérieur assez pour former un joint étanche aux fluides avec les parois internes du flacon (42) ; et
    dans lequel le piston, la coupelle, et le flacon sont moulés d'un seul tenant.
  2. Ensemble flacon filtrant selon la revendication 1, comprenant en outre un support de coupelle (36) à une extrémité distale (34) de la coupelle (30) venant en butée contre le filtre (40).
  3. Ensemble flacon filtrant selon la revendication 1, comprenant en outre un joint étanche s'étendant vers l'extérieur (22) adjacent à une extrémité proximale (12) du piston (10) dimensionné et configuré pour former un joint étanche aux fluides lorsqu'il est mis en prise avec les parois cylindriques du flacon (42).
  4. Ensemble flacon filtrant selon la revendication 2, dans lequel l'extrémité distale (14) du piston (10) présente un bord distal avec une nervure (31) s'étendant depuis celui-ci et orienté pour presser le filtre (40) contre la lèvre (41) de la coupelle (30).
  5. Ensemble flacon filtrant selon la revendication 1, comprenant en outre un capuchon amovible (52) recouvrant l'extrémité proximale (12) du piston (10).
  6. Ensemble flacon filtrant selon la revendication 3, comprenant en outre un trou d'évent (24) s'étendant à travers une paroi du piston (10) et situé adjacent au joint étanche (22) adjacent à l'extrémité proximale (12) du piston et distal à celle de la bride de piston (20).
  7. Procédé de formation d'un piston (10) pour l'ensemble flacon filtrant selon la revendication 1, le piston présentant un tube cylindrique avec des extrémités proximale (12) et distale (14) opposées, comprenant : la formation d'une bride de piston s'étendant vers l'extérieur (28) à l'extrémité distale du piston ; la formation d'un évidement cylindrique (26) sur une périphérie de l'extrémité distale du piston à l'extrémité distale du piston et adjacent à la bride de piston et sur le côté proximal de la bride de piston ; le placement d'un filtre (40) dans le fond d'une coupelle de retenue (30) laquelle coupelle est dimensionnée pour s'emboîter sur l'extrémité distale du piston, la coupelle de retenue présentant une extrémité proximale ouverte (32) et une lèvre s'étendant vers l'intérieur (41) au niveau d'une extrémité distale opposée (34) laquelle lèvre vient en butée contre une périphérie du filtre ; le placement de l'extrémité proximale ouverte de la coupelle sur l'extrémité distale du piston et la bride de piston pour former un emboîtement par pression entre l'extrémité proximale de la coupelle et l'évidement sur le piston et l'avancement de la coupelle de retenue le long du piston jusqu'à ce que l'extrémité distale du piston vienne en butée contre le filtre, la coupelle de retenue présentant un joint étanche s'étendant vers l'extérieur (38) à l'extrémité proximale dimensionné pour venir en prise étanche avec l'intérieur du flacon filtrant (42) pendant l'utilisation, la coupelle de retenue étant fabriquée en un matériau suffisamment flexible pour se bomber vers l'extérieur au niveau de la bride de piston avec la bride de piston et la coupelle de retenue étant dimensionnée pour s'étendre vers l'extérieur sur une distance suffisante pour former un joint étanche aux fluides avec des parois du flacon filtrant pendant l'utilisation
    dans lequel la paroi latérale de la coupelle est déformée vers l'extérieur de sorte que le diamètre externe de la coupelle et du piston assemblés soit plus grand que le diamètre du corps de piston, et dans lequel la bride de piston fait bomber la paroi latérale de la coupelle vers l'extérieur assez pour former un joint étanche aux fluides avec les parois internes du flacon.
  8. Procédé selon la revendication 7, comprenant en outre la fourniture d'un support de filtre (36) sur l'extrémité distale (34) de la coupelle de retenue (30), le support de coupelle et filtre (36) étant situé pour venir en butée contre le filtre (40) pendant l'utilisation.
  9. Procédé selon la revendication 7, comprenant en outre la fourniture d'un support de piston et filtre (16) sur l'extrémité distale (14) du piston (10), le support de piston et filtre (16) étant situé pour venir en butée contre le filtre (40) pendant l'utilisation.
  10. Procédé selon la revendication 8, comprenant en outre la fourniture d'un support de piston et filtre (16) sur l'extrémité distale (14) du piston (10), le support de piston et filtre (16) étant situé pour venir en butée contre le filtre (40) pendant l'utilisation.
  11. Procédé selon la revendication 8, comprenant en outre une nervure (31) sur un bord distal du piston (10) situé pour former un siège tourné axialement sur une périphérie du filtre (40).
EP12199346.3A 2008-03-21 2009-02-20 Flacon filtrant doté d'un piston tubulaire, d'une coupelle de retenue et d'un filtre Active EP2574326B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/053,241 US7790117B2 (en) 2008-03-21 2008-03-21 Filter vial
EP09722888A EP2268252B1 (fr) 2008-03-21 2009-02-20 Flacon filtrant avec piston tubulaire, coupelle de retenue et filtre
PCT/US2009/034736 WO2009117212A1 (fr) 2008-03-21 2009-02-20 Flacon filtrant avec piston tubulaire, coupelle de retenue et filtre

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EP09722888A Division EP2268252B1 (fr) 2008-03-21 2009-02-20 Flacon filtrant avec piston tubulaire, coupelle de retenue et filtre

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EP2574326A2 EP2574326A2 (fr) 2013-04-03
EP2574326A3 EP2574326A3 (fr) 2014-09-03
EP2574326B1 true EP2574326B1 (fr) 2022-04-06

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EP (2) EP2268252B1 (fr)
JP (2) JP5491489B2 (fr)
AU (1) AU2009225901B2 (fr)
CA (1) CA2719056C (fr)
DK (2) DK2268252T3 (fr)
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WO (1) WO2009117212A1 (fr)

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AU2009225901B2 (en) 2014-12-11
NZ588043A (en) 2012-05-25
US8925734B2 (en) 2015-01-06
EP2574326A3 (fr) 2014-09-03
DK2574326T3 (da) 2022-06-27
US20120251413A1 (en) 2012-10-04
US20100300959A1 (en) 2010-12-02
US20090238725A1 (en) 2009-09-24
AU2009225901A1 (en) 2009-09-24
CA2719056C (fr) 2016-04-26
EP2574326A2 (fr) 2013-04-03
JP2014193316A (ja) 2014-10-09
EP2268252A1 (fr) 2011-01-05
JP2011515149A (ja) 2011-05-19
WO2009117212A1 (fr) 2009-09-24
CA2719056A1 (fr) 2009-09-24
DK2268252T3 (da) 2013-03-11
US9409165B2 (en) 2016-08-09
US8211384B2 (en) 2012-07-03
JP5922167B2 (ja) 2016-05-24
US20150118127A1 (en) 2015-04-30
US7790117B2 (en) 2010-09-07
EP2268252B1 (fr) 2013-01-02
US8383066B2 (en) 2013-02-26
JP5491489B2 (ja) 2014-05-14
US20130327700A1 (en) 2013-12-12

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