EP2567218A4 - Wide-field lensless fluorescent imaging on a chip - Google Patents

Wide-field lensless fluorescent imaging on a chip Download PDF

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Publication number
EP2567218A4
EP2567218A4 EP11777881.1A EP11777881A EP2567218A4 EP 2567218 A4 EP2567218 A4 EP 2567218A4 EP 11777881 A EP11777881 A EP 11777881A EP 2567218 A4 EP2567218 A4 EP 2567218A4
Authority
EP
European Patent Office
Prior art keywords
chip
wide
fluorescent imaging
lensless
field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11777881.1A
Other languages
German (de)
French (fr)
Other versions
EP2567218A2 (en
Inventor
Aydogan Ozcan
Ahmet F. Coskun
Ikbal Sencan
Ting-Wei Su
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of EP2567218A2 publication Critical patent/EP2567218A2/en
Publication of EP2567218A4 publication Critical patent/EP2567218A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • H01L27/14601—Structural or functional details thereof
    • H01L27/14625—Optical elements or arrangements associated with the device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G01N2201/0833—Fibre array at detector, resolving
EP11777881.1A 2010-05-03 2011-04-25 Wide-field lensless fluorescent imaging on a chip Withdrawn EP2567218A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33079910P 2010-05-03 2010-05-03
US201161430449P 2011-01-06 2011-01-06
PCT/US2011/033819 WO2011139641A2 (en) 2010-05-03 2011-04-25 Wide-field lensless fluorescent imaging on a chip

Publications (2)

Publication Number Publication Date
EP2567218A2 EP2567218A2 (en) 2013-03-13
EP2567218A4 true EP2567218A4 (en) 2017-11-08

Family

ID=44904321

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11777881.1A Withdrawn EP2567218A4 (en) 2010-05-03 2011-04-25 Wide-field lensless fluorescent imaging on a chip

Country Status (5)

Country Link
US (1) US9331113B2 (en)
EP (1) EP2567218A4 (en)
JP (1) JP2013525811A (en)
CA (1) CA2797566A1 (en)
WO (1) WO2011139641A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102834718A (en) * 2010-01-12 2012-12-19 耐克思乐生物科学有限责任公司 Systems and methods for counting cells and biomolecules
EP2550522B1 (en) 2010-03-23 2016-11-02 California Institute of Technology Super resolution optofluidic microscopes for 2d and 3d imaging
EP2633267A4 (en) 2010-10-26 2014-07-23 California Inst Of Techn Scanning projective lensless microscope system
US9569664B2 (en) 2010-10-26 2017-02-14 California Institute Of Technology Methods for rapid distinction between debris and growing cells
US9643184B2 (en) 2010-10-26 2017-05-09 California Institute Of Technology e-Petri dishes, devices, and systems having a light detector for sampling a sequence of sub-pixel shifted projection images
WO2012119114A2 (en) * 2011-03-03 2012-09-07 California Institute Of Technology E-petri dishes, devices, and systems
WO2012119094A2 (en) 2011-03-03 2012-09-07 California Institute Of Technology Light guided pixel
US9715099B2 (en) 2011-11-07 2017-07-25 The Regents Of The University Of California Maskless imaging of dense samples using multi-height lensfree microscope
US9013691B2 (en) * 2012-01-29 2015-04-21 Ramot At Tel-Aviv University Snapshot spectral imaging based on digital cameras
JP6139565B2 (en) 2012-02-06 2017-05-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ Portable rapid diagnostic test reader
WO2013131017A1 (en) * 2012-03-02 2013-09-06 Laxco, Inc. Multichannel analytical instruments for use with specimen holders
US9683938B2 (en) * 2013-07-31 2017-06-20 The Regents Of The University Of California Fluorescent imaging using a flatbed scanner
US9413987B2 (en) 2014-03-13 2016-08-09 Qualcomm Incorporated Facet shape and distribution pattern for lensless imaging
CN107003238B (en) * 2014-07-07 2021-01-12 生物辐射实验室股份有限公司 Contact imager
US10871745B2 (en) 2014-08-01 2020-12-22 The Regents Of The University Of California Device and method for iterative phase recovery based on pixel super-resolved on-chip holography
EP3311163B1 (en) * 2015-06-19 2020-08-05 The Regents of the University of California Micro-plate reader for elisa testing
EP3325943B1 (en) * 2015-07-17 2021-05-12 Bio-Rad Laboratories, Inc. Contact imaging devices for fluorescence applications
US10248838B2 (en) 2015-12-04 2019-04-02 The Regents Of The University Of California Method and device for single molecule imaging
US10838192B2 (en) 2016-05-10 2020-11-17 The Regents Of The University Of California Method and device for high-resolution color imaging using merged images from holographic and lens-based devices
WO2017196995A1 (en) 2016-05-11 2017-11-16 The Regents Of The University Of California Method and system for pixel super-resolution of multiplexed holographic color images
WO2018057972A1 (en) 2016-09-23 2018-03-29 The Regents Of The University Of California System and method for determining yeast cell viability and concentration
WO2018064660A1 (en) 2016-09-30 2018-04-05 University Of Utah Research Foundation Lensless imaging device
WO2018165590A1 (en) 2017-03-10 2018-09-13 The Regents Of The University Of California Mobile microscopy system for air quality monitoring
US11514325B2 (en) 2018-03-21 2022-11-29 The Regents Of The University Of California Method and system for phase recovery and holographic image reconstruction using a neural network
US11222415B2 (en) 2018-04-26 2022-01-11 The Regents Of The University Of California Systems and methods for deep learning microscopy
EP3803384A4 (en) 2018-06-04 2021-08-11 The Regents of University of California Deep learning-enabled portable imaging flow cytometer for label-free analysis of water samples
JP2022504466A (en) 2018-10-08 2022-01-13 バイオエレクトロニカ コーポレイション Systems and methods for optically processing samples
EP3867637A4 (en) 2018-10-18 2022-01-05 The Regents Of The University Of California Device and method for motility-based label-free detection of motile objects in a fluid sample
US11262286B2 (en) 2019-04-24 2022-03-01 The Regents Of The University Of California Label-free bio-aerosol sensing using mobile microscopy and deep learning
US11460395B2 (en) 2019-06-13 2022-10-04 The Regents Of The University Of California System and method for measuring serum phosphate levels using portable reader device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04116452A (en) * 1990-09-07 1992-04-16 Canon Inc Microscopic infrared atr measuring apparatus
JPH11190694A (en) * 1997-12-26 1999-07-13 Shimadzu Corp Atr mapping method
US20030175160A1 (en) * 2002-02-14 2003-09-18 Archibald William B. High throughput screening with parallel vibrational spectroscopy
EP3136079A1 (en) * 2009-10-20 2017-03-01 The Regents of The University of California Incoherent lensfree cell holography and microscopy on a chip

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US6556299B1 (en) * 1996-07-10 2003-04-29 Packard Instrument Company, Inc. Imaging system for fluorescence assays
US5917605A (en) 1997-05-13 1999-06-29 Colvin, Jr.; Arthur E. Fluorescence sensing device
US6682927B2 (en) 1998-10-05 2004-01-27 Duke University Methods and apparatus for the high through-put detection of binding interactions in vivo
DE10036457A1 (en) * 2000-07-26 2002-02-14 Giesing Michael Use of an imaging photoelectric area sensor for evaluating biochips and imaging processes therefor
US7286224B2 (en) 2004-12-21 2007-10-23 Palo Alto Research Center Incorporated Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems
US20100144053A1 (en) * 2006-12-04 2010-06-10 Parallel Synthesis Technologies Multiplex assay reader system
JP5002813B2 (en) 2007-02-06 2012-08-15 国立大学法人浜松医科大学 Fluorescence measuring device
EP2134871B1 (en) 2007-03-30 2012-03-07 Pacific Biosciences of California, Inc. Systems and methods for enhancing fluorescent signals
EP2150806A4 (en) * 2007-05-10 2013-01-02 Pacific Biosciences California Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US7817278B2 (en) * 2007-08-08 2010-10-19 Agilent Technologies, Inc. Surface plasmon resonance sensor apparatus having multiple dielectric layers
JP2009044538A (en) * 2007-08-09 2009-02-26 Hitachi Ltd Monitoring system and imaging device employed therefor
US8618508B2 (en) * 2008-09-25 2013-12-31 Koninklijke Philips N.V. Detection system and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04116452A (en) * 1990-09-07 1992-04-16 Canon Inc Microscopic infrared atr measuring apparatus
JPH11190694A (en) * 1997-12-26 1999-07-13 Shimadzu Corp Atr mapping method
US20030175160A1 (en) * 2002-02-14 2003-09-18 Archibald William B. High throughput screening with parallel vibrational spectroscopy
EP3136079A1 (en) * 2009-10-20 2017-03-01 The Regents of The University of California Incoherent lensfree cell holography and microscopy on a chip

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A F COSKUN ET AL: "Lensfree Fluorescent On-Chip Imaging Using Compressive Sampling", OPTICS AND PHOTONICS NEWS., vol. 21, no. 12, 1 December 2010 (2010-12-01), US, pages 27, XP055411272, ISSN: 1047-6938, DOI: 10.1364/OPN.21.12.000027 *
AHMET F COSKUN ET AL: "Lensless wide-field fluorescent imaging on a chip using compressive decoding of sparse objects", OPTICS EXPRESS, vol. 18, no. 10, 5 May 2010 (2010-05-05), pages 10510 - 10523, XP055411058 *
AHMET F COSKUN ET AL: "Wide-field lensless fluorescent imaging of transgenic Caenorhabditis Elegans on a chip", LASERS AND ELECTRO-OPTICS (CLEO), LASER SCIENCE TO PHOTONIC APPLICATIONS)-CLEO: 2011 - LASER SCIENCE TO PHOTONIC APPLICATIONS- 1-6 MAY 2011, BALTIMORE, MD, USA, IEEE, US, 1 May 2011 (2011-05-01), pages 1 - 2, XP031891239, ISBN: 978-1-4577-1223-4 *
AHMET F. COSKUN ET AL: "Lensless On-Chip Fluorescent Imaging Over an Ultra Wide Field-of-View", ASME 2010 5TH FRONTIERS IN BIOMEDICAL DEVICES CONFERENCE AND EXHIBITION, 20 September 2010 (2010-09-20), pages 51, XP055411277, ISBN: 978-0-7918-4945-3, DOI: 10.1115/BioMed2010-32016 *
AHMET F. COSKUN ET AL: "Wide field-of-view lens-free fluorescent imaging on a chip", LAB ON A CHIP, vol. 10, no. 7, 25 February 2010 (2010-02-25), pages 824 - 827, XP055411085, ISSN: 1473-0197, DOI: 10.1039/b926561a *
COSKUN A F ET AL: "Lensless fluorescent on-chip microscopy using a fiber-optic taper", ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY,EMBC, 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE, IEEE, 30 August 2011 (2011-08-30), pages 5981 - 5984, XP032320047, ISBN: 978-1-4244-4121-1, DOI: 10.1109/IEMBS.2011.6091478 *

Also Published As

Publication number Publication date
CA2797566A1 (en) 2011-11-10
US9331113B2 (en) 2016-05-03
WO2011139641A3 (en) 2012-02-02
EP2567218A2 (en) 2013-03-13
WO2011139641A2 (en) 2011-11-10
JP2013525811A (en) 2013-06-20
US20130092821A1 (en) 2013-04-18

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: SENCAN, IKBAL

Inventor name: SU, TING-WEI

Inventor name: OZCAN, AYDOGAN

Inventor name: COSKUN, AHMET F.

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20171009

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