Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N5/00—Radiation therapy
  • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
  • A61N5/1048—Monitoring, verifying, controlling systems and methods
  • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N5/00—Radiation therapy
  • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
  • A61N5/1048—Monitoring, verifying, controlling systems and methods
  • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
  • A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source

Definitions

• the invention relates to a device for X-ray based highlighting of soft tissues in medical imaging.
• This apparatus and an associated method can be used in particular in a beam Thera ⁇ pie réelle or be in radiotherapy ver ⁇ turns.
• Radiation therapy is generally intended to irradiate a target area within the human body to fight disease, especially cancer.
• a high radiation dose is deliberately generated in an irradiation center (isocenter) of an irradiation device or radiotherapy device.
• a radiation therapy machine will contact me ⁇ dizinisch ionizing radiation on humans to cure diseases or to delay its progression, especially in tumors.
• high-energy beams mainly gamma radiation, X-rays and electrons are used. It is also possible to use systems for treatment with neutrons, protons and heavy ions.
• a certain desired Dosisvertei ⁇ lung is to be realized in a target volume with a radiation therapy device.
• the problem frequently arises that the goal of Be ⁇ radiation in the body is movable.
• a tumor in the abdominal area shifts during the breathing process.
• a tumor may also have grown or already shrunk in the period between irradiation planning and actual irradiation. Therefore, it is possible to determine the location of the irradiation target in the body during the irradiation by imaging to control the beam accordingly or if necessary to cancel the irradiation and thus to increase the success of the therapy.
• One goal in radiotherapy is one with the help of
• Real-time guided treatment without having to reposition the patient during treatment.
• radiation therapy systems with integrated X-ray imaging or separate computed tomography or magnetic resonance imaging that support treatment planning.
• Radiation therapy systems with integrated X-ray imaging do not provide high resolution soft tissue contrast images for precise treatment or irradiation, nor do they provide a necessary opportunity to adapt to treatment in real time based on the images produced. That is, an adjustment for respiration or patient movement during treatment is currently not possible.
• This insert is concernedge ⁇ starting disadvantageous in that the contrast produced is not suitable to visualize soft tissue, and is limited in precision in the radiation treatment. Furthermore, real-time adaptation of the treatment plan can not be achieved.
• One aspect of the invention is a control required for the therapy ⁇
• the radiation dose which emerges on an X-ray-based soft tissue highlighting phase contrast imaging which can be preferably used in a radiation therapy device.
• the result of soft tissue imaging can be used for real-time and non-real-time therapy planning, as well as adjustment of the treatment plan or radiation dose.
• the radiation dose control here comprises: a) anatomical imaging for tumor localization before, during and after the irradiation
• a development of the invention provides a high-quality soft tissue imaging highlighting such to implemen ⁇ animals that a monochromatic X-ray source is used.
• a monochromatic X-ray source typically produces protons with a narrow wavelength window to allow phase contrast imaging for the imaging of soft tissues.
• an improved soft-tissue contrast can be generated by applying a K-absorption band.
• a further embodiment of the invention provides to implement a high-resolution soft-tissue imaging by an energy-suppressing X-ray detector.
• an energy-suppressing X-ray detector Preferably, stray radiation due to a narrow photon energy range is suppressed. Further, an increased contrast are generated by a dependent by wavelength ex absorption (especially color) or spektoskopische Informati ⁇ on.
• a further embodiment of the invention provides that the high quality soft tissue imaging is implemented by highlighting a coherent X-ray source, which generates photons with a kon ⁇ stant relative phase.
• An X-ray interpherometer can be used for phase-sensitive imaging.
• Another embodiment of the invention contemplates implementing high quality soft tissue imaging as follows. Incoherent x-ray sources producing photons with a random phase distribution are preferably used together with an interpherometer. In order to implement a phase-contrast imaging, in this case a so-called "grating" is applied, whereby a regular spatial accumulation of corresponding ⁇ len, identical, parallel and elongated elements will be produced.
• a further aspect of the invention provides a method for position control of X-ray based imaging means (S, D) for highlighting soft tissue of a target area provided within a radiotherapy apparatus for phase contrast imaging, wherein with respect to the Target area regardless of the device means (T) to be positioned for radiotherapy.
• a further embodiment of the invention provides that control signals output by a control device cause avoidance of a collision between the imaging means (S, D) and the device means (T) for radiotherapy.
• the invention has the following advantages: There is provided a radiation therapy system having integrated high quality soft-tissue highlighting imaging, similar to magnetic resonance imaging, to enable high-precision radiation treatment.
• the high-precision radiation therapy of the invention has economically similar expenses on as already Exists ⁇ Ionizing Radiation therapy approaches.
• the figure shows an example of a radiation therapy device in which a positioning of the X-ray source S and the X-ray detector D makes possible a radiation coverage of the entire patient's body P from every possible angle. This is indicated by the illustrated arrows and circles.
• the accelerator shown (accelerator) or Betrah- radiation source for the T Thearapie makes it possible to cover the whole Pati ⁇ ducks body with rays from every possible angle. This is indicated by the illustrated arrows and circles.
• the positioning or arrangement of the x - ray sources and detector combination wherein x - ray sources and - detector in Reference statically to one another - for example, both may be attached to the "ends" of a C-arm, and the accelerator
• An unillustrated hardware ⁇ or software control that is integrated into the radiation therapy device or deducted from the radiation therapy machine are independently Steue ⁇ approximately signals. leads to this, prevents a collision of the components S, D and T in their positioning.

Landscapes

• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Pathology (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Radiology & Medical Imaging (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Radiation-Therapy Devices (AREA)
• Apparatus For Radiation Diagnosis (AREA)

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• 2010
  • 2010-04-16 DE DE102010015224A patent/DE102010015224A1/de not_active Withdrawn
• 2011
  • 2011-03-23 CA CA2796233A patent/CA2796233A1/en not_active Abandoned
  • 2011-03-23 RU RU2012148712/14A patent/RU2012148712A/ru unknown
  • 2011-03-23 JP JP2013504191A patent/JP2013524882A/ja active Pending
  • 2011-03-23 BR BR112012026128A patent/BR112012026128A2/pt not_active IP Right Cessation
  • 2011-03-23 WO PCT/EP2011/054392 patent/WO2011128189A1/de active Application Filing
  • 2011-03-23 US US13/641,488 patent/US20130034208A1/en not_active Abandoned
  • 2011-03-23 CN CN2011800193102A patent/CN102844076A/zh active Pending
  • 2011-03-23 EP EP11712798A patent/EP2558163A1/de not_active Withdrawn

Non-Patent Citations (1)

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