EP2541120A1 - Aluminiumflasche für Gasgemische aus Stickstoffmonoxid/Stickstoff, und ihr Einsatz zur Behandlung von Gefäßverengungen in der Lunge - Google Patents

Aluminiumflasche für Gasgemische aus Stickstoffmonoxid/Stickstoff, und ihr Einsatz zur Behandlung von Gefäßverengungen in der Lunge Download PDF

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Publication number
EP2541120A1
EP2541120A1 EP12171927A EP12171927A EP2541120A1 EP 2541120 A1 EP2541120 A1 EP 2541120A1 EP 12171927 A EP12171927 A EP 12171927A EP 12171927 A EP12171927 A EP 12171927A EP 2541120 A1 EP2541120 A1 EP 2541120A1
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EP
European Patent Office
Prior art keywords
mixture
main body
gas
container according
aluminum alloy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12171927A
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English (en)
French (fr)
Inventor
Pierre de Villemeur
Laurent Lecourt
Bénédicte Levinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Air Liquide SA
Air Liquide Sante International SA
LAir Liquide SA pour lEtude et lExploitation des Procedes Georges Claude
Air Liquide Sante France SA
Original Assignee
Air Liquide SA
Air Liquide Sante International SA
LAir Liquide SA pour lEtude et lExploitation des Procedes Georges Claude
Air Liquide Sante France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Air Liquide SA, Air Liquide Sante International SA, LAir Liquide SA pour lEtude et lExploitation des Procedes Georges Claude, Air Liquide Sante France SA filed Critical Air Liquide SA
Publication of EP2541120A1 publication Critical patent/EP2541120A1/de
Withdrawn legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C1/00—Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge
    • F17C1/14—Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge constructed of aluminium; constructed of non-magnetic steel
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C13/00—Details of vessels or of the filling or discharging of vessels
    • F17C13/002—Details of vessels or of the filling or discharging of vessels for vessels under pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2201/00—Vessel construction, in particular geometry, arrangement or size
    • F17C2201/01—Shape
    • F17C2201/0104—Shape cylindrical
    • F17C2201/0109—Shape cylindrical with exteriorly curved end-piece
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2201/00—Vessel construction, in particular geometry, arrangement or size
    • F17C2201/01—Shape
    • F17C2201/0104—Shape cylindrical
    • F17C2201/0119—Shape cylindrical with flat end-piece
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2201/00—Vessel construction, in particular geometry, arrangement or size
    • F17C2201/03—Orientation
    • F17C2201/032—Orientation with substantially vertical main axis
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2201/00—Vessel construction, in particular geometry, arrangement or size
    • F17C2201/05—Size
    • F17C2201/058—Size portable (<30 l)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
    • F17C2203/0602—Wall structures; Special features thereof
    • F17C2203/0612—Wall structures
    • F17C2203/0614—Single wall
    • F17C2203/0617—Single wall with one layer
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
    • F17C2203/0634—Materials for walls or layers thereof
    • F17C2203/0636—Metals
    • F17C2203/0646—Aluminium
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
    • F17C2203/0634—Materials for walls or layers thereof
    • F17C2203/0636—Metals
    • F17C2203/0648—Alloys or compositions of metals
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0323—Valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0338—Pressure regulators
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2221/00—Handled fluid, in particular type of fluid
    • F17C2221/01—Pure fluids
    • F17C2221/014—Nitrogen
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2221/00—Handled fluid, in particular type of fluid
    • F17C2221/03—Mixtures
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
    • F17C2223/01—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the phase
    • F17C2223/0107—Single phase
    • F17C2223/0123—Single phase gaseous, e.g. CNG, GNC
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
    • F17C2223/03—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the pressure level
    • F17C2223/036—Very high pressure (>80 bar)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2260/00—Purposes of gas storage and gas handling
    • F17C2260/01—Improving mechanical properties or manufacturing
    • F17C2260/011—Improving strength
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2260/00—Purposes of gas storage and gas handling
    • F17C2260/01—Improving mechanical properties or manufacturing
    • F17C2260/012—Reducing weight
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2260/00—Purposes of gas storage and gas handling
    • F17C2260/02—Improving properties related to fluid or fluid transfer
    • F17C2260/024—Improving metering
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2260/00—Purposes of gas storage and gas handling
    • F17C2260/05—Improving chemical properties
    • F17C2260/053—Reducing corrosion
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2270/00—Applications
    • F17C2270/02—Applications for medical applications
    • F17C2270/025—Breathing

Definitions

  • the invention relates to a NO / N 2 mixture conditioning vessel comprising a main body made of aluminum or an aluminum alloy, in particular a cylindrical gas cylinder, and its use in the treatment of pulmonary vasoconstrictions. in the adult or the child.
  • Gaseous NO / N 2 mixtures are commonly used to treat pulmonary vasoconstriction in adults or children, particularly in neonates with primary pulmonary hypertension or in patients undergoing cardiac surgery.
  • NO / N 2 mixtures are conventionally packaged in steel gas cylinders. Typically, these bottles contain 100 to 1000 ppm by volume of NO and nitrogen (N 2 ) for the rest. These bottles usually have a water capacity of 2 to 50 liters, which allows to introduce a total load of up to 15 m 3 of NO / N 2 mixture.
  • the packaging that is to say the bottling of these mixtures, is done in gas conditioning centers.
  • packaging containers must also not be overweight and especially withstand shocks and gas pressure of up to several hundred bar, typically 200 to 300 bar, and corrosion.
  • the object of the present invention is to solve these problems, that is to say to minimize said difference in capacity by obtaining a final load as close as possible to the load reference, that is to say a difference of order of +/- 1.5% or less, while offering a container packaging resistant to shocks and high pressures, as well as corrosion, but without presenting too much weight.
  • the solution of the invention is a NO / N 2 mixture conditioning container comprising a main body comprising an internal volume having a capacity of between 2 and 30 liters and containing a NO / N 2 mixture at a pressure greater than atmospheric pressure.
  • the main body being formed of an aluminum alloy, characterized in that the main body is formed of an aluminum alloy comprising predominantly aluminum, that is to say more than 50% by weight or even more than 60% by weight, preferably more than 75% by weight, and a mass proportion of Cr between 0.05 and 0.80%, Cu between 1 and 3%, Pb of not more than 100 ppm, Zn between 5 and 8%, and Mg between 1 and 3%.
  • the aluminum alloy must be chosen carefully so as not to cause excessive fragility of the bottles.
  • This fragility can be avoided or minimized by controlling in particular the composition of the chosen aluminum alloy, that is to say the content of the various elements of the alloy, in particular that in Mg, Cr, Cu and / or Zn, but also the lead content of the alloy and incidentally the grain size of the alloy.
  • the invention also relates to a method for conditioning a NO / N 2 mixture in a conditioning container according to the invention, comprising a main body comprising an internal volume into which the NO / N 2 mixture is introduced at a pressure greater than the atmospheric pressure.
  • the invention also relates to the use of a container according to the invention comprising a main body comprising an internal volume, said main body being formed of aluminum or an aluminum alloy, for conditioning a mixture gaseous NO / N 2 containing from 1 to 1000 ppm by volume of NO and nitrogen for the remainder.
  • the invention also relates to a gaseous mixture conditioning system NO / N 2 comprising a container according to the invention.
  • the invention also relates to a NO / N 2 mixture dispensing system that can be used for the treatment of pulmonary hypertension in adults, children or newborns, including a ventilator delivering a gas. containing oxygen, such as air or an oxygen / nitrogen mixture, comprising a patient circuit connecting said ventilator to a patient interface, for example a breathing mask or a cannula, characterized in that the patient circuit is supplied with gas by a container according to the invention, in particular a gas bottle.
  • the gas passes through a control device, such as the device Opti Kinox Air Liquide Health, arranged between the (or) container and the patient circuit.
  • the invention also relates to a NO / N 2 gas mixture for use in treating or preventing pulmonary vasoconstriction or pulmonary hypertension in an adult, child or newborn, wherein the NO / N mixture 2 is administered by inhalation, advantageously by means of a NO / N 2 mixture dispensing installation comprising a fan comprising a patient circuit connecting said ventilator to a patient interface, said patient circuit being supplied with NO / N 2 gas mixture delivered by a container according to the invention, in particular a gas bottle, whose main body is formed of an aluminum alloy comprising aluminum (for the most part) and a mass proportion of Cr between 0.05 and 0.80%; , Cu between 1 and 3%, Pb at most 100 ppm, Zn between 5 and 8%, and Mg between 1 and 3%.
  • the gaseous mixture NO / N 2 is used to treat a newborn with primary pulmonary hypertension or an adult, a child or a newborn to undergo, undergoing or having undergone cardiac surgery.
  • FIG. 1 attached an embodiment of a container according to the invention (sectional view), namely a bottle of gas mixture NO / nitrogen mixture which consists of a main body 1 of generally cylindrical shape comprising a constriction or neck 2 at which is the opening 5 of the gas passage and at its other end, a flat bottom 3 on which the bottle rests when it is placed on a support, such as the ground 6.
  • a bottle of gas mixture NO / nitrogen mixture which consists of a main body 1 of generally cylindrical shape comprising a constriction or neck 2 at which is the opening 5 of the gas passage and at its other end, a flat bottom 3 on which the bottle rests when it is placed on a support, such as the ground 6.
  • a NO / nitrogen mixture containing up to 1000 ppm by volume of NO and nitrogen for the remainder, for example 225, 450 or 800 ppm vol., Is packaged in the bottle at a pressure of more than 150 bar, by example of 180 bar.
  • a valve 4 or an integrated pressure reducer valve is mounted, for example screwed, at the neck 2 of the bottle so as to control the flow rate and / or the pressure of the gas leaving the container.
  • the body 1 of the bottle is formed of an aluminum alloy
  • alloy compositions A and B are given in the following Table.
  • the Figure 2 attached hereto illustrates an embodiment of a NO / N 2 mixture dispensing installation comprising a fan 10 comprising a patient circuit 11 connecting the fan 10 to a patient interface 14.
  • the patient circuit 11 is supplied with gas by a receptacle 1 according to the Figure 1 whose composition is for example that of the alloy A or B of the preceding table.
  • the ventilator 10 thus supplies with respiratory gas enriched in NO, a respiratory circuit or patient circuit 11 with two branches, that is to say with an inspiratory branch 12 and a branch expiratory 13.
  • the inspiratory branch 12 is designed to convey a breathing gas, for example air, oxygen-enriched air, oxygen or a nitrogen / O 2 mixture, from the ventilator 10 to the patient 15
  • the exhalation branch 13 is designed to convey the exhaled gas by the patient 15, thus rich in CO 2 , to the ventilator 10.
  • the administration of the gas is by means of a patient interface 14, for example a respiratory mask, a probe or a tracheal cannula or any other suitable gas delivery device.
  • the fan 1 is supplied with a gas containing oxygen, for example air (O 2 content of 21% by volume), air enriched with oxygen (O 2 content> 21% by volume). or pure oxygen (100% O 2 ).
  • a gas containing oxygen for example air (O 2 content of 21% by volume), air enriched with oxygen (O 2 content> 21% by volume). or pure oxygen (100% O 2 ).
  • the oxygen-containing gas comes from a gas source 17, such as one or more gas cylinders, a gas mixer in which is operated for example a mixture of air and oxygen, or one or more gas pipelines conveying one or more gases, for example a pipe carrying oxygen from an oxygen production unit, such as a modulated pressure unit (PSA), or an oxygen storage unit, such as a buffer or storage tank.
  • a gas source 17 such as one or more gas cylinders, a gas mixer in which is operated for example a mixture of air and oxygen, or one or more gas pipelines conveying one or more gases, for example a pipe carrying oxygen from an oxygen production unit, such as a modulated pressure unit (PSA), or an oxygen storage unit, such as a buffer or storage tank.
  • PSA modulated pressure unit
  • oxygen storage unit such as a buffer or storage tank.
  • the oxygen-rich gas is delivered by the ventilator 10 into the inspiratory branch 12 of the patient circuit 11.
  • a NO distribution device 16 is fluidly connected to said inspiratory branch 12 of the patient circuit 11 to deliver, via a feed line 18, a NO / N 2 mixture, for example formed of 400, 800 or 1000 ppmv. NO and nitrogen for the rest.
  • the NO distribution device 16 is itself fed with a NO / N 2 mixture, via a gas supply line 19, with a container 1 of NO / N 2 forming part of a storage and distribution system according to the invention.
  • the NO / N 2 container is an aluminum alloy gas cylinder (alloy A or B for example) containing 2, 5 or 11 liters (water equivalent), equipped with a built-in pressure regulating valve, preferably protected by a rollover protection hood.
  • the integrated regulator valve also called “RDI” allows to control the gas outlet of container 1 and its outlet pressure. Controllers control the release of the gas and also adjust the output pressure level.
  • Such an installation is suitable for treatment with inhaled NO administration, pulmonary vasoconstriction or pulmonary hypertension in a patient 15, who may be an adult, a child or a newborn.
  • the NO / N 2 gas mixture conveyed to the patient 15 by the patient circuit 11 and distributed by means of the interface 14, is particularly recommended for treating a newborn with primary pulmonary hypertension or an adult. a child or newborn who has to undergo, undergoing or having undergone cardiac surgery.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP12171927A 2011-06-29 2012-06-14 Aluminiumflasche für Gasgemische aus Stickstoffmonoxid/Stickstoff, und ihr Einsatz zur Behandlung von Gefäßverengungen in der Lunge Withdrawn EP2541120A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1155789A FR2977298B1 (fr) 2011-06-29 2011-06-29 Bouteille en aluminium pour melange gazeux no/azote

Publications (1)

Publication Number Publication Date
EP2541120A1 true EP2541120A1 (de) 2013-01-02

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EP12171927A Withdrawn EP2541120A1 (de) 2011-06-29 2012-06-14 Aluminiumflasche für Gasgemische aus Stickstoffmonoxid/Stickstoff, und ihr Einsatz zur Behandlung von Gefäßverengungen in der Lunge

Country Status (3)

Country Link
US (2) US20130000638A1 (de)
EP (1) EP2541120A1 (de)
FR (1) FR2977298B1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015086946A1 (fr) 2013-12-12 2015-06-18 Air Liquide Sante (International) Système de stockage et de distribution d'un mélange gazeux no/azote

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3018584B1 (fr) * 2014-03-12 2016-04-15 Air Liquide Capotage de protection avec systeme d’accrochage pivotant pour bouteille de gaz

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4747890A (en) * 1986-07-24 1988-05-31 Societe Metallurgieque De Gerzat Al-base alloy hollow bodies under pressure
EP0589807A1 (de) * 1992-09-22 1994-03-30 Société Métallurgique de Gerzat Aluminium-Legierung für Hohlkörper für Druckbehälter
US5932037A (en) * 1993-04-15 1999-08-03 Luxfer Group Limited Method of making hollow bodies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3130908A1 (en) * 2009-06-30 2010-12-30 Mallinckrodt Hospital Products IP Limited Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4747890A (en) * 1986-07-24 1988-05-31 Societe Metallurgieque De Gerzat Al-base alloy hollow bodies under pressure
EP0589807A1 (de) * 1992-09-22 1994-03-30 Société Métallurgique de Gerzat Aluminium-Legierung für Hohlkörper für Druckbehälter
US5932037A (en) * 1993-04-15 1999-08-03 Luxfer Group Limited Method of making hollow bodies

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015086946A1 (fr) 2013-12-12 2015-06-18 Air Liquide Sante (International) Système de stockage et de distribution d'un mélange gazeux no/azote
FR3015000A1 (fr) * 2013-12-12 2015-06-19 Air Liquide Sante Int Systeme de stockage et de distribution de melanges no/azote
CN106415109A (zh) * 2013-12-12 2017-02-15 法国液化空气保健国际公司 用于储存和分配no/氮气气态混合物的系统
AU2014363284B2 (en) * 2013-12-12 2018-10-18 Air Liquide Sante (International) System for storing and distributing an NO/nitrogen gaseous mixture
CN106415109B (zh) * 2013-12-12 2019-04-05 法国液化空气保健国际公司 用于储存和分配no/氮气气态混合物的系统

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FR2977298B1 (fr) 2015-02-06
FR2977298A1 (fr) 2013-01-04
US20130269829A1 (en) 2013-10-17

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