EP2495242A4 - Novel vascular leak inhibitor - Google Patents
Novel vascular leak inhibitorInfo
- Publication number
- EP2495242A4 EP2495242A4 EP20100827132 EP10827132A EP2495242A4 EP 2495242 A4 EP2495242 A4 EP 2495242A4 EP 20100827132 EP20100827132 EP 20100827132 EP 10827132 A EP10827132 A EP 10827132A EP 2495242 A4 EP2495242 A4 EP 2495242A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- vascular leak
- novel vascular
- inhibitor
- leak inhibitor
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002792 vascular Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20090103450 | 2009-10-29 | ||
PCT/KR2010/007533 WO2011053048A2 (en) | 2009-10-29 | 2010-10-29 | Novel vascular leak inhibitor |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2495242A2 EP2495242A2 (en) | 2012-09-05 |
EP2495242A4 true EP2495242A4 (en) | 2013-04-10 |
EP2495242B1 EP2495242B1 (en) | 2016-05-04 |
Family
ID=43922871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10827132.1A Active EP2495242B1 (en) | 2009-10-29 | 2010-10-29 | Novel vascular leak inhibitor |
Country Status (6)
Country | Link |
---|---|
US (1) | US8889840B2 (en) |
EP (1) | EP2495242B1 (en) |
JP (1) | JP5701308B2 (en) |
KR (1) | KR101293278B1 (en) |
CN (1) | CN102656153B (en) |
WO (1) | WO2011053048A2 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140142053A1 (en) * | 2011-05-20 | 2014-05-22 | Universiti Putra Malaysia | Use of a Composition Comprising Acylated Steryl Glucoside in the Manufacture of a Product |
KR101352635B1 (en) * | 2011-12-29 | 2014-01-20 | 연세대학교 산학협력단 | Novel Blocker for Vascular Leakage |
KR101481709B1 (en) * | 2014-01-03 | 2015-02-02 | 인하대학교 산학협력단 | Composition for preventing or treating erectile dysfunction comprising Sac-1004 compound |
MX2017011879A (en) | 2015-03-20 | 2018-04-10 | Univ Aarhus | Inhibitors of pcsk9 for treatment of lipoprotein metabolism disorders. |
JP6386173B2 (en) * | 2015-07-16 | 2018-09-05 | インテリジェント シンセティック バイオロジー センター | Composition for preventing or treating vascular leakage syndrome |
US9637514B1 (en) | 2015-10-26 | 2017-05-02 | MAX BioPharma, Inc. | Oxysterols and hedgehog signaling |
WO2018054959A1 (en) * | 2016-09-20 | 2018-03-29 | Aarhus Universitet | Compounds for treatment of lipoprotein metabolism disorders |
KR101988882B1 (en) | 2017-12-29 | 2019-06-13 | 충남대학교산학협력단 | A composition comprising ginsenoside Rk1 or Rg5 for preventing or treating sepsis |
KR102175436B1 (en) * | 2018-09-03 | 2020-11-06 | 연세대학교 산학협력단 | A pharmaceutical composition for functional recovery of cord blood endothelial progenitor cells and treat of preeclampsia by Ginseng including Rg3 |
CN109381478A (en) * | 2018-10-31 | 2019-02-26 | 青岛大学附属医院 | A kind of miRNA inhibits new vessels to generate and inhibit the application in the reagent of VEGF-A factor expression in preparation |
US20220152067A1 (en) * | 2019-04-29 | 2022-05-19 | lndustry-Academic Cooperation Foundation, Yonsei University | Cancer Immunotherapy Adjuvant |
KR102124470B1 (en) * | 2019-12-13 | 2020-06-18 | 주식회사 큐라클 | Preparation method of vascular leakage blockers with a high yield |
KR102223276B1 (en) | 2020-05-04 | 2021-03-05 | 주식회사 큐라클 | New crystalline form of vascular leak blocker compound |
CA3133441C (en) * | 2020-05-04 | 2023-01-03 | Koo Hyeon Ahn | New crystalline form of vascular leakage blocker compound |
CN114306350B (en) * | 2022-01-13 | 2023-01-24 | 四川大学华西医院 | Application of cholesterol sulfate in preparation of medicine for preventing sepsis |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5736536A (en) * | 1994-08-19 | 1998-04-07 | Bristol-Myers Squibb Company | Method for treating vascular leak syndrome |
WO2006007910A1 (en) * | 2004-07-20 | 2006-01-26 | Santhera Pharmaceuticals (Schweiz) Ag | Use of non-glucocorticoid steroids for the treatment of muscular dystrophy |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3483232A (en) * | 1965-06-11 | 1969-12-09 | American Cyanamid Co | Method of preparing steroids and products resulting therefrom |
JPS518259A (en) * | 1974-07-13 | 1976-01-23 | Nippon Shinyaku Co Ltd | Suteriru 6600 ashiru beetaaadd gurukoshidooyobisuteriru 2*3*4*6600 tetoraashiru beetaaadd gurukoshidono seizohoho |
JPS51143656A (en) * | 1975-06-05 | 1976-12-10 | Teijin Ltd | A process for preparing 7-dehydro cholesterol |
DE2632677A1 (en) * | 1976-07-16 | 1978-01-26 | Schering Ag | PROCESS FOR THE MANUFACTURE OF ANDROSTANE-17-ONE DERIVATIVES AND THEIR USE |
JPS60161911A (en) * | 1984-01-31 | 1985-08-23 | Kanebo Ltd | Skin cosmetic |
US4783528A (en) * | 1987-06-05 | 1988-11-08 | University Of Miami (Department Of Chemistry) | Steroidal lariat ethers |
CA2115371A1 (en) * | 1992-06-10 | 1993-12-23 | Chiaki Saito | Process for producing a cholesterol-reduced substance |
GB9300125D0 (en) * | 1993-01-06 | 1993-03-03 | Scotia Holdings Plc | Compositions containing esters of unsaturated fatty acids |
US5977095A (en) * | 1993-03-09 | 1999-11-02 | University Of Utah Research Foundation | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and respiratory distress syndrome |
GB9401402D0 (en) * | 1994-01-25 | 1994-03-23 | Erba Carlo Spa | New method of treating dyslipidemias |
US5763435A (en) | 1995-11-21 | 1998-06-09 | Children's Hospital Medical Center | Sulfate conjugates of ursodeoxycholic acid, and their beneficial use in inflammatory disorders |
WO2001045751A1 (en) * | 1999-12-22 | 2001-06-28 | The Scripps Research Institute | Angiogenesis and vascular permeability modulators and inhibitors |
IL156429A0 (en) * | 2003-06-12 | 2004-01-04 | Peptor Ltd | Cell permeable conjugates of peptides for inhibition of protein kinases |
KR100750988B1 (en) | 2005-03-18 | 2007-08-22 | 주식회사 유니젠 | Composition having ginsenosides for treating or preventing diabetes |
-
2010
- 2010-10-29 CN CN201080048983.6A patent/CN102656153B/en active Active
- 2010-10-29 JP JP2012536689A patent/JP5701308B2/en active Active
- 2010-10-29 KR KR1020100107346A patent/KR101293278B1/en not_active IP Right Cessation
- 2010-10-29 EP EP10827132.1A patent/EP2495242B1/en active Active
- 2010-10-29 WO PCT/KR2010/007533 patent/WO2011053048A2/en active Application Filing
- 2010-10-29 US US13/504,368 patent/US8889840B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5736536A (en) * | 1994-08-19 | 1998-04-07 | Bristol-Myers Squibb Company | Method for treating vascular leak syndrome |
WO2006007910A1 (en) * | 2004-07-20 | 2006-01-26 | Santhera Pharmaceuticals (Schweiz) Ag | Use of non-glucocorticoid steroids for the treatment of muscular dystrophy |
Non-Patent Citations (5)
Title |
---|
BOSE A K ET AL: "TRIS(3,6-DIOXAHEPTYL)AMINE: A SUPERIOR COMPLEXING AGENT FOR DISSOLVING METAL REACTIONS", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 28, no. 22, 1 January 1987 (1987-01-01), pages 2503 - 2506, XP002068631, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)95452-2 * |
GEOFFROY P ET AL: "Synthesis of highly pure oxyphytosterols and (oxy)phytosterol esters", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 73, no. 7, 1 August 2008 (2008-08-01), pages 702 - 707, XP022673870, ISSN: 0039-128X, [retrieved on 20080217], DOI: 10.1016/J.STEROIDS.2008.02.004 * |
J. BRYAN JONES ET AL: "Steroids and Steroidases. XVI. An Evaluation of Synthetic Routes to Variously C-17-Substituted [Delta] 5 -3-Ketosteroids", CANADIAN JOURNAL OF CHEMISTRY, vol. 50, no. 16, 15 August 1972 (1972-08-15), pages 2712 - 2718, XP055055236, ISSN: 0008-4042, DOI: 10.1139/v72-435 * |
See also references of WO2011053048A2 * |
SETO H ET AL: "Synthesis of 6-oxy functionalized campest-4-en-3-ones: efficient hydroperoxidation at C-6 of campest-5-en-3-one with molecular oxygen and silica gel", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 65, no. 8, 1 August 2000 (2000-08-01), pages 443 - 449, XP004215772, ISSN: 0039-128X, DOI: 10.1016/S0039-128X(00)00105-7 * |
Also Published As
Publication number | Publication date |
---|---|
WO2011053048A3 (en) | 2011-11-03 |
CN102656153B (en) | 2015-02-18 |
KR20110047170A (en) | 2011-05-06 |
EP2495242B1 (en) | 2016-05-04 |
EP2495242A2 (en) | 2012-09-05 |
WO2011053048A2 (en) | 2011-05-05 |
CN102656153A (en) | 2012-09-05 |
KR101293278B1 (en) | 2013-08-09 |
US20120245110A1 (en) | 2012-09-27 |
JP5701308B2 (en) | 2015-04-15 |
JP2013509401A (en) | 2013-03-14 |
US8889840B2 (en) | 2014-11-18 |
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