EP2492678A1 - Sampling device for ion mobility spectrometer, method of using same and ion mobility spectrometer comprising sampling device - Google Patents
Sampling device for ion mobility spectrometer, method of using same and ion mobility spectrometer comprising sampling device Download PDFInfo
- Publication number
- EP2492678A1 EP2492678A1 EP11778785A EP11778785A EP2492678A1 EP 2492678 A1 EP2492678 A1 EP 2492678A1 EP 11778785 A EP11778785 A EP 11778785A EP 11778785 A EP11778785 A EP 11778785A EP 2492678 A1 EP2492678 A1 EP 2492678A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- component
- sample
- sample feeding
- ion mobility
- mobility spectrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
Definitions
- the present invention relates to an ion mobility detecting technique. More particularly, the present invention relates to a sample feeding device for an ion mobility spectrometer and a method for detecting solid and gaseous samples using the sample feeding device. In addition, the present invention also relates to an ion mobility spectrometer having the sample feeding device.
- detectors for safety inspection mainly detect harmful substances such as explosives and narcotics by an ion mobility spectrometry.
- detectors comprise a sample feeding device.
- the sample feeding device can gasify and desorb solid particles or gas entering into the device.
- the gasified sample molecules are then introduced into an ionization region by air flow. After that, the ionized sample molecules enter into a drift region.
- the molecules are identified based on their drift time in the drift region.
- the actual sample feeding devices are classified as both a gaseous sample feeding device and a solid sample feeding device.
- a sample collecting paper or a sample collecting rod is provided for the solid sample feeding device. Trace residual substance is collected by wiping a surface of an object under inspection with the collecting paper, and then the collecting paper or the sample collecting rod is inserted into the solid sample feeding device, and thereby information about the residual substance on the surface of the object is obtained through detection.
- the gaseous sample feeding device directly extracts gas released by an object under inspection to detect substance.
- An early commercially available detector typically has function of feeding only one type of sample, for example SMITH's desktop Ionscan_5000DT only having solid sample feeding function.
- Sample feeding devices with both gaseous and solid sample feeding ability are commercially available.
- a portion of patents has been applied to the product, for example SABER EXV, SABER 4000, and MMTD of SMTH, whose characteristic is to employ two separate sample feeding inlets.
- SABER 4000 The disadvantage of SABER 4000 is that the volume of the sample feeding device is large, and occupies one fifth space of the detector.
- the sample feeding device in the desktop detector generally only has the solid sample feeding ability.
- the ion mobility spectrometer has a built-in concentrating device so as to simplify its arrangement and operation procedure; and on the other hand, the detector can sensitively and conveniently detect trace level of the residual solid on the object under inspection and gas with an extremely low concentration.
- an object of the present invention is to solve at least one of the above problems and defects in the prior art.
- a sample feeding device for an ion mobility spectrometer, which is adapted to guide a sample to be detected into an inlet of a drift tube of the ion mobility spectrometer.
- This sample feeding device can feed ot gaseous sample and solid sample. Since the sample feeding device only has one sample feeding inlet, the design of the sample feeding device is simplified, and the volume of the corresponding device becomes relatively small. Therefore, this sample feeding device is capable of applying in both portable detectors and desktop detectors.
- the sample feeding device comprises: a solid sample feeding component, a sample inlet component, an attachment component, and a gaseous sample feeding component.
- the solid sample feeding component has an internal cavity defined therein, one end of the solid sample feeding component is communicated with the sample inlet component through the internal cavity, while the other end of the solid sample feeding component is communicated with the inlet of the ion drift tube through the attachment component;
- the gaseous sample feeding component comprises a body and an external attachment component, the body has a gas channel therein, and the external attachment component includes an inlet hole which is communicated with the gas channel, wherein when the extern attachment component is fitted with the sample inlet component, the body is inserted into the internal cavity, so that a channel of the solid sample feeding component is closed, while only the gas channel of the gaseous sample feeding component is communicated with the inlet of the drift tube of the ion mobility spectrometer.
- the sample inlet component comprises a guide groove and a photo diode.
- the photo diode detects the sample and then sends a trigger signal.
- the sample feeding device further comprises a semi-permeable membrane component, which comprises a suction hole, a mounting, a locking hoop and a semi-permeable membrane, wherein a position of the suction hole of the semi-permeable membrane component corresponds to that of a suction hole of a suction component, and the locking hoop has an annular outer periphery.
- the semi-permeable membrane is secured to the mounting by the annular outer periphery and an outer surface of the locking hoop is sealed against the suction component.
- the internal cavity is in a flat shape, a central portion of the internal cavity is in the form of arc and two ends of the internal cavity on both side of the central portion are in the form of square.
- the body of the gaseous sample feeding component has a cylindrical shape.
- the flat-like shape has a height between 1 and 10 mm, and a width between 15 and 50mm.
- the sample feeding device further comprises a suction component, which is attached to the attachment component, thereby forming a suction gas flow in order to remove the gaseous sample not entering into the inlet of the drift tube by suction.
- a method of guiding a solid sample to be detected by using the sample feeding device of the ion mobility spectrometer comprising: detaching the gaseous sample feeding component; inserting the solid sample into the internal cavity of the solid sample feeding component through the guide groove of the sample inlet component; sending out a trigger signal by the photo diode after the photo diode detects the solid sample to start a heating component disposed outside the internal cavity and the ion mobility spectrometer; vaporizing the solid sample in the internal cavity, and guiding the vaporized solid sample into the inlet of the drift tube of the ion mobility spectrometer through the internal cavity; and detecting the sample within the ion mobility spectrometer.
- a method of guiding a gaseous sample to be detected by using the sample feeding device of the ion mobility spectrometer comprising: inserting the gaseous sample feeding component; sucking the gaseous sample to be detected into the body of the gaseous sample feeding component through an gas inlet; guiding the gaseous sample to be detected into the inlet of the drift tube of the ion mobility spectrometer through the gas channel of the gaseous sample feeding component; and detecting the sample within the ion mobility spectrometer.
- the present invention further provides an ion mobility spectrometer, comprising: a drift tube adapted to ionize and drift the sample to be detected which is guided into the ion mobility spectrometer; and the sample feeding device adapted to guide the sample to be detected into the inlet of the drift tube.
- the sample feeding device of the present invention has both solid and gaseous sample feeding function. Since only one sample feeding inlet is employed, it is possible to reduce the volume and space of the sample feeding device and to effectively reduce the volume of the ion mobility spectrometer.
- the sample feeding modes are switched by inserting and removing the gaseous sample feeding component so that the sample feeding device can simply and conveniently switch between the gaseous and solid sample feeding modes.
- a sample feeding device 10 includes: a solid sample feeding component 100, a sample inlet component 200, a attachment component 300, and a gaseous sample feeding component 500.
- the solid sample feeding component 100 has an internal cavity 101 (shown in figure 3 in detail) defined therein. One end of the solid sample feeding component 100 is communicated with the sample inlet component 200 through the internal cavity 101, while the other end of the solid sample feeding component 100 is communicated with an inlet 400 of an ion drift tube through the attachment component 300.
- the gaseous sample feeding component 500 includes a body 501 and an external attachment component 502 (as shown in figure 5 in detail).
- the body 501 has a gas channel 503 therein, and the external attachment component 502 includes an inlet hole 504 which is communicated with the gas channel 503.
- the external attachment component 502 is fitted with the sample inlet component 200, the body 501 is inserted into the internal cavity 101, so that a channel of the solid sample feeding component 100 is closed, while only the gas channel 503 of the gaseous sample feeding component 500 is communicated with the inlet 400 of the drift tube of the ion mobility spectrometer.
- FIG 2 it shows the sample inlet component 200.
- the sample inlet component 200 includes a guide groove 201 and a photo diode 202.
- the photo diode 202 detects the sample and then sends a trigger signal.
- an installation hole 203 may be disposed in the sample inlet component.
- the sample inlet component 200 is assembled with other components by the installation hole 203.
- a person skilled in the art also can assemble the sample inlet component with other components by using other conventional means.
- the guide groove 201 has a relatively large opening, so that the collecting paper is easily inserted into the solid sample inlet component 200.
- a radiator is disposed at the photo diode 202, so that the photo diode 202 always operates at a relative low temperature for ensuring the detector performance.
- the internal cavity 101 is in a flat-like shape. Specifically, a central portion of the internal cavity 101 is in the form of arc and two ends of the internal cavity on both sides of the central portion are in the form of square.
- the body 501 of the gaseous sample feeding component 500 is cylindrical. In this way, it can ensure that solid sample feeding efficiency is not affected and the gaseous sample feeding function can also be performed.
- the flat-like shape has a height between 1 and 10 mm, and a width between 15 and 50mm. In the present embodiment, the flat-like shape has a height of 3mm and a width of 22 mm.
- FIGS 6 and 7 are schematic views showing a suction component 600 and a semi-permeable membrane 700, respectively.
- the suction component 600 includes suction holes 601.
- the suction component 600 is attached to the attachment component 300, thereby forming a suction gas flow in order to remove the gaseous sample not entering into the inlet of the drift tube by suction.
- the arrangement and construction of the suction component are described herein only as an example, and thus the person skilled in the art can employ any other conventional technical means in the art to remove the gaseous sample not entering into the inlet of the drift tube by suction.
- the sample feeding device of the present invention also includes a semi-permeable membrane disposed between the inlet 400 of the drift tube and the end of the channel of the internal cavity.
- the semi-permeable membrane can be disposed on the semi-permeable membrane component 700 as shown in figure 7 .
- the semi-permeable membrane component 700 includes suction holes 701 of which a position correspond to a position of the suction holes 601 of the suction component.
- the semi-permeable membrane component 700 further includes auxiliary components such as a mounting 702, and a locking hoop 703 to support and secure the semi-permeable membrane.
- the mounting 702 is made of metal material, and employs aluminium plated with nickel in the present embodiment.
- the locking hoop 703 is made of fluorine rubber (or medical-grade silicone rubber), which is resistant to high temperature and does not emit gaseous foreign substance. Since the material of locking hoop 703 can be resistant to high temperature, i.e. the fluorine rubber is resistant to high temperature of 250°C, it does not adhere to the metal surface.
- the annular outer periphery is capable of securing the soft semi-permeable membrane onto the mounting 702, while ensuring the tightness. It is ensured that the interior of the drift tube is sealed by sealing an outer planar surface of the locking hoop 703 against the suction component 600. A high-temperature state of the semi-permeable membrane is obtained by heat conducted from the sample inlet and the drift tube. It should be understood that the arrangement and construction of the semi-permeable membrane are described herein only as an example, and thus the person skilled in the art can employ any other conventional technical means in the art to achieve this function.
- a recess of the suction component 600 is used to house the semi-permeable membrane component 700.
- a gas flow in front of the semi-permeable membrane is pumped out by two suction holes 601.
- the sample feeding device of the present invention also includes auxiliary components such as an upper cover 800, stay plates 901 and 902, an attachment member 903, and a bottom plate 904 for supporting and attaching.
- the sample feeding device 10 is attached to the drift tube by the attachment member 903.
- sealing devices are disposed between the semi-permeable membrane component and the fixation sample feeding component, the gaseous sample feeding component as well as the inlet of the drift tube to achieve the air-tightness. Since the person skilled in the art can design and produce those components by the conventional technical means in the art, in combination with the practical situation, and those components are not a main part of the present invention, these are not described in detail.
- the solid sample feeding component 100 has the function of quickly heating sample.
- heating components are disposed outside the internal cavity, for example by winding the heating filaments, so that the internal cavity 101 is always kept at a high temperature.
- the sample is vaporized by using laser in the internal cavity 101 for an instant.
- the electrically heating filaments are employed and the internal cavity 101 is surrounded by thermal insulation material, so that the temperature of the solid sample feeding component 100 is kept at 180°C all the time.
- a surface of metal component in the gas path passing the gas is polished or plated with nickel, so that the surface is smooth, thereby reducing the absorption of the gas by the metal component.
- a solid sample feeding mode (the gaseous sample feeding component 500 is detached), after a collecting paper with the sample passes through the sample inlet component 200 with the guide groove 201, the photo diode 202 detects the solid sample, and the photo diode sends a trigger signal to start the ion mobility spectrometer.
- the solid sample is vaporized in the internal cavity 101, and the vaporized sample flows into the inlet 400 of the ion mobility spectrometer through the internal cavity, and the sample is detected within the ion mobility spectrometer.
- the detecting steps are as follows: the gaseous sample to be detected is input into the body 501 of the gaseous sample feeding component 500 through the gas inlet 504; the gaseous sample to be detected is guided into the inlet 400 of the drift tube of the ion mobility spectrometer through the gas channel of the gaseous sample feeding component 500; and the gaseous sample is detected in the ion mobility spectrometer.
- the gaseous sample feeding component 500 is kept at a high temperature since the gaseous sample feeding component 500 is located in the high-temperature internal cavity 101.
- the process of detecting the sample to be detected by the ion mobility spectrometer including the above sample feeding device includes the following steps:
- the collecting paper When performing the solid sample feeding function, the collecting paper is inserted into the guide groove 201, so that after entering the solid sample feeding component 100, the sample is quickly heated up and becomes sample vapour.
- This sample vapour reaches the semi-permeable membrane component under the action of the gas flow, and a gas flow mass which runs at a high speed and has a large surface area, is formed in front of the semi-permeable membrane.
- a part of the sample enters into the interior of the drift tube by penetrating through the semi-permeable membrane, and is entrained by the gas flow in the interior of the drift tube to enter into an ionization region.
- the ions of the ionized sample (which are actually charged sample cluster, and referred to as sample ions hereinafter) reach a collecting electrode under the action of the drift electric field. Further, the sample is identified based on the ion drift time.
- the gaseous sample feeding component 500 When performing gaseous sample feeding function, the gaseous sample feeding component 500 is inserted into the solid sample feeding component 100, and the channel of the solid sample feeding component 100 is closed, while only the gas channel of the gaseous sample feeding component 500 acts. Under the action of a high speed suction gas flow, the gaseous sample reaches the semi-permeable membrane after passing through the channel of the gaseous sample feeding component 500. Similarly, a gas flow mass which runs at a high speed and has a large surface area, is formed in the front of the semi-permeable membrane. The sample penetrating through the semi-permeable membrane enters into the ionization region and the drift region so as to be analyzed, thereby obtaining the information about the substance component.
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
Description
- The present invention relates to an ion mobility detecting technique. More particularly, the present invention relates to a sample feeding device for an ion mobility spectrometer and a method for detecting solid and gaseous samples using the sample feeding device. In addition, the present invention also relates to an ion mobility spectrometer having the sample feeding device.
- Currently commercially available detectors for safety inspection mainly detect harmful substances such as explosives and narcotics by an ion mobility spectrometry. Such detectors comprise a sample feeding device.
- The sample feeding device can gasify and desorb solid particles or gas entering into the device. The gasified sample molecules are then introduced into an ionization region by air flow. After that, the ionized sample molecules enter into a drift region. The molecules are identified based on their drift time in the drift region. The actual sample feeding devices are classified as both a gaseous sample feeding device and a solid sample feeding device. A sample collecting paper or a sample collecting rod is provided for the solid sample feeding device. Trace residual substance is collected by wiping a surface of an object under inspection with the collecting paper, and then the collecting paper or the sample collecting rod is inserted into the solid sample feeding device, and thereby information about the residual substance on the surface of the object is obtained through detection. In contrast, the gaseous sample feeding device directly extracts gas released by an object under inspection to detect substance. An early commercially available detector typically has function of feeding only one type of sample, for example SMITH's desktop Ionscan_5000DT only having solid sample feeding function. Recently, in order to improve the ability of the sample feeding device, Sample feeding devices with both gaseous and solid sample feeding ability are commercially available. Furthermore, a portion of patents has been applied to the product, for example SABER EXV, SABER 4000, and MMTD of SMTH, whose characteristic is to employ two separate sample feeding inlets. When detecting gaseous sample, it is needed to insert a PTFE sheet at a solid sample feeding inlet to close a sample feeding gas path. The disadvantage of SABER 4000 is that the volume of the sample feeding device is large, and occupies one fifth space of the detector. However, the sample feeding device in the desktop detector generally only has the solid sample feeding ability. These factors make constraint to the miniaturization of the detector and restrict the function of the product.
- In viewing of the above, there is a need in the prior art to develop a practical ion mobility spectrometer with solid and gaseous sample feeding apparatus. On one hand, the ion mobility spectrometer has a built-in concentrating device so as to simplify its arrangement and operation procedure; and on the other hand, the detector can sensitively and conveniently detect trace level of the residual solid on the object under inspection and gas with an extremely low concentration.
- Therefore, an object of the present invention is to solve at least one of the above problems and defects in the prior art.
- In accordance with an aspect of the present invention, there is provided a sample feeding device for an ion mobility spectrometer, which is adapted to guide a sample to be detected into an inlet of a drift tube of the ion mobility spectrometer. This sample feeding device can feed ot gaseous sample and solid sample. Since the sample feeding device only has one sample feeding inlet, the design of the sample feeding device is simplified, and the volume of the corresponding device becomes relatively small. Therefore, this sample feeding device is capable of applying in both portable detectors and desktop detectors.
- The sample feeding device comprises: a solid sample feeding component, a sample inlet component, an attachment component, and a gaseous sample feeding component. The solid sample feeding component has an internal cavity defined therein, one end of the solid sample feeding component is communicated with the sample inlet component through the internal cavity, while the other end of the solid sample feeding component is communicated with the inlet of the ion drift tube through the attachment component; the gaseous sample feeding component comprises a body and an external attachment component, the body has a gas channel therein, and the external attachment component includes an inlet hole which is communicated with the gas channel, wherein when the extern attachment component is fitted with the sample inlet component, the body is inserted into the internal cavity, so that a channel of the solid sample feeding component is closed, while only the gas channel of the gaseous sample feeding component is communicated with the inlet of the drift tube of the ion mobility spectrometer.
- Preferably, the sample inlet component comprises a guide groove and a photo diode. When a solid sample sheet enters into the internal cavity through the guide groove, the photo diode detects the sample and then sends a trigger signal.
- Preferably, the sample feeding device further comprises a semi-permeable membrane component, which comprises a suction hole, a mounting, a locking hoop and a semi-permeable membrane, wherein a position of the suction hole of the semi-permeable membrane component corresponds to that of a suction hole of a suction component, and the locking hoop has an annular outer periphery. The semi-permeable membrane is secured to the mounting by the annular outer periphery and an outer surface of the locking hoop is sealed against the suction component.
- In one preferred embodiment of the present invention, the internal cavity is in a flat shape, a central portion of the internal cavity is in the form of arc and two ends of the internal cavity on both side of the central portion are in the form of square. The body of the gaseous sample feeding component has a cylindrical shape.
- Preferably, the flat-like shape has a height between 1 and 10 mm, and a width between 15 and 50mm.
- Furthermore, the sample feeding device further comprises a suction component, which is attached to the attachment component, thereby forming a suction gas flow in order to remove the gaseous sample not entering into the inlet of the drift tube by suction.
- In accordance with another aspect of the present invention, there is provided a method of guiding a solid sample to be detected by using the sample feeding device of the ion mobility spectrometer, comprising: detaching the gaseous sample feeding component; inserting the solid sample into the internal cavity of the solid sample feeding component through the guide groove of the sample inlet component; sending out a trigger signal by the photo diode after the photo diode detects the solid sample to start a heating component disposed outside the internal cavity and the ion mobility spectrometer; vaporizing the solid sample in the internal cavity, and guiding the vaporized solid sample into the inlet of the drift tube of the ion mobility spectrometer through the internal cavity; and detecting the sample within the ion mobility spectrometer.
- In accordance with yet another aspect of the present invention, there is provided a method of guiding a gaseous sample to be detected by using the sample feeding device of the ion mobility spectrometer, comprising: inserting the gaseous sample feeding component; sucking the gaseous sample to be detected into the body of the gaseous sample feeding component through an gas inlet; guiding the gaseous sample to be detected into the inlet of the drift tube of the ion mobility spectrometer through the gas channel of the gaseous sample feeding component; and detecting the sample within the ion mobility spectrometer.
- In addition, the present invention further provides an ion mobility spectrometer, comprising: a drift tube adapted to ionize and drift the sample to be detected which is guided into the ion mobility spectrometer; and the sample feeding device adapted to guide the sample to be detected into the inlet of the drift tube.
- The above non-specific embodiments of the present invention have at least one or more of the following advantages and effects:
- The sample feeding device of the present invention has both solid and gaseous sample feeding function. Since only one sample feeding inlet is employed, it is possible to reduce the volume and space of the sample feeding device and to effectively reduce the volume of the ion mobility spectrometer. The sample feeding modes are switched by inserting and removing the gaseous sample feeding component so that the sample feeding device can simply and conveniently switch between the gaseous and solid sample feeding modes.
-
-
Figure 1 is a cross sectional view of a sample feeding device according to an embodiment of the present invention; -
Figure 2 is a schematic view showing a sample inlet component according to an embodiment of the present invention; -
Figure 3 is a schematic view showing a solid sample feeding component and an attachment component assembled together according to an embodiment of the present invention; -
Figure 4 is a cross sectional view showing the solid sample feeding component and the attachment component assembled together according to the embodiment of the present invention; -
Figure 5 is a schematic view showing a gaseous sample feeding component according to an embodiment of the present invention; -
Figure 6 is a schematic view showing a suction component according to an embodiment of the present invention; and -
Figure 7 is a schematic view showing a semi-permeable membrane component according to an embodiment of the present invention. - The technical solution of the present invention is further explained in detail through the embodiment taken in conjunction with the
figures 1-7 of the accompanying drawings. Throughout the specification, the same or similar reference number is designated as the component having the same or similar function. The description of the present embodiment is intended to explain the generally inventive concept of the present invention below with reference to the accompanying drawings, rather than is interpreted as a limitation to the present invention. - As shown in
figures 1-5 , asample feeding device 10 includes: a solidsample feeding component 100, asample inlet component 200, aattachment component 300, and a gaseoussample feeding component 500. The solidsample feeding component 100 has an internal cavity 101 (shown infigure 3 in detail) defined therein. One end of the solidsample feeding component 100 is communicated with thesample inlet component 200 through theinternal cavity 101, while the other end of the solidsample feeding component 100 is communicated with aninlet 400 of an ion drift tube through theattachment component 300. The gaseoussample feeding component 500 includes abody 501 and an external attachment component 502 (as shown infigure 5 in detail). Thebody 501 has agas channel 503 therein, and theexternal attachment component 502 includes aninlet hole 504 which is communicated with thegas channel 503. When theexternal attachment component 502 is fitted with thesample inlet component 200, thebody 501 is inserted into theinternal cavity 101, so that a channel of the solidsample feeding component 100 is closed, while only thegas channel 503 of the gaseoussample feeding component 500 is communicated with theinlet 400 of the drift tube of the ion mobility spectrometer. - In accordance with the preferred embodiment of the present invention, as shown in
figure 2 , it shows thesample inlet component 200. Thesample inlet component 200 includes aguide groove 201 and a photo diode 202. When a solid sample sheet enters into theinternal cavity 101 through theguide groove 201, the photo diode 202 detects the sample and then sends a trigger signal. Furthermore, aninstallation hole 203 may be disposed in the sample inlet component. Thesample inlet component 200 is assembled with other components by theinstallation hole 203. A person skilled in the art also can assemble the sample inlet component with other components by using other conventional means. In addition, theguide groove 201 has a relatively large opening, so that the collecting paper is easily inserted into the solidsample inlet component 200. A radiator is disposed at the photo diode 202, so that the photo diode 202 always operates at a relative low temperature for ensuring the detector performance. - As shown in
figures 3-5 , in accordance with one preferred embodiment of the present invention, theinternal cavity 101 is in a flat-like shape. Specifically, a central portion of theinternal cavity 101 is in the form of arc and two ends of the internal cavity on both sides of the central portion are in the form of square. Correspondingly, thebody 501 of the gaseoussample feeding component 500 is cylindrical. In this way, it can ensure that solid sample feeding efficiency is not affected and the gaseous sample feeding function can also be performed. The flat-like shape has a height between 1 and 10 mm, and a width between 15 and 50mm. In the present embodiment, the flat-like shape has a height of 3mm and a width of 22 mm. -
Figures 6 and 7 are schematic views showing asuction component 600 and asemi-permeable membrane 700, respectively. In one preferred embodiment, thesuction component 600 includes suction holes 601. As shown infigure 1 , thesuction component 600 is attached to theattachment component 300, thereby forming a suction gas flow in order to remove the gaseous sample not entering into the inlet of the drift tube by suction. It should be understood that the arrangement and construction of the suction component are described herein only as an example, and thus the person skilled in the art can employ any other conventional technical means in the art to remove the gaseous sample not entering into the inlet of the drift tube by suction. - The sample feeding device of the present invention also includes a semi-permeable membrane disposed between the
inlet 400 of the drift tube and the end of the channel of the internal cavity. The semi-permeable membrane can be disposed on thesemi-permeable membrane component 700 as shown infigure 7 . Thesemi-permeable membrane component 700 includes suction holes 701 of which a position correspond to a position of the suction holes 601 of the suction component. Thesemi-permeable membrane component 700 further includes auxiliary components such as a mounting 702, and alocking hoop 703 to support and secure the semi-permeable membrane. The mounting 702 is made of metal material, and employs aluminium plated with nickel in the present embodiment. Thelocking hoop 703 is made of fluorine rubber (or medical-grade silicone rubber), which is resistant to high temperature and does not emit gaseous foreign substance. Since the material of lockinghoop 703 can be resistant to high temperature, i.e. the fluorine rubber is resistant to high temperature of 250°C, it does not adhere to the metal surface. The annular outer periphery is capable of securing the soft semi-permeable membrane onto the mounting 702, while ensuring the tightness. It is ensured that the interior of the drift tube is sealed by sealing an outer planar surface of thelocking hoop 703 against thesuction component 600. A high-temperature state of the semi-permeable membrane is obtained by heat conducted from the sample inlet and the drift tube. It should be understood that the arrangement and construction of the semi-permeable membrane are described herein only as an example, and thus the person skilled in the art can employ any other conventional technical means in the art to achieve this function. - As shown in
figure 6 , a recess of thesuction component 600 is used to house thesemi-permeable membrane component 700. A gas flow in front of the semi-permeable membrane is pumped out by two suction holes 601. - Furthermore, the sample feeding device of the present invention also includes auxiliary components such as an
upper cover 800, stayplates attachment member 903, and abottom plate 904 for supporting and attaching. Thesample feeding device 10 is attached to the drift tube by theattachment member 903. Moreover, sealing devices are disposed between the semi-permeable membrane component and the fixation sample feeding component, the gaseous sample feeding component as well as the inlet of the drift tube to achieve the air-tightness. Since the person skilled in the art can design and produce those components by the conventional technical means in the art, in combination with the practical situation, and those components are not a main part of the present invention, these are not described in detail. - When detecting a solid sample, it should be vaporized. Thus, the solid
sample feeding component 100 has the function of quickly heating sample. Generally, heating components are disposed outside the internal cavity, for example by winding the heating filaments, so that theinternal cavity 101 is always kept at a high temperature. Alternatively, the sample is vaporized by using laser in theinternal cavity 101 for an instant. In one preferred embodiment of the present invention, the electrically heating filaments are employed and theinternal cavity 101 is surrounded by thermal insulation material, so that the temperature of the solidsample feeding component 100 is kept at 180°C all the time. - In addition, a surface of metal component in the gas path passing the gas is polished or plated with nickel, so that the surface is smooth, thereby reducing the absorption of the gas by the metal component.
- Operations of detecting the solid sample and gaseous sample by using the sample feeding device of the present invention are described below:
- In a solid sample feeding mode (the gaseous
sample feeding component 500 is detached), after a collecting paper with the sample passes through thesample inlet component 200 with theguide groove 201, the photo diode 202 detects the solid sample, and the photo diode sends a trigger signal to start the ion mobility spectrometer. The solid sample is vaporized in theinternal cavity 101, and the vaporized sample flows into theinlet 400 of the ion mobility spectrometer through the internal cavity, and the sample is detected within the ion mobility spectrometer. - In a gaseous sample feeding mode (the gaseous
sample feeding component 500 is inserted), the detecting steps are as follows: the gaseous sample to be detected is input into thebody 501 of the gaseoussample feeding component 500 through thegas inlet 504; the gaseous sample to be detected is guided into theinlet 400 of the drift tube of the ion mobility spectrometer through the gas channel of the gaseoussample feeding component 500; and the gaseous sample is detected in the ion mobility spectrometer. Because the channel of the solid sample feeding component is closed, the gaseous sample is guided in the front of the semi-permeable membrane only through the gas channel of the gaseous sample feeding component, and then enters into the inlet of the drift tube; and the gaseoussample feeding component 500 is kept at a high temperature since the gaseoussample feeding component 500 is located in the high-temperatureinternal cavity 101. - In accordance with one preferred embodiment of the present invention, the process of detecting the sample to be detected by the ion mobility spectrometer including the above sample feeding device includes the following steps:
- When performing the solid sample feeding function, the collecting paper is inserted into the
guide groove 201, so that after entering the solidsample feeding component 100, the sample is quickly heated up and becomes sample vapour. This sample vapour reaches the semi-permeable membrane component under the action of the gas flow, and a gas flow mass which runs at a high speed and has a large surface area, is formed in front of the semi-permeable membrane. A part of the sample enters into the interior of the drift tube by penetrating through the semi-permeable membrane, and is entrained by the gas flow in the interior of the drift tube to enter into an ionization region. The ions of the ionized sample (which are actually charged sample cluster, and referred to as sample ions hereinafter) reach a collecting electrode under the action of the drift electric field. Further, the sample is identified based on the ion drift time. - When performing gaseous sample feeding function, the gaseous
sample feeding component 500 is inserted into the solidsample feeding component 100, and the channel of the solidsample feeding component 100 is closed, while only the gas channel of the gaseoussample feeding component 500 acts. Under the action of a high speed suction gas flow, the gaseous sample reaches the semi-permeable membrane after passing through the channel of the gaseoussample feeding component 500. Similarly, a gas flow mass which runs at a high speed and has a large surface area, is formed in the front of the semi-permeable membrane. The sample penetrating through the semi-permeable membrane enters into the ionization region and the drift region so as to be analyzed, thereby obtaining the information about the substance component. - Although some embodiments of the general inventive concept are illustrated and explained, it would be appreciated by those skilled in the art that modifications and variations may be made in these embodiments without departing from the principles and spirit of the overall inventive concept of the disclosure, the scope of which is defined in the claims and their equivalents.
Claims (10)
- A sample feeding device for an ion mobility spectrometer, which is adapted to guide a sample to be detected into an inlet of a drift tube of the ion mobility spectrometer, the sample feeding device comprising:a solid sample feeding component;a sample inlet component;a attachment component, wherein the solid sample feeding component has an internal cavity defined therein, one end of the solid sample feeding component is communicated with the sample inlet component through the internal cavity, while the other end of the solid sample feeding component is communicated with the inlet of the ion drift tube through the attachment component; anda gaseous sample feeding component, comprising a body and an external attachment component, wherein the body has a gas channel therein, and the external attachment component includes an inlet hole which is communicated with the gas channel, wherein when the external attachment component is fitted with the sample inlet component, the body is inserted into the internal cavity, so that a channel of the solid sample feeding component is closed, and only the gas channel of the gaseous sample feeding component is communicated with the inlet of the drift tube of the ion mobility spectrometer.
- The sample feeding device for the ion mobility spectrometer according to claim 1, characterized in that:the sample inlet component comprises a guide groove and an photo diode, when a solid sample sheet enters the internal cavity through the guide groove, the photo diode detects the sample and then sends a trigger signal.
- The sample feeding device for the ion mobility spectrometer according to claim 1 or 2, characterized in that:the sample feeding device further comprises a semi-permeable membrane component, which comprises a suction hole, a mounting, a locking hoop and a semi-permeable membrane,wherein a position of the suction hole corresponds to a position of a suction hole of a suction component, the locking hoop has an annular outer periphery, the semi-permeable membrane is secured to the mounting by the annular outer periphery and an outer surface of the locking hoop is sealed against the suction component.
- The sample feeding device for the ion mobility spectrometer according to claim 1, characterized in that:the internal cavity has a flat shape, a central portion of the internal cavity is in the form of arc and two ends of the internal cavity on both sides of the central portion are in the form of square.
- The sample feeding device for the ion mobility spectrometer according to claim 4, characterized in that:the flat-like shape has a height between 1 and 10 mm, and a width between 15 and 50mm.
- The sample feeding device for the ion mobility spectrometer according to claim 5, characterized in that:the body of the gaseous sample feeding component is in a cylindrical shape.
- The sample feeding device for the ion mobility spectrometer according to claim 1, characterized in that:the sample feeding device further comprises a suction component, which is attached to the attachment component, thereby forming a suction gas flow so as to remove the gaseous sample not entering the inlet of the drift tube by suction.
- A method of guiding a solid sample to be detected by using the sample feeding device for an ion mobility spectrometer as claimed in claim 3, comprising:detaching the gaseous sample feeding component;inserting a solid sample into the internal cavity of the solid sample feeding component through the guide groove of the sample inlet component;sending out a trigger signal by a photo diode after the photo diode detects the solid sample to start a heating component disposed outside the internal cavity and the ion mobility spectrometer;vaporizing the solid sample in the internal cavity, and guiding the vaporized solid sample into the inlet of the drift tube of the ion mobility spectrometer through the internal cavity; anddetecting the sample within the ion mobility spectrometer.
- A method of guiding a gaseous sample to be detected by using the sample feeding device for the ion mobility spectrometer as claimed in claim 1, comprising:inserting the gaseous sample feeding component;inputting a gaseous sample to be detected into the body of the gaseous sample feeding component through a gas inlet;guiding the gaseous sample to be detected into the inlet of the drift tube of the ion mobility spectrometer through the gas channel of the gaseous sample feeding component; anddetecting the sample within the ion mobility spectrometer.
- An ion mobility spectrometer, comprising:a drift tube adapted to ionize and drift a sample to be detected which is guided into the ion mobility spectrometer; anda sample feeding device as claimed in any one of claims 1-7, adapted to guide the sample to be detected into an inlet of the drift tube.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL11778785T PL2492678T3 (en) | 2010-12-31 | 2011-04-27 | Sampling device for ion mobility spectrometer, method of using same and ion mobility spectrometer comprising sampling device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010624243.4A CN102565181B (en) | 2010-12-31 | 2010-12-31 | Sample injection device for ion mobility spectrometer (IMS), use method thereof and IMS |
PCT/CN2011/073390 WO2012088809A1 (en) | 2010-12-31 | 2011-04-27 | Sampling device for ion mobility spectrometer, method of using same and ion mobility spectrometer comprising sampling device |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2492678A1 true EP2492678A1 (en) | 2012-08-29 |
EP2492678A4 EP2492678A4 (en) | 2013-08-21 |
EP2492678B1 EP2492678B1 (en) | 2015-07-08 |
Family
ID=45638241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11778785.3A Active EP2492678B1 (en) | 2010-12-31 | 2011-04-27 | Sampling device for ion mobility spectrometer, method of using same and ion mobility spectrometer comprising sampling device |
Country Status (5)
Country | Link |
---|---|
US (1) | US8362422B2 (en) |
EP (1) | EP2492678B1 (en) |
CN (2) | CN102565181B (en) |
PL (1) | PL2492678T3 (en) |
WO (1) | WO2012088809A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201314252D0 (en) * | 2013-08-08 | 2013-09-25 | Smiths Detection Watford Ltd | Apparatus and method |
CN106996892A (en) * | 2017-03-28 | 2017-08-01 | 四川出入境检验检疫局检验检疫技术中心 | Food contact sheet material specific transfer experiment sampling infuser device |
CN111220688A (en) * | 2018-11-26 | 2020-06-02 | 中国科学院大连化学物理研究所 | Ion mobility spectrometer with solid-liquid-gas sampling device |
CN110208039B (en) * | 2019-06-27 | 2021-12-10 | 山东安准智能科技有限公司 | Sampler, rapid heating sample introduction system and rapid detection method |
CN112103171B (en) * | 2020-09-18 | 2023-10-13 | 中国科学院空天信息创新研究院 | Passive sample injection device and application |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050133716A1 (en) * | 1999-07-21 | 2005-06-23 | Miller Raanan A. | Explosives detection using differential ion mobility spectrometry |
US20080121797A1 (en) * | 2006-11-28 | 2008-05-29 | Excellims Corporation | Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5053343A (en) * | 1985-02-15 | 1991-10-01 | Environmental Technologies Group, Inc. | Selective ionization of gas constituents using electrolytic reactions |
EP0458622A3 (en) * | 1990-05-22 | 1992-01-22 | Barringer Technologies Inc. | Method and apparatus for collection and analysis of desquamated skin particulates or other tissue |
US6888128B2 (en) * | 2002-02-15 | 2005-05-03 | Implant Sciences Corporation | Virtual wall gas sampling for an ion mobility spectrometer |
JP3673789B2 (en) | 2003-03-31 | 2005-07-20 | 株式会社日立製作所 | Vaporized gas detection method and vaporized gas detection apparatus |
US7071465B2 (en) * | 2003-10-14 | 2006-07-04 | Washington State University Research Foundation | Ion mobility spectrometry method and apparatus |
US7388195B2 (en) * | 2004-09-30 | 2008-06-17 | Charles Stark Draper Laboratory, Inc. | Apparatus and systems for processing samples for analysis via ion mobility spectrometry |
CN2927049Y (en) | 2006-02-21 | 2007-07-25 | 公安部第三研究所 | Gasified substance ion transferring rate qualitative analyzer |
CN101113969B (en) * | 2006-07-27 | 2010-05-12 | 中国科学院大连化学物理研究所 | Sample feeder device of solid body and liquid example |
CN101210910B (en) * | 2006-12-31 | 2011-03-09 | 同方威视技术股份有限公司 | Gas filtering buffering integrative device |
CN201130166Y (en) | 2007-08-10 | 2008-10-08 | 上海新漫传感技术研究发展有限公司 | Multifunctional sampling apparatus for ion mobility spectrometer |
CN102592940B (en) * | 2007-12-27 | 2015-07-22 | 同方威视技术股份有限公司 | Ion migration spectrometer and method thereof |
CN101728208B (en) * | 2008-10-20 | 2012-09-26 | 同方威视技术股份有限公司 | Ion gate and method of bipolar ion mobility spectrometry |
CN101752176B (en) * | 2008-12-17 | 2012-02-08 | 中国科学院大连化学物理研究所 | Array ion migration tube |
CN201561956U (en) * | 2009-06-05 | 2010-08-25 | 中国科学院上海应用物理研究所 | Ion mobility spectrometer |
CN102033100B (en) * | 2009-09-25 | 2013-03-13 | 同方威视技术股份有限公司 | Detecting system of ion migration spectrometer (IMS) using doping agent and detecting method thereof |
CN101819179B (en) * | 2010-04-01 | 2012-12-12 | 公安部第三研究所 | Single-pipe double-chamber suction test paper dual-sampling cation and anion mobility spectrum dual measuring pipe |
CN202002909U (en) * | 2010-12-31 | 2011-10-05 | 同方威视技术股份有限公司 | Ionic migration spectrometer and sample injection device for same |
-
2010
- 2010-12-31 CN CN201010624243.4A patent/CN102565181B/en active Active
- 2010-12-31 CN CN201310689311.9A patent/CN103698387B/en active Active
-
2011
- 2011-04-27 WO PCT/CN2011/073390 patent/WO2012088809A1/en active Application Filing
- 2011-04-27 EP EP11778785.3A patent/EP2492678B1/en active Active
- 2011-04-27 PL PL11778785T patent/PL2492678T3/en unknown
- 2011-04-27 US US13/142,500 patent/US8362422B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050133716A1 (en) * | 1999-07-21 | 2005-06-23 | Miller Raanan A. | Explosives detection using differential ion mobility spectrometry |
US20080121797A1 (en) * | 2006-11-28 | 2008-05-29 | Excellims Corporation | Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection |
Non-Patent Citations (2)
Title |
---|
ARCE ET AL: "Sample-introduction systems coupled to ion-mobility spectrometry equipment for determining compounds present in gaseous, liquid and solid samples", TRAC, TRENDS IN ANALYTICAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 2, 19 January 2008 (2008-01-19), pages 139-150, XP022520324, ISSN: 0165-9936, DOI: 10.1016/J.TRAC.2008.01.001 * |
See also references of WO2012088809A1 * |
Also Published As
Publication number | Publication date |
---|---|
US8362422B2 (en) | 2013-01-29 |
PL2492678T3 (en) | 2015-12-31 |
WO2012088809A1 (en) | 2012-07-05 |
CN102565181A (en) | 2012-07-11 |
CN103698387A (en) | 2014-04-02 |
US20120168616A1 (en) | 2012-07-05 |
EP2492678A4 (en) | 2013-08-21 |
CN102565181B (en) | 2014-04-09 |
CN103698387B (en) | 2016-03-23 |
EP2492678B1 (en) | 2015-07-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8362422B2 (en) | Sample feeding device for ion mobility spectrometer, method of using the same and ion mobility spectrometer | |
JP6042965B2 (en) | Sample introduction device | |
US8161830B2 (en) | Method, apparatus, and system for integrated vapor and particulate sampling | |
US7449685B2 (en) | Gas monitoring apparatus | |
US8304716B2 (en) | Sampling device for ion migration spectrometer and method for using the same, and ion migration spectrometer | |
JP4303499B2 (en) | Chemical agent detection device | |
CN106525523B (en) | Thermal analysis sample injector for ion mobility spectrometer | |
KR102056235B1 (en) | Apparatus for measuring dissolved gas and oil immersed transformer having the same | |
EP2520922B1 (en) | Sample introducing device of trace detection meter and trace detection meter with sample introducing device | |
RU2759819C2 (en) | Intake flow system for sampler | |
JP3787116B2 (en) | How to detect chemical agents | |
US10665446B2 (en) | Surface layer disruption and ionization utilizing an extreme ultraviolet radiation source | |
CA2672248A1 (en) | Detection apparatus | |
JP2009115651A (en) | Sample inlet device, sample analyzer, and sample analysis system | |
CA2672249A1 (en) | Detector apparatus and pre-concentrators | |
CN111105983A (en) | Normal-pressure photoionization power supply device enhanced by direct current | |
US20150059497A1 (en) | Aerosol collecting device | |
US7270020B2 (en) | Instrument assemblies and analysis methods | |
EP2423663B1 (en) | Trace detection device and analysis method therefor | |
JP6224823B2 (en) | Mass spectrometer and cartridge used in mass spectrometer | |
CN113804747A (en) | Thermal desorption sampling device, thermal desorption equipment and ion mobility spectrometer detection equipment | |
CN105548328A (en) | Detector for propofol in blood, and applications thereof | |
JP2011237453A (en) | Sample collection device | |
RU2801343C1 (en) | Ionization device, mass spectrometry system and ionization method | |
JP2009047710A (en) | Detection method of chemical |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20111114 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
R17P | Request for examination filed (corrected) |
Effective date: 20111114 |
|
R17P | Request for examination filed (corrected) |
Effective date: 20111114 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: H01J 49/04 20060101ALI20130218BHEP Ipc: H01J 49/40 20060101AFI20130218BHEP Ipc: G01N 27/64 20060101ALI20130218BHEP |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Ref document number: 602011017741 Country of ref document: DE Free format text: PREVIOUS MAIN CLASS: G01N0027640000 Ipc: H01J0049400000 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20130722 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: H01J 49/04 20060101ALI20130716BHEP Ipc: H01J 49/40 20060101AFI20130716BHEP Ipc: G01N 27/64 20060101ALI20130716BHEP |
|
DAX | Request for extension of the european patent (deleted) | ||
17Q | First examination report despatched |
Effective date: 20140606 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
INTG | Intention to grant announced |
Effective date: 20150126 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 735967 Country of ref document: AT Kind code of ref document: T Effective date: 20150715 Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602011017741 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MK05 Ref document number: 735967 Country of ref document: AT Kind code of ref document: T Effective date: 20150708 |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: MP Effective date: 20150708 |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
REG | Reference to a national code |
Ref country code: PL Ref legal event code: T3 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20151009 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20151008 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20151109 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20151108 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602011017741 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
26N | No opposition filed |
Effective date: 20160411 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160430 Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: LU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160427 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20161230 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160502 Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160430 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160430 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160427 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20110427 Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160430 Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20150708 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: PL Payment date: 20200311 Year of fee payment: 10 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20200416 Year of fee payment: 10 |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20210427 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20210427 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PL Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20210427 |
|
P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230526 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20230307 Year of fee payment: 13 |