EP2454170A1 - Fluid reservoir - Google Patents

Fluid reservoir

Info

Publication number
EP2454170A1
EP2454170A1 EP10737469A EP10737469A EP2454170A1 EP 2454170 A1 EP2454170 A1 EP 2454170A1 EP 10737469 A EP10737469 A EP 10737469A EP 10737469 A EP10737469 A EP 10737469A EP 2454170 A1 EP2454170 A1 EP 2454170A1
Authority
EP
European Patent Office
Prior art keywords
fluid
storage space
liquid
fluid reservoir
filling body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10737469A
Other languages
German (de)
French (fr)
Other versions
EP2454170B1 (en
Inventor
Lutz Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thinxxs Microtechnology GmbH
Original Assignee
Thinxxs Microtechnology GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thinxxs Microtechnology GmbH filed Critical Thinxxs Microtechnology GmbH
Publication of EP2454170A1 publication Critical patent/EP2454170A1/en
Application granted granted Critical
Publication of EP2454170B1 publication Critical patent/EP2454170B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B65D81/268—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants the absorber being enclosed in a small pack, e.g. bag, included in the package
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber

Definitions

  • the invention relates to a fluid reservoir, in particular a fluid reservoir for integration into a miniaturized flow cell, having a storage space which is enclosed by two bodies in fluid-tight contact with one another.
  • the invention further relates to a method for producing such a fluid storage.
  • Fluid accumulators of this type are known, e.g. as emptied by deformation blister memory.
  • the dome-like storage space such Blister Grande always contains a certain amount of residual air, which affects the exact dosage dispensed volume of liquid.
  • the compressible residual air quantity initially ensures a delay of the liquid delivery.
  • an uncontrolled subsequent discharge of fluid occurs as a result of the relaxation of the residual air quantity.
  • Attempts to avoid the inclusion of residual air by completely filling the storage space with the liquid in the production of the memory this leads to an undesired displacement of liquid in a gap between the adjacent bodies due to the curved meniscus fluid '.
  • the invention has for its object to provide a new fluid accumulator of the type mentioned above, which allows a more accurate dosage dispensed amounts of liquid.
  • the fluid reservoir according to the invention which achieves this object is characterized in that a solid filling body filling the remaining storage space is arranged in the storage space in addition to a stored liquid.
  • a depression is formed in the first body, the liquid to be stored is filled into the depression and the depression is fluid-tightly covered by a second body to form the reservoir, wherein according to the invention the depression is only partially filled with the liquid and into the depression Furthermore, a solid packing is used, which completely fills the storage space together with the filled liquid.
  • liquid and filling body can form no residual air cushion in the storage space, which could delay or uncontrollably prolong the delivery of liquid.
  • the second body is so no or only a small fluid meniscus opposite.
  • a liquid meniscus facing the first body could be smoothed out by the filling body immersed in the liquid.
  • the two body enclosing the storage space are not only fluid-tight, if necessary under pressure, to each other, but are also connected to each other, in particular welded together and / or glued.
  • the two bodies abut each other with flat surfaces and the filling body has a flush surface with these flat surfaces.
  • At least one of the two bodies can be formed by a film which is deformable for emptying the memory and, for example, covers a depression forming the storage space in a thicker plate.
  • the film itself has a bulge forming the reservoir, so that a reservoir is formed in the form of a blister.
  • two films form the memory, of which at least one is deformed.
  • the films consist for example of plastic, aluminum or plastic coated aluminum and are glued together fluid-tight or welded.
  • the filling body is connected to one of the two bodies, in particular integrally connected, wherein the filling body protrudes from the one body into a recess forming the storage space and formed by the other body.
  • the protruding filling body enters the depression and displaces all air therefrom.
  • the volume of the part of the storage space filled by the liquid can be small compared to the total volume of the storage space, i.e., by varying the size of the filling body, the fillable amounts of liquid can be varied for a given total volume of the storage space.
  • the filler body may be attached to a punch for deformation of the mentioned
  • the filler can form a tool for producing an outlet opening, which can be actuated by deformation of the film.
  • the packing may e.g. comprise a mandrel or a slide, which pierces a film or / and brings a predetermined breaking point to bursting.
  • the filler may be a body melting at room temperature. For example, a piece of ice forming the packing may then provide for the dilution of a stored aqueous fluid.
  • the filler may also be provided for interaction with the stored liquid, wherein in addition to chemical reactions, for example, the inclusion of unwanted portions of the liquid, such as particles, oxygen or ions, would be possible.
  • the filler has a hydrophilic surface, which advantageously allows easy wetting by the stored liquid.
  • the packing can be designed to receive gas, which advantageously removes small amounts of residual air from the storage space.
  • the liquid could be degassed prior to storage so that it can absorb residual air.
  • the filling body fills up a step-shaped projection of the bulge.
  • the e.g. dome-shaped bulge then transmits no forces on the lower edge of the foot or bulge when deformed.
  • the formation of an outlet opening by breaking a predetermined breaking point at the foot edge is not hindered.
  • the filler has gaps, openings and / or channels of certain dimensions, which are wetted by the liquid to be stored while displacing the air during insertion of the filling body into the storage.
  • the liquid to be stored by means of these contours to the fluidic output of the memory, such. a blister channel known in the art, passed in a controlled manner.
  • the flow cell connected to the reservoir can be connected to an injection needle and the fluid to be stored can be connected
  • a medicament wherein the emptying of the memory is suitable for administering a medicament similar to a syringe.
  • the storage space is preferably elongated to form.
  • FIG. 1 is a partial sectional view of a flow cell with an integrated memory according to the prior art
  • Fig. 2 is a sectional partial view of a flow cell with a first
  • Fig. 3 shows a second embodiment of an inventive
  • FIG. 4 shows a third exemplary embodiment of a store according to the invention with a filling body arranged in a stepped approach of a blister bulge
  • FIG. 5 shows a fourth embodiment of a memory according to the invention with a trained as a slider filler
  • FIG. 6 shows a fifth exemplary embodiment of a store according to the invention with a filling body comprising a mandrel
  • FIG. 7 shows a sixth exemplary embodiment of a store according to the invention with a packing adapted to a press die
  • FIG. 8 shows an illustration of the production of a store according to the invention
  • Fi. 9 and 10 show two further embodiments of memory according to the invention.
  • a flow cell shown in fragmentary form in FIG. 1 and the following figures has a plastic plate 1 with cavities which are covered by a film 2 connected to the plastic plate 1.
  • a chamber 3 and a transport channel 4 can be seen as cavities, in FIG.
  • a fluid reservoir is arranged on the plastic plate 1, the two films 6 and 6 connected to one another in a planar manner
  • the film 6 is in turn connected on its side facing away from the film 7 with the plastic plate 1.
  • the foils 6, 7 can be welded together and the foil 6 can be welded or glued to the plate 1 and / or connected by double-sided adhesive film (not shown).
  • the film 7 has a dome-shaped bulge 8, through which a storage space for receiving a liquid 9 is formed between the films 6, 7. At 10 can be broken by pressure on the bulge 8 leading to the transport channel 4 opening channel.
  • a residual air cushion 1 1 is formed in the storage space.
  • the residual air is compressed, which after bursting of the opening channel 10 forming the predetermined breaking point leads to an uncontrolled discharge of liquid from the storage space.
  • a plate-shaped solid packing 12 is arranged in the storage space of a memory 5a, which completely fills the storage space together with a liquid contained in the storage space 9a. Only in a narrow gap between the plate edge surface of the filling body 12 and the wall of the storage space liquid 9a can pass. The shape of the edge of the packing determines the position and size of the gap. A plate surface 13 of the filling body 12 facing the film 6 therefore terminates flush with the contact surface 14 formed between the films 6, 7. In contrast to the memory 5, no or hardly any residual air is present in the storage space of the storage 5a. Likewise, the storage space of a memory 5b shown in FIG. 3 contains no residual air.
  • the memory 5b differs from the memory 5a in that a filling body 15 is significantly thicker than the plate-shaped filling body 12. Accordingly, a smaller volume of liquid 9b is included in the reservoir 5b.
  • Fig. 3 illustrates. Can (for a given size of the bulge) by varying the plate thickness and geometry different sized storage spaces for liquids are formed, with very small storage spaces can be produced with exactly measured volume.
  • FIG. 4 shows a memory 5c with a bulge 8c, which has a stepped extension 16.
  • a formed by the step approach 16 part of the storage space is filled by a plate-shaped packing 17 whose thickness is between the thickness of the packing 12 and the filling body 15. Due to the stepped approach, a base point 18 of the bulge 8c is offset laterally relative to the base 19 of a dome part of the bulge 8c, so that a pressure exerted on the dome part transmits only weakly reduced to the base point 18. Bursting in a predetermined breaking point present at 18 is not hindered by the pressure exerted on the bulge 8c.
  • a fluid reservoir 5d shown in FIG. 5 has a filling body 20, which is articulated at 21.
  • a compressive force on the bulge 8d in accordance with arrow 22 there is therefore a displacement of a part of the filling body 22 according to arrow 23, wherein the filling body at 24 forms a predetermined breaking point to form an outlet opening.
  • the filling body 25 comprises a mandrel 26 which, upon exertion of a compressive force on the bulge 8e according to arrow 22 (FIG. 5), can be pushed through the foil 6 to form an outlet opening, so that the reservoir 5e in conjunction with the transport channel 27 mentioned above stands.
  • a memory 5f shown in FIG. 7 has a filling body 28 which, on its side facing away from the film 6, is shaped in accordance with a pressure stamp 29 for exerting a compressive force on the bulge 8f.
  • Fig. 8 exemplifies the manufacture of the memory 5f shown in Fig. 7.
  • the bulge 8f is formed, in the case of a plastic film, e.g. by hot-forming, in the case of aluminum foil typically used for blisters, by cold-drawing. Liquid to be stored 9f is filled in the vessel space formed by the bulge 8f. Wherein the dashed line 30 in Fig. 8b indicates the resulting liquid level.
  • the filling body 28 is then inserted into the bulge 8f, wherein the surface 13f of the filling body 28 facing away from the liquid 9f terminates flush with the surface 14f of the film 7 or protrudes slightly beyond it.
  • the film 7 is joined to the film 6 to form a closed storage space, wherein the storage space is filled with residual air by the liquid 9f and the filling body 28.
  • FIGS. 9 and 10 show memories similar to the memory of FIG. 4 with a step approach 16g and 16h, respectively.
  • a packing 17g arranged in the stepped shoulder 16g has an indentation 35 at the edge. When the reservoir is emptied, fluid is supplied through this slot 35 to an exit port of the reservoir at 24g.
  • a packing 17h of the accumulator of Fig. 10 has a central passage and a radial passage 37 leading to a storage outlet 24h for.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Composite Materials (AREA)
  • Medicinal Chemistry (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention relates to a fluid reservoir, in particular a fluid reservoir to be integrated into a miniaturized flow cell, comprising a reservoir space, which is enclosed by two bodies (6,7) that lie against each other in a fluid-tight manner. According to the invention, in addition to a stored liquid (9), a solid filling body (12) that fills the remaining reservoir space is arranged in the reservoir space. A part of the reservoir space filled by the stored liquid is preferably bounded predominately by one of the two bodies (6,7) and the solid filling body (12).

Description

Beschreibung:  Description:
„Fluidspeicher" "Fluid reservoir"
Die Erfindung betrifft einen Fluidspeicher, insbesondere einen Fluidspeicher zur Integration in eine miniaturisierte Flusszelle, mit einem Speicherraum, der durch zwei fluiddicht aneinander anliegende Körper umschlossen ist. The invention relates to a fluid reservoir, in particular a fluid reservoir for integration into a miniaturized flow cell, having a storage space which is enclosed by two bodies in fluid-tight contact with one another.
Die Erfindung betrifft ferner ein Verfahren zur Herstellung eines solchen Fluid- speichers.  The invention further relates to a method for producing such a fluid storage.
Fluidspeicher solcher Art sind bekannt, z.B. als durch Verformung entleerbare Blisterspeicher. Der domartige Speicherraum solcher Blisterspeicher enthält stets eine gewisse Menge an Restluft, welche die genaue Dosierung abgegebener Flüssigkeitsvolumen beeinträchtigt. Die komprimierbare Restluftmenge sorgt zunächst für eine Verzögerung der Flüssigkeitsabgabe. Beim Nachlassen eines manuellen oder maschinellen Pressdrucks auf den Blister kommt es infolge Entspannung der Restluftmenge zu einer unkontrollierten nachträglichen Fluidaus- schüttung. Versucht man bei der Herstellung des Speichers den Einschluss von Restluft durch vollständige Auffüllung des Speicherraums mit der Flüssigkeit zu vermeiden, so führt dies infolge des gewölbten Flüssigkeitsmeniskus' zu einer unerwünschten Verdrängung von Flüssigkeit in einen Spalt zwischen den aneinander anliegenden Körpern. Fluid accumulators of this type are known, e.g. as emptied by deformation blister memory. The dome-like storage space such Blisterspeicher always contains a certain amount of residual air, which affects the exact dosage dispensed volume of liquid. The compressible residual air quantity initially ensures a delay of the liquid delivery. When a manual or mechanical pressing pressure on the blister subsides, an uncontrolled subsequent discharge of fluid occurs as a result of the relaxation of the residual air quantity. Attempts to avoid the inclusion of residual air by completely filling the storage space with the liquid in the production of the memory, this leads to an undesired displacement of liquid in a gap between the adjacent bodies due to the curved meniscus fluid '.
Der Erfindung liegt die Aufgabe zugrunde, einen neuen Fluidspeicher der eingangs erwähnten Art zu schaffen, der eine genauere Dosierung abgegebener Flüssigkeitsmengen ermöglicht. Der diese Aufgabe lösende Fluidspeicher nach der Erfindung ist dadurch gekennzeichnet, dass in dem Speicherraum neben einer gespeicherten Flüssigkeit ein den übrigen Speicherraum ausfüllender fester Füllkörper angeordnet ist. Zur Herstellung eines solchen Fluidspeichers wird in dem ersten Körper eine Vertiefung gebildet, die zu speichernde Flüssigkeit in die Vertiefung eingefüllt und die Vertiefung durch einen zweiten Körper unter Bildung des Speicherrαums fluiddicht abgedeckt, wobei erfindungsgemäß die Vertiefung nur teilweise mit der Flüssigkeit ausgefüllt und in die Vertiefung ferner ein fester Füllkörper eingesetzt wird, der zusammen mit der eingefüllten Flüssigkeit den Speicherraum vollständig ausfüllt. The invention has for its object to provide a new fluid accumulator of the type mentioned above, which allows a more accurate dosage dispensed amounts of liquid. The fluid reservoir according to the invention which achieves this object is characterized in that a solid filling body filling the remaining storage space is arranged in the storage space in addition to a stored liquid. In order to produce such a fluid reservoir, a depression is formed in the first body, the liquid to be stored is filled into the depression and the depression is fluid-tightly covered by a second body to form the reservoir, wherein according to the invention the depression is only partially filled with the liquid and into the depression Furthermore, a solid packing is used, which completely fills the storage space together with the filled liquid.
Indem Flüssigkeit und Füllkörper den Speicherraum vollständig oder nahezu vollständig ausfüllen, kann sich im Speicherraum kein Restluftpolster bilden, das die Flüssigkeitsabgabe verzögern oder unkontrolliert verlängern könnte. By filling the storage space completely or almost completely, liquid and filling body can form no residual air cushion in the storage space, which could delay or uncontrollably prolong the delivery of liquid.
Vorzugsweise ist ein durch die gespeicherte Flüssigkeit ausgefüllter Teil des Preferably, a filled by the stored liquid part of the
Speicherraums ganz oder überwiegend durch einen der beiden Körper und den festen Füllkörper begrenzt. Das heißt, bei der Herstellung des Speichers wird die im ersten Körper zugewandte Oberfläche der Flüssigkeit ganz oder teilweise durch den Füllkörper abgedeckt, gegen den dann der zweite Körper beim Schließen des Speicherraums angelegt wird. Dem zweiten Körper liegt so kein oder nur ein kleiner Flüssigkeitsmeniskus gegenüber. Alternativ könnte durch den in die Flüssigkeit versenkten Füllkörper ein dem ersten Körper zugewandter Flüssigkeitsmeniskus glatt- gezogen werden.  Storage space entirely or predominantly limited by one of the two bodies and the solid packing. That is, in the manufacture of the memory, the surface of the liquid facing the first body is completely or partially covered by the filling body, against which the second body is then applied when closing the storage space. The second body is so no or only a small fluid meniscus opposite. Alternatively, a liquid meniscus facing the first body could be smoothed out by the filling body immersed in the liquid.
Beim Abdecken der Vertiefung durch den zweiten Körper kann es daher weder zu einem Lufteinschluss im Speicherraum noch zu einer unerwünschten Verdrängung von Flüssigkeit in den Spalt zwischen den Körpern kommen. Vorzugsweise liegen die beiden den Speicherraum umschließenden Körper nicht nur fluiddicht, ggf. unter Druck, aneinander an, sondern sind auch miteinander verbunden, insbesondere miteinander verschweißt oder/und verklebt.  When the depression is covered by the second body, it is therefore impossible for any air to be trapped in the storage space or undesired displacement of liquid into the gap between the bodies. Preferably, the two body enclosing the storage space are not only fluid-tight, if necessary under pressure, to each other, but are also connected to each other, in particular welded together and / or glued.
In einer bevorzugten Ausführungsform der Erfindung liegen die beiden Körper mit ebenen Flächen aneinander an und der Füllkörper weist eine zu diesen ebenen Flächen bündige Fläche auf. Bei Abdeckung der genannten Vertiefung durch den zweiten Körper entsteht somit keinerlei Lufteinschluss zwischen den beiden Körpern. Wenigstens einer der beiden Körper kann durch eine Folie gebildet sein, die zur Entleerung des Speichers verformbar ist und z.B. eine den Speicherraum bildende Vertiefung in einer dickeren Platte abdeckt. In einer besonders bevorzugten Ausführungsform der Erfindung weist jedoch die Folie selbst eine den Speicherrαum bildende Ausbauchung auf, so dass ein Speicher in Form eines Blisters gebildet ist. Insbesondere bilden zwei Folien den Speicher, von denen wenigstens eine verformt ist. Die Folien bestehen z.B. aus Kunststoff, Aluminium oder mit Kunststoff beschichtetem Aluminium und sind miteinander fluiddicht verklebt oder verschweißt werden. In a preferred embodiment of the invention, the two bodies abut each other with flat surfaces and the filling body has a flush surface with these flat surfaces. When covering said recess by the second body thus no air inclusion between the two bodies. At least one of the two bodies can be formed by a film which is deformable for emptying the memory and, for example, covers a depression forming the storage space in a thicker plate. In a particularly preferred embodiment of the invention, however, the film itself has a bulge forming the reservoir, so that a reservoir is formed in the form of a blister. In particular, two films form the memory, of which at least one is deformed. The films consist for example of plastic, aluminum or plastic coated aluminum and are glued together fluid-tight or welded.
In einer Ausführungsform der Erfindung ist der Füllkörper mit einem der beiden Körper verbunden, insbesondere einstückig verbunden, wobei der Füllkörper von dem einen Körper in eine den Speicherraum bildende, durch den anderen Körper gebildete Vertiefung hinein vorsteht. Bei der Abdeckung der Vertiefung durch den einen Körper gelangt der vorstehende Füllkörper in die Vertiefung und verdrängt daraus sämtliche Luft. Das Volumen des durch die Flüssigkeit ausgefüllten Teils des Speicherraums kann klein im Vergleich zum Gesamtvolumen des Speicherraums sein, d.h., durch Variation der Größe des Füllkörpers lassen sich bei gegebenem Gesamtvolumen des Speicherraums die einfüllbaren Flüssigkeitsmengen variieren. Der Füllkörper kann eine an einen Stempel zur Verformung der genannten In one embodiment of the invention, the filling body is connected to one of the two bodies, in particular integrally connected, wherein the filling body protrudes from the one body into a recess forming the storage space and formed by the other body. When the depression is covered by the one body, the protruding filling body enters the depression and displaces all air therefrom. The volume of the part of the storage space filled by the liquid can be small compared to the total volume of the storage space, i.e., by varying the size of the filling body, the fillable amounts of liquid can be varied for a given total volume of the storage space. The filler body may be attached to a punch for deformation of the mentioned
Ausbauchung angepasste Oberfläche aufweisen. Ein die Blisterausbauchung zusammendrückender Stempel wird so zentriert und eine unerwünschte Faltenbildung der Blisterfolie verhindert. In weiterer Ausgestaltung der Erfindung kann der Füllkörper ein Werkzeug zur Herstellung einer Austrittsöffnung bilden, das sich durch Verformung der Folie betätigen lässt. Der Füllkörper kann z.B. einen Dorn oder einen Schieber umfassen, der eine Folie durchstößt oder/und eine Sollbruchstelle zum Bersten bringt. Bei dem Füllkörper kann es sich um einen bei Raumtemperatur schmelzenden Körper handeln. Zum Beispiel ein den Füllkörper bildendes Eisstück kann dann für die Verdünnung einer gespeicherten wässrigen Flüssigkeit sorgen. Have bulge adapted surface. A stamp compressing the blister bulge is thus centered and prevents unwanted wrinkling of the blister film. In a further embodiment of the invention, the filler can form a tool for producing an outlet opening, which can be actuated by deformation of the film. The packing may e.g. comprise a mandrel or a slide, which pierces a film or / and brings a predetermined breaking point to bursting. The filler may be a body melting at room temperature. For example, a piece of ice forming the packing may then provide for the dilution of a stored aqueous fluid.
Der Füllkörper kann ferner zur Wechselwirkung mit der gespeicherten Flüssigkeit vorgesehen sein, wobei neben chemischen Reaktionen z.B. die Aufnahme unerwünschter Anteile aus der Flüssigkeit, wie z.B. Partikel, Sauerstoff oder Ionen, möglich wäre. In weiterer Ausgestaltung der Erfindung weist der Füllkörper eine hydrophile Oberfläche auf, die vorteilhaft eine leichte Benetzung durch die gespeicherte Flüssigkeit ermöglicht. The filler may also be provided for interaction with the stored liquid, wherein in addition to chemical reactions, for example, the inclusion of unwanted portions of the liquid, such as particles, oxygen or ions, would be possible. In a further embodiment of the invention, the filler has a hydrophilic surface, which advantageously allows easy wetting by the stored liquid.
In weiterer Ausgestaltung der Erfindung kann der Füllkörper zur Aufnahme von Gas ausgelegt sein, wobei er vorteilhaft geringe Restluftmengen aus dem Speicherraum entfernt. Alternativ ließe sich die Flüssigkeit vor der Speicherung entgasen, so dass sie Restluft aufnehmen kann. In a further embodiment of the invention, the packing can be designed to receive gas, which advantageously removes small amounts of residual air from the storage space. Alternatively, the liquid could be degassed prior to storage so that it can absorb residual air.
Es versteht sich, dass der Füllkörper aus mehreren Teilen bestehen könnte. It is understood that the packing could consist of several parts.
In einer besonders bevorzugten Ausführungsform füllt der Füllkörper einen stufenförmigen Ansatz der Ausbauchung auf. Die z.B. kalottenförmige Ausbauchung überträgt dann bei ihrer Verformung keine Kräfte auf den unteren Fußrand oder Ausbauchung. Die Bildung einer Austrittsöffnung durch Aufbrechen einer Sollbruchstelle am Fußrand wird nicht behindert. In a particularly preferred embodiment, the filling body fills up a step-shaped projection of the bulge. The e.g. dome-shaped bulge then transmits no forces on the lower edge of the foot or bulge when deformed. The formation of an outlet opening by breaking a predetermined breaking point at the foot edge is not hindered.
In einer weiteren bevorzugten Ausführungsform der Erfindung weist der Füllkörper Spalte, Durchbrüche und/oder Kanäle bestimmter Abmessungen auf, die beim Einsetzen des Füllkörpers in den Speicher von der zu speichernden Flüssigkeit unter Verdrängung der Luft benetzt werden. Beim Ausdrücken wird die zu speichernde Flüssigkeit mit Hilfe dieser Konturen zum fluidischen Ausgang des Speichers, wie z.B. einem nach dem Stand der Technik bekannten Blisterkanal, in kontrollierter Art und Weise geleitet. In a further preferred embodiment of the invention, the filler has gaps, openings and / or channels of certain dimensions, which are wetted by the liquid to be stored while displacing the air during insertion of the filling body into the storage. When expressing the liquid to be stored by means of these contours to the fluidic output of the memory, such. a blister channel known in the art, passed in a controlled manner.
In einer weiteren Ausführungsform kann die mit dem Speicher verbundene Flusszelle mit einer Injektionsnadel verbunden und das zu speichernde Fluid ein In a further embodiment, the flow cell connected to the reservoir can be connected to an injection needle and the fluid to be stored can be connected
Medikament sein, wobei das Entleeren des Speichers zur Verabreichung eines Medikaments vergleichbar einer Spritze geeignet ist. Der Speicherraum ist dazu vorzugsweise länglich ausgeformt. A medicament, wherein the emptying of the memory is suitable for administering a medicament similar to a syringe. The storage space is preferably elongated to form.
Die Erfindung wird nachfolgend anhand von Ausführungsbeispielen und der beiliegenden, sich auf diese Ausführungsbeispiele beziehenden Zeichnungen weiter erläutert. Es zeigen: The invention will be explained below with reference to embodiments and the accompanying, relating to these embodiments drawings. Show it:
Fig. 1 eine geschnittene Teildarstellung einer Flusszelle mit einem integrierten Speicher nach dem Stand der Technik, Fig. 2 eine geschnittene Teildαrstellung einer Flusszelle mit einem ersten1 is a partial sectional view of a flow cell with an integrated memory according to the prior art, Fig. 2 is a sectional partial view of a flow cell with a first
Ausführungsbeispiel für einen erfindungsgemäßen Speicher, Embodiment of a memory according to the invention,
Fig. 3 ein zweites Ausführungsbeispiel für einen erfindungsgemäßen  Fig. 3 shows a second embodiment of an inventive
Speicher mit einem gegenüber dem Speicher von Fig. 2 verkleiner- fem Speichervolumen für Flüssigkeit,  Storage with a storage volume for liquid which is smaller than the storage of FIG. 2,
Fig. 4 ein drittes Ausführungsbeispiel für einen Speicher nach der Erfindung mit einen in einem Stufenansatz einer Blisterausbauchung angeordneten Füllkörper,  4 shows a third exemplary embodiment of a store according to the invention with a filling body arranged in a stepped approach of a blister bulge,
Fig. 5 ein viertes Ausführungsbeispiel für einen Speicher nach der Erfindung mit einem als Schieber ausgebildeten Füllkörper,  5 shows a fourth embodiment of a memory according to the invention with a trained as a slider filler,
Fig. 6 ein fünftes Ausführungsbeispiel für einen Speicher nach der Erfindung mit einem einen Dorn umfassenden Füllkörper,  6 shows a fifth exemplary embodiment of a store according to the invention with a filling body comprising a mandrel,
Fig. 7 ein sechstes Ausführungsbeispiel für einen Speicher nach der Erfindung mit einem an einen Pressstempel angepassten Füllkörper, Fig. 8 eine die Herstellung eines erfindungsgemäßen Speichers erläuternde  7 shows a sixth exemplary embodiment of a store according to the invention with a packing adapted to a press die, FIG. 8 shows an illustration of the production of a store according to the invention
Darstellung, und  Representation, and
Fi. 9 und 10 zwei weitere Ausführungsbeispiele für Speicher nach der Erfindung.  Fi. 9 and 10 show two further embodiments of memory according to the invention.
Eine in Fig. 1 und den folgenden Figuren jeweils ausschnittsweise dargestellte Fluss- zelle weist eine Kunststoffplatte 1 mit Kavitäten auf, die durch eine mit der Kunststoffplatte 1 verbundene Folie 2 abgedeckt sind. In den Figuren 1 bis 5 sowie der Fig. 7 sind als Kavitäten eine Kammer 3 und ein Transportkanal 4 erkennbar, in Fig.A flow cell shown in fragmentary form in FIG. 1 and the following figures has a plastic plate 1 with cavities which are covered by a film 2 connected to the plastic plate 1. In FIGS. 1 to 5 and in FIG. 7, a chamber 3 and a transport channel 4 can be seen as cavities, in FIG.
6 nur ein Transportkanal 27. 6 only one transport channel 27th
Auf ihrer der Folie 2 abgewandten Seite ist auf der Kunststoffplatte 1 jeweils ein Fluidspeicher angeordnet, der zwei flächig miteinander verbundene Folien 6 und On its side facing away from the film 2, in each case a fluid reservoir is arranged on the plastic plate 1, the two films 6 and 6 connected to one another in a planar manner
7 umfasst. Die Folie 6 ist auf ihrer der Folie 7 abgewandten Seite ihrerseits mit der Kunststoffplatte 1 verbunden. Die Folien 6,7 können miteinander und die Folie 6 kann mit der Platte 1 verschweißt oder/und verklebt sein und/oder mittels doppelseitigem Klebefilm (nicht gezeigt) verbunden sein. 7 includes. The film 6 is in turn connected on its side facing away from the film 7 with the plastic plate 1. The foils 6, 7 can be welded together and the foil 6 can be welded or glued to the plate 1 and / or connected by double-sided adhesive film (not shown).
Gemäß Fig. 1 weist die Folie 7 eine kalottenförmige Ausbauchung 8 auf, durch die zwischen den Folien 6,7 ein Speicherraum für die Aufnahme einer Flüssigkeit 9 gebildet ist. Bei 10 lässt sich durch Druck auf die Ausbauchung 8 ein zu dem Transportkanal 4 führender Öffnungskanal aufbrechen. According to FIG. 1, the film 7 has a dome-shaped bulge 8, through which a storage space for receiving a liquid 9 is formed between the films 6, 7. At 10 can be broken by pressure on the bulge 8 leading to the transport channel 4 opening channel.
Wie Fig. 1 erkennen lässt, ist in dem Speicherraum ein Restluftpolster 1 1 gebildet. Beim Zusammendrücken der Ausbauchung 8 wird die Restluft komprimiert, was nach Bersten der den Öffnungskanal 10 bildenden Sollbruchstelle zu einer unkontrollierten Abführung von Flüssigkeit aus dem Speicherraum führt. As can be seen Fig. 1, a residual air cushion 1 1 is formed in the storage space. When compressing the bulge 8, the residual air is compressed, which after bursting of the opening channel 10 forming the predetermined breaking point leads to an uncontrolled discharge of liquid from the storage space.
Bei dem Ausführungsbeispiel von Fig. 2 ist im Speicherraum eines Speichers 5a ein plattenförmiger fester Füllkörper 12 angeordnet, der zusammen mit einer im Speicherraum enthaltenen Flüssigkeit 9a den Speicherraum vollständig ausfüllt. Nur in einen schmalen Spalt zwischen der Plattenrandfläche des Füllkörpers 12 und der Wand des Speicherraums kann Flüssigkeit 9a gelangen. Die Formgebung des Randes des Füllkörpers bestimmt hierbei die Lage und Größe des Spaltes. Eine der Folie 6 zugewandte Plattenfläche 13 des Füllkörpers 12 schließt daher bündig mit der zwischen den Folien 6,7 gebildeten Anlagefläche 14 ab. Im Unterschied zu dem Speicher 5 ist in dem Speicherraum des Speichers 5a keine oder kaum noch Restluft vorhanden. Ebenso enthält der Speicherraum eines in Fig. 3 gezeigten Speichers 5b keine Restluft. Der Speicher 5b unterscheidet sich von dem Speicher 5a dadurch, dass ein Füllkörper 15 deutlich dicker als der plattenförmige Füllkörper 12 ist. Entsprechend ist in dem Speicher 5b ein kleineres Volumen einer Flüssigkeit 9b eingeschlossen. Wie Fig. 3 verdeutlicht. Können (bei gegebener Größe der Ausbauchung) durch Variation der Plattendicke und -geometrie unterschiedlich große Speicherräume für Flüssigkeiten gebildet werden, wobei auch sehr kleine Speicherräume mit genau bemessenem Volumen herstellbar sind. In the embodiment of Fig. 2, a plate-shaped solid packing 12 is arranged in the storage space of a memory 5a, which completely fills the storage space together with a liquid contained in the storage space 9a. Only in a narrow gap between the plate edge surface of the filling body 12 and the wall of the storage space liquid 9a can pass. The shape of the edge of the packing determines the position and size of the gap. A plate surface 13 of the filling body 12 facing the film 6 therefore terminates flush with the contact surface 14 formed between the films 6, 7. In contrast to the memory 5, no or hardly any residual air is present in the storage space of the storage 5a. Likewise, the storage space of a memory 5b shown in FIG. 3 contains no residual air. The memory 5b differs from the memory 5a in that a filling body 15 is significantly thicker than the plate-shaped filling body 12. Accordingly, a smaller volume of liquid 9b is included in the reservoir 5b. As Fig. 3 illustrates. Can (for a given size of the bulge) by varying the plate thickness and geometry different sized storage spaces for liquids are formed, with very small storage spaces can be produced with exactly measured volume.
Fig. 4 zeigt einen Speicher 5c mit einer Ausbauchung 8c, die einen Stufenansatz 16 aufweist. Ein durch den Stufenansatz 16 gebildeter Teil des Speicherraums ist durch einen plattenförmigen Füllkörper 17 ausgefüllt, dessen Dicke zwischen der Dicke des Füllkörpers 12 und der des Füllkörpers 15 liegt. Durch den Stufenansatz ist ein Fußpunkt 18 der Ausbauchung 8c zum Fußpunkt 19 eines Kalottenteils der Ausbauchung 8c seitlich versetzt, so dass ein auf den Kalottenteil ausgeübter Press- druck sich nur abgeschwächt vermindert auf den Fußpunkt 18 überträgt. Das Bersten in einer bei 18 vorhandenen Sollbruchstelle wird durch den auf die Ausbauchung 8c ausgeübten Druck dadurch nicht behindert. FIG. 4 shows a memory 5c with a bulge 8c, which has a stepped extension 16. A formed by the step approach 16 part of the storage space is filled by a plate-shaped packing 17 whose thickness is between the thickness of the packing 12 and the filling body 15. Due to the stepped approach, a base point 18 of the bulge 8c is offset laterally relative to the base 19 of a dome part of the bulge 8c, so that a pressure exerted on the dome part transmits only weakly reduced to the base point 18. Bursting in a predetermined breaking point present at 18 is not hindered by the pressure exerted on the bulge 8c.
Ein in Fig. 5 gezeigter Fluidspeicher 5d weist einen Füllkörper 20 auf, der bei 21 gelenkig ausgebildet ist. Unter Ausübung einer Druckkraft auf die Ausbauchung 8d gemäß Pfeil 22 kommt es daher gemäß Pfeil 23 zu einer Verschiebung eines Teils des Füllkörpers 22, wobei der Füllkörper bei 24 zur Bildung einer Austrittsöffnung eine Sollbruchstelle aufstößt. Aus Fig. 6 geht ein Speicher 5e mit einem Füllkörper 25 hervor. Der Füllkörper 25 umfαsst einen Dorn 26, der sich bei Ausübung einer Druckkraft auf die Ausbauchung 8e gemäß Pfeil 22 (Fig. 5) unter Bildung eines Austrittsöffnung durch die Folie 6 hindurchstoßen lässt, so dass der Speicher 5e in Verbindung mit dem oben genannten Transportkanal 27 steht. A fluid reservoir 5d shown in FIG. 5 has a filling body 20, which is articulated at 21. By exerting a compressive force on the bulge 8d in accordance with arrow 22, there is therefore a displacement of a part of the filling body 22 according to arrow 23, wherein the filling body at 24 forms a predetermined breaking point to form an outlet opening. From FIG. 6, a storage 5e with a filling body 25 emerges. The filling body 25 comprises a mandrel 26 which, upon exertion of a compressive force on the bulge 8e according to arrow 22 (FIG. 5), can be pushed through the foil 6 to form an outlet opening, so that the reservoir 5e in conjunction with the transport channel 27 mentioned above stands.
Bei den Ausführungsbeispielen von Fig. 5 und 6 grenzt die im Speicherraum enthaltene Flüssigkeit nur in einem verhältnismäßig kleinen, in Bezug auf In the embodiments of Figs. 5 and 6, the liquid contained in the storage space is limited only in a relatively small, with respect to
Flüssigkeitsverdrängung unkritischen Bereich 31 bzw. 32 an die Folie 6 an.  Fluid displacement uncritical region 31 or 32 to the film 6 at.
Ein in Fig. 7 gezeigter Speicher 5f weist einen Füllkörper 28 auf, der auf seiner der Folie 6 abgewandten Seite entsprechend einem Druckstempel 29 zum Ausüben einer Druckkraft auf die Ausbauchung 8f geformt ist. A memory 5f shown in FIG. 7 has a filling body 28 which, on its side facing away from the film 6, is shaped in accordance with a pressure stamp 29 for exerting a compressive force on the bulge 8f.
Es wird nun auf Fig.8 Bezug genommen, welche beispielhaft die Herstellung des in Fig. 7 gezeigten Speichers 5f erläutert. Reference is now made to Fig. 8 which exemplifies the manufacture of the memory 5f shown in Fig. 7.
Gemäß Fig. 8a wird in einem ersten Schritt in der Folie 7 die Ausbauchung 8f gebil- det, im Fall einer Kunststofffolie z.B. durch Warmtiefziehen, im Fall einer typischerweise für Blister verwendeten Aluminiumfolie durch Kalttiefziehen. In den durch die Ausbauchung 8f gebildeten Gefäßraum wird zu speichernde Flüssigkeit 9f eingefüllt. Wobei die Strichlinie 30 in Fig. 8b den sich ergebenden Flüssigkeitsspiegel andeutet. According to Fig. 8a, in a first step in the film 7, the bulge 8f is formed, in the case of a plastic film, e.g. by hot-forming, in the case of aluminum foil typically used for blisters, by cold-drawing. Liquid to be stored 9f is filled in the vessel space formed by the bulge 8f. Wherein the dashed line 30 in Fig. 8b indicates the resulting liquid level.
Im folgenden Schritt gemäß Fig.8c wird dann der Füllkörper 28 in die Ausbauchung 8f eingesetzt, wobei die der Flüssigkeit 9f abgewandte Oberfläche 13f des Füllkörpers 28 bündig mit der Oberfläche 14f der Folie 7 abschließt oder leicht über diese übersteht. In the following step according to FIG. 8c, the filling body 28 is then inserted into the bulge 8f, wherein the surface 13f of the filling body 28 facing away from the liquid 9f terminates flush with the surface 14f of the film 7 or protrudes slightly beyond it.
Im letzten Schritt gemäß Fig.8d wird die Folie 7 mit der Folie 6 unter Bildung eines geschlossenen Speicherraums verbunden, wobei der Speicherraum durch die Flüssigkeit 9f und den Füllkörper 28 restluftfrei ausgefüllt ist.  In the last step according to FIG. 8d, the film 7 is joined to the film 6 to form a closed storage space, wherein the storage space is filled with residual air by the liquid 9f and the filling body 28.
Fig. 9 und 10 zeigen dem Speicher von Fig. 4 ähnliche Speicher mit einem Stufenansatz 16g bzw. 16h. Ein in dem Stufenansatz 16g angeordneter Füllkörper 17g weist am Rand eine Einschlitzung 35 auf. Beim Entleeren des Speichers wird Flüssigkeit durch diese Einschlitzung 35 hindurch einer Austrittsöffnung des Speichers bei 24g zugeführt. Ein Füllkörper 17h des Speichers von Fig. 10 weist einen zentralen Durchgang und einen radialen Kanal 37 auf, der zu einer Speicheraustrittsöffnung 24h für. FIGS. 9 and 10 show memories similar to the memory of FIG. 4 with a step approach 16g and 16h, respectively. A packing 17g arranged in the stepped shoulder 16g has an indentation 35 at the edge. When the reservoir is emptied, fluid is supplied through this slot 35 to an exit port of the reservoir at 24g. A packing 17h of the accumulator of Fig. 10 has a central passage and a radial passage 37 leading to a storage outlet 24h for.

Claims

Patentansprüche: claims:
1. Fluidspeicher, insbesondere zur Integration in eine miniaturisierte Flusszelle, mit einem Speicherraum, der durch fluiddicht aneinander anliegende Körper [6,7] umschlossen ist, 1. fluid reservoir, in particular for integration into a miniaturized flow cell, with a storage space which is enclosed by fluid-tight abutting bodies [6,7],
dadurch gekennzeichnet,  characterized,
dass in dem Speicherraum neben einer gespeicherten Flüssigkeit (9) ein den übrigen Speicherraum ausfüllender fester Füllkörper (12;15;17;20;25;28) angeordnet ist.  in that a solid filling body (12; 15; 17; 20; 25; 28) filling the remaining storage space is arranged in the storage space next to a stored liquid (9).
2. Fluidspeicher nach Anspruch 1 , 2. fluid reservoir according to claim 1,
dadurch gekennzeichnet,  characterized,
dass ein durch die gespeicherte Flüssigkeit (9) ausgefüllter Teil des Speicherraums überwiegend durch einen der beiden Körper (7) und den festen Füll- körper ( 12; 15; 17;20;25;28) begrenzt ist.  a part of the storage space filled by the stored liquid (9) is predominantly delimited by one of the two bodies (7) and the solid filling body (12; 15; 17; 20; 25; 28).
3. Fluidspeicher nach Anspruch 1 oder 2, 3. fluid reservoir according to claim 1 or 2,
dadurch gekennzeichnet,  characterized,
dass die beiden fluiddicht aneinander anliegenden Körper (6,7) miteinander verbunden, insbesondere miteinander verschweißt oder/und verklebt sind.  the two bodies (6, 7) lying against each other in a fluid-tight manner are connected to one another, in particular welded or glued together.
4. Fluidspeicher nach einem der Ansprüche 1 bis 3, 4. fluid reservoir according to one of claims 1 to 3,
dadurch gekennzeichnet,  characterized,
dass die beiden Körper (6,7) mit ebenen Flächen (14) fluiddicht aneinander anliegen und der Füllkörper (12;15;17;20;25;28) eine zu den ebenen Flächen the two bodies (6, 7) bear fluid-tight contact with flat surfaces (14) and the filling body (12; 15; 17; 20; 25; 28) bears against the flat surfaces
(14) bündige Fläche (13) aufweist. (14) has a flush surface (13).
5. Fluidspeicher nach einem der Ansprüche 1 bis 4, 5. fluid reservoir according to one of claims 1 to 4,
dadurch gekennzeichnet,  characterized,
dass wenigstens einer der beiden Körper (6,7) durch eine Folie gebildet ist.  in that at least one of the two bodies (6, 7) is formed by a foil.
6. Fluidspeicher nach Anspruch 5, 6. fluid reservoir according to claim 5,
dadurch gekennzeichnet,  characterized,
dass die Folie eine verformbare Ausbauchung (8) zur Bildung des Speicher- raums aufweist.  the film has a deformable bulge (8) for forming the storage space.
7. Fluidspeicher nach einem der Ansprüche 1 bis 6, 7. Fluid reservoir according to one of claims 1 to 6,
dadurch gekennzeichnet, dass der Füllkörper mit einem der beiden Körper, insbesondere einstückig, verbunden ist und von dem einen Körper in eine den Speicherraum bildende durch den anderen Körper gebildete Vertiefung hinein vorsteht. characterized, in that the filling body is connected to one of the two bodies, in particular in one piece, and from which one body protrudes into a depression forming the storage space formed by the other body.
8. Fluidspeicher nach einem der Ansprüche 1 bis 7, 8. fluid reservoir according to one of claims 1 to 7,
dadurch gekennzeichnet,  characterized,
dass das Volumen des durch die Flüssigkeit (9b) ausgefüllten Teils des Speicherraums klein im Vergleich zum Gesamtvolumen des Speicherraums ist.  the volume of the storage space filled by the liquid (9b) is small compared to the total volume of the storage space.
9. Fluidspeicher nach einem der Ansprüche 6 bis 8, 9. fluid reservoir according to one of claims 6 to 8,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper (28) eine an einen Stempel (29) zur Verformung der Ausbauchung (8f) zum Herausdrücken der gespeicherten Flüssigkeit ange- passte Oberfläche aufweist.  in that the filling body (28) has a surface adapted to a punch (29) for deforming the bulge (8f) for pushing out the stored liquid.
10. Fluidspeicher nach einem der Ansprüche 6 bis 9, 10. Fluid reservoir according to one of claims 6 to 9,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper (20,25) ein Werkzeug zur Herstellung einer Austrittsöffnung (24) bildet, das sich unter Verformung der Ausbauchung (8d,8e) betätigen lässt.  in that the filling body (20, 25) forms a tool for producing an outlet opening (24) which can be actuated while deforming the bulge (8d, 8e).
1 1 . Fluidspeicher nach Anspruch 10, 1 1. Fluid store according to claim 10,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper (20,25) einen Dorn (26) umfasst oder/und einen Schieber bildet.  in that the filling body (20, 25) comprises a mandrel (26) or / and forms a slide.
12. Fluidspeicher nach einem der Ansprüche 1 bis 1 1 , 12. Fluid store according to one of claims 1 to 1 1,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper ein bei Raumtemperatur schmelzender Körper ist.  that the filler is a melting at room temperature body.
13. Fluidspeicher nach einem der Ansprüche 1 bis 12, 13. Fluid store according to one of claims 1 to 12,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper zur Wechselwirkung mit der Flüssigkeit vorgesehen ist.  that the filling body is provided for interaction with the liquid.
14. Fluidspeicher nach einem der Ansprüche 1 bis 13, 14. Fluid reservoir according to one of claims 1 to 13,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper eine hydrophile Oberfläche aufweist. the filler has a hydrophilic surface.
15. Fluidspeicher nach einem der Ansprüche 1 bis 14, 15. Fluid reservoir according to one of claims 1 to 14,
dadurch gekennzeichnet,  characterized,
dass die Flüssigkeit eine vor dem Einschluss in den Speicherraum wenigstens teilweise entgaste Flüssigkeit ist.  in that the liquid is a liquid which is at least partially degassed before being enclosed in the storage space.
16. Fluidspeicher nach einem der Ansprüche 1 bis 15, 16. Fluid store according to one of claims 1 to 15,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper zur Aufnahme von Restluft geeignet ist.  that the filling body is suitable for receiving residual air.
17. Fluidspeicher nach einem der Ansprüche 1 bis 16, 17. Fluid reservoir according to one of claims 1 to 16,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper mehrteilig ausgebildet ist.  that the filling body is designed in several parts.
18. Fluidspeicher nach einem der Ansprüche 6 bis 17, 18. Fluid store according to one of claims 6 to 17,
dadurch gekennzeichnet,  characterized,
dass der Speicherraum einen stufenförmigen Ansatz (16) aufweist der bis auf einen Randbereich durch den Füllkörper (17) ausgefüllt ist.  the storage space has a step-shaped projection (16) which is filled up to an edge area by the filling body (17).
19. Fluidspeicher nach einem der Ansprüche 1 bis 18, 19. Fluid store according to one of claims 1 to 18,
dadurch gekennzeichnet,  characterized,
dass der Füllkörper (17g, 17h) einen Durchbruch, Kanal oder/und einen Ein- schlitzung zum Leiten der Flüssigkeit zu einem Speicherausgang (24g,24h) aufweist.  in that the filling body (17g, 17h) has an opening, channel or / and a slot for directing the liquid to a storage outlet (24g, 24h).
20. Verfahren zur Herstellung eines Fluidspeichers, insbesondere eines Fluid- speichers für die Integration in eine miniaturisierte Flusszelle, wobei in einem ersten Körper (7) eine Vertiefung (8f) gebildet, eine gespeicherte Flüssigkeit (9) in die Vertiefung (8f) eingefüllt und die Vertiefung (8f) unter Bildung eines Speicherraums durch einen zweiten Körper (6) fluiddicht abgedeckt wird, dadurch gekennzeichnet, 20. A method for producing a fluid reservoir, in particular a fluid storage for integration into a miniaturized flow cell, wherein in a first body (7) formed a recess (8f), a stored liquid (9) filled in the recess (8f) and the depression (8f) is fluid-tightly covered by a second body (6) to form a storage space, characterized in that
dass die Vertiefung (f) nur teilweise mit der Flüssigkeit (9f ) gefüllt und in die Vertiefung (8f) ein fester Füllkörper (28) eingesetzt wird, der zusammen mit der Flüssigkeit (9f) den Speicherraum vollständig ausfüllt.  the depression (f) is only partially filled with the liquid (9f) and a solid filler (28) is inserted into the depression (8f), which together with the liquid (9f) completely fills the storage space.
21. Verfahren nach Anspruch 20, 21. The method according to claim 20,
dadurch gekennzeichnet, dass die dem zweiten Körper (6) zugewandte Oberfläche der Flüssigkeit (9f) ganz oder zu einem überwiegenden Teil durch den Füllkörper (28) abgedeckt wird. characterized, in that the surface of the liquid (9f) facing the second body (6) is completely or to a large extent covered by the filling body (28).
EP10737469.6A 2009-07-11 2010-06-07 Fluid reservoir Active EP2454170B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009032744A DE102009032744A1 (en) 2009-07-11 2009-07-11 fluid reservoir
PCT/DE2010/000646 WO2011006460A1 (en) 2009-07-11 2010-06-07 Fluid reservoir

Publications (2)

Publication Number Publication Date
EP2454170A1 true EP2454170A1 (en) 2012-05-23
EP2454170B1 EP2454170B1 (en) 2014-08-13

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US (1) US8783488B2 (en)
EP (1) EP2454170B1 (en)
DE (1) DE102009032744A1 (en)
WO (1) WO2011006460A1 (en)

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Also Published As

Publication number Publication date
WO2011006460A1 (en) 2011-01-20
US20120187117A1 (en) 2012-07-26
US8783488B2 (en) 2014-07-22
EP2454170B1 (en) 2014-08-13
DE102009032744A1 (en) 2011-01-13

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