EP2452149A2 - Plate heat exchanger - Google Patents
Plate heat exchangerInfo
- Publication number
- EP2452149A2 EP2452149A2 EP10724312A EP10724312A EP2452149A2 EP 2452149 A2 EP2452149 A2 EP 2452149A2 EP 10724312 A EP10724312 A EP 10724312A EP 10724312 A EP10724312 A EP 10724312A EP 2452149 A2 EP2452149 A2 EP 2452149A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- heat exchanger
- plates
- plate heat
- plate
- exchanger according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28D—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
- F28D9/00—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall
- F28D9/0031—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits for one heat-exchange medium being formed by paired plates touching each other
- F28D9/0043—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits for one heat-exchange medium being formed by paired plates touching each other the plates having openings therein for circulation of at least one heat-exchange medium from one conduit to another
- F28D9/005—Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits for one heat-exchange medium being formed by paired plates touching each other the plates having openings therein for circulation of at least one heat-exchange medium from one conduit to another the plates having openings therein for both heat-exchange media
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F17/00—Removing ice or water from heat-exchange apparatus
- F28F17/005—Means for draining condensates from heat exchangers, e.g. from evaporators
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F21/00—Constructions of heat-exchange apparatus characterised by the selection of particular materials
- F28F21/06—Constructions of heat-exchange apparatus characterised by the selection of particular materials of plastics material
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F2275/00—Fastening; Joining
- F28F2275/02—Fastening; Joining by using bonding materials; by embedding elements in particular materials
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F2275/00—Fastening; Joining
- F28F2275/06—Fastening; Joining by welding
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F2280/00—Mounting arrangements; Arrangements for facilitating assembling or disassembling of heat exchanger parts
- F28F2280/06—Adapter frames, e.g. for mounting heat exchanger cores on other structure and for allowing fluidic connections
Definitions
- the invention relates to a plate heat exchanger having a plurality of flow channels having plates, wherein a first plate has a front side with at least one
- Heat exchangers that are very inexpensive in terms of material and manufacturing. From DE 10 2006 013 503 Al a plate heat exchanger with a plurality of flow channels having plates is known. A first plate has at least one flow channel for a first fluid and a second plate has at least one flow channel for a second fluid. The plates have fürgangso réelleen via which the flow channels for the same fluid are each connected together.
- EP 0 038 454 A2 discloses a plate heat exchanger consisting of a multiplicity of extruded individual plates
- Object of the present invention is therefore, a
- the task is combined with the preamble of
- Claim 1 characterized in that a front plate, which is upstream of the front of the first plate having connections for the first fluid and for the second fluid, that a closure plate forms the conclusion of the juxtaposed plates, that the plates and terminals are made of plastic, and that the plates are tightly glued or welded together.
- the plate heat exchanger according to the invention is simple
- Plastic welding process can be dispensed with seals.
- the plate heat exchangers can be so cheap
- the inventive plate heat exchanger for applications in the pharmaceutical, biotechnology and
- the plates are flat on their sides facing away from the front sides. This has the advantage that the plates can be strung together in any order.
- the plates have, on their back sides facing away from the front sides, mirror-symmetrical flow channels corresponding to the flow channels of the adjacent front sides.
- the flow channels of the plates each have flow direction.
- the flow straightener are designed as arranged in the flow ducts barriers or partitions.
- Partitions of flow channels for the first fluid and flow channels for the second fluid are preferably arranged perpendicular to each other. This contributes to a better heat exchange.
- the plates have a collecting space.
- the plenum is located in the vertical direction below. As far as a gas is passed through the first flow channel, which condenses due to cooling, collects in the plenum Condensate, which has a condensate connection in the
- Front panel is derived.
- Invention are the plates and connections from a
- the plates and terminals are made of polycarbonate (PC), polyethylene terephthalate (PET), acrylonitrile-butadiene-styrene (ABS), polyphenylene ether (PPE) or polyphenylene sulfide (PPS), the plate heat exchangers are
- the plate heat exchanger is connected to a bioreactor, which is preferably also sterilizable.
- connection for the output of the first fluid connectable to an input of a sterile filter, while the connections for the second fluid can be connected to a Kuhlniklauf.
- Liquid vapors taken up during the gassing of the bioreactor are condensed and the condensate is returned to the bioreactor.
- the dried waste gas can now be discharged via a sterile filter without blocking it with condensed liquid.
- the inlet for the first fluid is connected to a medium supply line for supplying the medium and the exit point for the first fluid is connected to an inflow port of the bioreactor the second fluid is connected to a temperature control circuit.
- Figure 1 a spatial representation of a
- Figure 2 a front view of a plate of a
- FIG. 3 is a rear view of the plate of FIG. 2;
- Figure 4 a front view of a front panel of a
- FIG. 5 shows a rear view of the front plate of FIG. 4 with a flow channel for a first fluid, which is designed mirror-symmetrically to the flow channel of FIG. 2, FIG.
- FIG. 6 a front view of a closure plate of a
- Figure 7 a schematic representation of a
- FIG. 8 a process diagram of a bioreactor in conjunction with a plate heat exchanger as
- a plate heat exchanger 1 consists essentially of a plurality of first plates 40 and second plates 50 with flow channels 4, 5, a front plate 6 and a
- the first plate 40 has a front side 2 and a
- the first plate 40 has in its lower left and upper left corners
- a flat depression is arranged, which forms the flow channel 4 and extends into the fürgangso réelleen 8, 9.
- the flow channel 4 points in the horizontal direction from the side walls
- the maanderformigen flow channel 4 form The rear side 41 is flat, that is without a flow channel, formed.
- the second plate 50 has on its front side 3 a flat depression, which forms the flow channel 5 and extends into the right fürgangso réelleen 17, 18.
- the flow channel 5 has vertically extending Stromungsbarrieren 15, which form a Stromungsrichter 16.
- the plate 50 outside the flow channel 5 does not need to correspond.
- the plate 50 has a rear side facing away from its front side 3 51, which is flat and thus has no flow channel.
- the plate heat exchanger 1 has on its front side the front plate 6 with its connections 21, 22 for the first fluid and connections 23, 24 for the second fluid.
- the connection 21 is in communication with the passage openings 8, 19 and serves to supply the first fluid, which is discharged again via the connection 22, which communicates with the passage openings 9, 20.
- the front panel may optionally have a flow channel 4 'on its rear side, which is not shown in FIG.
- the port 23 communicates with the passage openings 14 and 18 and serves to supply the second fluid, while the port 24 communicates with the fürgangso réelleen 13 and 17 in communication and is used for the discharge of the second fluid.
- the plate heat exchanger 1 is closed at its end facing away from the front panel 6 by the end plate 7.
- the end plate 7 may have a flow channel 4 in this embodiment and has no Mandarin in this embodiment. In an embodiment of the end plate 7, not shown, this is identical to the front panel 6 and is arranged in the plate heat exchanger 1 mirror-symmetrical to the front panel 6.
- the front side of the end plate may have a flow channel 4 as shown in FIG. 1, but may also be planar and thus formed without a flow channel 4 and may furthermore not be represented through openings
- the front plate 6 and the end plate 7 are each with
- the plates 40 and 50 are at their backs, as explained above, each flat, while the back of the front panel 6 and / or the front of the
- End plate 7 may be formed plan or alternatively a flow channel 4, 4 'may have.
- the plates 40, 50, 6 and 7 are each glued to their adjacent plate.
- the embodiment of Figure 2 shows a plate 40 'and 50' with a flow channel 4 'on its front side 2' for a first fluid, which is formed for example as a cooling medium.
- the first plate 40 'and 50' in their lower left and upper left corners through openings 8 ', 9' for the first fluid.
- the flow channel 4 ' is arranged, which is in communication with the passage openings 8', 9 '. Outside the flow channel 4 ', the side 2' in the vertical direction at the top and bottom right each of the through holes 13 ', 14'.
- the rear side 41 'of the first plate 40' (see FIG. 3) has a flow channel 5 'for a second fluid.
- the plate 40 'and the plate 50' are exactly identical.
- the plates 40 'and 50' can be turned into a plate heat exchanger
- Rear side of the composite plates 40 'and 50' each have a flow channel 4 'and 5'.
- the flow channel 4 'and 5' In the lower vertical area, the
- Stromungskanal 5 'a collecting space 25 which serves to receive condensate, which is discharged via a condensate connection 26 which is arranged on the front panel 6' (see Figure 4).
- the passage openings 13 'and 14' for the second fluid of the plate 50 ' are elongated and correspond with fürgangso réelleen 13', 14 'of the plate 40' (see Figure 2).
- the rear side 51 'of the plate 50' (see FIG. 3) has a flow channel 4 'of a further identical plate 40' or the flow channel 4 'of an end plate 7'.
- the plate heat exchanger 1, 1 ' according to the exemplary embodiments of Figures 1 to 6 sxnd formed from polycarbonate (PC). They are readily gamma-irradiated and are for
- Hot plate exchangers 1, 1 ' are sterilized with superheated steam.
- Plate heat exchanger 1 ' connected to a bioreactor 27' and is used as Abgaskuhler.
- the exhaust gas is discharged from the head space 28 of the bioreactor 27 'via an exhaust pipe 29, which is connected to the port 23' of the plate heat exchanger 1 ', into the top of the plate heat exchanger 1'.
- the gas stream is split via the flow channel 5' over the individual front sides 3 'of the plates 50'.
- the gas stream is cooled when flowing down to the plate wall and discharged via the port 24' and further via a sterile filter 30 to the
- cooling medium is introduced from the primary cooler 33 from below via the connection 21 'into the plate heat exchanger 1'.
- Kuhlmedium introduced into the individual flow channels 4 'and takes the heat from the plates 40' and 50 'on.
- the cooling medium heats up.
- the cooling medium is collected in the passage opening 9 'and is required via the connection 22' back into the primary cooler 33.
- the cooling medium is circulated.
- the medium to be heated is introduced from a Vorratsbehalter not shown in the plate heat exchanger 1 from above via the terminal 23.
- the material flow over the resulting from the fürgangso réelleen 14 and 18 flow distributor in the individual channels 5 distributed.
- the media stream is warmed up when flowing down the plate wall. The media streams are merged and sent to the output or
- heating medium is introduced from below by a thermostat 32 via the connection 21 into the plate heat exchanger 1.
- the heating medium is introduced into the individual channels 4 and gives the heat to the plates 40 and 50 from.
- the heating medium is conveyed from the outlet or from the connection 22 back into the thermostat 32.
- the heating medium is circulated.
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- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
Abstract
Description
Plattenwärmetauscher Plate heat exchanger
Beschreibung description
Gebiet der Erfindung Field of the invention
Die Erfindung betrifft einen Plattenwarmetauscher mit einer Mehrzahl von Stromungskanale aufweisenden Platten, wobei eine erste Platte eine Vorderseite mit mindestens einem The invention relates to a plate heat exchanger having a plurality of flow channels having plates, wherein a first plate has a front side with at least one
Stromungskanal für ein erstes Fluid und eine zweite Platte eine Vorderseite mit mindestens einem Stromungskanal für ein zweites Fluid aufweist, und wobei die Platten Flow channel for a first fluid and a second plate having a front side with at least one flow channel for a second fluid, and wherein the plates
Durchgangsoffnungen aufweisen, über die die Stromungskanale für das gleiche Fluid jeweils miteinander verbunden sind. Having Durchgangsoffnungen over which the flow channels for the same fluid are connected to each other.
Stand der Technik State of the art
In der Pharmazie, Biotechnologie und in der In pharmacy, biotechnology and in the
Lebensmittelindustrie müssen häufig gasformige oder auch flussige Medien erwärmt oder gekühlt werden. Um solche thermischen Vorgange durchzufuhren, werden üblicherweise Wärmetauscher verwendet. Dabei wird Warme vom wärmeren Medium zum kälteren Medium transportiert. Die Medien sind dabei voneinander getrennt. Dabei besteht der Bedarf nach Food industry often gaseous or liquid media must be heated or cooled. To perform such thermal processes, heat exchangers are commonly used. Warmth is transported from the warmer medium to the colder medium. The media are separated from each other. There is a need for
Wärmetauschern, die im Hinblick auf Material und Herstellung sehr preiswert sind. Aus der DE 10 2006 013 503 Al ist ein Plattenwarmetauscher mit einer eine Mehrzahl von Stromungskanale aufweisenden Platten bekannt. Eine erste Platte weist dabei mindestens einen Stromungskanal für ein erstes Fluid und eine zweite Platte weist dabei mindestens einen Stromungskanal für ein zweites Fluid auf. Die Platten weisen Durchgangsoffnungen auf, über die die Stromungskanale für das gleiche Fluid jeweils miteinander verbunden sind. Heat exchangers that are very inexpensive in terms of material and manufacturing. From DE 10 2006 013 503 Al a plate heat exchanger with a plurality of flow channels having plates is known. A first plate has at least one flow channel for a first fluid and a second plate has at least one flow channel for a second fluid. The plates have Durchgangsoffnungen via which the flow channels for the same fluid are each connected together.
Nachteilig dabei ist, dass die Platten über Dichtungen relativ aufwendig gegeneinander abgedichtet werden oder, soweit sie aus einem Keramikmaterial ausgebildet sind, ist es bekannt, sie in einem aufwendigen Verfahren stoffschlussig zu einem monolithischen Block zu fugen. Beide nach diesem The disadvantage here is that the plates are relatively expensive sealed against each other via seals or, as far as they are made of a ceramic material, it is known to cohesively join them in a complex process to form a monolithic block. Both after this
Verfahren hergestellten Vorrichtungen sind entsprechend aufwendig und teuer in der Herstellung . Method produced devices are correspondingly expensive and expensive to manufacture.
Aus EP 0 038 454 A2 ist ein Plattenwarmetauscher bestehend aus einer Vielzahl extrudierter Einzelplatten aus EP 0 038 454 A2 discloses a plate heat exchanger consisting of a multiplicity of extruded individual plates
Polycarbonat bekannt. Polycarbonate known.
Nachteilig dabei ist, dass die Platten keinen internen The disadvantage here is that the plates have no internal
Stromungsverteiler bzw. Stromungsrichter besitzen. Somit müssen weitere aufwendige Bauteile zur Fluidverteilung bereitgestellt werden. Beim Zusammensetzen ergeben sich Have flow distributor or rectifier. Thus, more expensive components for fluid distribution must be provided. When composing arise
Schwierigkeiten, eine für Sterilanwendungen notwendige Difficulties, one necessary for sterile applications
Dichtigkeit zu gewahrleisten. Aufgabenstellung To ensure tightness. task
Aufgabe der vorliegenden Erfindung ist es daher, einen Object of the present invention is therefore, a
Plattenwarmetauscher zur Verfugung zu stellen, der im To provide plate heat exchanger in the
Hinblick auf Material und Herstellung einfach und With regard to material and manufacturing simple and
kostengünstig ausgebildet ist. is formed inexpensively.
Darstellung der Erfindung Presentation of the invention
Die Aufgabe wird in Verbindung mit dem Oberbegriff des The task is combined with the preamble of
Anspruches 1 dadurch gelost, dass eine Frontplatte, die der Vorderseite der ersten Platte vorgelagert ist, Anschlüsse für das erste Fluid und für das zweite Fluid aufweist, dass eine Abschlussplatte den Abschluss der aneinandergereihten Platten bildet, dass die Platten und Anschlüsse aus Kunststoff ausgebildet sind, und dass die Platten dicht miteinander verklebt oder verschweißt sind . Claim 1, characterized in that a front plate, which is upstream of the front of the first plate having connections for the first fluid and for the second fluid, that a closure plate forms the conclusion of the juxtaposed plates, that the plates and terminals are made of plastic, and that the plates are tightly glued or welded together.
Der erfindungsgemaße Plattenwarmetauscher ist einfach The plate heat exchanger according to the invention is simple
aufgebaut und lasst sich durch einfache Herstellung seiner Platten aus Kunststoff, zum Beispiel durch Spritzguss der Platten, kostengünstig herstellen. Durch das Verkleben bzw. durch das Verbinden der Platten in einem built and can be produced inexpensively by simple production of its plates made of plastic, for example by injection molding of the plates. By gluing or by connecting the plates in one
Kunststoffschweißverfahren kann auf Dichtungen verzichtet werden. Die Plattenwarmetauscher können so gunstig Plastic welding process can be dispensed with seals. The plate heat exchangers can be so cheap
hergestellt werden, dass sie als Einwegwarmetauscher be prepared as a disposable heat exchanger
verwendet werden können. Dadurch kann auf eine aufwendige Reinigung oder gar Demontage verzichtet werden. Durch ihren Aufbau sind die erfindungsgemaßen Plattenwarmetauscher für Anwendungen aus dem Pharma-, Biotechnologie- und can be used. This can be dispensed with a costly cleaning or disassembly. Due to their structure, the inventive plate heat exchanger for applications in the pharmaceutical, biotechnology and
Lebensmittelbereich geeignet. Nach einer bevorzugten Ausfuhrungsform der Erfindung sind die Platten an ihren den Vorderseiten abgewandten Ruckseiten eben ausgebildet. Dies hat den Vorteil, dass die Platten in beliebiger Reihenfolge aneinandergereiht werden können. Food sector suitable. According to a preferred embodiment of the invention, the plates are flat on their sides facing away from the front sides. This has the advantage that the plates can be strung together in any order.
Nach einer weiteren bevorzugten Ausfuhrungsform der Erfindung weisen die Platten an ihren den Vorderseiten abgewandten Ruckseiten den Stromungskanalen der benachbarten Vorderseiten entsprechende spiegelsymmetrische Stromungskanale auf. According to a further preferred embodiment of the invention, the plates have, on their back sides facing away from the front sides, mirror-symmetrical flow channels corresponding to the flow channels of the adjacent front sides.
Dadurch ist es insbesondere möglich, die ersten Platten und die zweiten Platten baugleich auszubilden, wobei die zweiten Platten gegenüber den ersten Platten entsprechend um 180° gewendet montiert werden. Hierdurch wird für die erste und zweite Platte nur eine Form benotigt, was die Herstellung erheblich vereinfacht. This makes it possible in particular to form the first plates and the second plates of identical construction, wherein the second plates are mounted relative to the first plates turned by 180 °. As a result, only one form is needed for the first and second plate, which considerably simplifies the production.
Nach einer bevorzugten Ausfuhrungsform der Erfindung weisen die Stromungskanale der Platten jeweils Stromungsrichter auf. Die Stromungsrichter sind dabei als in den Stromungskanalen angeordnete Barrieren bzw. Trennwände ausgebildet. Die According to a preferred embodiment of the invention, the flow channels of the plates each have flow direction. The flow straightener are designed as arranged in the flow ducts barriers or partitions. The
Trennwände von Stromungskanalen für das erste Fluid und von Stromungskanalen für das zweite Fluid sind vorzugsweise senkrecht zueinander angeordnet. Dies tragt zu einem besseren Wärmeaustausch bei. Partitions of flow channels for the first fluid and flow channels for the second fluid are preferably arranged perpendicular to each other. This contributes to a better heat exchange.
Nach einer weiteren bevorzugten Ausfuhrungsform der Erfindung weisen die Platten einen Sammelraum auf. Der Sammelraum befindet sich in vertikaler Richtung unten. Soweit durch den ersten Stromungskanal ein Gas geleitet wird, das aufgrund von Kühlung kondensiert, sammelt sich in dem Sammelraum das Kondensat, das über einen Kondensatanschluss in der According to a further preferred embodiment of the invention, the plates have a collecting space. The plenum is located in the vertical direction below. As far as a gas is passed through the first flow channel, which condenses due to cooling, collects in the plenum Condensate, which has a condensate connection in the
Frontplatte abgeleitet wird. Front panel is derived.
Gemäß einer weiteren bevorzugten Ausfuhrungsform der According to a further preferred embodiment of the
Erfindung sind die Platten und Anschlüsse aus einem Invention are the plates and connections from a
sterilisierbaren Kunststoff ausgebildet. Dadurch ist es möglich, die Plattenwarmetauscher steril verpackt zu liefern. sterilizable plastic formed. This makes it possible to deliver the plate heat exchanger sterile packed.
Soweit die Platten und Anschlüsse aus Polycarbonat (PC) , Polyethylenterephthalat (PET) , Acrylnitril-Butadien-Styrol (ABS), Polyphenylenether (PPE) oder Polyphenylensulfid (PPS) hergestellt sind, sind die Plattenwarmetauscher Insofar as the plates and terminals are made of polycarbonate (PC), polyethylene terephthalate (PET), acrylonitrile-butadiene-styrene (ABS), polyphenylene ether (PPE) or polyphenylene sulfide (PPS), the plate heat exchangers are
sterilisierbar, indem sie mit Gamma- oder Betastrahlen bestrahlt werden. Auch ist es möglich, die sterilizable by being irradiated with gamma or beta rays. Also, it is possible the
Plattenwarmetauscher durch Autoklavieren mit Heißdampf zu sterilisieren . Sterilize plate heat exchanger by autoclaving with superheated steam.
Nach einer weiteren bevorzugten Ausfuhrungsform der Erfindung ist der Plattenwarmetauscher mit einem Bioreaktor verbunden, der vorzugsweise ebenfalls sterilisierbar ist. According to a further preferred embodiment of the invention, the plate heat exchanger is connected to a bioreactor, which is preferably also sterilizable.
So ist zur Abgaskuhlung eines aus dem Bioreaktor So is one of the bioreactor for exhaust gas cooling
abzuführenden Gases der Anschluss für den Eingang des ersten Fluids mit einer Abgasleitung des Bioreaktors und der discharged gas to the connection for the input of the first fluid with an exhaust pipe of the bioreactor and the
Anschluss für den Ausgang des ersten Fluids mit einem Eingang eines Sterilfilters verbindbar, wahrend die Anschlüsse für das zweite Fluid mit einem Kuhlkreislauf verbunden werden können. Beim Begasen des Bioreaktors aufgenommene Flϋssigkeitsdämpfe werden kondensiert und das Kondensat dem Bioreaktor wieder zugeführt, das getrocknete Abgas kann nun problemlos über einen Sterilfilter abgeführt werden, ohne diesen durch kondensierte Flüssigkeit zu verblocken. Connection for the output of the first fluid connectable to an input of a sterile filter, while the connections for the second fluid can be connected to a Kuhlkreislauf. Liquid vapors taken up during the gassing of the bioreactor are condensed and the condensate is returned to the bioreactor. The dried waste gas can now be discharged via a sterile filter without blocking it with condensed liquid.
Nach einer weiteren bevorzugten Ausführungsform der Erfindung ist zur Vorwärmung eines dem Bioreaktor zuzuführenden Mediums der Anschluss für den Eingang des ersten Fluids mit einer Medienzuleitung zur Zuführung des Mediums und der Anschluss für den Ausgang des ersten Fluids mit einem Zuflussanschluss des Bioreaktors verbunden, wobei die Anschlüsse für das zweite Fluid mit einem Temperierkreislauf verbunden sind. According to a further preferred embodiment of the invention, for preheating a medium to be fed to the bioreactor, the inlet for the first fluid is connected to a medium supply line for supplying the medium and the exit point for the first fluid is connected to an inflow port of the bioreactor the second fluid is connected to a temperature control circuit.
Dadurch können insbesondere lange Aufheizzeiten des befüllten Bioreaktors vermieden werden. As a result, in particular long heating times of the filled bioreactor can be avoided.
Weitere Merkmale der Erfindung ergeben sich aus der Further features of the invention will become apparent from the
nachfolgenden ausführlichen Beschreibung und den beigefügten Zeichnungen, in denen bevorzugte Ausführungsformen der following detailed description and the accompanying drawings in which preferred embodiments of
Erfindung beispielhaft veranschaulicht sind. Invention are exemplified.
Kurzbeschreibungen der Zeichnungen In den Zeichnungen zeigen: Brief Description of the Drawings In the drawings:
Figur 1: eine raumliche Darstellung eines Figure 1: a spatial representation of a
Plattenwarmetauschers als Explosionszeichnung, Plate heat exchanger as exploded view,
Figur 2: eine Vorderansicht einer Platte eines Figure 2: a front view of a plate of a
Plattenwarmetauschers in einer weiteren Plate heat exchanger in another
bevorzugten Ausfuhrungsform mit einem Stromungskanal für ein erstes Fluid, preferred embodiment with a flow channel for a first fluid,
Figur 3: eine Ruckansicht der Platte von Figur 2, FIG. 3 is a rear view of the plate of FIG. 2;
Figur 4 : eine Vorderansicht einer Frontplatte eines Figure 4: a front view of a front panel of a
Plattenwarmetauschers mit Anschlüssen für ein erstes Fluid, für ein zweites Fluid sowie einem KondensatanSchluss, Plate heat exchanger with connections for a first fluid, for a second fluid and a condensate connection,
Figur 5: eine Ruckansicht der Frontplatte von Figur 4 mit einem Stromungskanal für ein erstes Fluid, der spiegelsymmetrisch zu dem Stromungskanal von Fig 2 ausgebildet ist, 5 shows a rear view of the front plate of FIG. 4 with a flow channel for a first fluid, which is designed mirror-symmetrically to the flow channel of FIG. 2, FIG.
Figur 6: eine Vorderansicht einer Abschlussplatte eines FIG. 6: a front view of a closure plate of a
Plattenwarmetauschers mit einem Stromungskanal für ein erstes Fluid, Plate heat exchanger with a flow channel for a first fluid,
Figur 7: eine schematische Darstellung eines Figure 7: a schematic representation of a
Prozessschemas eines Bioreaktors in Verbindung mit einem Wärmeplattentauscher, der als Process Schemes of a bioreactor in connection with a heat plate exchanger, as
Abgaskühler ausgebildet ist, und Exhaust gas cooler is formed, and
Figur 8: ein Prozessschema eines Bioreaktors in Verbindung mit einem Plattenwärmetauscher als FIG. 8: a process diagram of a bioreactor in conjunction with a plate heat exchanger as
Medienbeheizung zur Vorwärmung beim Befüllen des Bioreaktors . Media heating for preheating when filling the bioreactor.
Beschreibung der Ausfuhrunqsbeispiele Description of the exemplary embodiments
Ein Plattenwarmetauscher 1 besteht im Wesentlichen aus einer Mehrzahl von ersten Platten 40 und zweiten Platten 50 mit Stromungskanalen 4, 5, einer Frontplatte 6 und einer A plate heat exchanger 1 consists essentially of a plurality of first plates 40 and second plates 50 with flow channels 4, 5, a front plate 6 and a
Abschlussplatte 7. End plate 7.
Die erste Platte 40 weist eine Vorderseite 2 und eine The first plate 40 has a front side 2 and a
Ruckseite 41 auf. In vertikaler Richtung weist die erste Platte 40 in ihren Ecken unten links und oben links Back 41. In the vertical direction, the first plate 40 has in its lower left and upper left corners
Durchgangsoffnungen 8, 9 für ein erstes Fluid auf. Auf der Vorderseite 2 der Platte 40 ist eine flachige Vertiefung angeordnet, die den Stromungskanal 4 bildet und sich bis in die Durchgangsoffnungen 8, 9 erstreckt. Der Stromungskanal 4 weist in horizontaler Richtung von den Seitenwanden her Through openings 8, 9 for a first fluid. On the front side 2 of the plate 40, a flat depression is arranged, which forms the flow channel 4 and extends into the Durchgangsoffnungen 8, 9. The flow channel 4 points in the horizontal direction from the side walls
Stromungsbarrieren 10, 11 eines Stromungsrichters 12 auf, die sich in horizontaler Richtung überlappen und so einen Stromungsbarrieren 10, 11 of a Stromungsrichters 12, which overlap in the horizontal direction and so on
maanderformigen Stromungskanal 4 bilden. Die Ruckseite 41 ist eben, das heißt ohne Stromungskanal, ausgebildet. maanderformigen flow channel 4 form. The rear side 41 is flat, that is without a flow channel, formed.
Außerhalb des Stromungskanals 4 weist die erste Platte 40 in vertikaler Richtung oben rechts und unten rechts jeweils Durchgangsoffnungen 13, 14 auf. Outside the flow channel 4, the first plate 40 in the vertical direction at the top right and bottom right through Durchgangsoffnungen 13, 14 on.
Die zweite Platte 50 weist an ihrer Vorderseite 3 eine flachige Vertiefung auf, die den Stromungskanal 5 bildet und sich bis in die rechten Durchgangsoffnungen 17, 18 erstreckt. Der Stromungskanal 5 weist in vertikaler Richtung verlaufende Stromungsbarrieren 15 auf, die einen Stromungsrichter 16 bilden. In den linken Ecken weist die Platte 50 außerhalb des Stromungskanals 5 Durchgangsoffnungen 19, 20 auf, die mit den Durchgangsoffnungen 8, 9 der Platte 40 korrespondieren. The second plate 50 has on its front side 3 a flat depression, which forms the flow channel 5 and extends into the right Durchgangsoffnungen 17, 18. The flow channel 5 has vertically extending Stromungsbarrieren 15, which form a Stromungsrichter 16. In the left corners, the plate 50 outside the flow channel 5 Durchgangsoffnungen 19, 20, which with the Through openings 8, 9 of the plate 40 correspond.
Entsprechend korrespondieren die Durchgangsoffnungen 17, 18 der Platte 50 mit den Durchgangsoffnungen 13, 14 der Platte 40. Die Platte 50 weist eine ihrer Vorderseite 3 abgewandte Ruckseite 51 auf, die eben ausgebildet ist und somit keinen Stromungskanal aufweist. Corresponding Durchgangsoffnungen 17, 18 of the plate 50 with the Durchgangsoffnungen 13, 14 of the plate 40. The plate 50 has a rear side facing away from its front side 3 51, which is flat and thus has no flow channel.
Der Plattenwarmetauscher 1 weist an seiner Vorderseite die Frontplatte 6 mit ihren Anschlüssen 21, 22 für das erste Fluid und Anschlüssen 23, 24 für das zweite Fluid auf. Dabei steht der Anschluss 21 mit den Durchgangsoffnungen 8, 19 in Verbindung und dient zur Zufuhrung des ersten Fluids, das über den Anschluss 22, der mit den Durchgangsoffnungen 9, 20 in Verbindung steht, wieder abgeführt wird. The plate heat exchanger 1 has on its front side the front plate 6 with its connections 21, 22 for the first fluid and connections 23, 24 for the second fluid. In this case, the connection 21 is in communication with the passage openings 8, 19 and serves to supply the first fluid, which is discharged again via the connection 22, which communicates with the passage openings 9, 20.
Die Frontplatte kann optional auf ihrer in Figur 1 nicht gezeigten Ruckseite einen Stromungskanal 4' aufweisen. The front panel may optionally have a flow channel 4 'on its rear side, which is not shown in FIG.
Der Anschluss 23 steht mit den Durchgangsoffnungen 14 und 18 in Verbindung und dient zur Zufuhrung des zweiten Fluids, wahrend der Anschluss 24 mit den Durchgangsoffnungen 13 und 17 in Verbindung steht und zur Ableitung des zweiten Fluids genutzt wird. The port 23 communicates with the passage openings 14 and 18 and serves to supply the second fluid, while the port 24 communicates with the Durchgangsoffnungen 13 and 17 in communication and is used for the discharge of the second fluid.
Der Plattenwarmetauscher 1 wird an seinem der Frontplatte 6 abgewandten Ende durch die Abschlussplatte 7 abgeschlossen. Die Abschlussplatte 7 kann bei dieser Ausfuhrungsform einen Stromungskanal 4 aufweisen und hat in dieser Ausfuhrungsform keine Durchgangsoffnungen. In einer nicht dargestellten Ausfuhrungsform der Abschlussplatte 7 ist diese baugleich zu der Frontplatte 6 und ist in dem Plattenwarmetauscher 1 spiegelsymmetrisch zur Frontplatte 6 angeordnet. The plate heat exchanger 1 is closed at its end facing away from the front panel 6 by the end plate 7. The end plate 7 may have a flow channel 4 in this embodiment and has no Durchgangsoffnungen in this embodiment. In an embodiment of the end plate 7, not shown, this is identical to the front panel 6 and is arranged in the plate heat exchanger 1 mirror-symmetrical to the front panel 6.
Die Vorderseite der Abschlussplatte kann wie in der Figur 1 gezeigt einen Stromungskanal 4 aufweisen, kann jedoch auch eben und somit ohne Stromungskanal 4 ausgebildet sein und kann weiterhin nicht dargestellte Durchgangsoffnungen The front side of the end plate may have a flow channel 4 as shown in FIG. 1, but may also be planar and thus formed without a flow channel 4 and may furthermore not be represented through openings
aufweisen, die mit den Durchgangsoffnungen der Platten 40 und 50 korrespondieren. have, corresponding to the Durchgangsoffnungen of the plates 40 and 50.
Bei einer besonders bevorzugten Ausfuhrungsform sind die Frontplatte 6 und die Abschlussplatte 7 jeweils mit In a particularly preferred embodiment, the front plate 6 and the end plate 7 are each with
Durchgangsoffnungen versehen, um den Querschnitt der Durchgangsoffnungen provided to the cross section of
Fluidversorgung zu vergrößern, ohne die Dimensionierung der Anschlüsse 21, 22, 23 und 24 verandern zu müssen. Auf diese Weise kann besonders vorteilhaft der Druckverlust beim Ein- und Ausstromen der Fluide in den und aus dem Wärmetauscher 1 minimiert werden. To increase fluid supply, without having to change the sizing of the terminals 21, 22, 23 and 24. In this way, the pressure loss during inflow and outflow of the fluids into and out of the heat exchanger 1 can be minimized particularly advantageous.
Die Platten 40 und 50 sind an ihren Ruckseiten, wie oben erläutert, jeweils eben ausgebildet, wahrend die Ruckseite der Frontplatte 6 und/oder die Vorderseite der The plates 40 and 50 are at their backs, as explained above, each flat, while the back of the front panel 6 and / or the front of the
Abschlussplatte 7 plan ausgebildet sein kann oder alternativ einen Stromungskanal 4, 4' aufweisen kann. Die Platten 40, 50, 6 und 7 sind jeweils mit der ihnen benachbarten Platte verklebt . Das Ausführungsbeispiel der Figur 2 zeigt eine Platte 40' bzw. 50' mit einem Strömungskanal 4' auf ihrer Vorderseite 2' für ein erstes Fluid, das beispielsweise als Kühlmedium ausgebildet ist. End plate 7 may be formed plan or alternatively a flow channel 4, 4 'may have. The plates 40, 50, 6 and 7 are each glued to their adjacent plate. The embodiment of Figure 2 shows a plate 40 'and 50' with a flow channel 4 'on its front side 2' for a first fluid, which is formed for example as a cooling medium.
In vertikaler Richtung weist die erste Platte 40' bzw. 50' in ihren Ecken unten links und oben links Durchgangsöffnungen 8', 9' für das erste Fluid auf. Auf der Vorderseite 2' der Platte 40' ist der Strömungskanal 4' angeordnet, der mit den Durchgangsöffnungen 8', 9' in Verbindung steht. Außerhalb des Strömungskanals 4' weist die Seite 2' in vertikaler Richtung oben und unten rechts jeweils die Durchgangsöffnungen 13', 14' auf. In the vertical direction, the first plate 40 'and 50' in their lower left and upper left corners through openings 8 ', 9' for the first fluid. On the front side 2 'of the plate 40', the flow channel 4 'is arranged, which is in communication with the passage openings 8', 9 '. Outside the flow channel 4 ', the side 2' in the vertical direction at the top and bottom right each of the through holes 13 ', 14'.
Die Rückseite 41' der ersten Platte 40' (siehe Figur 3) weist einen Strömungskanal 5' für ein zweites Fluid auf. The rear side 41 'of the first plate 40' (see FIG. 3) has a flow channel 5 'for a second fluid.
Die Platte 40' und die Platte 50' sind exakt baugleich. The plate 40 'and the plate 50' are exactly identical.
Analog zu der in Figur 1 gezeigten Plattenabfolge können die Platten 40' und 50' zu einem Plattenwärmetauscher Analogous to the plate sequence shown in FIG. 1, the plates 40 'and 50' can be turned into a plate heat exchanger
zusammengesetzt werden, wobei die Platten 50' gegenüber den baugleichen Platten 40' entsprechend um 180° gewendet are assembled, wherein the plates 50 'relative to the identical plates 40' corresponding turned by 180 °
montiert werden. Im Unterschied zu der Ausführungsform nach Figur 1, bei welcher die Rückseiten der Platten 40 und 50 jeweils eben sind, resultiert aus dieser Montage ein to be assembled. In contrast to the embodiment of Figure 1, in which the back sides of the plates 40 and 50 are each planar, resulting from this assembly
Plattenwärmetauscher 1, bei welchem die Vorder- und die Plate heat exchanger 1, in which the front and the
Rückseite der zusammengesetzten Platten 40' und 50' jeweils einen Strömungskanal 4' bzw. 5' aufweisen. Im in vertikaler Richtung unteren Bereich weist der Rear side of the composite plates 40 'and 50' each have a flow channel 4 'and 5'. In the lower vertical area, the
Stromungskanal 5' einen Sammelraum 25 auf, der zur Aufnahme von Kondensat dient, das über einen Kondensatanschluss 26, der an der Frontplatte 6' (siehe Figur 4) angeordnet ist, abgeführt wird. Die Durchgangsoffnungen 13' und 14' für das zweite Fluid der Platte 50' sind länglich ausgebildet und korrespondieren mit Durchgangsoffnungen 13', 14' der Platte 40' (siehe Figur 2) . Stromungskanal 5 'a collecting space 25 which serves to receive condensate, which is discharged via a condensate connection 26 which is arranged on the front panel 6' (see Figure 4). The passage openings 13 'and 14' for the second fluid of the plate 50 'are elongated and correspond with Durchgangsoffnungen 13', 14 'of the plate 40' (see Figure 2).
Die Ruckseite 51' der Platte 50' (siehe Figur 3) weist einen dem Stromungskanal 4' einer weiteren baugleichen Platte 40' oder dem Stromungskanal 4' einer Abschlussplatte 7' The rear side 51 'of the plate 50' (see FIG. 3) has a flow channel 4 'of a further identical plate 40' or the flow channel 4 'of an end plate 7'.
entsprechenden Stromungskanal für ein erstes Fluid auf. corresponding flow channel for a first fluid.
Die Plattenwarmetauscher 1, 1' nach den Ausfuhrungsbeispielen der Figuren 1 bis 6 sxnd aus Polycarbonat (PC) ausgebildet. Sie sind ohne weiteres Gamma-bestrahlbar und sind für The plate heat exchanger 1, 1 'according to the exemplary embodiments of Figures 1 to 6 sxnd formed from polycarbonate (PC). They are readily gamma-irradiated and are for
jegliche Sterilanwendung im Temperaturbereich bis 1100C, kurzzeitig sogar bis 125 C geeignet. Damit können die Any sterile application in the temperature range up to 110 0 C, for a short time even up to 125 C suitable. So that can
Warmeplattentauscher 1, 1' auch mit Heißdampf sterilisiert werden . Hot plate exchangers 1, 1 'are sterilized with superheated steam.
Gemäß dem Ausfuhrungsbeispiel der Figur 7 ist der According to the exemplary embodiment of Figure 7 is the
Plattenwarmetauscher 1' mit einem Bioreaktor 27' verbunden und wird als Abgaskuhler genutzt. Das Abgas wird aus dem Kopfraum 28 des Bioreaktors 27' über eine Abgasleitung 29, die mit dem Anschluss 23' des Plattenwarmetauschers 1' verbunden ist, oben in den Plattenwarmetauscher 1' Plate heat exchanger 1 'connected to a bioreactor 27' and is used as Abgaskuhler. The exhaust gas is discharged from the head space 28 of the bioreactor 27 'via an exhaust pipe 29, which is connected to the port 23' of the plate heat exchanger 1 ', into the top of the plate heat exchanger 1'.
eingeleitet. Im Plattenwarmetauscher 1' wird der Gasstrom über den Stromungskanal 5' über die einzelnen Vorderseiten 3' der Platten 50' aufgeteilt. An den Vorderseiten der Platten 3' der Platten 50" wird der Gasstrom beim Strömen nach unten an der Plattenwand abgekühlt und über den Anschluss 24' abgeführt und weiter über einen Sterilfilter 30 an die initiated. In the plate heat exchanger 1 ', the gas stream is split via the flow channel 5' over the individual front sides 3 'of the plates 50'. At the front of the plates 3 'of the plates 50 ", the gas stream is cooled when flowing down to the plate wall and discharged via the port 24' and further via a sterile filter 30 to the
Umgebung abgegeben. Durch die Abgaskuhlung im Environment submitted. Due to the exhaust gas cooling in the
Plattenwarmetauscher 1' wird die Luftfeuchte des Abgases abgesenkt, wobei im Bioreaktor aufgenommenes flussiges Medium kondensiert, über den Kondensatanschluss 26 abgeleitet und dem Bioreaktor 27' über eine Schlauchpumpe wieder zugeführt wird. Plate heat exchanger 1 ', the humidity of the exhaust gas is lowered, wherein captured in the bioreactor liquid medium condensed, discharged via the condensate port 26 and the bioreactor 27' is fed back via a peristaltic pump.
Im Gegenstrom dazu wird Kuhlmedium vom Primarkuhler 33 von unten über den Anschluss 21' in den Plattenwarmetauscher 1' eingeleitet. Aus den Durchgangsoffnungen 8' wird das In countercurrent thereto, cooling medium is introduced from the primary cooler 33 from below via the connection 21 'into the plate heat exchanger 1'. From the Durchgangsoffnungen 8 'is the
Kuhlmedium in die einzelnen Stromungskanale 4' eingeleitet und nimmt die Warme von den Platten 40' und 50' auf. Das Kuhlmedium erwärmt sich dabei. Das Kuhlmedium wird in der Durchgangsoffnung 9' gesammelt und über den Anschluss 22' zurück in den Primarkuhler 33 gefordert. Das Kuhlmedium wird im Kreislauf gefuhrt. Kuhlmedium introduced into the individual flow channels 4 'and takes the heat from the plates 40' and 50 'on. The cooling medium heats up. The cooling medium is collected in the passage opening 9 'and is required via the connection 22' back into the primary cooler 33. The cooling medium is circulated.
Nach dem Ausfuhrungsbeispiel der Figur 8 ist der After the exemplary embodiment of Figure 8 is the
Plattenwarmetauscher 1 mit dem Bioreaktor 27 über eine Plate heat exchanger 1 with the bioreactor 27 via a
Zuleitung 31 verbunden. Dabei wird der Plattenwarmetauscher 1 genutzt, um dem Bioreaktor 27 zuzuführendes Medium Lead 31 connected. In this case, the plate heat exchanger 1 is used to the bioreactor 27 zuzuführendes medium
vorzuwärmen . preheat.
Das zu beheizende Medium wird aus einem nicht dargestellten Vorratsbehalter in den Plattenwarmetauscher 1 von oben über den Anschluss 23 eingeleitet. Im Plattenwarmetauscher 1 wird der Stoffstrom über den sich aus den Durchgangsoffnungen 14 und 18 ergebenden Stromungsverteiler in die einzelnen Kanäle 5 verteilt. In den Strömungsrichtern 12 wird der Medienstrom beim Strömen nach unten an der Plattenwand aufgewärmt. Die Medienströme werden zusammengeführt und zum Ausgang bzw. The medium to be heated is introduced from a Vorratsbehalter not shown in the plate heat exchanger 1 from above via the terminal 23. In the plate heat exchanger 1, the material flow over the resulting from the Durchgangsoffnungen 14 and 18 flow distributor in the individual channels 5 distributed. In the flow straighteners 12, the media stream is warmed up when flowing down the plate wall. The media streams are merged and sent to the output or
Anschluss 24 geleitet. Vom Anschluss 24 wird das vorgewärmte Medium in den Bioreaktor 27 gefördert. Port 24 headed. From port 24, the preheated medium is fed into the bioreactor 27.
Im Gegenstrom dazu wird Heizmedium von einem Thermostaten 32 von unten über den Anschluss 21 in den Plattenwärmetauscher 1 eingeleitet. Im sich aus den Durchgangsöffnungen 8 und 9 ergebenden Strömungsverteiler wird das Heizmedium in die einzelnen Kanäle 4 eingeleitet und gibt die Wärme an die Platten 40 und 50 ab. Das Heizmedium wird vom Ausgang bzw. vom Anschluss 22 zurück in den Thermostaten 32 gefördert. Das Heizmedium wird im Kreislauf geführt. In countercurrent thereto, heating medium is introduced from below by a thermostat 32 via the connection 21 into the plate heat exchanger 1. In the resulting from the through holes 8 and 9 flow distributor, the heating medium is introduced into the individual channels 4 and gives the heat to the plates 40 and 50 from. The heating medium is conveyed from the outlet or from the connection 22 back into the thermostat 32. The heating medium is circulated.
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009032370A DE102009032370A1 (en) | 2009-07-08 | 2009-07-08 | Plate heat exchanger |
| PCT/EP2010/003490 WO2011003496A2 (en) | 2009-07-08 | 2010-06-10 | Plate heat exchanger |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2452149A2 true EP2452149A2 (en) | 2012-05-16 |
| EP2452149B1 EP2452149B1 (en) | 2019-03-06 |
Family
ID=42664529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP10724312.3A Active EP2452149B1 (en) | 2009-07-08 | 2010-06-10 | Plate heat exchanger |
Country Status (5)
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|---|---|
| US (1) | US9228784B2 (en) |
| EP (1) | EP2452149B1 (en) |
| JP (1) | JP5892930B2 (en) |
| DE (2) | DE102009032370A1 (en) |
| WO (1) | WO2011003496A2 (en) |
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| DE102008058444B4 (en) * | 2007-11-21 | 2020-03-26 | Antacor Ltd. | Method and use of a device for the production of fuels, humus or suspensions thereof |
-
2009
- 2009-07-08 DE DE102009032370A patent/DE102009032370A1/en not_active Withdrawn
-
2010
- 2010-06-04 DE DE202010007615U patent/DE202010007615U1/en not_active Expired - Lifetime
- 2010-06-10 US US13/379,387 patent/US9228784B2/en active Active
- 2010-06-10 EP EP10724312.3A patent/EP2452149B1/en active Active
- 2010-06-10 WO PCT/EP2010/003490 patent/WO2011003496A2/en not_active Ceased
- 2010-06-10 JP JP2012518770A patent/JP5892930B2/en active Active
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2011003496A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012532307A (en) | 2012-12-13 |
| WO2011003496A3 (en) | 2011-03-03 |
| JP5892930B2 (en) | 2016-03-23 |
| DE102009032370A1 (en) | 2011-01-13 |
| WO2011003496A2 (en) | 2011-01-13 |
| DE202010007615U1 (en) | 2010-08-26 |
| US20120103579A1 (en) | 2012-05-03 |
| EP2452149B1 (en) | 2019-03-06 |
| US9228784B2 (en) | 2016-01-05 |
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