EP2433607B1 - Blood plasma collection bottle - Google Patents

Description

The present invention relates to a blood plasma collection bottle made of plastic for storing blood plasma in the frozen state with a bottle body having a cross section of rectangular basic shape in horizontal section and having a bottleneck on its upper side.

Blood plasma collection containers have been known in the form of plastic bags for many years and have proven themselves through the use of materials such as ethylene-vinyl acetate (EVA) and polyethylene (PE) during freezing. The disadvantage of blood plasma collection containers in the form of blood bags is the poor handling, as they can not be set up without tools or special designs and also there is a risk that they will be damaged in the frozen state when dropped. In addition, they bulge out unchecked, so that the amount is difficult to control.

For this Reason in DE 20 2007 012 912 U1 proposed to use blood plasma collection bottles made of plastic, the bottle body in horizontal section has a cross-section rectangular basic shape and has on its upper side a closed by a cover bottle neck. On the cover plate two connection points are provided, of which one connection point for filling the bottle body is provided with blood plasma and the other connection point of the venting and sampling is used. On the cover plate, a lid can be fastened to protect the connection points. This has two slots, which serve the implementation of fixed at the connection points hoses.

During the plasma dispensing, the lid is in a position where the tubing passes unhindered through the slots. After completion of the plasma donation, the tubes are cut off and welded. To fix the free ends of the cut tubes, the lid is rotated, pulling the free ends into the lid.

Although the known blood plasma collection bottle has proven itself in practice, efforts are still being made to further improve functionality and manageability.

Object of the present invention is therefore to design a blood plasma collection bottle made of plastic for the storage of plasma in the frozen state of the type mentioned so that their handling is improved. In particular, the dimensional stability should be increased and the usability should be simplified.

This object is inventively achieved in that the side surfaces of the bottle body each define a flat or slightly inwardly curved area, followed by the rounded to the end faces areas. It has been shown that such designed bottle body are particularly dimensionally stable. This is especially true when the areas are slightly curved inward, with the dome having a maximum depth of 2mm, especially 1.5mm from the edges of the dome. The inward curvature a kind of bias is achieved, which counteracts buckling of the bottle body during filling. The stability of the bottle is further increased when the flat or slightly inwardly curved portions have a hexagonal shape, the bases are at the transition areas of the side surfaces to the top and bottom of the bottle body and preferably such hexagonal evenly designed that the between the bases lying corners are positioned approximately at the central height of the bottle body. The bottle body then has a shape obtained by flattening an oval or round body, in which case the sides of the hexagonal faces lying between the bases are slightly rounded.

In a further embodiment of the invention, three leveling feet can be provided on the underside of the bottle body. In this way it is achieved that the blood plasma collection bottle according to the invention can be stably placed.

Furthermore, the bottle body may include a plurality of stiffening beads that extend around the bottle body and are preferably positioned to function, at least in part, as a level indicator. Preferably, a total of four stiffening beads are formed on the bottle body, in particular two Stiffening beads are provided on the upper bottle body half and two stiffening beads in the lower bottle body half.

In a further embodiment of the blood plasma collection bottle according to the invention, which is not necessarily bound to the flat configuration of the bottle body, can be provided on the upper side of the bottle body on opposite sides of the bottle neck and laterally spaced from this connection points, of which one connection point filling the bottle body with blood plasma serves and the other terminal of the Endlüftung and sampling serves, and that at the connection points substantially L-shaped connectors (ellbow connectors) are provided, wherein in each case one connector leg is connected to the bottle body and the other connector leg is directed to the bottle neck and a hose carries, which extends over the bottleneck.

In this embodiment, the connection points are arranged on the left and right of the bottle neck and not as in the prior art on the bottle neck itself, whereby the height is reduced. Substantially L-shaped connectors are provided at the connection points in such a way that the hoses connected to the connectors extend over the bottleneck. This allows a total compact arrangement.

In a manner known per se, a cover can be fixed or fixable on the bottleneck and in particular on the cover of the bottleneck on its upper side be. This can be configured such that it engages in the fixed state over the neck of the bottle protruding portions of the tubes and so positioned.

In an embodiment of the invention, it may be provided that the cover has recesses associated with the connectors / hoses and open towards the underside of the cover, which engage and are penetrated by the hose sections protruding above the bottle neck when the cover is fixed to the bottle neck , In addition, the lid may have on the inside holding webs, which engage over the long connector legs / hose sections and position when the lid is fixed to the bottle neck.

Furthermore, a locking mechanism can be provided, via which the lid is fixed to the bottle neck and in particular the cover plate when the lid is pressed onto the bottleneck from above. In this case, the latching mechanism preferably has a first detent position, in which the lid can be released again from the bottle neck, and a second detent position, in which the lid is pushed further onto the bottle neck than in the first detent position and in a release of the lid of the bottleneck is prevented. In this embodiment, the cover is in the delivery state detachably attached to the bottle neck, ie it is locked in the upper, first latching point. This makes it possible to detach the lid for filling the blood plasma collection bottle and then welding off the connectors from the bottleneck. After the welding off, the lid can then finally be at the bottleneck be fixed by being brought into the second detent position in which a release is no longer possible.

In an embodiment of this embodiment it can be provided that latching noses are formed on the lower, open lid edge, which engage when pressing the lid on the bottleneck with a formed on the bottleneck retaining web and in particular the outer edge region of the cover, are elastically expanded and the resiliently spring back further impressions and engage behind the retaining web to produce the first detent position.

At the top of the bottle neck and in particular the cover plate can be formed upstanding web and on the inside cover a corresponding to the web recording, which engage with each other when the lid is pressed onto the bottle neck and that on the web and the recording locking elements are formed of the latching mechanism, which come into engagement with each other in the second detent position.

In this case, a latching opening may be formed in the web, in which engages a receiving side provided latching element in the second detent position.

Finally, holding elements, in particular holding clips for the detachable attachment of sample tubes, may be provided on the lid and in particular on the upper side of the lid. This allows the delivery of the sample tubes as a unit with the blood plasma collection bottle.

Figur 1

eine Blutplasmasammelflasche gemäß der vorliegenden Erfindung in Vorderansicht;

Figur 2

die Blutplasmasammelflasche aus Figur 1 in perspektivischer Explosionsansicht;

Figur 3

die Blutplasmasammelflasche aus Figur 1 in perspektivischer Darstellung von schräg unten;

Figur 4

die Blutplasmasammelflasche aus Figur 1 von unten betrachtet;

Figur 5

die Blutplasmasammelflasche aus Figur 1 in Draufsicht;

Figur 6

in vergrößerter Darstellung den oberen Bereich der Blutplasmasammelflasche bei entferntem Deckel;

Figur 7

die Blutplasmasammelflasche aus Figur 1 in einer Seitenansicht; und

Figur 8

in perspektivischer Darstellung den Deckel der Blutplasmasammelflasche von schräg unten.

With regard to further advantageous embodiments of the invention, reference is made to the dependent claims and the following description of an embodiment with reference to the accompanying drawings. In the drawing shows:

FIG. 1

a blood plasma collection bottle according to the present invention in front view;

FIG. 2

the blood plasma collection bottle FIG. 1 in a perspective exploded view;

FIG. 3

the blood plasma collection bottle FIG. 1 in perspective view obliquely from below;

FIG. 4

the blood plasma collection bottle FIG. 1 viewed from below;

FIG. 5

the blood plasma collection bottle FIG. 1 in plan view;

FIG. 6

on an enlarged scale, the upper area of the blood plasma collection bottle with the lid removed;

FIG. 7

the blood plasma collection bottle FIG. 1 in a side view; and

FIG. 8

in perspective view of the lid of the blood plasma collection bottle from diagonally below.

In the drawing, a blood plasma collection bottle for storing blood plasma in the frozen state according to the present invention is shown. The blood plasma collection bottle is made of plastic, in particular polyethylene (PE) and has a bottle body 1, which has a cross-section rectangular basic shape in horizontal section and carries on its upper side a bottle neck 2 with a top provided cover plate 2a. As can be clearly seen in the drawing, the side surfaces of the bottle body 1 each define a flat portion 3 of hexagonal shape, the bases 3a, 3b lie at the transition areas of the side surfaces to the top and bottom of the bottle body 1, wherein the between the bases 3a, 3b lying corners E are positioned approximately at the central height of the bottle body 1. In this case, the sides 3c, 3d, 3e, 3f of the hexagonal surface 3 lying between the base sides 3a, 3b are slightly rounded off. On the flat side surfaces of the bottle body 1 close to the end faces, which have a rounded shape. Overall, therefore, the bottle body 1 has a shape that is obtained when flattening a base round or oval shape. It can not be seen in the drawing that the flat areas 3 can also be slightly curved inwards, the curvature in the center of the hexagonal area 3 having a depth of about 1.5 mm with respect to the edges of the hexagonal area 3. By this configuration, a kind of bias is achieved, which counteracts buckling of the bottle body 1 when filling with blood plasma.

Furthermore, the bottle body 1 has a total of four stiffening beads 5, which extend around the bottle body 1, wherein two stiffening beads 5 are provided in the upper bottle body half and two stiffening beads 5 in the lower bottle body half. The upper two stiffening beads 5 act as a level indicator.

On the underside of the bottle body 1, three adjustable feet 4 are provided, by which it is ensured that the flat blood plasma collection bottle can be stably placed.

At the top of the bottle body 1, two connection points 7a, 7b are provided on opposite sides of the bottle neck 2 and laterally spaced therefrom, one of which 7a serves to fill the bottle body 1 with blood plasma and the other connection point 7b serves for venting and sampling. At the connection points 7a, 7b firmly connected to the bottle body 1 connecting piece 8 are provided, on which L-shaped connectors 9 are held insoluble. At the points away from the connecting piece 8 connector legs hoses 10 are attached. The arrangement is made such that the connector legs facing away from the connecting piece are directed towards the bottle neck 2, so that the tubes 10 held thereon extend over the cover plate 2a of the bottle neck 2. In the drawing, the hoses 10 are shown in the abgeschweißten state in which the hose ends are located directly above the cover plate 2a. In unswelded condition are the Hoses 10 significantly longer, with one tube extending to the plasmapheresis device and the other tube carries a vent and a device for sampling.

On the cover plate 2a of the bottle neck 2, a lid 11 is fixed. This is designed such that it overlaps in the fixed state over the bottle neck 2 projecting portions of the tubes 10 and protects against access from the outside. Specifically, the lid 11 has the hoses 10 associated and the lid bottom side open, slot-shaped recesses 12, which come into engagement with the projecting over the bottle neck 2 tube sections and are penetrated by these, when the lid 11 is fixed by the bottle neck 2.

The fixing of the lid 11 to the bottle neck 2 via a latching mechanism when the lid 11 is pressed from above onto the bottle neck 2. In this case, the latching mechanism comprises a first detent position, in which the lid 11 can be released again from the bottle neck 2, and a second detent position, in which a release of the lid 11 of the bottle neck 2 is substantially no longer possible. Specifically, latching lugs 13 are formed on the lower, open lid edge, which come when depressing the lid 11 on the bottle neck 2 with the outer edge region of the cover plate 2 engage, are elastically expanded and elastically spring back on further depression of the lid 11 and to produce the first Detent position engage behind the cover plate 2a. In the FIG. 8 is clearly visible that the locking lugs 13 substantially extend over the entire lower edge region of the lid 11. The required elasticity for widening the cover 11 is replaced by the recesses 12 for the tubes 10. The engagement between the locking lugs 13 and the cover 2akann be solved again by the lower edge regions of the lid 11 are bent manually outwards.

In the FIGS. 6 and 8th Furthermore, it can be clearly seen that an upright projecting web 14 is formed on the upper side of the cover plate 2a and a receptacle 15 corresponding to the web 14 is formed on the inner side of the cover, which engage with one another when the cover 11 is pressed onto the bottle neck 2. In this case, 14 resting latching opening 16 is formed on the web, with which a receiving side provided latching tooth 12 engages when the lid 11 is pushed beyond the first detent position on the bottle neck 2 in the second detent position. The engagement region between the latching opening 16 and the latching tooth 17 is not accessible from the outside, so that a release of this connection is prevented.

Finally, in the FIG. 7 clearly recognizable that the lid 11 carries at its top retaining clips 18 for releasably attaching sample tube 19.

In the delivery state, the lid 11 is fixed on the bottleneck 2 via the upper, first latching point. After the blood plasma collection bottle has been filled in the usual way, the lid 11 is removed, and then the tubes 10 are welded so that they are under the lid 11 Find a place. After welding, the lid 11 is again attached to the bottle neck 2 and thereby depressed so far that a fixation on the second detent position takes place, so that a renewed removal of the lid 11 is prevented. Thus, the hoses 10 are inaccessible for subsequent manipulation.

Claims (12)

1. A blood plasma collecting flask made of plastic for the storage of blood plasma in a frozen state with a flask body (1) having a cross section of rectangular shape in horizontal section and on its upper side a flask neck (2), characterized in that the side surfaces of the flask neck (2) each defining a flat or a slightly curved inward region (3), the curvature has a maximum depth of 2 mm, particularly of 1.5 mm, to which connect to the end faces rounded areas, and that the flat or slightly inwardly curved areas have a hexagonal form, the base sides (3a, 3b) of which lay on the crossover areas of the lateral faces to the upper side and lower side of the flask body (1), wherein in particular the flat or slightly curved areas (3) have a uniformly hexagonal form such that the corners (E) lay between the base sides are positioned approximately half way up the flask body (1).
2. The blood plasma collection flask according to claim 1, characterized in that the sides of the hexagonal surfaces (3) lying between the base sides (3a, 3b) are slightly rounded.
3. The blood plasma collection flask according to one of the preceding claims, characterized in that on the underside of the flask body (1) three adjustable feet (4) are provided.
4. The blood plasma collection flask according to one of the preceding claims, characterized in that the flask body (1) has a plurality of stiffing bulges (5) extending around the flask body (1).
5. The blood plasma collection flask according to claim 4, characterized in that the stiffing bulges (5) function at least partially as a level indicator.
6. The blood plasma collection flask according to claim 4 or 5, characterized in that a total of four stiffing bulges (5) on the flask body (1) are formed, wherein in particular two stiffing bulges (5) are provided at the top of the flask body and two stiffing bulges (5) are provided at the bottom of the flask body.
7. The blood plasma collection flask according to one of the preceding claims, characterized in that at the top of the flask body (1) on opposite sides of the flask neck (2) and laterally spaced therefrom connection points (7a, 7b) are provided, of which the one connection point (7a ) is used for filling the flask body (1) with blood plasma and the other connection point (7b) for ventilation and taking samples, and that at the connection points (7a, 7b) are provided in the substantially L-shaped connectors (9), wherein each connector leg is connected to the flask body (1) and the other connector leg is directed to the flask neck (2) and having a tube (10), extending over the flask neck (2).
8. The blood plasma collection flask according to claim 7, characterized in that the connector legs facing away from the flask body (2) are directed in the way that the connected tubes (10) above the flask neck (2) are spaced from each other.
9. The blood plasma collection flask according to claim 7 or 8, characterized in that a lid (11) on the flask neck (2) and in particular on a neck of the flask (2) occluding at its upper side cover plate (2a) is fixed or can be fixed, and the lid (11) is designed such that in a fixed state, the tubes (10) extend the flasks neck (2) and protects it against access from the outside.
10. The blood plasma collection flask according to claim 9, characterized in that the cover (11) the tubes (10) associated with and the lid underside is open towards recesses (12), which protrudes with the over the flask neck (2) tube portions come intro engagement, and be penetrated by this when the lid (11) is fixed to the bottle neck.
11. The blood plasma collection flask according to claim 9 or 10, characterized in that the lid inner side has retaining webs, which engage over the projecting over the flask neck tube sections and position when the lid is fixed to the flask neck.
12. The blood plasma collection flask according to any one of claims 9 to 11, characterized in that on the cover (11) and in particular the lid top retaining elements, especially retaining clips (18) for releasable attachment of sample tubes (19) are provided.

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