EP2431355A4 - NOVEL VI-CRYSTALLINE FORM OF AGOMÉLATINE ITS PREPARATION METHOD AND APPLICATION - Google Patents
NOVEL VI-CRYSTALLINE FORM OF AGOMÉLATINE ITS PREPARATION METHOD AND APPLICATIONInfo
- Publication number
- EP2431355A4 EP2431355A4 EP10750350A EP10750350A EP2431355A4 EP 2431355 A4 EP2431355 A4 EP 2431355A4 EP 10750350 A EP10750350 A EP 10750350A EP 10750350 A EP10750350 A EP 10750350A EP 2431355 A4 EP2431355 A4 EP 2431355A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- agomelatine
- preparation
- application
- crystalline form
- new crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910047329.2A CN101585779B (zh) | 2009-03-10 | 2009-03-10 | 阿戈美拉汀的晶型vi及其制备方法和应用 |
PCT/CN2010/070931 WO2010102554A1 (zh) | 2009-03-10 | 2010-03-09 | 阿戈美拉汀的新晶型ⅵ及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2431355A1 EP2431355A1 (en) | 2012-03-21 |
EP2431355A4 true EP2431355A4 (en) | 2012-08-08 |
Family
ID=41370233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10750350A Withdrawn EP2431355A4 (en) | 2009-03-10 | 2010-03-09 | NOVEL VI-CRYSTALLINE FORM OF AGOMÉLATINE ITS PREPARATION METHOD AND APPLICATION |
Country Status (27)
Country | Link |
---|---|
US (1) | US8614251B2 (zh) |
EP (1) | EP2431355A4 (zh) |
JP (1) | JP2012519715A (zh) |
KR (1) | KR20110123266A (zh) |
CN (1) | CN101585779B (zh) |
AP (1) | AP3049A (zh) |
AU (1) | AU2010223720B2 (zh) |
BR (1) | BRPI1013249A2 (zh) |
CA (1) | CA2754276A1 (zh) |
CL (1) | CL2011002231A1 (zh) |
CO (1) | CO6410293A2 (zh) |
CR (1) | CR20110457A (zh) |
CU (1) | CU20110162A7 (zh) |
EA (1) | EA019127B1 (zh) |
EC (1) | ECSP11011309A (zh) |
GE (1) | GEP20146114B (zh) |
HN (1) | HN2011002408A (zh) |
IL (1) | IL214683A0 (zh) |
MA (1) | MA33100B1 (zh) |
MX (1) | MX2011009339A (zh) |
NI (1) | NI201100167A (zh) |
PE (1) | PE20120653A1 (zh) |
SG (2) | SG173692A1 (zh) |
TN (1) | TN2011000426A1 (zh) |
UA (1) | UA100476C2 (zh) |
WO (1) | WO2010102554A1 (zh) |
ZA (1) | ZA201106049B (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101585779B (zh) | 2009-03-10 | 2014-04-02 | 上海医药工业研究院 | 阿戈美拉汀的晶型vi及其制备方法和应用 |
WO2011006387A1 (zh) * | 2009-07-11 | 2011-01-20 | 浙江华海药业股份有限公司 | 阿戈美拉汀的制备方法、阿戈美拉汀晶形及其制备方法 |
CN101955440B (zh) * | 2009-07-17 | 2014-04-09 | 江苏万特制药有限公司 | 一种阿戈美拉汀新晶型及其制备方法 |
CN102050756A (zh) * | 2009-11-09 | 2011-05-11 | 北京利乐生制药科技有限公司 | 阿戈美拉汀新晶型及其制备方法 |
CN102190595A (zh) | 2010-03-17 | 2011-09-21 | 上海医药工业研究院 | 阿戈美拉汀溴化氢水合物及其制备方法 |
CN102557979B (zh) * | 2010-12-16 | 2014-11-26 | 北大方正集团有限公司 | 一种阿戈美拉汀的晶型、其制备方法、用途及药物组合物 |
WO2012093402A1 (en) * | 2011-01-04 | 2012-07-12 | Symed Labs Limited | Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide |
CN102690210A (zh) * | 2011-03-23 | 2012-09-26 | 上海医药工业研究院 | 阿戈美拉汀的新晶型ⅶ、其制备方法、应用和包含其的药物组合物 |
CN102690209A (zh) * | 2011-03-23 | 2012-09-26 | 上海医药工业研究院 | 阿戈美拉汀的混晶(形式-ⅷ)、其制备方法、应用和包含其的药物组合物 |
FR2978916B1 (fr) | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
EP2771312B1 (en) | 2011-11-30 | 2017-05-31 | ratiopharm GmbH | Agomelatine-urea complex and crystalline forms thereof |
FR3001894A1 (fr) | 2013-02-08 | 2014-08-15 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
CN103690499B (zh) * | 2013-12-23 | 2015-05-06 | 天津泰普药品科技发展有限公司 | 一种稳定的晶i型阿戈美拉汀片剂及其制备方法 |
WO2015124496A1 (en) | 2014-02-19 | 2015-08-27 | Synthon B.V. | Pharmaceutical composition comprising amorphous agomelatine |
PL3075724T3 (pl) | 2015-03-31 | 2023-12-27 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Stała postać agomelatyny |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050182276A1 (en) * | 2004-02-13 | 2005-08-18 | Jean-Claude Souvie | Process for the synthesis and crystalline form of agomelatine |
EP1752444A1 (fr) * | 2005-08-03 | 2007-02-14 | Les Laboratoires Servier | Nouvelle forme cristalline IV de l'Agomelatine, son procédé de preparation et les compositions pharmaceutiques qui la contiennent |
EP2319827A1 (en) * | 2009-11-09 | 2011-05-11 | Ratiopharm GmbH | Process for the production of polymorph form I of agomelatine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2866334B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine |
FR2889523B1 (fr) * | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2889521B1 (fr) * | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2899472B1 (fr) * | 2006-04-07 | 2008-09-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee |
FR2923482B1 (fr) * | 2007-11-09 | 2010-01-29 | Servier Lab | Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
CN101585779B (zh) * | 2009-03-10 | 2014-04-02 | 上海医药工业研究院 | 阿戈美拉汀的晶型vi及其制备方法和应用 |
-
2009
- 2009-03-10 CN CN200910047329.2A patent/CN101585779B/zh not_active Expired - Fee Related
-
2010
- 2010-03-09 WO PCT/CN2010/070931 patent/WO2010102554A1/zh active Application Filing
- 2010-03-09 CA CA2754276A patent/CA2754276A1/en not_active Abandoned
- 2010-03-09 AP AP2011005914A patent/AP3049A/xx active
- 2010-03-09 PE PE2011001513A patent/PE20120653A1/es not_active Application Discontinuation
- 2010-03-09 EP EP10750350A patent/EP2431355A4/en not_active Withdrawn
- 2010-03-09 US US13/138,615 patent/US8614251B2/en not_active Expired - Fee Related
- 2010-03-09 UA UAA201111757A patent/UA100476C2/ru unknown
- 2010-03-09 BR BRPI1013249A patent/BRPI1013249A2/pt not_active Application Discontinuation
- 2010-03-09 JP JP2011553265A patent/JP2012519715A/ja active Pending
- 2010-03-09 EA EA201101304A patent/EA019127B1/ru not_active IP Right Cessation
- 2010-03-09 AU AU2010223720A patent/AU2010223720B2/en not_active Ceased
- 2010-03-09 SG SG2011058559A patent/SG173692A1/en unknown
- 2010-03-09 KR KR1020117021813A patent/KR20110123266A/ko not_active Application Discontinuation
- 2010-03-09 GE GEAP201012406A patent/GEP20146114B/en unknown
- 2010-03-09 MX MX2011009339A patent/MX2011009339A/es not_active Application Discontinuation
- 2010-03-09 SG SG2011088564A patent/SG177886A1/en unknown
- 2010-03-09 MA MA34144A patent/MA33100B1/fr unknown
-
2011
- 2011-08-16 IL IL214683A patent/IL214683A0/en unknown
- 2011-08-17 TN TN2011000426A patent/TN2011000426A1/fr unknown
- 2011-08-17 ZA ZA2011/06049A patent/ZA201106049B/en unknown
- 2011-08-23 CU CU20110162A patent/CU20110162A7/es unknown
- 2011-08-24 CR CR20110457A patent/CR20110457A/es unknown
- 2011-08-26 CO CO11109271A patent/CO6410293A2/es not_active Application Discontinuation
- 2011-09-07 EC EC2011011309A patent/ECSP11011309A/es unknown
- 2011-09-08 NI NI201100167A patent/NI201100167A/es unknown
- 2011-09-09 HN HN2011002408A patent/HN2011002408A/es unknown
- 2011-09-09 CL CL2011002231A patent/CL2011002231A1/es unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050182276A1 (en) * | 2004-02-13 | 2005-08-18 | Jean-Claude Souvie | Process for the synthesis and crystalline form of agomelatine |
CN1680284A (zh) * | 2004-02-13 | 2005-10-12 | 瑟维尔实验室 | 阿戈美拉汀的新合成方法、新晶型及其药物组合物 |
EP1752444A1 (fr) * | 2005-08-03 | 2007-02-14 | Les Laboratoires Servier | Nouvelle forme cristalline IV de l'Agomelatine, son procédé de preparation et les compositions pharmaceutiques qui la contiennent |
EP2319827A1 (en) * | 2009-11-09 | 2011-05-11 | Ratiopharm GmbH | Process for the production of polymorph form I of agomelatine |
Non-Patent Citations (3)
Title |
---|
See also references of WO2010102554A1 * |
TINANT B ET AL: "N-[2-(7-METHOXY-1-NAPHTHYL)ETHYL]-ACETAMIDE, A POTENT MELATONIN ANALOG", ACTA CRYSTALLOGRAPHICA SECTION C. CRYSTAL STRUCTURE COMMUNICATIONS, MUNKSGAARD, COPENHAGEN, DK, vol. C50, no. 6, 1 January 1994 (1994-01-01), pages 907 - 910, XP009047983, ISSN: 0108-2701, DOI: 10.1107/S0108270193012922 * |
YOUS S ET AL: "NOVEL NAPHTHALENIC LIGANDS WITH HIGH AFFINITY FOR THE MELATIONIN RECEPTOR", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 35, no. 8, 17 April 1992 (1992-04-17), pages 1484 - 1486, XP002016145, ISSN: 0022-2623, DOI: 10.1021/JM00086A018 * |
Also Published As
Publication number | Publication date |
---|---|
EA201101304A1 (ru) | 2012-04-30 |
CN101585779B (zh) | 2014-04-02 |
EP2431355A1 (en) | 2012-03-21 |
WO2010102554A1 (zh) | 2010-09-16 |
KR20110123266A (ko) | 2011-11-14 |
CO6410293A2 (es) | 2012-03-30 |
AP2011005914A0 (en) | 2011-10-31 |
CL2011002231A1 (es) | 2012-02-03 |
BRPI1013249A2 (pt) | 2016-04-05 |
SG177886A1 (en) | 2012-02-28 |
AU2010223720B2 (en) | 2012-05-03 |
CU20110162A7 (es) | 2012-02-15 |
CN101585779A (zh) | 2009-11-25 |
CR20110457A (es) | 2011-09-21 |
SG173692A1 (en) | 2011-09-29 |
IL214683A0 (en) | 2011-11-30 |
US8614251B2 (en) | 2013-12-24 |
ECSP11011309A (es) | 2011-10-31 |
AP3049A (en) | 2014-11-30 |
AU2010223720A1 (en) | 2011-09-08 |
HN2011002408A (es) | 2014-06-23 |
EA019127B1 (ru) | 2014-01-30 |
UA100476C2 (en) | 2012-12-25 |
TN2011000426A1 (en) | 2013-03-27 |
MA33100B1 (fr) | 2012-03-01 |
PE20120653A1 (es) | 2012-06-14 |
GEP20146114B (en) | 2014-07-10 |
JP2012519715A (ja) | 2012-08-30 |
CA2754276A1 (en) | 2010-09-16 |
MX2011009339A (es) | 2011-09-27 |
US20120004313A1 (en) | 2012-01-05 |
NI201100167A (es) | 2012-01-11 |
ZA201106049B (en) | 2012-10-31 |
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Legal Events
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Ipc: A61P 25/20 20060101ALI20120702BHEP Ipc: A61P 25/22 20060101ALI20120702BHEP Ipc: A61K 31/165 20060101ALI20120702BHEP Ipc: A61P 25/18 20060101ALI20120702BHEP Ipc: A61P 9/00 20060101ALI20120702BHEP Ipc: A61P 5/00 20060101ALI20120702BHEP Ipc: A61P 25/24 20060101ALI20120702BHEP Ipc: C07C 233/18 20060101AFI20120702BHEP Ipc: A61P 1/00 20060101ALI20120702BHEP Ipc: A61P 25/00 20060101ALI20120702BHEP |
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17Q | First examination report despatched |
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Effective date: 20131213 |