EP2429463B1 - Endoprothèse - Google Patents

Endoprothèse Download PDF

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Publication number
EP2429463B1
EP2429463B1 EP10720904.1A EP10720904A EP2429463B1 EP 2429463 B1 EP2429463 B1 EP 2429463B1 EP 10720904 A EP10720904 A EP 10720904A EP 2429463 B1 EP2429463 B1 EP 2429463B1
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EP
European Patent Office
Prior art keywords
stent
struts
length
loop
loops
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EP10720904.1A
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German (de)
English (en)
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EP2429463A1 (fr
Inventor
Gael Dreher
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Angiomed GmbH and Co Medizentechnik KG
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Angiomed GmbH and Co Medizentechnik KG
Angiomed AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91508—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a difference in amplitude along the band
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91583—Adjacent bands being connected to each other by a bridge, whereby at least one of its ends is connected along the length of a strut between two consecutive apices within a band
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped

Definitions

  • This invention relates to a stent formed by slitting a tube to create a matrix of struts which are separated from each other by no more than the width of the slit and which lie parallel to each other and to the longitudinal axis of the tube, the slitted tube being radially expandable to a stenting disposition in which the struts exhibit a zigzag pattern in successive loops around the circumference of the stent, the angle each strut makes with the longitudinal axis increasing as the stent diameter increases, the zigzag pattern exhibiting a cusp between any two adjacent struts, with selected tied cusps of any one loop being connected by a bridge to a facing cusp of the adjacent loop, the bridge extending in a direction parallel to the longitudinal axis of the tube, and with intervening free cusps, between any two bridge of a loop, not being connected to the adjacent loop, the zigzag pattern exhibiting a lengthwise staggering of circumferentially adjacent said slit
  • Self-expanding stents for the arterio-vascular system need to demonstrate a predictable and lengthy resistance to fatigue failure. Furthermore, the process used to manufacture self-expanding stents needs to be rigorous and competitive. Applicant discloses in WO 2008/119837 an attractive stent design that lends itself to manufacture by laser cutting of a tube of stent material such as nickel titanium shape memory alloy. The slits that are cut in the tube by the laser are all straight and parallel to the axis of the tube, leaving the slits cut by the laser parallel with each other so that the struts of the stent, that lie between adjacent slits, are themselves also straight and parallel with the axis of the tube (at least in the moment that they are formed). Modelling of the stress distribution in the struts of the stent matrix is therefore a task that is relatively simple, by which we mean, simple when compared with a stent matrix in which the struts are not straight or not of constant cross section.
  • a stent design should be amenable to delivery through a tortuous bodily lumen, and then, for some applications, competent to endure severe bending, even after deployment, to follow without undue difficulty the changes of shape and configuration of the bodily lumen in which they are installed.
  • Between adjacent struts of a zigzag turn around the stented bodily lumen there are the "cusps" or "peaks” where two adjacent struts come together.
  • the peaks of the adjacent loops do not clash, "head-to-head” when the bodily lumen bends, and the stent with it.
  • WO 2008/119837 offers a stent design that, even though it is simple, achieves a configuration, upon deployment, in which the peaks of one ring face the valleys of the adjacent stenting loop, rather than its peaks.
  • stents are progressively installed, in ever more "bendy" lumens of the human body, there is an increasing requirement for such stents to undergo severe bending, after deployment, without that bending giving rise to any tissue damage in the stented lumen. Head-to-head clashes of cusps ought to be scrupulously avoided.
  • Applicant's earlier WO 01/32102 provides capacity to bend, in a simple linear strut matrix, by sacrificing part of the surface area of the cylinder to so-called "scrap portions" of the cylinder that are cut out of it and discarded, to leave significant end to end gaps between facing cusps of struts.
  • the facing cusps approximate. The gap gets smaller but does not close completely. It is time-consuming and expensive to remove the scrap portions during manufacture and removing them conflicts with the objective of using the maximum possible surface area of the stent to push on bodily tissue to keep the stented bodily lumen patent.
  • WO2009/003584 is another publication of a self-expanding stent matrix with gaps between end to end facing cusps of colinear struts, which therefore suffers from the same disadvantages of the stent matrices disclosed in Applicant's aforesaid WO 01/32102 .
  • the present invention arises out of an appreciation by the present invention that the stent architectures disclosed in WO 2008/119837 are unexpectedly susceptible of further improvement. There is a further design simplification, that makes available enhanced design modelling, simpler manufacture and the chance to secure yet further improvements in stent performance after implantation.
  • a stent in the field of this invention in which a majority of the struts in any one of the successive loops share a first common length X, and any remaining struts in said one loop share a second common length Y, wherein Y ⁇ X.
  • the loops of the stent can be endless, which is to say that the stent matrix exhibits a stack of endless loops arranged along a longitudinal axis of the stent, and each joined to the axially adjacent loop by one or more bridges.
  • the loops of the stent can be the successive turns of a spiral that runs all the way from one end of the stent to the other. It is trite to observe that a chain is only as strong as its weakest link.
  • no struts having a length longer than the common length X there is present no individual strut that can pull down the performance of the struts of the strut majority. It is in this way that the difference between the stents of the present invention, and those of Applicant's earlier WO 2008/119837 , can best be appreciated.
  • each loop of a stent exhibits one or more repeat units that are constituted by a plurality of struts of the loop.
  • the archetypal stent of the present invention exhibits struts that share a common thickness in the radial direction of the stent, and a uniform width, transverse to their length and thickness.
  • stents in which the width of each strut varies, along the length of the strut are also envisaged.
  • One advantage of such architecture is that it can be used to optimize the distribution of stress in each one of the struts, the optimization being done by appropriate variation of the widths of the struts.
  • the level of stress after deployment anywhere in the strut, to be at the same level, by providing that the struts are wider at their roots, close to a cusp of the zigzag ring, than they are along their length, midway between the respective cusps at each end of the strut in view.
  • the stent may be desirable to provide the stent with end loops, one at each end of the length of the stent, that differ from the loops intermediate the two end loops.
  • the loop at one end of the stent is a special end loop, but the loop at the other end of the stent is not special. Any such special end loops might exhibit a strut length that is greater than in the intermediate loops, resulting in the axial length of such an end loop of the stent, as such, being greater than the axial length of each of the intermediate loops of the stent.
  • the stent with a plurality of radiopaque markers, likely located on one or both of the opposed ends of the stent. It might be attractive to locate the markers within the axial length of the end loop, so that they do not protrude beyond the length of the stent as such. Any such markers within the length of the stent can be asymmetric, in the sense that they are cantilevered from a cusp of the end loop of the stent, and are asymmetric about a mirror plane, parallel to the length of the stent and passing through the point where the marker is joined to the cusp of the end loop of the stent.
  • each radiopaque marker is intended to be readily detectable by the radiologist and so will benefit from a relatively large surface area. It will generally be attractive for this large surface area to be part of the generally cylindrical envelope in which the stent matrix is located. In other words, each radiopaque marker will preferably have opposed major surfaces that are each part-cylindrical.
  • FIG. 1 the drawing shows a portion of the length of the stent (10), but the entirety of its circumference, yet laid out flat.
  • the bridge (12) is parted along a notional parting line 14, that appears at both the top and the bottom of the drawing Figure, to divide the bridge (12) into a portion (12-1) on the top of the drawing and a portion (12-2) at the lower end of the drawing.
  • Other bridges along that line of the length of the stent, (16, 18 and 20), are similarly split lengthwise notionally, for the purposes of the laid flat display in Fig. 1 .
  • Each endless loop (30, 32, 34, 36, 38 and 40) of the stent portion shown in Fig. 1 exhibits a zigzag sequence of 24 struts, of which 8 of the struts, designated 42, have a shorter length Y than the length X of the remaining 16 struts (44).
  • bridges (12) that tie together two facing cusps of two adjacent zigzag rings, and which may be designated to "bridges" to join together adjacent loops of the stent matrix, with free cusps (46), not attached to the adjacent zigzag loop, lying in between any pair of the set of four bridges that join together any particular adjacent zigzag loops of the matrix.
  • any free cusp of any zigzag loop lies circumferentially in the gap between two cusps of the facing axial end of the next adjacent zigzag loop of the matrix.
  • This effect is caused by the length differential of the struts, the shorter struts Y being somewhat more resistant to bending, when the radial expansion takes place, than the slightly longer struts (44) of length Y.
  • each zigzag loop of the stent matrix exhibits 40 struts rather than 24.
  • each zigzag loop is connected to the axially adjacent zigzag stenting loop by a set of four bridges (12), evenly distributed around the circumference of the stent, just as in the embodiment of Figs. 1 and 2 .
  • Figs. 6 and 7 show the Fig. 3 arrangement radially expanded, with Fig. 6 corresponding to Fig. 2 , and Fig. 7 being useful in that it shows the stent in three dimensions whereby one can readily imagine the structure stenting surrounding bodily tissue and keeping open (patterned) the lumen inside the cylindrical stent matrix.
  • Figs. 4 and 5 the concern is with how to bring the stent matrix to a close, at one end of the stent cylinder. From Fig. 4 , it is immediately apparent that, in the end loop (50), the axial ends of that loop differ. At the axial end (52) all cusps lie in the same plane transverse to the long axis of the stent. However, at the other axial end of the end loop (50), where it faces the next adjacent stenting loop (56), the cusps are not all in the same plane but, instead, vary in axial position in order to face, head-to-head, the cusps of the adjacent loop (56).
  • a minority of the struts of the end loop (50) are exhibiting a longer length that the majority of struts in the end loop (50).
  • the longer struts of the end loops provide such a transition length, where the stent, thanks to the greater length of the struts, imposes less force on the lumen wall.
  • Stents typically carry radiopaque markers at their ends in order that the radiologist may know with precision exactly where are the ends of the stent in relation to the length of the bodily lumen to be stented. Whereas such markers typically protrude beyond the axial length of the stent proper, Fig. 5 shows an embodiment in which the markers can be set into the length of the stent, located in circumferential gaps between spaced apart cusps in the end annulus (52) of the end ring (50).
  • the present invention is not concerned with specific coatings of stents, or applications of stents.
  • the skilled reader will not need to be told in this application what possibilities exist for covering a stent matrix with a graft material, or a medically active material, nor with what categories of bodily lumen the stent may be useful for.
  • the skilled reader will also immediately appreciate the simplicity of the arrangements illustrated in the accompanying drawings, together with the performance characteristics evident from Figs. 2 , 6 and 7 and the opportunities evident from Figs. 1 , 3 and 5 to provide radiopaque markers as desired.
  • the archetypal stent is cylindrical when relaxed.
  • the technical field of stents includes stent grafts and includes many proposals for a stent matrix which is a relaxed configuration is not strictly cylindrical.
  • those skilled in the art are familiar with the so-called “flared” stents that exhibit at least a portion of the stent length not of constant diameter. Stents with outwardly flared ends are relatively common. All are within the scope of this invention.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Claims (12)

  1. Endoprothèse vasculaire (10) formée par le fendage d'un tube en vue de créer une matrice d'entretoises (42, 44) séparées les unes des autres au maximum par la largeur de la fente et qui sont parallèles les unes par rapport aux autres et par rapport à l'axe longitudinal du tube, le tube fendu pouvant s'étendre radialement jusqu'à une disposition d'implantation d'endoprothèse dans laquelle les entretoises présentent un profil en zigzag en boucles successives autour de la circonférence de l'endoprothèse, l'angle formé par chaque entretoise avec l'axe longitudinal augmentant lorsque le diamètre de l'endoprothèse augmente ;
    le profil en zigzag présentant une cuspide (46, 48) entre deux entretoises adjacentes quelconques ;
    des cuspides liées sélectionnées de toute boucle étant reliées par un pont (12) à une cuspide en regard de la boucle adjacente, ledit pont s'étendant dans une direction parallèle à l'axe longitudinal du tube ;
    et les cuspides libres intermédiaires (46), entre deux ponts quelconques d'une boucle, n'étant pas reliées à la boucle adjacente ;
    et la matrice d'entretoises étant dépourvue d'espace significatif extrémité à extrémité entre les paires en regard desdites cuspides libres intermédiaires ;
    le profil en zigzag présentant un échelonnement en longueur desdites fentes circonférentiellement adjacentes tel que les longueurs de deux entretoises circonférentiellement adjacentes sur le profil en zigzag qui flanquent une cuspide liée sont différentes et, en outre, tel que dans ladite disposition d'implantation d'endoprothèse les cuspides libres de boucles adjacentes sont déplacées circonférentiellement l'une par rapport à l'autre ;
    et caractérisé en ce que :
    une majorité, mais pas la totalité, des entretoises (44) dans l'une quelconque des boucles successives partagent une première longueur X commune, et toutes les entretoises (42) restantes dans ladite boucle partagent une seconde longueur commune Y, dans laquelle Y < X.
  2. Endoprothèse selon la revendication 1, les boucles étant sans fin.
  3. Endoprothèse selon la revendication 1, les boucles étant des spires successives d'une spirale.
  4. Endoprothèse selon l'une quelconque des revendications précédentes, dans laquelle une durée de vie en fatigue calculée desdites entretoises restantes, avec une longueur commune Y, est supérieure à une durée de vie en fatigue calculée des entretoises de la majorité, avec une longueur commune X.
  5. Endoprothèse selon l'une quelconque des revendications précédentes, dans laquelle chaque boucle présente au moins une unité répétée constituée d'une pluralité d'entretoises de la boucle, et il n'y a qu'une seule entretoise de longueur Y par unité répétée.
  6. Endoprothèse selon l'une quelconque des revendications précédentes, dans laquelle les entretoises de longueur X et les entretoises de longueur Y partagent une épaisseur commune dans le sens radial de l'endoprothèse.
  7. Endoprothèse selon l'une quelconque des revendications précédentes, dans laquelle les entretoises de longueur X et les entretoises de longueur Y partagent une largeur commune, transversale à leur longueur.
  8. Endoprothèse selon l'une quelconque des revendications précédentes, et comprenant une boucle d'extrémité (50) au niveau de l'une des extrémités, ou des deux, de la longueur axiale de l'endoprothèse, dans laquelle boucle d'extrémité la longueur de l'entretoise est plus grande que dans les boucles entre les extrémités de l'entretoise, la longueur axiale de la boucle d'extrémité en tant que telle étant ainsi supérieure à la longueur axiale de toute autre boucle de l'endoprothèse.
  9. Endoprothèse selon l'une quelconque des revendications précédentes, et comprenant une pluralité de marqueurs radio-opaques (60) situés sur au moins l'une des extrémités opposées de l'endoprothèse.
  10. Endoprothèse selon la revendication 9, dans laquelle les marqueurs sont situés sur un anneau (52) qui repose dans la longueur de la boucle d'extrémité de l'endoprothèse adjacente auxdits marqueurs.
  11. Endoprothèse selon la revendication 10, dans laquelle chaque marqueur est un bras asymétrique.
  12. Endoprothèse selon la revendication 9, 10 ou 11, dans laquelle ledit marqueur a des surfaces principales opposées qui sont chacune en partie cylindriques.
EP10720904.1A 2009-05-14 2010-05-12 Endoprothèse Active EP2429463B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17841609P 2009-05-14 2009-05-14
GBGB0908315.5A GB0908315D0 (en) 2009-05-14 2009-05-14 Stent
PCT/EP2010/056557 WO2010130788A1 (fr) 2009-05-14 2010-05-12 Endoprothèse

Publications (2)

Publication Number Publication Date
EP2429463A1 EP2429463A1 (fr) 2012-03-21
EP2429463B1 true EP2429463B1 (fr) 2014-12-17

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EP10720904.1A Active EP2429463B1 (fr) 2009-05-14 2010-05-12 Endoprothèse

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US8303644B2 (en) * 2007-05-04 2012-11-06 Abbott Cardiovascular Systems Inc. Stents with high radial strength and methods of manufacturing same
US10973656B2 (en) 2009-09-18 2021-04-13 Spinal Surgical Strategies, Inc. Bone graft delivery system and method for using same

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SG86458A1 (en) * 2000-03-01 2002-02-19 Medinol Ltd Longitudinally flexible stent
US7223283B2 (en) * 2002-10-09 2007-05-29 Boston Scientific Scimed, Inc. Stent with improved flexibility
US6814746B2 (en) * 2002-11-01 2004-11-09 Ev3 Peripheral, Inc. Implant delivery system with marker interlock
KR100667618B1 (ko) * 2005-09-23 2007-01-11 휴메드 주식회사 이중배열 스트럿을 갖는 혈관용 스텐트
GB0616999D0 (en) * 2006-08-29 2006-10-04 Angiomed Ag Annular mesh
WO2008028964A2 (fr) 2006-09-07 2008-03-13 Angiomed Gmbh & Co. Medizintechnik Kg Implant hélicoïdal comportant des extrémités différentes
GB0706499D0 (en) 2007-04-03 2007-05-09 Angiomed Ag Bendable stent
DE102007030753A1 (de) * 2007-07-02 2009-01-08 Acandis Gmbh & Co. Kg Stent

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EP2429463A1 (fr) 2012-03-21
CA2761759C (fr) 2017-08-22
ES2531638T3 (es) 2015-03-18
CA2761759A1 (fr) 2010-11-18
US20120143307A1 (en) 2012-06-07
WO2010130788A1 (fr) 2010-11-18
US8852262B2 (en) 2014-10-07
GB0908315D0 (en) 2009-06-24

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