EP2427559A4 - Biotransformation à l aide de candida génétiquement modifié - Google Patents

Biotransformation à l aide de candida génétiquement modifié

Info

Publication number
EP2427559A4
EP2427559A4 EP10800135.5A EP10800135A EP2427559A4 EP 2427559 A4 EP2427559 A4 EP 2427559A4 EP 10800135 A EP10800135 A EP 10800135A EP 2427559 A4 EP2427559 A4 EP 2427559A4
Authority
EP
European Patent Office
Prior art keywords
biotransformation
genetically modified
modified candida
candida
genetically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10800135.5A
Other languages
German (de)
English (en)
Other versions
EP2427559A2 (fr
Inventor
Jon Ness
Jeremy Minshull
Richard A Gross
Wenhua Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polytechnic Institute of NYU
DNA Twopointo Inc
Original Assignee
Polytechnic Institute of NYU
DNA Twopointo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/436,729 external-priority patent/US8158391B2/en
Application filed by Polytechnic Institute of NYU, DNA Twopointo Inc filed Critical Polytechnic Institute of NYU
Publication of EP2427559A2 publication Critical patent/EP2427559A2/fr
Publication of EP2427559A4 publication Critical patent/EP2427559A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6431—Linoleic acids [18:2[n-6]]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/649—Biodiesel, i.e. fatty acid alkyl esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP10800135.5A 2009-05-06 2010-05-06 Biotransformation à l aide de candida génétiquement modifié Withdrawn EP2427559A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17606409P 2009-05-06 2009-05-06
US12/436,729 US8158391B2 (en) 2009-05-06 2009-05-06 Production of an α-carboxyl-ω-hydroxy fatty acid using a genetically modified Candida strain
PCT/US2010/001361 WO2011008231A2 (fr) 2009-05-06 2010-05-06 Biotransformation à l’aide de candida génétiquement modifié

Publications (2)

Publication Number Publication Date
EP2427559A2 EP2427559A2 (fr) 2012-03-14
EP2427559A4 true EP2427559A4 (fr) 2013-09-18

Family

ID=43450025

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10800135.5A Withdrawn EP2427559A4 (fr) 2009-05-06 2010-05-06 Biotransformation à l aide de candida génétiquement modifié

Country Status (2)

Country Link
EP (1) EP2427559A4 (fr)
WO (1) WO2011008231A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2841796C (fr) 2011-07-06 2021-06-29 Verdezyne, Inc. Procedes biologiques pour la preparation d'acide gras dicarboxylique
DE102011110946A1 (de) * 2011-08-15 2016-01-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen
EP2776385A1 (fr) 2011-12-20 2014-09-17 DSM IP Assets B.V. Procédé de préparation de l'acide azéléique à partir de l'acide 9-octadécènedioïque
JP6053124B2 (ja) * 2012-10-18 2016-12-27 花王株式会社 糖脂質の製造方法
CA2895124C (fr) * 2012-12-19 2024-01-23 Verdezyne, Inc. Procedes biologiques pour la preparation d'un acide dicarboxylique gras
EP2746397A1 (fr) * 2012-12-21 2014-06-25 Evonik Industries AG Fabrication d'acides gras oméga-aminés
JP6323940B2 (ja) * 2013-12-26 2018-05-16 花王株式会社 アルキルポリグリコシドの製造方法
KR101837130B1 (ko) 2016-03-18 2018-03-09 한국생명공학연구원 효모 캔디다 뷰티리 sh-14 유래의 신규 리파아제 및 그의 용도
CN112746026B (zh) * 2019-10-31 2023-01-10 中国石油化工股份有限公司 一株维斯假丝酵母及其应用
CN112961790B (zh) * 2021-03-29 2022-11-01 江西沃邦兴环保科技有限公司 一种耐高盐环境的异养硝化菌及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040146999A1 (en) * 1997-07-21 2004-07-29 E.I. Du Pont De Nemours And Company Transformed yeast strains and their use for the production of monoterminal and diterminal aliphatic carboxylates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254466A (en) * 1989-11-06 1993-10-19 Henkel Research Corporation Site-specific modification of the candida tropicals genome
JP3574682B2 (ja) * 1993-09-24 2004-10-06 ダイセル化学工業株式会社 新規な酵素、該酵素を製造する方法、該酵素をコードするｄｎａ、該ｄｎａを含む形質転換体、該酵素による光学活性アルコール等の製造方法
CN1556855A (zh) * 2000-11-20 2004-12-22 卡吉尔公司 3-羟基丙酸及其它有机化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040146999A1 (en) * 1997-07-21 2004-07-29 E.I. Du Pont De Nemours And Company Transformed yeast strains and their use for the production of monoterminal and diterminal aliphatic carboxylates

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AYALA M ET AL: "Enzymatic activation of alkanes: constraints and prospective", APPLIED CATALYSIS A: GENERAL, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 272, no. 1-2, 28 September 2004 (2004-09-28), pages 1 - 13, XP004527126, ISSN: 0926-860X, DOI: 10.1016/J.APCATA.2004.05.046 *
DEBARBER A E ET AL: "omega-Hydroxylation of farnesol by mammalian cytochromes P450", BIOCHIMICA AND BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS, ELSEVIER, AMSTERDAM, NL, vol. 1682, no. 1-3, 1 June 2004 (2004-06-01), pages 18 - 27, XP004510873, ISSN: 1388-1981, DOI: 10.1016/J.BBALIP.2004.01.003 *
ESCHENFELDT WILLIAM H ET AL: "Transformation of fatty acids catalyzed by cytochrome P450 monooxygenase enzymes of Candida tropicalis", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 69, no. 10, 1 October 2003 (2003-10-01), pages 5992 - 5999, XP002438651, ISSN: 0099-2240, DOI: 10.1128/AEM.69.10.5992-5999.2003 *
PICATAGGIO ET AL: "Metabolic enginering of Candida tropicalis for the production of long-chain dicarboxylic acids", BIOTECHNOLOGY. THE INTERNATIONAL MONTHLY FOR INDUSTRIAL BIOLOGY,, vol. 10, 1 August 1992 (1992-08-01), pages 894 - 898, XP002113145, ISSN: 0733-222X, DOI: 10.1038/NBT0892-894 *

Also Published As

Publication number Publication date
WO2011008231A3 (fr) 2011-06-16
EP2427559A2 (fr) 2012-03-14
WO2011008231A2 (fr) 2011-01-20

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Inventor name: GROSS, RICHARD A

Inventor name: LU, WENHUA

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