EP2412440A1 - System und Verfahren zur Abgabe von Flüssigkeit aus einem Behälter und in einen Flüssigkeitsbehälter - Google Patents

System und Verfahren zur Abgabe von Flüssigkeit aus einem Behälter und in einen Flüssigkeitsbehälter Download PDF

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Publication number
EP2412440A1
EP2412440A1 EP11175868A EP11175868A EP2412440A1 EP 2412440 A1 EP2412440 A1 EP 2412440A1 EP 11175868 A EP11175868 A EP 11175868A EP 11175868 A EP11175868 A EP 11175868A EP 2412440 A1 EP2412440 A1 EP 2412440A1
Authority
EP
European Patent Office
Prior art keywords
receptacle
fluid
protrusion
tip
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11175868A
Other languages
English (en)
French (fr)
Inventor
Tipton Lee Golias
Ronald Allen Mayes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helena Laboratories Corp
Original Assignee
Helena Laboratories Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helena Laboratories Corp filed Critical Helena Laboratories Corp
Publication of EP2412440A1 publication Critical patent/EP2412440A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details

Definitions

  • Embodiments relate in general to a system and method for dispensing the contents of a fluid container directly into a receptacle and, more particularly, to a system and method for dispensing the contents of a test tube directly into a cartridge-type receptacle.
  • Test tubes are commonly used as collection containers for blood specimens and other liquids, such as biological fluids.
  • an anticoagulant is placed in the test tube and a blood specimen is withdrawn from a patient directly into the test tube.
  • the test tube is closed with a rubber stopper.
  • the blood or other fluid must be removed from the test tube to analyze it.
  • the task of conveniently and efficiently dispensing fluid from a test tube onto a desired surface must be routinely performed by laboratory workers in a variety of circumstances.
  • care must be taken when dispensing such fluids to avoid contamination of the fluid to be tested, such as when dispensed fluid is drawn back into the test tube.
  • Care must also be taken to avoid spillage of the fluid and the possibility of the fluid becoming airborne, such as when the fluid is dispensed from the test tube too rapidly, which can expose the laboratory worker to the fluid as well as any diseases that may be carried by the fluid.
  • Pipettes are typically used to transfer the fluid from the test tube into an aperture in the cartridge. But the use of the pipette required removal of the stopper from the test tube thus again creating an aerosol as the stopper is removed, thus exposing the laboratory worker to any contaminants and diseases contained in the biological fluid.
  • Embodiments are directed to a system for dispensing fluid directly from a container into a cartridge type receptacle without the need for removing a closure or stopper from the container thus avoiding the creation of the undesirable aerosol effect.
  • a fluid dispenser punctures the stopper of the container and, upon creation of an increase of pressure within the container, such as by flexing the stopper inwardly, fluid exits the container through the dispenser.
  • a receptacle preferably a cartridge-type receptacle, has an aperture to receive the fluid dispenser such that the fluid exiting the container through the dispenser flows directly into the receptacle.
  • FIG. 1 is a side elevation partially cross-sectional view of a fluid dispensing system, showing a fluid dispenser inserted through a closure of a test tube such that, after relative movement between the test tube and/or the fluid dispenser, the closure flexes to pressurize the interior of the test tube resulting in a portion of a fluid in the test tube being dispensed.
  • FIG. 2 is a perspective illustration of a cartridge-type receptacle.
  • FIG. 3 is a side elevation partial cross-sectional view of a first embodiment of the interface between a fluid dispenser and a hole in a fluid receptacle.
  • FIG. 4 is a side elevation partial cross-sectional view of a second embodiment of the interface between a fluid dispenser and a hole in a fluid receptacle.
  • FIG. 5 is a side elevation partial cross-sectional view of a third embodiment of the interface between a fluid dispenser and a hole in a fluid receptacle.
  • Embodiments herein are directed to systems and methods for dispensing fluid from a container. Embodiments will be explained in connection with the dispensing blood from a test tube, but the detailed description is intended only as exemplary. Indeed, it will be appreciated that aspects can be used in connection with other containers as well as with other fluids. Embodiments are shown in FIGS. 3-5 , but they are not limited to the illustrated structure or application.
  • a fluid dispenser includes a base 12 having opposed first and second sides 14, 16, respectively.
  • the base 12 can be generally circular in cross-sectional shape.
  • the base 12 can have any suitable conformation, such as being rectangular, triangular, oval or polygonal.
  • An elongated puncturing shaft 20 can extend from the first side 14 of the base 12.
  • the puncturing shaft 20 can extend at any suitable angle relative to the first side 14 of the base 12.
  • the puncturing shaft 20 can be substantially perpendicular to the first side 14 of the base 12.
  • the puncturing shaft 20 can be substantially centrally located on the first side 14 of the base 12.
  • the puncturing shaft 20 can include a stem portion 22 that can extend directly from the first side 14 of the base 12.
  • the stem portion 22 can transition to a cannula portion 24.
  • the cannula portion 24 can culminate in a tip 25 which may be pointed or chamfered to facilitate puncturing.
  • the transition between the stem portion 22 and the cannula portion 24 can have any suitable configuration.
  • the transition between the stem portion 22 and the cannula portion 24 can include a shoulder 26, which may determine an insertion length of the puncturing shaft 20 into the container.
  • the stem portion 22 and cannula portion can each have a substantially circular cross-section with the diameter of the circular cross-section of stem portion 22 being greater than the substantially circular cross-section diameter of the cannula portion 24, thereby forming the shoulder 26.
  • the cannula portion 24 can include a plurality of serrations, teeth, or barbs (not shown) for resisting any tendency of the cannula portion 24 from accidentally withdrawing from the item into which it is inserted, such as the closure of a test tube or other container.
  • the serrations can minimize subsequent movement of the fluid dispenser 10 after it has been attached to a container.
  • a hollow protrusion 28 can extend from the second side 16 of the base 12.
  • the protrusion 28 may be the only structure that extends from the second side 16 of the base 12.
  • the protrusion 28 can extend at any suitable angle relative to the second side 16 of the base 12.
  • the protrusion 28 can be substantially perpendicular to the second side 16 of the base 12.
  • the protrusion 28 can be substantially centrally located on the second side 16 of the base 12.
  • the hollow interior of the protrusion 28 can be substantially aligned with the hollow interior of the puncturing shaft 20.
  • the protrusion 28 can terminate at a tip 30.
  • the protrusion 28 can have an associated length Lp defined as the distance between the second side 16 of the base 12 and the tip 30.
  • the protrusion 28 can have any suitable conformation.
  • the protrusion 28 can be substantially circular in cross-section.
  • the protrusion 28 can be rectangular, triangular, oval or polygonal.
  • the protrusion 28 can include one or more side walls 32, depending on the configuration of the protrusion 28. For instance, when the protrusion 28 is substantially circular, the protrusion 28 can have a single continuous side wall 28. When the protrusion 28 is polygonal, the protrusion 28 can have a plurality of side walls 32.
  • the one or more side walls 32 can be substantially straight. Alternatively, the one or more side walls 32 can be tapered.
  • a flow passage 34 can extend through the fluid dispenser 10 from the protrusion 28 to the cannula portion 24.
  • the flow passage 34 can have an inlet opening 36 in the cannula portion 24, such as at the cannula tip 25.
  • the flow passage 34 can have an outlet opening 38 in the protrusion 28, such as at the protrusion tip 30.
  • the flow passage 34 can extend from the inlet opening 36 to the outlet opening 38.
  • the flow passage 34 can have any suitable size and shape.
  • the cross-sectional size and shape of the flow passage 34 can be substantially constant along its length or at least one of the cross-sectional size and shape of the flow passage 34 can vary along at least a portion of the flow passage 34.
  • the flow passage 34 can be substantially circular in cross-sectional shape.
  • the flow passage 34 can be substantially straight.
  • the flow passage 34 can include one or more bends, turns, curves and/or angles.
  • the fluid dispenser 10 can be a unitary structure. That is, all portions of the fluid dispenser 10 can be formed as a single structure, such as by plastic injection molding. Alternatively, at least a portion of the fluid dispenser 10 can be made separately and/or of a different material. For instance, the cannula portion 24 can be made of metal, and the rest of the fluid dispenser 10 can be made of plastic. In such case, stem portion 22 can be molded around the metal cannula portion 24, or the metal cannula portion 24 can be received in a passage in the stem portion 22. At least a portion of the fluid dispenser 10 can be transparent, such as by using a transparent plastic material, thereby allowing a user a greater field of view during use.
  • Embodiments of systems and methods herein can include a container 40.
  • the container 40 can have an opening 42.
  • the container 40 can include an inner chamber 44 having an associated volume.
  • the container 40 can be a test tube in which the opening 42 is provided at a first end 48 thereof. The second end 50 of the test tube can be closed.
  • test tube for convenience, the following discussion will be made in connection with a test tube, but it will be understood that embodiments are not limited to test tubes, as any suitable container can be used.
  • the open first end 48 of the test tube can be closed by a closure 52.
  • Any suitable structure can be used for the closure 52.
  • the closure 52 can form a seal with the opening 42.
  • the closure 52 can be a rubber stopper or other structure that is reusable, resealable, repuncturable, flexible and/or resilient.
  • the closure 52 can be force fit into the opening 42 of the test tube and retained in place by at least friction.
  • the inner chamber 44 of the test tube can include a fluid 60.
  • the fluid 60 can be any type of fluid.
  • the fluid 60 can be blood or another biological fluid.
  • FIG. 2 illustrates in general terms a cartridge-type receptacle 70 into which fluid is to be placed for subsequent evaluation.
  • the receptacle which will be described as a cartridge for convenience only, is a generally thin, flat, rectangular member having an aperture 72 and an interior passageway 80.
  • the aperture or hole 70 can extend to a first depth within the receptacle such that the aperture will be in fluid communication with the interior passageway 80.
  • the first depth may be considered to extend from the top of the receptacle to an interior floor 74 of the receptacle.
  • the distance from the top of the receptacle 70 to the interior floor 74 of the receptacle can be considered as the depth 74 of the hole and may be designated L d .
  • the diameter of the hole 72 at the top surface of the cartridge is sufficient to receive at least a portion of the diameter of the protrusion 28 as will be more fully described below.
  • the hole 72 which is formed in the receptacle, can have any suitable cross-sectional shape which is thus defined by the size and shape of the interior wall 78 of the hole.
  • the cross-sectional diameter of the hole 72 can be substantially constant, as is shown in FIG. 3 .
  • the cross-sectional size of the hole 72 can vary.
  • the cross-sectional diameter of the hole 72 can be conical or chamfered to decrease in the downward direction toward the floor 74 as is shown in FIG. 4 .
  • One or more projections 76 can extend from the wall 78, as is shown in FIG. 5 .
  • the fluid receptacle 70 can include more than one hole 72.
  • the fluid receptacle 70 can include an elongated channel 80 for receiving a fluid.
  • the channel 80 can be in direct or indirect fluid communication with the hole 72. In some instances, there can be more than one channel 80 associated with the hole 72. At least a portion of the channel 80 can extend within the interior of the fluid receptacle 70.
  • the channel 80 can have any suitable size or shape.
  • the cross-sectional area of the channel 80 can be substantially constant along its length.
  • the cross-sectional area of the channel 80 can vary along at least a portion of its length.
  • the channel 80 can be substantially straight.
  • the channel 80 can include one or more bends, turns, curves or angles.
  • the fluid receptacle 70 can be a test cartridge for use in connection with a blood/biological fluid analysis device.
  • the fluid receptacle can be a test cartridge for an i-STAT 1 handheld analysis device, which is available from Abbott Laboratories, Abbott Park, Illinois.
  • the fluid receptacle 70 can include sensors, electronic components and circuitry to conduct analysis of the fluid and/or for operative communication with a blood/biological fluid analysis device.
  • the fluid receptacle 70 can provide an interface for operative connection and/or communication with another device, such as a blood/biological fluid analysis device.
  • the receptacle 70 is generally rectangular shaped, including a rectangular base 82 and a generally rectangular upper member 84.
  • the channel 80 may extend partially in the upper member 84 and thereafter downwardly into the base 82. Alternatively, the channel 80 may be solely in the upper member 84 or solely in the base 82.
  • the fluid 60 to be dispensed can be collected within the inner chamber 44 of the container 40 by conventional techniques and sealed with a closure 52.
  • the fluid dispenser 10 can then inserted through the closure 52.
  • the puncturing shaft 20 can be inserted through the closure 52 until the shoulder 26 of the puncturing shaft 20 engages and abuts against the closure 52.
  • the base 12 may be gripped or held during insertion of puncturing shaft 20 into the closure 52.
  • the stem portion 22 can provide structural support for the cannula portion 24 and can help to prevent any accidental breakage of the cannula portion 24 during insertion of the puncturing shaft 20 into the closure 52.
  • At least a part of the cannula portion 24 can extend into the inner chamber 44, thereby establishing fluid communication between the inner chamber 44 of the test tube and the exterior of the test tube.
  • the test tube (with dispenser 10 attached) can be inverted into the position generally shown in FIG. 1 .
  • the depth L d of the hole 72 is greater than the length Lp of the protrusion.
  • the second side 16 of the base 12 will contact the top of the receptacle 70. This contact prevents the dispenser protrusion from making contact with the floor 74 of the receptacle, thus reducing, if not eliminating entirely, the effect of a vacuum and/or the capillary effect.
  • FIG. 4 A second embodiment is illustrated in FIG. 4 , in which the side wall 78 is tapered and the diameter of the side wall 32 of the protrusion 28 may engage the side wall 78 at a point above the floor 74, thus physically preventing the dispenser protrusion from making contact with the floor 74 of the receptacle, thus reducing, if not eliminating entirely, the effect of a vacuum and/or the capillary effect.
  • the interior of the hole 72 can include an interior projection 76 that limits the degree of insertion of the protrusion 28 into the hole 72. This interior projection may be accomplished during the manufacture or molding of the receptacle.
  • the protrusion tip 30 is spaced from the interior floor 74 at the bottom of the hole 72. That is, various means are provided maintain the protrusion tip 30 spaced a desired distance from the floor 74 of the receptacle.
  • the test tube may be moved toward the fluid dispenser 10 and/or the fluid dispenser 10 may be moved toward the test tube such that the shoulder 26 causes the inward flexing of the closure 52 relative to the test tube, as is shown in FIG. 1 .
  • the volume of the interior of the test tube is reduced thereby increasing the pressure within the interior of the test tube and the pressure increase ultimately results in a pumping or dispensing of a corresponding small volume (such as a droplet 61) of the fluid 60 from the test tube.
  • a droplet 61 of fluid 60 can enter the flow passage 34 through the inlet opening 36, flow through the flow passage 34 and exit through the outlet opening 38.
  • the fluid can be dispensed into the hole 72. This process can be repeated as many times as necessary to dispense the desired amount of fluid from the test tube directly into the cartridge hole 72.
  • FIG. 1 and FIG. 2 individually are, conceptually, part of the prior art.
  • the term "conceptually” is used to indicate that, inter alia, (1) the relative proportion of Lp being less than L d , is not part of the prior art, (2) the use of an interior conical or chamfered side wall to limit the depth to which the tip 30 can be inserted is not part of the prior art, and (3) the use of the interior protrusion to limit the depth to which the tip 30 can be inserted is not part of the prior art.
  • the prior art did not provide for direct transfer or direct dispensing from a container into a cartridge.
  • systems and methods described herein can facilitate the convenient and efficient dispensing fluid from a test tube into a fluid receptacle.
  • Systems and methods herein can also help to avoid contamination of the fluid to be tested.
  • By providing a spacing between the bottom 74 of the interior of the cartridge and the fluid dispenser tip 30, the possibility that fluid dispensed into the hole 72 will be inadvertently drawn back into the test tube such as by capillary action can be minimized or eliminated.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Sampling And Sample Adjustment (AREA)
EP11175868A 2010-07-29 2011-07-28 System und Verfahren zur Abgabe von Flüssigkeit aus einem Behälter und in einen Flüssigkeitsbehälter Withdrawn EP2412440A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/845,880 US20120024416A1 (en) 2010-07-29 2010-07-29 System and method for dispensing fluid from a container and into a fluid receptacle

Publications (1)

Publication Number Publication Date
EP2412440A1 true EP2412440A1 (de) 2012-02-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP11175868A Withdrawn EP2412440A1 (de) 2010-07-29 2011-07-28 System und Verfahren zur Abgabe von Flüssigkeit aus einem Behälter und in einen Flüssigkeitsbehälter

Country Status (5)

Country Link
US (1) US20120024416A1 (de)
EP (1) EP2412440A1 (de)
JP (1) JP2013011577A (de)
AU (1) AU2011205088A1 (de)
CA (1) CA2747461A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111468203A (zh) * 2020-03-20 2020-07-31 浙江拱东医疗器械股份有限公司 一种双色注塑翻盖密封结构的试剂管

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9146247B2 (en) 2011-07-22 2015-09-29 Roche Diagnostics Hematology, Inc. Sample applicator sensing and positioning
EP2872869B1 (de) 2012-07-13 2020-05-27 Roche Diagnostics Hematology, Inc. Kontrollierte abgabe von proben auf substrate
US20160271613A1 (en) * 2015-03-19 2016-09-22 Biomedical Polymers, Inc. Molded plastic needle stick accident prevention dispenser

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020143293A1 (en) * 2001-03-30 2002-10-03 Becton Dickinson And Company Adaptor for use with point-of-care testing cartridge
WO2003064996A2 (en) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Bio-safe dispenser and optical analysis disc assembly
WO2006069328A2 (en) * 2004-12-21 2006-06-29 Fastraq, Inc. Cartridge for diagnostic assays
US20070231214A1 (en) * 2006-03-28 2007-10-04 Fujifilm Corporation Pipette tip, liquid receiving structure, liquid supply device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020143293A1 (en) * 2001-03-30 2002-10-03 Becton Dickinson And Company Adaptor for use with point-of-care testing cartridge
WO2003064996A2 (en) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Bio-safe dispenser and optical analysis disc assembly
WO2006069328A2 (en) * 2004-12-21 2006-06-29 Fastraq, Inc. Cartridge for diagnostic assays
US20070231214A1 (en) * 2006-03-28 2007-10-04 Fujifilm Corporation Pipette tip, liquid receiving structure, liquid supply device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111468203A (zh) * 2020-03-20 2020-07-31 浙江拱东医疗器械股份有限公司 一种双色注塑翻盖密封结构的试剂管
CN111468203B (zh) * 2020-03-20 2024-06-07 浙江拱东医疗器械股份有限公司 一种双色注塑翻盖密封结构的试剂管

Also Published As

Publication number Publication date
JP2013011577A (ja) 2013-01-17
US20120024416A1 (en) 2012-02-02
CA2747461A1 (en) 2012-01-29
AU2011205088A1 (en) 2012-02-16

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