EP2391372A4 - Verfahren zur behandlung von östrogenrezeptor-positivem tumor mittels hemmung des x-box-bindenden proteins 1 - Google Patents
Verfahren zur behandlung von östrogenrezeptor-positivem tumor mittels hemmung des x-box-bindenden proteins 1Info
- Publication number
- EP2391372A4 EP2391372A4 EP10736464.8A EP10736464A EP2391372A4 EP 2391372 A4 EP2391372 A4 EP 2391372A4 EP 10736464 A EP10736464 A EP 10736464A EP 2391372 A4 EP2391372 A4 EP 2391372A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibition
- methods
- binding protein
- estrogen receptor
- positive cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14851809P | 2009-01-30 | 2009-01-30 | |
PCT/US2010/022552 WO2010088498A1 (en) | 2009-01-30 | 2010-01-29 | Methods for treating estrogen receptor positive cancer by x-box binding protein 1 inhibition |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2391372A1 EP2391372A1 (de) | 2011-12-07 |
EP2391372A4 true EP2391372A4 (de) | 2013-07-03 |
Family
ID=42396035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10736464.8A Withdrawn EP2391372A4 (de) | 2009-01-30 | 2010-01-29 | Verfahren zur behandlung von östrogenrezeptor-positivem tumor mittels hemmung des x-box-bindenden proteins 1 |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2391372A4 (de) |
CA (1) | CA2749947A1 (de) |
WO (1) | WO2010088498A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201291460A1 (ru) | 2010-05-28 | 2013-11-29 | Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Олигобензамидные соединения и их применение |
WO2012109238A2 (en) | 2011-02-07 | 2012-08-16 | President And Fellows Of Harvard College | Methods for increasing immune responses using agents that directly bind to and activate ire-1 |
GB201109965D0 (en) * | 2011-06-10 | 2011-07-27 | Cancer Res Inst Royal | Materials and methods for treating estrogen receptor alpher(ER) positive cancer |
US8754124B2 (en) | 2011-11-23 | 2014-06-17 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
US8835493B2 (en) | 2011-11-23 | 2014-09-16 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds for use in treating cancers |
WO2013134774A1 (en) * | 2012-03-09 | 2013-09-12 | Cornell University | Modulation of breast cancer growth by modulation of xbp1 activity |
DK3049521T3 (en) * | 2013-09-25 | 2019-04-23 | Univ Cornell | Compounds for inducing antitumor immunity and methods thereof |
WO2020011909A1 (en) * | 2018-07-11 | 2020-01-16 | Secarna Pharmaceuticals Gmbh & Co. Kg | Nucleic acid polymers inhibiting the expression of xbp1 |
US20230026844A1 (en) * | 2019-12-12 | 2023-01-26 | University Of Maryland, Baltimore | Inhibitors of Cancer Biomarkers and Uses Thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004020610A2 (en) * | 2002-08-30 | 2004-03-11 | President And Fellows Of Harvard College | Methods and compositions for modulating xbp-1 activity |
WO2007101224A2 (en) * | 2006-02-27 | 2007-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitors of the unfolded protein response and methods for their use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2396062C (en) * | 1999-12-30 | 2009-11-17 | President And Fellows Of Harvard College | Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or t cell subset activity by modulation of xbp-1 activity |
AU2002234799A1 (en) * | 2000-12-08 | 2002-06-18 | Ipsogen | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
JP2008538284A (ja) * | 2005-04-04 | 2008-10-23 | ベリデックス・エルエルシー | 乳房の腫瘍のレーザーマイクロダイセクションおよびマイクロアレイ解析が、エストロゲン受容体に関係する遺伝子および経路を明らかにする |
-
2010
- 2010-01-29 EP EP10736464.8A patent/EP2391372A4/de not_active Withdrawn
- 2010-01-29 WO PCT/US2010/022552 patent/WO2010088498A1/en active Application Filing
- 2010-01-29 CA CA2749947A patent/CA2749947A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004020610A2 (en) * | 2002-08-30 | 2004-03-11 | President And Fellows Of Harvard College | Methods and compositions for modulating xbp-1 activity |
WO2007101224A2 (en) * | 2006-02-27 | 2007-09-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitors of the unfolded protein response and methods for their use |
Non-Patent Citations (2)
Title |
---|
B. P. GOMEZ ET AL: "Human X-Box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines", THE FASEB JOURNAL, vol. 21, no. 14, 20 July 2007 (2007-07-20), pages 4013 - 4027, XP055061962, ISSN: 0892-6638, DOI: 10.1096/fj.06-7990com * |
See also references of WO2010088498A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP2391372A1 (de) | 2011-12-07 |
CA2749947A1 (en) | 2010-08-05 |
WO2010088498A1 (en) | 2010-08-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20110830 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20130603 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/113 20100101ALI20130527BHEP Ipc: A61K 31/7088 20060101ALI20130527BHEP Ipc: A61K 31/00 20060101ALI20130527BHEP Ipc: A61K 31/70 20060101AFI20130527BHEP Ipc: A61K 39/395 20060101ALI20130527BHEP Ipc: A61K 35/12 20060101ALI20130527BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20130801 |