EP2391372A4 - Verfahren zur behandlung von östrogenrezeptor-positivem tumor mittels hemmung des x-box-bindenden proteins 1 - Google Patents

Verfahren zur behandlung von östrogenrezeptor-positivem tumor mittels hemmung des x-box-bindenden proteins 1

Info

Publication number
EP2391372A4
EP2391372A4 EP10736464.8A EP10736464A EP2391372A4 EP 2391372 A4 EP2391372 A4 EP 2391372A4 EP 10736464 A EP10736464 A EP 10736464A EP 2391372 A4 EP2391372 A4 EP 2391372A4
Authority
EP
European Patent Office
Prior art keywords
inhibition
methods
binding protein
estrogen receptor
positive cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10736464.8A
Other languages
English (en)
French (fr)
Other versions
EP2391372A1 (de
Inventor
David Kiewlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Bayer Healthcare LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Publication of EP2391372A1 publication Critical patent/EP2391372A1/de
Publication of EP2391372A4 publication Critical patent/EP2391372A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP10736464.8A 2009-01-30 2010-01-29 Verfahren zur behandlung von östrogenrezeptor-positivem tumor mittels hemmung des x-box-bindenden proteins 1 Withdrawn EP2391372A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14851809P 2009-01-30 2009-01-30
PCT/US2010/022552 WO2010088498A1 (en) 2009-01-30 2010-01-29 Methods for treating estrogen receptor positive cancer by x-box binding protein 1 inhibition

Publications (2)

Publication Number Publication Date
EP2391372A1 EP2391372A1 (de) 2011-12-07
EP2391372A4 true EP2391372A4 (de) 2013-07-03

Family

ID=42396035

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10736464.8A Withdrawn EP2391372A4 (de) 2009-01-30 2010-01-29 Verfahren zur behandlung von östrogenrezeptor-positivem tumor mittels hemmung des x-box-bindenden proteins 1

Country Status (3)

Country Link
EP (1) EP2391372A4 (de)
CA (1) CA2749947A1 (de)
WO (1) WO2010088498A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012013855A (es) 2010-05-28 2013-04-08 Univ Texas Compuestos de oligobenzamida y su uso.
US9956236B2 (en) 2011-02-07 2018-05-01 Cornell University Methods for increasing immune responses using agents that directly bind to and activate IRE-1
GB201109965D0 (en) * 2011-06-10 2011-07-27 Cancer Res Inst Royal Materials and methods for treating estrogen receptor alpher(ER) positive cancer
US8835493B2 (en) 2011-11-23 2014-09-16 Board Of Regents, The University Of Texas System Oligo-benzamide compounds for use in treating cancers
WO2013078277A1 (en) 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Oligo-benzamide compounds and their use in treating cancers
WO2013134774A1 (en) * 2012-03-09 2013-09-12 Cornell University Modulation of breast cancer growth by modulation of xbp1 activity
DK3049521T3 (en) * 2013-09-25 2019-04-23 Univ Cornell Compounds for inducing antitumor immunity and methods thereof
WO2020011909A1 (en) * 2018-07-11 2020-01-16 Secarna Pharmaceuticals Gmbh & Co. Kg Nucleic acid polymers inhibiting the expression of xbp1
WO2021119561A1 (en) * 2019-12-12 2021-06-17 University Of Maryland, Baltimore Inhibitors of cancer biomarkers and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004020610A2 (en) * 2002-08-30 2004-03-11 President And Fellows Of Harvard College Methods and compositions for modulating xbp-1 activity
WO2007101224A2 (en) * 2006-02-27 2007-09-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibitors of the unfolded protein response and methods for their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1626056B1 (de) * 1999-12-30 2012-03-28 President and Fellows of Harvard College Verfahren und Zusammensetzungen zur Modulierung des Hepatozytenwachstums, der Differenzierung von Plasmazellen oder der Aktivität von T-Zellen durch Modulierung der Aktivität von XBP-1
AU2002234799A1 (en) * 2000-12-08 2002-06-18 Ipsogen Gene expression profiling of primary breast carcinomas using arrays of candidate genes
MX2007012395A (es) * 2005-04-04 2008-04-14 Johnson & Johnson Microdiseccion de laser y analisis de microarreglo de tumores de mama revelan genes y rutas relacionados con el receptor de estrogeno.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004020610A2 (en) * 2002-08-30 2004-03-11 President And Fellows Of Harvard College Methods and compositions for modulating xbp-1 activity
WO2007101224A2 (en) * 2006-02-27 2007-09-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibitors of the unfolded protein response and methods for their use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B. P. GOMEZ ET AL: "Human X-Box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines", THE FASEB JOURNAL, vol. 21, no. 14, 20 July 2007 (2007-07-20), pages 4013 - 4027, XP055061962, ISSN: 0892-6638, DOI: 10.1096/fj.06-7990com *
See also references of WO2010088498A1 *

Also Published As

Publication number Publication date
EP2391372A1 (de) 2011-12-07
WO2010088498A1 (en) 2010-08-05
CA2749947A1 (en) 2010-08-05

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Legal Events

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RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/113 20100101ALI20130527BHEP

Ipc: A61K 31/7088 20060101ALI20130527BHEP

Ipc: A61K 31/00 20060101ALI20130527BHEP

Ipc: A61K 31/70 20060101AFI20130527BHEP

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