EP2365068A3 - Enzymes for starch processing - Google Patents

Enzymes for starch processing Download PDF

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Publication number
EP2365068A3
EP2365068A3 EP11162460A EP11162460A EP2365068A3 EP 2365068 A3 EP2365068 A3 EP 2365068A3 EP 11162460 A EP11162460 A EP 11162460A EP 11162460 A EP11162460 A EP 11162460A EP 2365068 A3 EP2365068 A3 EP 2365068A3
Authority
EP
European Patent Office
Prior art keywords
enzymes
starch processing
polypeptides
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11162460A
Other languages
German (de)
French (fr)
Other versions
EP2365068A2 (en
EP2365068B1 (en
Inventor
Shiro Fukuyama
Tomoko Matsui
Chee-Leong Soon
Eric Allain
Anders Viksoe-Nielsen
Ye Liu
Junxin Duan
Wenping Wu
Lene Nonboe Andersen
Hiroaki Udagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Novozymes North America Inc
Original Assignee
Novozymes AS
Novozymes North America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes AS, Novozymes North America Inc filed Critical Novozymes AS
Publication of EP2365068A2 publication Critical patent/EP2365068A2/en
Publication of EP2365068A3 publication Critical patent/EP2365068A3/en
Application granted granted Critical
Publication of EP2365068B1 publication Critical patent/EP2365068B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C12N9/242—Fungal source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2428—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01001—Alpha-amylase (3.2.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01003—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Abstract

The present invention relates to polypeptides comprising a carbohydrate-binding module amino acid sequence and an alpha-amylase amino acid sequence as well as to the application of such polypeptides.
EP11162460.7A 2004-12-22 2005-12-22 Enzymes for starch processing Active EP2365068B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63861404P 2004-12-22 2004-12-22
US65061205P 2005-02-07 2005-02-07
EP05855308.2A EP1831385B1 (en) 2004-12-22 2005-12-22 Enzymes for starch processing

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP05855308.2A Division-Into EP1831385B1 (en) 2004-12-22 2005-12-22 Enzymes for starch processing
EP05855308.2A Division EP1831385B1 (en) 2004-12-22 2005-12-22 Enzymes for starch processing
EP05855308.2 Division 2005-12-22

Publications (3)

Publication Number Publication Date
EP2365068A2 EP2365068A2 (en) 2011-09-14
EP2365068A3 true EP2365068A3 (en) 2011-12-21
EP2365068B1 EP2365068B1 (en) 2017-03-01

Family

ID=36602341

Family Applications (3)

Application Number Title Priority Date Filing Date
EP05855308.2A Active EP1831385B1 (en) 2004-12-22 2005-12-22 Enzymes for starch processing
EP05855307.4A Active EP1831384B1 (en) 2004-12-22 2005-12-22 Polypeptides having glucoamylase activity and polynucleotides encoding same
EP11162460.7A Active EP2365068B1 (en) 2004-12-22 2005-12-22 Enzymes for starch processing

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP05855308.2A Active EP1831385B1 (en) 2004-12-22 2005-12-22 Enzymes for starch processing
EP05855307.4A Active EP1831384B1 (en) 2004-12-22 2005-12-22 Polypeptides having glucoamylase activity and polynucleotides encoding same

Country Status (10)

Country Link
US (5) US7326548B2 (en)
EP (3) EP1831385B1 (en)
JP (2) JP5160899B2 (en)
AR (1) AR051864A1 (en)
AU (2) AU2005319074B2 (en)
CA (2) CA2591745C (en)
DK (3) DK1831385T3 (en)
ES (3) ES2552635T3 (en)
MX (2) MX2007007107A (en)
WO (2) WO2006069289A2 (en)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106533A1 (en) 2003-05-30 2004-12-09 Novozymes A/S Alcohol product processes
EP1641932B1 (en) 2003-06-25 2011-05-25 Novozymes A/S Process for the hydrolysis of starch
EP1831383A1 (en) * 2004-12-22 2007-09-12 Novozymes A/S Fermentation product processes
US8841091B2 (en) 2004-12-22 2014-09-23 Novozymes Als Enzymes for starch processing
US7326548B2 (en) * 2004-12-22 2008-02-05 Novozymes Als Polypeptides having glucoamylase activity and polynucleotides encoding same
CN101268195A (en) 2005-09-20 2008-09-17 诺维信北美公司 Process of producing a fermentation product
EP1966386A4 (en) 2005-12-22 2009-06-17 Novozymes North America Inc Processes for producing a fermentation product
US8076112B2 (en) 2006-03-22 2011-12-13 Novozymes A/S Fermentation processes
MX2008013100A (en) * 2006-04-19 2008-10-27 Novozymes North America Inc Polypeptides having glucoamylase activity and polynucleotides encoding same.
DE602007003225D1 (en) * 2006-06-15 2009-12-24 Novozymes North America Inc METHOD FOR PRODUCING A STARCH HYDROLYZATE
EP2038408A1 (en) * 2006-06-22 2009-03-25 Novozymes A/S Preparation of dough and baked products
US10023881B2 (en) 2007-04-24 2018-07-17 Novozymes A/S Detoxifying pre-treated lignocellulose-containing materials
US9695549B2 (en) 2007-09-03 2017-07-04 Norozymes Als Detoxifying and recycling of washing solution used in pretreatment of lignocellulose-containing materials
WO2009030728A2 (en) * 2007-09-05 2009-03-12 Novozymes A/S Enzyme compositions with stabilizing constituent
WO2009102205A1 (en) * 2008-02-14 2009-08-20 Wageningen Universiteit Nucleotide sequences coding for cis-aconitic decarboxylase and use thereof
WO2009114403A1 (en) * 2008-03-11 2009-09-17 Danisco Us Inc., Genencor Division Use of rhizopus amylases in granular starch hydrolysis
US8530216B2 (en) 2008-05-16 2013-09-10 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
US8153006B1 (en) 2008-06-05 2012-04-10 Procorp Enterprises, Llc Anaerobic treatment process for ethanol production
EP2364363A2 (en) 2008-06-23 2011-09-14 Novozymes A/S Processes for producing fermentation products
EP2326723B1 (en) * 2008-08-20 2016-07-06 Novozymes A/S Processes for producing fermentation products
DK2344650T3 (en) 2008-09-30 2014-07-14 Novozymes North America Inc IMPROVEMENT OF ENZYMATIC HYDROLYSE OF TREATED LIGNOCELLULOSE-CONTAINING DISTILLERS DRIED GRAIN WITH SOLUBLES (DDG / S)
EP2358878B1 (en) 2008-11-20 2014-10-15 Novozymes Inc. Polypeptides having amylolytic enhancing activity and polynucleotides encoding same
US20120028299A1 (en) 2008-12-30 2012-02-02 Novozymes North America, Inc. Enzymatic Hydrolysis Of Pretreated Lignocellulose-Containing Material With Dissolved Air Flotation Sludge
WO2010078392A2 (en) 2008-12-31 2010-07-08 Novozymes North America, Inc. Processes of producing fermentation products
WO2010088447A1 (en) * 2009-01-30 2010-08-05 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
WO2010091221A1 (en) 2009-02-06 2010-08-12 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
JP5193905B2 (en) * 2009-03-04 2013-05-08 麒麟麦酒株式会社 Method for producing ethanol from cereal raw materials
AU2010238649B2 (en) 2009-04-24 2013-11-21 Novozymes North America, Inc. Antistaling process for flat bread
CN102471784A (en) 2009-07-07 2012-05-23 诺维信公司 Process for treating a substrate with an enzyme
WO2011008785A2 (en) 2009-07-17 2011-01-20 Novozymes A/S A method of analyzing cellulose decay in cellulosic material hydrolysis
CN102665425A (en) 2009-09-30 2012-09-12 诺维信公司 Steamed bread preparation methods and steamed bread improving compositions
EP2507372B1 (en) 2009-11-30 2015-02-25 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
WO2011066560A1 (en) 2009-11-30 2011-06-03 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
WO2011068803A1 (en) 2009-12-01 2011-06-09 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
CN102791854A (en) 2009-12-22 2012-11-21 诺维信公司 Pullulanase variants and uses thereof
CA2786006C (en) 2010-01-04 2020-03-10 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
CA2788548A1 (en) 2010-01-29 2011-08-04 Novozymes A/S Biogas production process with enzymatic pre-treatment
WO2011100161A1 (en) 2010-02-09 2011-08-18 Novozymes North America, Inc. Addition of alpha - glucosidase and cobalt for producing fermentation products from starch
CN102918160B (en) 2010-03-30 2016-01-06 诺维信北美公司 Produce the method for tunning
MX338068B (en) 2010-04-14 2016-04-01 Novozymes As Polypeptides having glucoamylase activity and polynucleotides encoding same.
AU2011263706B2 (en) 2010-06-11 2014-07-24 Novozymes A/S Enzymatic flour correction
CN103068989B (en) 2010-06-25 2015-09-09 诺维信公司 There are the polynucleotide of promoter activity
WO2011161207A1 (en) 2010-06-25 2011-12-29 Novozymes A/S Polynucleotides having promoter activity
CN103068978B (en) 2010-06-25 2017-01-18 诺维信公司 Polynucleotides having leader sequence function
WO2012018775A1 (en) 2010-08-02 2012-02-09 Novozymes North America, Inc. Process of producing a fermentation product
US9732332B2 (en) * 2010-11-08 2017-08-15 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
ES2649555T3 (en) * 2010-11-08 2018-01-12 Novozymes A/S Polypeptides with glucoamylase activity and polynucleotides that encode them
CA2817224A1 (en) 2010-11-19 2012-05-24 Novozymes North America, Inc. Processes of producing a fermentation product
EP2646558B1 (en) 2010-11-30 2016-07-20 Novozymes, Inc. Promoters for expressing genes in a fungal cell
US8924138B2 (en) 2010-12-07 2014-12-30 Vnomics Corp. System and method for measuring and reducing vehicle fuel waste
EP2654567B1 (en) 2010-12-22 2018-04-04 Novozymes North America, Inc. Process for producing fermentation products from starch containing materials
US20130330797A1 (en) 2011-01-04 2013-12-12 Novozymes A/S Process for Producing Biogas from Pectin and Lignocellulose Containing Material
WO2012109119A2 (en) 2011-02-07 2012-08-16 Novozymes North America, Inc. Process of producing a fermentation product
EP2527432A1 (en) 2011-05-23 2012-11-28 Novozymes A/S Bi-directional cytosine deaminase-encoding selection marker
EP2527448A1 (en) 2011-05-23 2012-11-28 Novozymes A/S Simultaneous site-specific integrations of multiple gene-copies in filamentous fungi
US20140106427A1 (en) 2011-06-28 2014-04-17 Novozymes A/S Biogas From Enzyme-Treated Bagasse
WO2013006756A2 (en) 2011-07-06 2013-01-10 Novozymes A/S Alpha amylase variants and polynucleotides encoding same
BR112013032861A2 (en) 2011-07-22 2017-01-24 Novozymes North America Inc methods for increasing cellulolytic enzyme activity during hydrolysis of cellulosic material, for hydrolyzing a pretreated cellulosic material, for producing a fermentation product, and for fermenting a pretreated cellulosic material
WO2013029496A1 (en) 2011-08-26 2013-03-07 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
MX351154B (en) 2011-09-06 2017-10-04 Novozymes As Glucoamylase variants and polynucleotides encoding same.
EP2748189B1 (en) * 2011-09-09 2017-11-15 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
US9567574B2 (en) 2011-09-09 2017-02-14 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
US20150031091A1 (en) * 2011-09-30 2015-01-29 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
US9909112B2 (en) 2011-09-30 2018-03-06 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
ES2627987T3 (en) * 2011-10-11 2017-08-01 Novozymes North America, Inc. Liquefaction process to produce fermentation products
IN2014CN03468A (en) 2011-10-11 2015-07-03 Novozymes As
US8697412B2 (en) 2011-11-28 2014-04-15 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
WO2013082486A1 (en) 2011-12-02 2013-06-06 Novozymes A/S Processes for producing fermentation products
WO2013083801A2 (en) 2011-12-09 2013-06-13 Novozymes A/S Biogas from substrates comprising animal manure and enzymes
US20150017670A1 (en) 2011-12-21 2015-01-15 Novozymes, Inc. Methods For Determining The Degradation Of A Biomass Material
ES2935920T3 (en) 2012-03-30 2023-03-13 Novozymes North America Inc Production processes of fermentation products
CN104334738B (en) 2012-03-30 2019-01-29 诺维信北美公司 The method for producing tunning
AR090949A1 (en) 2012-05-11 2014-12-17 Danisco Us Inc METHOD OF USING ASPERGILLUS CLAVATUS a-AMYLASE FOR SACARIFICATION
WO2014006140A1 (en) 2012-07-06 2014-01-09 Novozymes A/S Liquid enzyme composition and method for enzyme recovery
AR092113A1 (en) * 2012-08-16 2015-03-25 Danisco Us Inc METHOD OF USING ASPERGILLUS CLAVATUS AND ISOAMYLASE A-AMYLASE FOR SACARIFICATION
EP2884852B1 (en) 2012-08-17 2019-05-15 Novozymes A/S Thermostable asparaginase variants and polynucleotides encoding same
EP2885409A1 (en) 2012-08-17 2015-06-24 Novozymes A/S Methods for co-silencing expression of genes in filamentous fungal strains and uses thereof
WO2014039773A1 (en) * 2012-09-07 2014-03-13 Novozymes A/S Glucoamylase variants and polynucleotides encoding same and uses thereof
MX2015004329A (en) * 2012-10-10 2015-06-10 Danisco Inc Method of using alpha-amylase from talaromyces emersonii for saccharification.
US9765317B2 (en) 2012-12-17 2017-09-19 Novozymes A/S Alpha-amylases and polynucleotides encoding same
CN103275952B (en) * 2012-12-23 2014-09-24 北京挑战生物技术有限公司 Middle temperature acidic amylase AMY-8 and gene and application thereof
US11252968B2 (en) 2013-04-05 2022-02-22 Novozymes A/S Method of producing a baked product with alpha-amylase, lipase and phospholipase
ES2674701T3 (en) 2013-04-30 2018-07-03 Novozymes A/S Variants of glucoamylase and polynucleotides that encode them
WO2014177541A2 (en) 2013-04-30 2014-11-06 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
ES2754203T3 (en) 2013-06-24 2020-04-16 Novozymes As Oil extraction process from diluted stillage
CA2915336C (en) 2013-07-17 2024-03-12 Novozymes A/S Pullulanase chimeras and polynucleotides encoding same
CN105431528A (en) 2013-08-30 2016-03-23 诺维信公司 Enzyme composition and uses thereof
CN105934518A (en) 2013-09-11 2016-09-07 诺维信公司 Processes for producing fermentation products
CN105722969A (en) 2013-10-28 2016-06-29 丹尼斯科美国公司 Large scale genetically engineered active dry yeast
DK3097192T3 (en) 2014-01-22 2018-11-19 Novozymes As PULLULANASE VARIATIONS AND POLYNUCLEOTIDES CODING THEM
EP3102051B1 (en) 2014-02-07 2020-04-08 Novozymes A/S Compositions for producing glucose syrups
WO2015143144A1 (en) 2014-03-19 2015-09-24 Novozymes A/S Method for enhancing activity of an x143 polypeptide
US11072786B2 (en) 2014-04-10 2021-07-27 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
BE1022042B1 (en) 2014-09-29 2016-02-08 Puratos Nv IMPROVED CAKE FISH
WO2016062875A2 (en) 2014-10-23 2016-04-28 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
JP6277108B2 (en) * 2014-10-31 2018-02-07 日本ジフィー食品株式会社 Granular dry food and method for producing the same
WO2016087445A1 (en) 2014-12-01 2016-06-09 Novozymes A/S Improved production of glucose syrups
AU2016225049B2 (en) 2015-02-27 2022-03-31 Microbiogen Pty. Ltd. Processes of producing ethanol using a fermenting organism
WO2016196202A1 (en) 2015-05-29 2016-12-08 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
US10676727B2 (en) 2015-06-18 2020-06-09 Novozymes A/S Polypeptides having trehalase activity and the use thereof in process of producing fermentation products
WO2017015329A1 (en) 2015-07-23 2017-01-26 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
WO2017087330A1 (en) 2015-11-17 2017-05-26 Novozymes A/S Yeast strains suitable for saccharification and fermentation expressing glucoamylase and/or alpha-amylase
US10689630B2 (en) 2015-12-22 2020-06-23 Novozymes A/S Processes for producing fermentation products
WO2018075430A1 (en) 2016-10-17 2018-04-26 Novozymes A/S Methods of reducing foam during ethanol fermentation
WO2018093285A1 (en) 2016-11-18 2018-05-24 Baltika Breweries - Part Of The Carlsberg Group Method of producing a grain malt and the malt product obtained in this way
WO2018098381A1 (en) 2016-11-23 2018-05-31 Novozymes A/S Improved yeast for ethanol production
WO2018098124A1 (en) 2016-11-23 2018-05-31 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
EP3548615A1 (en) 2016-11-29 2019-10-09 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
CA3064042A1 (en) 2017-06-02 2018-12-06 Novozymes A/S Improved yeast for ethanol production
ES2908190T3 (en) 2017-06-28 2022-04-28 Novozymes As Polypeptides with trehalase activity and polynucleotides encoding them
MX2020001282A (en) 2017-08-08 2020-03-12 Novozymes As Polypeptides having trehalase activity and the use thereof in process of producing fermentation products.
US20200181663A1 (en) 2017-08-30 2020-06-11 Novozymes A/S Combined use of at least one endoprotease and at least one exo-protease in an ssf process for improving ethanol yield
BR112020004476A2 (en) 2017-09-15 2020-09-08 Novozymes A/S process for producing a fermentation product, and using a combination of enzymes
CN111148830A (en) 2017-10-04 2020-05-12 诺维信公司 Polypeptides having protease activity and polynucleotides encoding same
US11326187B2 (en) 2017-10-23 2022-05-10 Novozymes A/S Processes for producing a fermentation product
DE102017220757A1 (en) 2017-11-21 2019-05-23 Henkel Ag & Co. Kgaa Amylase and such containing detergent or cleaning agent
CN113286871A (en) 2018-01-29 2021-08-20 诺维信公司 Microorganisms with enhanced nitrogen utilization for ethanol production
US11473109B2 (en) 2018-02-15 2022-10-18 Novozymes A/S Yeast for ethanol production
CN112105729A (en) 2018-04-09 2020-12-18 诺维信公司 Polypeptides having alpha-amylase activity and polynucleotides encoding same
CN108611339B (en) * 2018-05-11 2021-05-25 中国农业科学院北京畜牧兽医研究所 Glucoamylase TlGa15 and gene and application thereof
DE102018208446A1 (en) 2018-05-29 2019-12-05 Henkel Ag & Co. Kgaa Improved washing performance with a new alpha-amylase from Fomes fomentarius (Ffo)
DE102018208443A1 (en) 2018-05-29 2019-12-05 Henkel Ag & Co. Kgaa Improved washing performance with a new alpha-amylase Irpex lacteus (IIa)
DE102018208444A1 (en) 2018-05-29 2019-12-05 Henkel Ag & Co. Kgaa Improved washing performance with a new alpha-amylase from Trametes hirsuta (Thi)
DE102018208445A1 (en) 2018-05-29 2019-12-05 Henkel Ag & Co. Kgaa Improved washing performance with a new alpha-amylase from Fomitopsis pinicola (Fpi)
MX2020012754A (en) 2018-05-31 2021-02-26 Novozymes As Processes for enhancing yeast growth and productivity.
WO2019238423A1 (en) 2018-06-12 2019-12-19 Novozymes A/S Less added sugar in baked products
EP3821024A1 (en) 2018-07-11 2021-05-19 Novozymes A/S Processes for producing fermentation products
CA3107110A1 (en) 2018-07-25 2020-01-30 Novozymes A/S Enzyme-expressing yeast for ethanol production
WO2020076697A1 (en) 2018-10-08 2020-04-16 Novozymes A/S Enzyme-expressing yeast for ethanol production
CN109385413B (en) * 2018-10-09 2021-03-26 中国农业科学院北京畜牧兽医研究所 Glucoamylase TlGA1931 and gene and application thereof
EP3918060A1 (en) 2019-01-31 2021-12-08 Novozymes A/S Polypeptides having xylanase activity and use thereof for improving the nutritional quality of animal feed
CN113490740A (en) 2019-03-18 2021-10-08 诺维信公司 Polypeptides having pullulanase activity suitable for use in liquefaction
BR112021017085A2 (en) 2019-04-02 2022-02-08 Novozymes As Process of producing a fermentation product
CA3146541A1 (en) 2019-07-09 2021-01-14 Dupont Nutrition Biosciences Aps Fat coated particulate enzyme compositions
MX2021015821A (en) 2019-07-26 2022-02-03 Novozymes As Microorganisms with improved nitrogen transport for ethanol production.
AR119596A1 (en) 2019-08-05 2021-12-29 Novozymes As ENZYME BLENDS AND PROCESSES FOR PRODUCING A HIGH-PROTEIN FOOD INGREDIENT FROM A BY-PRODUCT OF WHOLE VINASE
US20220307036A1 (en) 2019-08-06 2022-09-29 Novozymes A/S Fusion proteins for improved enzyme expression
WO2021046073A1 (en) 2019-09-05 2021-03-11 Dupont Nutrition Biosciences Aps Feed composition
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BR112022011634A2 (en) 2019-12-16 2022-08-30 Novozymes As PROCESSES FOR PRODUCTION OF A FERMENTATION PRODUCT, FOR DECREASE THE QUANTITY OF RESIDUAL STARCH PRESENT IN A LIQUEPHATE AND FOR INCREASE THE QUANTITY OF SHORT-CHAIN OLIGOSACCHARIDES PRESENT IN A LIQUEFATE
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WO2023079050A1 (en) 2021-11-04 2023-05-11 Dsm Ip Assets B.V. Recombinant yeast cell
WO2023079048A1 (en) 2021-11-04 2023-05-11 Dsm Ip Assets B.V. Process for the production of ethanol and recombinant yeast cell
WO2023122676A1 (en) * 2021-12-24 2023-06-29 Danisco Us Inc. Hybrid glucoamylases and methods of use thereof
WO2023213424A1 (en) 2022-05-04 2023-11-09 Novozymes A/S Brewing with thermostable amg variants
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
WO2023225510A1 (en) 2022-05-17 2023-11-23 Dupont Nutrition Biosciences Aps Feed additive comprising enzyme combinations
WO2024046595A1 (en) 2022-09-01 2024-03-07 Novozymes A/S Baking with thermostable amyloglucosidase (amg) variants (ec 3.2.1.3) and low added sugar
WO2024046594A1 (en) 2022-09-01 2024-03-07 Novozymes A/S Baking with thermostable amg glucosidase variants (ec 3.2.1.3) and low or no added emulsifier

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016633A1 (en) * 1996-10-11 1998-04-23 Novo Nordisk A/S Alpha-amylase fused to cellulose binding domain, for starch degradation
WO2003056002A1 (en) * 2001-12-21 2003-07-10 Unisearch Limited Improvement in amylase stability
WO2004055178A1 (en) * 2002-12-17 2004-07-01 Novozymes A/S Thermostable alpha-amylases
WO2006065579A2 (en) * 2004-12-02 2006-06-22 Novozymes North America, Inc. Desizing process
WO2006066579A1 (en) * 2004-12-22 2006-06-29 Novozymes A/S Starch process
WO2006066582A1 (en) * 2004-12-22 2006-06-29 Novozymes A/S Fermentation product processes

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4009074A (en) 1975-03-13 1977-02-22 Cpc International Inc. Preparation of levulose from granular starch
JPS5534046A (en) 1978-09-01 1980-03-10 Cpc International Inc Novel glucoamyrase having excellent heat resistance and production
JPS59140896A (en) 1983-01-17 1984-08-13 Norin Suisansyo Shokuhin Sogo Kenkyusho Saccharification of starch using enzyme produced by fungus of chalara genus
NO840200L (en) 1983-01-28 1984-07-30 Cefus Corp GLUCOAMYLASE CDNA.
JPS6070079A (en) * 1983-01-28 1985-04-20 シタス　コ−ポレイシヨン Glucoamylase gene
DK135983D0 (en) 1983-03-25 1983-03-25 Novo Industri As THE AMYLASEENZYM SYMBOL PRODUCT AND PROCEDURE FOR ITS MANUFACTURING AND USING
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US4536477A (en) 1983-08-17 1985-08-20 Cpc International Inc. Thermostable glucoamylase and method for its production
EP0140410B2 (en) 1983-09-11 1996-12-04 Gist-Brocades N.V. Novel enzyme product and its use in the saccharification of starch
US4587215A (en) 1984-06-25 1986-05-06 Uop Inc. Highly thermostable amyloglucosidase
ATE95837T1 (en) 1984-08-06 1993-10-15 Genencor Inc ENZYMATIC HYDROLYSIS OF GRANULAR STARCH DIRECTLY TO GLUCOSE.
US4628031A (en) 1984-09-18 1986-12-09 Michigan Biotechnology Institute Thermostable starch converting enzymes
US4885249A (en) 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
JPS62126989A (en) 1985-11-26 1987-06-09 Godo Shiyusei Kk Method for saccharifying starch by using enzyme produced by basidiomycetes belonging to genus corticium without steaming or boiling
DK122686D0 (en) 1986-03-17 1986-03-17 Novo Industri As PREPARATION OF PROTEINS
US4727046A (en) 1986-07-16 1988-02-23 Fairchild Semiconductor Corporation Method of fabricating high performance BiCMOS structures having poly emitters and silicided bases
WO1989001969A1 (en) 1987-09-04 1989-03-09 Novo-Nordisk A/S Process for the production of protein products in aspergillus and promoters for use in aspergillus
US5137819A (en) 1988-07-08 1992-08-11 University Of British Columbia Cellulose binding fusion proteins for immobilization and purification of polypeptides
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
IL97645A (en) 1990-03-23 1997-03-18 Gist Brocades Nv Production of enzymes in seeds and their use
KR100237148B1 (en) 1990-05-09 2000-01-15 한센 핀 베네드 A cellulase preparation comprising an endoglucanase enzyme
US5162210A (en) 1990-06-29 1992-11-10 Iowa State University Research Foundation Process for enzymatic hydrolysis of starch to glucose
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5231017A (en) 1991-05-17 1993-07-27 Solvay Enzymes, Inc. Process for producing ethanol
US5496934A (en) 1993-04-14 1996-03-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acids encoding a cellulose binding domain
US5861271A (en) 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
DE4343591A1 (en) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Process for the evolutionary design and synthesis of functional polymers based on shape elements and shape codes
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
CN1192108C (en) 1994-06-03 2005-03-09 诺沃奇梅兹生物技术有限公司 Purified myceliophthora laccase and nucleic acid encoding same
US6060305A (en) 1994-06-30 2000-05-09 Novo Nordisk Biotech, Inc. Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system
WO1996000787A1 (en) 1994-06-30 1996-01-11 Novo Nordisk Biotech, Inc. Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein
AR000862A1 (en) 1995-02-03 1997-08-06 Novozymes As VARIANTS OF A MOTHER-AMYLASE, A METHOD TO PRODUCE THE SAME, A DNA STRUCTURE AND A VECTOR OF EXPRESSION, A CELL TRANSFORMED BY SUCH A DNA STRUCTURE AND VECTOR, A DETERGENT ADDITIVE, DETERGENT COMPOSITION, A COMPOSITION FOR AND A COMPOSITION FOR THE ELIMINATION OF
KR100511499B1 (en) 1995-02-03 2005-12-21 노보자임스 에이/에스 A method of designing alpha-amylase mutants with predetermined properties
US6093562A (en) 1996-02-05 2000-07-25 Novo Nordisk A/S Amylase variants
DK0904360T3 (en) 1996-04-30 2013-10-14 Novozymes As Alpha-amylasemutanter
US6537792B1 (en) * 1996-07-24 2003-03-25 Iowa State University Protein engineering of glucoamylase to increase pH optimum, substrate specificity and thermostability
ES2256895T3 (en) 1996-09-19 2006-07-16 Novozymes A/S GUEST CELLS AND PROTEIN PRODUCTION METHODS.
BR9713242A (en) 1996-09-30 2000-01-18 Exseed Genetics L L C Encapsulation of polypeptides within the starch matrix
EP1023439B1 (en) 1997-10-13 2009-02-18 Novozymes A/S alpha-AMYLASE MUTANTS
ES2321043T3 (en) 1997-11-26 2009-06-01 Novozymes A/S THERMOSTABLE GLUCOAMYLASE.
DE69812699T2 (en) 1997-12-02 2004-03-11 Rockwool International A/S METHOD FOR PRODUCING GLASS-TYPE ARTIFICIAL FIBERS
DE29721138U1 (en) * 1997-12-03 1999-04-08 Iro Patent Ag Thread brake device
NZ505820A (en) 1998-02-27 2002-10-25 Novozymes As Enzyme variants based on the 3D structure of maltogenic alpha-amylase that have an altered pH optimum, thermostability, specific activity, cleavage pattern and ability to reduce the staling of bread
US6352851B1 (en) * 1998-07-15 2002-03-05 Novozymes A/S Glucoamylase variants
MXPA01000352A (en) 1998-07-15 2002-06-04 Novozymes As Glucoamylase variants.
DE69932345T2 (en) 1998-10-26 2007-07-19 Novozymes A/S PREPARATION AND SCALING OF INTERESTING DNA BANKS IN CELLS OF FILAMENTOUS MUSHROOMS
ATE414782T1 (en) 1998-12-23 2008-12-15 Novozymes As METHOD FOR PRODUCING POLYPEPTIDES IN MUTATED ASPERGILLUS CELLS
EP2278016B1 (en) 1999-03-22 2012-09-26 Novozymes Inc. Promoter sequences derived from Fusarium Venenatum and uses thereof
ATE360686T1 (en) 1999-03-30 2007-05-15 Novozymes As ALPHA-AMYLASE VARIANTS
WO2000075296A1 (en) * 1999-06-02 2000-12-14 Novozymes A/S Novel glucoamylase
US7135619B1 (en) 1999-06-11 2006-11-14 Wageningen Universiteit Expression in plants of starch binding domains and/or of protein-fusions containing starch binding domains
EP2009098A1 (en) 1999-07-09 2008-12-31 Novozymes A/S Glucoamylase variant
CA2408406C (en) 2000-06-02 2014-07-29 Novozymes A/S Cutinase variants
EP2308980A3 (en) 2000-08-01 2011-04-27 Novozymes A/S Alpha-amylase mutants with altered properties
ITBO20010102A1 (en) 2001-02-26 2002-08-26 Gd Spa METHOD AND UNIT FOR THE FORMATION OF A TOBACCO CORD
WO2003066826A2 (en) 2002-02-08 2003-08-14 Genencor International, Inc. Methods for producing ethanol from carbon substrates
JP2006504394A (en) 2002-02-08 2006-02-09 ジェネンコー・インターナショナル・インク Method for producing a final product from a carbon substrate
AU2003208074A1 (en) 2002-07-29 2004-02-16 Tagawasangyo Co., Ltd. Method of patterning molded article surface
AU2004208860A1 (en) 2003-02-06 2004-08-19 Novozymes A/S Human heavy chain antibody expression in filamentous fungi
ATE454446T1 (en) 2003-03-10 2010-01-15 Novozymes As METHOD FOR PRODUCING ALCOHOL
EP2534961A1 (en) 2003-03-10 2012-12-19 POET Research, Inc. Method for producing ethanol using raw starch
DE602004022929D1 (en) 2003-03-31 2009-10-15 Novozymes Inc PROCESS FOR THE PRODUCTION OF BIOLOGICAL SUBSTANCES I
WO2004111218A2 (en) 2003-06-13 2004-12-23 Novozymes A/S Method for producing glucoamylases and their uses
EP1641932B1 (en) * 2003-06-25 2011-05-25 Novozymes A/S Process for the hydrolysis of starch
MXPA06000212A (en) * 2003-06-25 2006-03-21 Novozymes As Enzymes for starch processing.
DK2213732T3 (en) * 2003-10-28 2014-08-18 Novozymes North America Inc Hybrid glucoamylases
US20060147581A1 (en) * 2004-12-22 2006-07-06 Novozymes A/S Hybrid enzymes
US7326548B2 (en) * 2004-12-22 2008-02-05 Novozymes Als Polypeptides having glucoamylase activity and polynucleotides encoding same
US20060257964A1 (en) * 2005-05-16 2006-11-16 Biosafe Systems L.L.C. Method of measuring the concentration of hydrogen peroxide, peroxyacetic acid, chlorinated compounds and other aqueous oxidizer compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016633A1 (en) * 1996-10-11 1998-04-23 Novo Nordisk A/S Alpha-amylase fused to cellulose binding domain, for starch degradation
WO2003056002A1 (en) * 2001-12-21 2003-07-10 Unisearch Limited Improvement in amylase stability
WO2004055178A1 (en) * 2002-12-17 2004-07-01 Novozymes A/S Thermostable alpha-amylases
WO2006065579A2 (en) * 2004-12-02 2006-06-22 Novozymes North America, Inc. Desizing process
WO2006066579A1 (en) * 2004-12-22 2006-06-29 Novozymes A/S Starch process
WO2006066582A1 (en) * 2004-12-22 2006-06-29 Novozymes A/S Fermentation product processes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MACHOVIC MARTIN ET AL: "A new clan of CBM families based on bioinformatics of starch-binding domains from families CBM20 and CBM21", FEBS JOURNAL, vol. 272, no. 21, November 2005 (2005-11-01), pages 5497 - 5513, XP002508400 *
NAGASAKA Y ET AL: "Purification and properties of the raw-starch-digesting glucoamylases from Corticium rolfsii", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 50, no. 3, 1 September 1998 (1998-09-01), pages 323 - 330, XP002506425, ISSN: 0175-7598, DOI: 10.1007/S002530051299 *

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