EP2323679A4 - Clip-hemmer und verfahren zur modulierung der immunfunktion - Google Patents
Clip-hemmer und verfahren zur modulierung der immunfunktionInfo
- Publication number
- EP2323679A4 EP2323679A4 EP09800699A EP09800699A EP2323679A4 EP 2323679 A4 EP2323679 A4 EP 2323679A4 EP 09800699 A EP09800699 A EP 09800699A EP 09800699 A EP09800699 A EP 09800699A EP 2323679 A4 EP2323679 A4 EP 2323679A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- immune function
- modulating immune
- clip inhibitors
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13155864.5A EP2633864A1 (de) | 2008-07-25 | 2009-07-23 | Clip-Hemmer und Verfahren zur Modulation der Immunfunktion |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13594208P | 2008-07-25 | 2008-07-25 | |
PCT/US2009/004328 WO2010011347A2 (en) | 2008-07-25 | 2009-07-23 | Clip inhibitors and methods of modulating immune function |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2323679A2 EP2323679A2 (de) | 2011-05-25 |
EP2323679A4 true EP2323679A4 (de) | 2012-08-22 |
Family
ID=41570789
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13155864.5A Withdrawn EP2633864A1 (de) | 2008-07-25 | 2009-07-23 | Clip-Hemmer und Verfahren zur Modulation der Immunfunktion |
EP09800699A Withdrawn EP2323679A4 (de) | 2008-07-25 | 2009-07-23 | Clip-hemmer und verfahren zur modulierung der immunfunktion |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13155864.5A Withdrawn EP2633864A1 (de) | 2008-07-25 | 2009-07-23 | Clip-Hemmer und Verfahren zur Modulation der Immunfunktion |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP2633864A1 (de) |
AU (1) | AU2009274512A1 (de) |
CA (1) | CA2737146A1 (de) |
WO (1) | WO2010011347A2 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015035414A1 (en) * | 2013-09-09 | 2015-03-12 | The Texas A&M University System | Treating neurological disorders |
EP3517117A1 (de) * | 2018-01-30 | 2019-07-31 | Medizinische Universität Wien | Arzneimittel zur vorbeugung oder behandlung von rhinovirusinfektionen |
US20230226135A9 (en) * | 2019-07-19 | 2023-07-20 | Bcell Solutions, Inc. | Acetylcholine modulation of immune function |
EP3818989A1 (de) * | 2020-03-12 | 2021-05-12 | Universität Greifswald | Peptide und oligonukleotide für einen sars-cov-2-impfstoff |
Citations (3)
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---|---|---|---|---|
WO2004043361A2 (en) * | 2002-11-08 | 2004-05-27 | Genentech, Inc. | Compositions and methods for the treatment of natural killer cell related diseases |
WO2005079523A2 (en) * | 2004-02-18 | 2005-09-01 | University Of Georgia Research Foundation, Inc. | Novel teleost derived antimicrobal polypeptides |
WO2009055005A2 (en) * | 2007-10-23 | 2009-04-30 | The Regents Of The University Of Colorado | Competitive inhibitors of invariant chain expression and/or ectopic clip binding |
Family Cites Families (54)
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US565354A (en) | 1896-08-04 | James h | ||
US1164308A (en) | 1914-11-02 | 1915-12-14 | Nils Nilson | Traction-plow. |
US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
US4415553A (en) | 1973-08-06 | 1983-11-15 | Dso "Pharmachim" | Compositions, processes for their preparation and method for treatment of neoplasms |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
US5520914A (en) | 1987-08-06 | 1996-05-28 | President And Fellows Of Harvard College | Antibodies to angiogenin: immunotherapeutic agents |
US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
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GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
WO1991003162A1 (en) | 1989-08-31 | 1991-03-21 | City Of Hope | Chimeric dna-rna catalytic sequences |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5972922A (en) | 1990-06-11 | 1999-10-26 | Alcon Laboratories, Inc. | Steroids which inhibit angiogenesis |
JP3257675B2 (ja) | 1990-10-12 | 2002-02-18 | マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー.ファウ. | 修飾リボザイム |
DE4216134A1 (de) | 1991-06-20 | 1992-12-24 | Europ Lab Molekularbiolog | Synthetische katalytische oligonukleotidstrukturen |
ATE297465T1 (de) | 1991-11-25 | 2005-06-15 | Enzon Inc | Verfahren zur herstellung von multivalenten antigenbindenden proteinen |
US5407686A (en) | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
US5652094A (en) | 1992-01-31 | 1997-07-29 | University Of Montreal | Nucleozymes |
WO1993016177A1 (en) | 1992-02-11 | 1993-08-19 | Cell Genesys, Inc. | Homogenotization of gene-targeting events |
NZ254646A (en) | 1992-08-19 | 1997-06-24 | Merrell Dow Pharma | Inhibition of angiogenesis by administration of a polyamide and a polyurea |
EP0752248B1 (de) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma |
US5792771A (en) | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
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US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
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JPH09507487A (ja) | 1994-01-05 | 1997-07-29 | アーキュール,インコーポレーテッド | 選ばれた性質を有するアミンイミドおよびオキサゾロンをベースとした分子の系統的モジュール製造 |
US5583034A (en) | 1994-02-22 | 1996-12-10 | La Jolla Institute For Allergy And Immunology | Enhancement of adoptosis using antisense oligonucleotides |
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US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
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US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
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US5696092A (en) | 1995-03-07 | 1997-12-09 | George Washington University | Methods and compositions for inhibiting metastasis of epithelial cell-derived cancers |
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US5639757A (en) | 1995-05-23 | 1997-06-17 | Pfizer Inc. | 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors |
AU7690896A (en) * | 1995-09-14 | 1997-04-01 | Universitat Tubingen | Recombinant polypeptide based on the primary sequence of the invariant chain with at least one primary sequence of a specific t-cell epitope or a protein derivative and nucleic acids coding for this recombinant polypeptide |
US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
AU1087797A (en) * | 1996-01-03 | 1997-08-01 | Australian National University, The | Clip analogues and autoimmune disease |
CA2253382A1 (en) | 1996-01-16 | 1997-07-24 | Ribozyme Pharmaceuticals, Inc. | Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules |
US6750044B1 (en) | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
-
2009
- 2009-07-23 AU AU2009274512A patent/AU2009274512A1/en not_active Abandoned
- 2009-07-23 EP EP13155864.5A patent/EP2633864A1/de not_active Withdrawn
- 2009-07-23 CA CA2737146A patent/CA2737146A1/en not_active Abandoned
- 2009-07-23 WO PCT/US2009/004328 patent/WO2010011347A2/en active Application Filing
- 2009-07-23 EP EP09800699A patent/EP2323679A4/de not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004043361A2 (en) * | 2002-11-08 | 2004-05-27 | Genentech, Inc. | Compositions and methods for the treatment of natural killer cell related diseases |
WO2005079523A2 (en) * | 2004-02-18 | 2005-09-01 | University Of Georgia Research Foundation, Inc. | Novel teleost derived antimicrobal polypeptides |
WO2009055005A2 (en) * | 2007-10-23 | 2009-04-30 | The Regents Of The University Of Colorado | Competitive inhibitors of invariant chain expression and/or ectopic clip binding |
Non-Patent Citations (8)
Title |
---|
ADAMS SHARLENE ET AL: "Biological activity and therapeutic potential of homologs of an Ii peptide which regulates antigenic peptide binding to cell surface MHC class II molecules", ARZNEIMITTEL FORSCHUNG. DRUG RESEARCH, ECV EDITIO CANTOR VERLAG, AULENDORF, DE, vol. 47, no. 9, 1 January 1997 (1997-01-01), pages 1069 - 1077, XP001526055, ISSN: 0004-4172 * |
CHRISTIE G ET AL: "Alzheimer's disease: correlation of the suppression of.beta.-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome", JOURNAL OF NEUROCHEMISTRY, WILEY INTERSCIENCE, NEW YORK, NY, US, vol. 73, no. 1, 1 January 1999 (1999-01-01), pages 195 - 204, XP002209921, ISSN: 0022-3042, DOI: 10.1046/J.1471-4159.1999.0730195.X * |
HILLMAN G G ET AL: "Generating MHC Class II+/Ii- phenotype after adenoviral delivery of both an expressible gene for MHC Class II inducer and an antisense Ii-RNA construct in tumor cells", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 10, no. 17, 1 August 2003 (2003-08-01), pages 1512 - 1518, XP009160950, ISSN: 0969-7128 * |
HITZEL CHRISTOPH ET AL: "The invariant chain derived fragment clip is an efficient in vitro inhibitor of peptide binding to MHC class II molecules", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 33, no. 1, 1 January 1996 (1996-01-01), pages 25 - 31, XP009160759, ISSN: 0161-5890, [retrieved on 19990426], DOI: 10.1016/0161-5890(95)00131-X * |
LU XUEQING ET AL: "Suppression of major histocompatibility complex class II-associated invariant chain enhances the potency of an HIV gp120 DNA vaccine", IMMUNOLOGY, BLACKWELL PUBLISHING, OXFORD, GB, vol. 120, no. 2, 1 February 2007 (2007-02-01), pages 207 - 216, XP002612403, ISSN: 0019-2805, DOI: 10.1111/J.1365-2567.2006.02492.X * |
STEIN R ET AL: "CD74: A new candidate target for the immunotherapy of B-cell neoplasms", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 13, no. 18, 15 September 2007 (2007-09-15), pages 5556S - 5563S, XP002510850, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-07-1167 * |
WU S ET AL: "The MHC class II-associated invariant chain-derived peptide CLIP binds to the peptide-binding groove of class II molecules", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 33, no. 4-5, 1 March 1996 (1996-03-01), pages 371 - 377, XP027285074, ISSN: 0161-5890, [retrieved on 19960301] * |
XU MINZHEN ET AL: "Immunotherapy of cancer by antisense inhibition of Ii protein, an immunoregulator of antigen selection by MHC class II molecules", CURRENT OPINION IN MOLECULAR THERAPEUTICS, CURRENT DRUGS, LONDON, GB, vol. 6, no. 2, 1 April 2004 (2004-04-01), pages 160 - 165, XP009115265, ISSN: 1464-8431 * |
Also Published As
Publication number | Publication date |
---|---|
CA2737146A1 (en) | 2010-01-28 |
EP2323679A2 (de) | 2011-05-25 |
AU2009274512A1 (en) | 2010-01-28 |
WO2010011347A2 (en) | 2010-01-28 |
WO2010011347A9 (en) | 2010-04-08 |
EP2633864A1 (de) | 2013-09-04 |
WO2010011347A3 (en) | 2010-05-27 |
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