EP2310060B1 - Beschichtungsverfahren für medizinische vorrichtungen - Google Patents

Beschichtungsverfahren für medizinische vorrichtungen Download PDF

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Publication number
EP2310060B1
EP2310060B1 EP09772829A EP09772829A EP2310060B1 EP 2310060 B1 EP2310060 B1 EP 2310060B1 EP 09772829 A EP09772829 A EP 09772829A EP 09772829 A EP09772829 A EP 09772829A EP 2310060 B1 EP2310060 B1 EP 2310060B1
Authority
EP
European Patent Office
Prior art keywords
cross
medical device
coating
linking agent
gelatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP09772829A
Other languages
English (en)
French (fr)
Other versions
EP2310060A2 (de
Inventor
Elisabeth Van Dongen
Sebastianus Kluijtmans
Jan Bouwstra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Manufacturing Europe BV
Original Assignee
Fujifilm Manufacturing Europe BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Manufacturing Europe BV filed Critical Fujifilm Manufacturing Europe BV
Priority to EP09772829A priority Critical patent/EP2310060B1/de
Publication of EP2310060A2 publication Critical patent/EP2310060A2/de
Application granted granted Critical
Publication of EP2310060B1 publication Critical patent/EP2310060B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
    • C09D189/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C09D189/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Prostheses (AREA)

Claims (14)

  1. Verfahren zum Beschichten einer medizinischen Einheit, umfassend die Schritte
    a. Imprägnieren der medizinischen Einheit mit einem Vernetzungsmittel und dann
    b. in Kontakt bringen der imprägnierten medizinischen Einheit mit einem proteinösen Beschichtungsmaterial, um Beschichten der medizinischen Einheit mit einem teilvernetzten proteinösen Material zu ergeben, und dann
    c. Härten des auf die medizinische Einheit geschichteten proteinösen Materials durch in Kontakt bringen mit einem weiteren Vernetzungsmittel, das von dem in Schritt a verwendeten verschieden ist; und
    wobei die Acidität des proteinösen Beschichtungsmaterials abhängig von dem verwendeten Protein und Vernetzungsmittel eingestellt wird.
  2. Verfahren gemäß Anspruch 1, wobei das Vernetzungsmittel ein Carbodiimid umfasst.
  3. Verfahren gemäß Anspruch 1 oder 2, wobei das Vernetzungsmittel ein Diisocyanat umfasst.
  4. Verfahren gemäß einem der Ansprüche 1-3, wobei das Vernetzungsmittel von Schritt a ein Diisocyanat umfasst und das Vernetzungsmittel von Schritt c ein Carbodiimid umfasst.
  5. Verfahren gemäß einem der Ansprüche 1-4, wobei das Vernetzungsmittel von Schritt a ein Carbodiimid umfasst und das Vernetzungsmittel von Schritt c ein Diisocyanat umfasst.
  6. Verfahren gemäß einem der Ansprüche 1-5, wobei das proteinöse Beschichtungsmaterial von Schritt b Collagen und/oder Gelatine umfasst.
  7. Verfahren gemäß einem der Ansprüche 1-6, wobei das proteinöse Beschichtungsmaterial von Schritt b nichtgelierende Gelatine umfasst.
  8. Verfahren gemäß Anspruch 7, wobei die nichtgelierende Gelatine ein rekombinantes Gelatine-artiges Protein umfasst.
  9. Verfahren gemäß Anspruch 7 oder 8, wobei die nichtgelierende Gelatine eine Bloom-Festigkeit von unter 50 g aufweist.
  10. Medizinische Einheit für die Implantation, umfassend eine biokompatible Beschichtung, erhalten durch das Verfahren gemäß einem der Ansprüche 1-9.
  11. Medizinische Einheit gemäß Anspruch 10, wobei die medizinische Einheit eine Gefäßprothese ist.
  12. Medizinische Einheit gemäß Anspruch 10, wobei die medizinische Einheit ein Knochenreparatur-Transplantat ist.
  13. Medizinische Einheit gemäß Anspruch 10, wobei die medizinische Einheit ein Dentalimplantat ist.
  14. Medizinische Einheit gemäß Anspruch 10, wobei die medizinische Einheit ein Katheter ist.
EP09772829A 2008-07-04 2009-06-25 Beschichtungsverfahren für medizinische vorrichtungen Not-in-force EP2310060B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09772829A EP2310060B1 (de) 2008-07-04 2009-06-25 Beschichtungsverfahren für medizinische vorrichtungen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08159740 2008-07-04
EP09772829A EP2310060B1 (de) 2008-07-04 2009-06-25 Beschichtungsverfahren für medizinische vorrichtungen
PCT/GB2009/050735 WO2010001149A2 (en) 2008-07-04 2009-06-25 Coating method for medical devices

Publications (2)

Publication Number Publication Date
EP2310060A2 EP2310060A2 (de) 2011-04-20
EP2310060B1 true EP2310060B1 (de) 2013-02-27

Family

ID=40089887

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09772829A Not-in-force EP2310060B1 (de) 2008-07-04 2009-06-25 Beschichtungsverfahren für medizinische vorrichtungen

Country Status (4)

Country Link
US (1) US20110106243A1 (de)
EP (1) EP2310060B1 (de)
JP (1) JP2011526510A (de)
WO (1) WO2010001149A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9192507B2 (en) 2001-08-31 2015-11-24 Orthopeutics, L.P. Tissue crosslinking for treatment of snoring and obstructive sleep apnea
US10278947B2 (en) 2007-02-28 2019-05-07 Orthopeutics, L.P. Crosslinker enhanced repair of connective tissues
US8486013B2 (en) * 2010-03-18 2013-07-16 Biotronik Ag Balloon catheter having coating
GB201018044D0 (en) 2010-10-26 2010-12-08 Fujifilm Mfg Europe Bv Non-natural gelatin-like proteins with enhanced functionality
WO2012173555A1 (en) * 2011-06-13 2012-12-20 Dentsply Ih Ab Collagen coated article
CN103550826B (zh) 2013-10-31 2015-07-08 广州优得清生物科技有限公司 异种角膜材料的制备方法
CN106264779A (zh) * 2016-08-05 2017-01-04 江苏百优达生命科技有限公司 一种带有预凝涂层的人工血管
DE102020123736A1 (de) * 2020-09-11 2022-03-17 Gelita Ag Verfahren zur Behandlung einer Oberfläche und Verwendung von Kollagenhydrolysat zur Behandlung einer Oberfläche

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288775A (en) * 1961-04-07 1966-11-29 Ciba Ltd Method of hardening gelatin by reacting with conjugated heterocyclic compounds containing halogen atoms and water-solubilizing acid groups
DE2439551C2 (de) * 1974-08-17 1985-11-21 Agfa-Gevaert Ag, 5090 Leverkusen Verfahren zur Härtung photographischer Schichten
EP0166998B1 (de) * 1984-06-04 1991-05-08 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medizinisches Werkzeug und Verfahren zur Herstellung
JPS60259269A (ja) * 1984-06-04 1985-12-21 テルモ株式会社 医療用具およびその製造方法
DE3608158A1 (de) * 1986-03-12 1987-09-17 Braun Melsungen Ag Mit vernetzter gelatine impraegnierte gefaessprothese und verfahren zu ihrer herstellung
US5157111A (en) * 1991-05-02 1992-10-20 Pachence James M Method of bonding collagen to fibers, particularly dacron
US5584875A (en) * 1991-12-20 1996-12-17 C. R. Bard, Inc. Method for making vascular grafts
US5660857A (en) * 1993-03-22 1997-08-26 Johnson & Johnson Medical Inc. Biopolymer composites
EP0717312A1 (de) * 1994-12-16 1996-06-19 Minnesota Mining And Manufacturing Company Gehärtete photographische Silberhalogenidelemente
US5869127A (en) * 1995-02-22 1999-02-09 Boston Scientific Corporation Method of providing a substrate with a bio-active/biocompatible coating
US5702754A (en) * 1995-02-22 1997-12-30 Meadox Medicals, Inc. Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings
WO1998018918A1 (en) * 1996-10-29 1998-05-07 Commonwealth Scientific And Industrial Research Organisation Stable expression of triple helical proteins
US6150081A (en) * 1997-12-24 2000-11-21 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
US6340465B1 (en) * 1999-04-12 2002-01-22 Edwards Lifesciences Corp. Lubricious coatings for medical devices
CN1309737C (zh) * 1999-11-12 2007-04-11 法布罗根股份有限公司 重组明胶
US6992172B1 (en) * 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
EP1238675A1 (de) * 2001-03-06 2002-09-11 Fuji Photo Film B.V. Rekombinante gelatineartige Proteine zur Verwendung als Plasmaexpander
JP2003048841A (ja) * 2001-08-03 2003-02-21 Yasuhiko Tabata 血管閉塞用組成物
WO2004085473A2 (en) * 2003-03-28 2004-10-07 Fuji Photo Film B.V. Rgd-enriched gelatine-like proteins with enhanced cell binding
AU2004308492A1 (en) * 2003-12-23 2005-07-14 Abbott Medical Optics Inc. Lubricious, biocompatible coatings for medical devices
KR100739528B1 (ko) * 2006-02-03 2007-07-13 재단법인서울대학교산학협력재단 제1형 교원질 부착 유도 펩타이드가 고정된 골이식재 및 조직공학용 지지체
EP1961411A1 (de) * 2007-02-21 2008-08-27 FUJIFILM Manufacturing Europe B.V. Zusammensetzung mit gesteuerter Freisetzung
EP1961414A1 (de) * 2007-02-21 2008-08-27 FUJIFILM Manufacturing Europe B.V. Rekombinante Gelatine enthaltende Zusammensetzung mit gesteuerter Freisetzung
WO2008103041A1 (en) * 2007-02-21 2008-08-28 Fujifilm Manufacturing Europe B.V. Recombinant gelatins
EP2188308B1 (de) * 2007-09-14 2012-05-30 Fujifilm Manufacturing Europe B.V. Ertragreiche absonderung eines multimeren rekombinanten proteins
WO2009082209A1 (en) * 2007-12-21 2009-07-02 Fujifilm Manufacturing Europe B.V. Improvement of the secretion yield of a protein of interest by in vivo proteolytic processing of a multimeric precursor

Also Published As

Publication number Publication date
EP2310060A2 (de) 2011-04-20
WO2010001149A3 (en) 2010-04-01
WO2010001149A2 (en) 2010-01-07
US20110106243A1 (en) 2011-05-05
JP2011526510A (ja) 2011-10-13
WO2010001149A9 (en) 2010-05-20

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