EP2307090A2 - Procédé et système pour enregistrer et promouvoir la régénération des nerfs périphériques - Google Patents

Procédé et système pour enregistrer et promouvoir la régénération des nerfs périphériques

Info

Publication number
EP2307090A2
EP2307090A2 EP09734126A EP09734126A EP2307090A2 EP 2307090 A2 EP2307090 A2 EP 2307090A2 EP 09734126 A EP09734126 A EP 09734126A EP 09734126 A EP09734126 A EP 09734126A EP 2307090 A2 EP2307090 A2 EP 2307090A2
Authority
EP
European Patent Office
Prior art keywords
nerve
agent
release
electrode
regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09734126A
Other languages
German (de)
English (en)
Inventor
Alexandros Beris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2307090A2 publication Critical patent/EP2307090A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0556—Cuff electrodes

Abstract

Cette invention concerne un procédé et un système pour enregistrer et promouvoir la régénération des nerfs périphériques après une lésion. Les système et procédé comprennent une électrode de stimulation qui est implantée dans le segment proximal du nerf, au moins une électrode d'enregistrement qui est implantée dans le segment distal du nerf, une unité électronique implantable, un dispositif implantable libérant des agents destinés à stimuler la régénération nerveuse, tel qu'une micro-pompe, et une unité de calcul qui est, de préférence, placée extracorporellement pour la communication de données et le transfert de courant à l'unité électronique. Les signaux électriques qui sont générés par le segment distal des nerfs lésés, après excitation électrique appropriée du segment distal dudit nerf lésé, sont enregistrés à divers instants. L'analyse des signaux électriques enregistrés est utilisée pour évaluer l'état et l'évolution des axones neuronaux en cours de régénération; cette évaluation permet de déterminer divers paramètres de contrôle. Lesdits paramètres de contrôle sont utilisés par l'unité électronique pour contrôler la libération des agents de stimulation de telle manière que le traitement soit efficace, tout en maintenant l'administration des agents de stimulation à des niveaux sûrs.
EP09734126A 2008-04-22 2009-04-15 Procédé et système pour enregistrer et promouvoir la régénération des nerfs périphériques Withdrawn EP2307090A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20080100282A GR1006568B (el) 2008-04-22 2008-04-22 Μεθοδος και συστημα για την καταγραφη και υποβοηθηση της αναγεννησης περιφερικου νευρου
PCT/GR2009/000024 WO2009130515A2 (fr) 2008-04-22 2009-04-15 Procédé et système pour enregistrer et promouvoir la régénération des nerfs périphériques

Publications (1)

Publication Number Publication Date
EP2307090A2 true EP2307090A2 (fr) 2011-04-13

Family

ID=40585045

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09734126A Withdrawn EP2307090A2 (fr) 2008-04-22 2009-04-15 Procédé et système pour enregistrer et promouvoir la régénération des nerfs périphériques

Country Status (3)

Country Link
EP (1) EP2307090A2 (fr)
GR (1) GR1006568B (fr)
WO (1) WO2009130515A2 (fr)

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US10588524B2 (en) * 2011-05-13 2020-03-17 Saluda Medical Pty Ltd Method and apparatus for measurement of neural response
JP6243328B2 (ja) 2011-05-13 2017-12-06 サルーダ・メディカル・ピーティーワイ・リミテッド 神経刺激を制御するための方法および装置
US9872990B2 (en) 2011-05-13 2018-01-23 Saluda Medical Pty Limited Method and apparatus for application of a neural stimulus
US10568559B2 (en) 2011-05-13 2020-02-25 Saluda Medical Pty Ltd Method and apparatus for measurement of neural response
CN103648583B (zh) 2011-05-13 2016-01-20 萨鲁达医疗有限公司 用于测量神经反应-a的方法和仪器
US9974455B2 (en) 2011-05-13 2018-05-22 Saluda Medical Pty Ltd. Method and apparatus for estimating neural recruitment
US9155892B2 (en) 2011-05-13 2015-10-13 Saluda Medical Pty Limited Method and apparatus for application of a neural stimulus
DK2908904T3 (da) 2012-11-06 2020-12-14 Saluda Medical Pty Ltd System til styring af vævs elektriske tilstand
WO2015070281A1 (fr) 2013-11-15 2015-05-21 Saluda Medical Pty Ltd Monitorage des potentiels d'action neuronaux dans le cerveau
AU2014353891B2 (en) 2013-11-22 2020-02-06 Saluda Medical Pty Ltd Method and device for detecting a neural response in a neural measurement
US10368762B2 (en) 2014-05-05 2019-08-06 Saluda Medical Pty Ltd. Neural measurement
DK3171929T3 (da) 2014-07-25 2021-05-25 Saluda Medical Pty Ltd Dosering til nervestimulation
US10597636B2 (en) 2014-09-19 2020-03-24 University Of Florida Research Foundation, Inc. Electroactive polymeric scaffolds and method for delivering nerve growth factor to nerve tissue
EP3215216A4 (fr) 2014-11-17 2018-08-22 Saluda Medical Pty Ltd Procédé et dispositif pour détecter une réponse neuronale dans des mesures neuronales
AU2015362075B2 (en) 2014-12-11 2021-03-11 Saluda Medical Pty Ltd Implantable electrode positioning
EP4285985A3 (fr) 2014-12-11 2024-01-17 Saluda Medical Pty Ltd Procédé et dispositif de commande de rétroaction de stimulation neuronale
AU2016208972B2 (en) 2015-01-19 2021-06-24 Saluda Medical Pty Ltd Method and device for neural implant communication
US10894158B2 (en) 2015-04-09 2021-01-19 Saluda Medical Pty Ltd Electrode to nerve distance estimation
CA2983336A1 (fr) 2015-05-31 2016-12-08 Saluda Medical Pty Ltd Surveillance de l'activite neurale du cerveau
WO2016191807A1 (fr) 2015-05-31 2016-12-08 Saluda Medical Pty Ltd Fixation d'électrode de neurostimulateur cérébral
CA2980482C (fr) 2015-06-01 2023-09-26 Saluda Medical Pty Ltd Neuromodulation des fibres motrices
US11191966B2 (en) 2016-04-05 2021-12-07 Saluda Medical Pty Ltd Feedback control of neuromodulation
US11179091B2 (en) 2016-06-24 2021-11-23 Saluda Medical Pty Ltd Neural stimulation for reduced artefact
WO2018232145A1 (fr) * 2017-06-14 2018-12-20 Wichita State University Appareil et méthode de régénération neurale
AU2018354250A1 (en) 2017-10-25 2020-06-11 Epineuron Technologies Inc. Systems and methods for delivering neuroregenerative therapy
US10589089B2 (en) 2017-10-25 2020-03-17 Epineuron Technologies Inc. Systems and methods for delivering neuroregenerative therapy
EP3784338A4 (fr) 2018-04-27 2022-01-19 Saluda Medical Pty Ltd Neurostimulation de nerfs mixtes
US11364381B2 (en) 2019-10-01 2022-06-21 Epineuron Technologies Inc. Methods for delivering neuroregenerative therapy and reducing post-operative and chronic pain

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Publication number Priority date Publication date Assignee Title
US20060089751A1 (en) * 1997-01-27 2006-04-27 Ewa Herbst Electronic delivery systems and methods with feedback
US20060194724A1 (en) * 2005-02-25 2006-08-31 Whitehurst Todd K Methods and systems for nerve regeneration
US8078275B2 (en) * 2005-04-15 2011-12-13 Functional Neuromodulation Inc. Regulation of neurotrophins
WO2008005843A2 (fr) * 2006-06-30 2008-01-10 Cyberkinetics Neurotechnology Systems, Inc. système de régénération des nerfs et dispositifs conducteurs associés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009130515A3 *

Also Published As

Publication number Publication date
WO2009130515A3 (fr) 2010-04-01
GR1006568B (el) 2009-10-13
WO2009130515A2 (fr) 2009-10-29

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