EP2307016A4 - A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate - Google Patents

A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Info

Publication number
EP2307016A4
EP2307016A4 EP09803180A EP09803180A EP2307016A4 EP 2307016 A4 EP2307016 A4 EP 2307016A4 EP 09803180 A EP09803180 A EP 09803180A EP 09803180 A EP09803180 A EP 09803180A EP 2307016 A4 EP2307016 A4 EP 2307016A4
Authority
EP
European Patent Office
Prior art keywords
bisphosphonate
salt
preventing
pharmaceutical composition
treating osteoporosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09803180A
Other languages
German (de)
French (fr)
Other versions
EP2307016A2 (en
Inventor
Jin Soo Lee
Yun Ha Hwang
Jei Man Ryu
Young Goo Jin
Ki Yoon Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong Wha Pharm Co Ltd
Original Assignee
Dong Wha Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Wha Pharm Co Ltd filed Critical Dong Wha Pharm Co Ltd
Publication of EP2307016A2 publication Critical patent/EP2307016A2/en
Publication of EP2307016A4 publication Critical patent/EP2307016A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
EP09803180A 2008-08-01 2009-07-31 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate Withdrawn EP2307016A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20080075791 2008-08-01
KR1020090007774A KR20100014090A (en) 2008-08-01 2009-01-31 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate
PCT/KR2009/004295 WO2010013975A2 (en) 2008-08-01 2009-07-31 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Publications (2)

Publication Number Publication Date
EP2307016A2 EP2307016A2 (en) 2011-04-13
EP2307016A4 true EP2307016A4 (en) 2011-12-28

Family

ID=42087985

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09803180A Withdrawn EP2307016A4 (en) 2008-08-01 2009-07-31 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Country Status (6)

Country Link
EP (1) EP2307016A4 (en)
JP (1) JP2011529876A (en)
KR (2) KR20100014090A (en)
CN (1) CN102149381A (en)
CA (1) CA2732864A1 (en)
WO (1) WO2010013975A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9187485B2 (en) 2007-02-02 2015-11-17 Baylor College Of Medicine Methods and compositions for the treatment of cancer and related hyperproliferative disorders
CN102149380B (en) * 2008-08-01 2012-12-05 同和药品株式会社 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt
JP2016534124A (en) * 2013-08-29 2016-11-04 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ Compositions and methods for the treatment of metabolism and weight related diseases
JP6660380B2 (en) 2014-09-29 2020-03-11 エー１２３ システムズ エルエルシーＡ１２３ Ｓｙｓｔｅｍｓ ＬＬＣ Method of making prelithiated silicon anode containing PVDF binder

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001991A1 (en) * 1999-07-01 2001-01-11 Merck & Co., Inc. Pharmaceutical tablets
WO2004056373A1 (en) * 2002-12-20 2004-07-08 F. Hoffmann-La Roche Ag High dose ibandronate formulation
WO2007089101A1 (en) * 2006-01-31 2007-08-09 Dong Wha Pharmaceutical Ind.Co., Ltd. Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same
WO2009017222A1 (en) * 2007-08-02 2009-02-05 Teijin Pharma Limited Preventive agent or therapeutic agent for disease caused by abnormal bone metabolism

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
CA2278190A1 (en) * 1997-02-04 1998-08-06 Hong-Suk Suh 3-amino-1,2-benzoisoxazole derivatives, process for preparation, and use thereof
US5998390A (en) * 1998-09-28 1999-12-07 The Research Foundation Of State University Of New York Combination of bisphosphonate and tetracycline
KR100317935B1 (en) * 1999-10-20 2001-12-22 유승필 Pharmaceutical compositions and preparations for treatment of metabolic bone disease
KR100454767B1 (en) * 2001-07-19 2004-11-03 동화약품공업주식회사 Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis
JP2003292453A (en) * 2002-04-02 2003-10-15 Asahi Kasei Corp Medicinal agent composition for treating bone disease
JPWO2005002590A1 (en) * 2003-07-01 2006-08-10 アステラス製薬株式会社 Bone mass increase inducer
JP2007502300A (en) * 2003-08-13 2007-02-08 カイロン　コーポレイション GSK-3 inhibitor and use thereof
US7410977B2 (en) * 2004-04-28 2008-08-12 Merck & Co., Inc. Fluorinated 4-azasteroids as androgen receptor modulators
AU2005260327B2 (en) * 2004-07-05 2009-10-01 Dong Wha Pharmaceutical Co., Ltd. Pharmaceutical composition for the treatment of bone fracture
JP2009017222A (en) * 2007-07-04 2009-01-22 Panasonic Corp Color adjustment apparatus, color adjustment method, and integrated circuit of color adjustment apparatus
CN102149380B (en) * 2008-08-01 2012-12-05 同和药品株式会社 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001991A1 (en) * 1999-07-01 2001-01-11 Merck & Co., Inc. Pharmaceutical tablets
WO2004056373A1 (en) * 2002-12-20 2004-07-08 F. Hoffmann-La Roche Ag High dose ibandronate formulation
WO2007089101A1 (en) * 2006-01-31 2007-08-09 Dong Wha Pharmaceutical Ind.Co., Ltd. Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same
WO2009017222A1 (en) * 2007-08-02 2009-02-05 Teijin Pharma Limited Preventive agent or therapeutic agent for disease caused by abnormal bone metabolism

Also Published As

Publication number Publication date
KR20100014174A (en) 2010-02-10
WO2010013975A2 (en) 2010-02-04
KR20100014090A (en) 2010-02-10
CA2732864A1 (en) 2010-02-04
CN102149381A (en) 2011-08-10
JP2011529876A (en) 2011-12-15
WO2010013975A3 (en) 2010-06-03
EP2307016A2 (en) 2011-04-13

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20110201

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AX Request for extension of the european patent

Extension state: AL BA RS

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20111124

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 45/06 20060101ALI20111118BHEP

Ipc: A61K 31/663 20060101ALI20111118BHEP

Ipc: A61P 19/10 20060101ALI20111118BHEP

Ipc: A61K 31/426 20060101AFI20111118BHEP

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