EP2300788A1 - Mesure non destructive du volume de remplissage d un récipient rempli de liquide - Google Patents

Mesure non destructive du volume de remplissage d un récipient rempli de liquide

Info

Publication number
EP2300788A1
EP2300788A1 EP09761496A EP09761496A EP2300788A1 EP 2300788 A1 EP2300788 A1 EP 2300788A1 EP 09761496 A EP09761496 A EP 09761496A EP 09761496 A EP09761496 A EP 09761496A EP 2300788 A1 EP2300788 A1 EP 2300788A1
Authority
EP
European Patent Office
Prior art keywords
container
liquid
determined
determining
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09761496A
Other languages
German (de)
English (en)
Inventor
Karl Hoberg
Stefan Nold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring GmbH
Nold Stefan
Soft Control Automatisierungstechnik GmbH
Original Assignee
CSL Behring GmbH Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CSL Behring GmbH Deutschland filed Critical CSL Behring GmbH Deutschland
Priority to EP09761496A priority Critical patent/EP2300788A1/fr
Publication of EP2300788A1 publication Critical patent/EP2300788A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
    • G01F23/28—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
    • G01F23/284—Electromagnetic waves
    • G01F23/292—Light, e.g. infrared or ultraviolet
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/3313—Optical measuring means used specific wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A61M2205/3382—Upper level detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like

Definitions

  • the invention relates to a method and a device for determining the filling volume of a sealed container, at least partially filled with a liquid, in particular of syringes, vials and ampoules, which can be filled with a liquid product, such as a vaccine.
  • a liquid drug such as a vaccine
  • a liquid drug is typically made from individual samples of a mass-produced and machine-filled batch, which often can have significantly more than 100 individual filled containers.
  • an at least partially filled sealed container which may be formed, for example, as a syringe, bottle, vial or as an ampoule, takes place in that a gross-net weighing is carried out with individual containers. So the container is successively, once with the therein lent product and weighed once without the drug. However, the container itself and the drug contained therein are destroyed. Such a volume and mass determination always causes some containers to be lost per batch. Depending on the product and batch size, this can add up to a loss of 50 to 200 units.
  • US 5,568,262 describes a nondestructive measuring method for a sealed and transparent container. It is intended to rotate the container at high speed about a horizontal axis, so that the liquid collects due to the centrifugal force in the outer regions of the container and forms a static bubble in the central region of the container. The size of this bubble is detected by means of a camera and electronic imaging means and subtracted from the previously otherwise determined volume of the transparent container.
  • the inner diameter of the container must be determined, for which a laser scanning method is proposed in which a laser light source is directed by means of a so-called scanning mirror successively to individual points of the container.
  • a silhouette image of the container is imaged on an opaque or matte screen and recorded by means of a video camera.
  • volume level control allows non-destructive measurement of the container's fill volume
  • its implementation is complex and cumbersome. It must be ensured in particular that the axis of rotation of the container coincides exactly with the optical axis of the optical measuring system. This sometimes requires complex positioning of the object to be measured and the measuring optics. Further, a Laser scanning method for determining the container geometries due to the necessary components relatively expensive to purchase.
  • Laser irradiation during this period can lead to a change of the specified properties for pharmaceutical products, therefore the exclusion of negative effects of the laser procedure has to be proven for each product within the scope of a validation.
  • the present invention is therefore based on the object to provide a simplified and at the same time improved method for determining the filling volume of a container filled with a liquid sealed container. This is intended to enable nondestructive measurement of the filling volume with relatively simple and inexpensive means to be implemented. In addition, the measurement accuracy compared to a gross-net weighing is to be improved. It is also an object of the invention to carry out a filling volume determination extremely precisely and with a significantly reduced expenditure of time.
  • the inventive method is characterized by a purely optical measurement and a purely optical determination of the filling volume of a container which is substantially transparent to the radiation used in the measurement.
  • the container is in an unchanged, rested position throughout the measurement process.
  • the preferably sealed containers are in particular syringes, vials and ampoules which are at least partially filled with a liquid product such as a vaccine. It is envisaged to supply the container to a purely optical inspection system and to position it in relation to an image-generating measuring system, to illuminate it using suitable electromagnetic radiation and to record corresponding image data by means of at least one spatially resolving detector, ie in the plane transverse to the optical axis finally to be fed to an evaluation unit.
  • the geometric measurement of the container and the liquid in the container is based on the recorded two-dimensional images of the filled container.
  • a rotation of the container is basically not required.
  • the optical measurement or recording of images of the filled container takes place in transmission geometry. That means a radiation or light source and an associated detector are arranged to each other so that the container to be measured is located between the detector and the radiation source. At least the detector is arranged and designed such that it can record at least a part of the electromagnetic radiation transmitted by the container in an image plane in a spatially resolved manner.
  • the filling volume determination of the liquid within the preferably closed container is determined directly from the obtained image data.
  • at least two parameters namely the filling level of the liquid in the container and an inner cross-sectional area of the container lying in the region of the filling level, are determined directly from the detected image data.
  • the filling volume then results as a product of level height and determined internal cross-sectional area.
  • the inner cross-sectional area is determined from the basic geometry of the container and the optically determinable inner cross-section of the container on which the measuring method is based and optionally specified by a user. If, for example, the container has a cylindrical geometry, its inside diameter D and also the filling height h are derived from the image data obtained.
  • the radiation source for the inventive method most different light sources with a spectral range from infrared to ultraviolet into consideration.
  • the electromagnetic radiation used may be monochromatic by use of appropriate filters or may have a broad spectrum of different wavelengths.
  • the entire optical measurement can be carried out by means of white light.
  • the inventive method is formed in particular for Greinkel cylindrical container, wherein the cylinder longitudinal axis is arranged perpendicular to the optical axis of the measuring system.
  • the determination of the wall thickness of the container is preferably carried out by a telecentric illumination of the container.
  • the container is subjected to a bundle of parallel light beams, which are generated by means of an object-side optics and imaged on the detector at least by means of a telecentric optics on the image side.
  • a telecentric optics on the image side.
  • the center jet and by some rays propagating through the wall of the tank. These are diffracted upon entry into the container wall and reflected at the interfaces to each optically thinner medium, that is at the interfaces to the container interior and exterior space.
  • individual intensity maxima arise on the detector, which correspond to the beams propagating through the object in one, two, four times parallel to the optical axis. From the distance of the individual intensity maxima and with knowledge of the refractive index of the container medium, the thickness of the container wall and / or the inner diameter of the container can be precisely determined.
  • the telecentric illumination is advantageous in that only the individual intensity maxima or intensity peaks of parallel rays are detected, while those rays which are no longer parallel to the optical axis due to the curved contour of the vessel do not reach the detector.
  • the wall thickness or the inner diameter of the container can be precisely determined not only at a single point, but over a longitudinal region along the cylinder longitudinal axis. In this way, even deviations in the wall thickness, in the inner diameter or deviations from an exact cylindrical shape of the container can be precisely determined and taken into account in the subsequent calculations of the filling volume.
  • a further advantage of the telecentric illumination of the object to be measured is that the width of a plug defining a cylindrical inner volume corresponds exactly to the outer diameter of the transparent container, preferably made of glass. In this way, the outer diameter of the container can be determined particularly simply and at the same time precisely.
  • the filling level of the liquid in the container is determined based on the positions of an upper and a lower liquid level from the detected image data.
  • the level height results from a subtraction of the determined positions of the liquid level and the given by the container lower limit of the liquid column.
  • the container In order to determine the level of the liquid or the positions of the liquid levels, the container is diffused or illuminated, so that the liquid Mirror or the outer circumference of the container can be imaged directly on the detector.
  • a broadband white light source can optionally be provided in combination with spectral filters. It is also possible to use light in the infrared wavelength range for this purpose.
  • the telecentric illumination of the object to be measured and its diffuse illumination can also be fed from a single light source.
  • the telecentric illumination provided for determining the inner diameter in a different spectral range, as provided for determining the fill level height.
  • both diffuse and telecentric illumination of the container simultaneously by using two detector or camera systems. Since, in the use of a telecentric lens, only beams propagating parallel to the optical axis are imaged on the detector, a simultaneous diffuse illumination or illumination of the container represents a hardly noticeable disturbance of the telecentric illumination and determination of the wall thickness.
  • a position determination of at least one liquid level takes place by means of line and / or column-wise comparison of intensities of individual pixels of the detector. It can also be provided, not only the measured intensities among each line and column wise, but also absolutely, that is to say to compare with a predetermined threshold. Such a threshold value can be determined and defined in particular during the calibration of the measuring system.
  • the relation of the number of pixels of the outer diameter determined in diffuse illumination to the telecentrically measured outer diameter can be determined. This allows a calibration of the system, namely the assignment of a number of pixels to actual length measures, so by determining a corresponding number of pixels, the actual height of the liquid column can be determined.
  • the constant magnification of the telecentric illumination is advantageously utilized.
  • the size of a characteristic object such as the width of a tip plug, is assigned to a number of pixels corresponding to the detector by means of the telecentric measuring arrangement. Due to the parallel beams used, the telecentric optics already permit an exact assignment of a number of pixels to an actual measured variable, for example the width of the syringe plug in mm.
  • the size of the same characteristic object preferably the width of the syringe stopper
  • the size of the same characteristic object can again be assigned a pixel number.
  • the optical axis of the measuring system is aligned perpendicular to the cylinder axis of the cylindrical container.
  • the upper and / or lower liquid level can be formed either as a straight line or as an oval on the detector. If one of the liquid levels represents an oval, the curved outer contours of the liquid level are determined from the obtained image data and subjected to geometric averaging in the downstream evaluation unit, so that instead of the actually measured oval liquid level, an averaged straight-line liquid level is used to control the fill level can.
  • the container in particular a syringe with an upwardly directed tip in the measuring system is arranged, so that the liquid-directed boundary surface of the container internal volume limiting plug at the same time corresponds to the lower liquid level.
  • the plug preferably has a very different transmission characteristic for the radiation used than the active agent and the container wall. He also has a dark color, preferably black, so that the image data obtained are particularly rich in contrast.
  • the active substance enclosed in the container preferably has a different transmission characteristic with respect to the container material, so that distinct intensity differences in the recorded image data can be recognized at the interface between the substances and the liquid or the container outer wall.
  • the position of the plug can be determined by scanning and analyzing the captured image line by line in a direction perpendicular to the plug surface. In this case, each row is assumed as a stopper position, which has the largest gray value change compared to an adjacent line. In this way, for example, a possibly disturbing influence of adhering to the stopper air bubbles can be eliminated.
  • the transverse extent that is, the diameter of the preferably non-transparent plug can be determined.
  • the positions of the liquid levels and the dimensions of the plug are determined as pixels in the evaluation unit downstream of the detector.
  • the evaluation unit compares the number of pixels of the thus determined outer diameter with the measured via telecentric optics outer diameter. About this ratio, the pixel number of the level height is converted into an actual length measure.
  • the number of pixels corresponding to the filling level height and the diameter of the container are determined, which are converted into geometric and actual length dimensions and volumes by means of a previously performed calibration.
  • a device for concentrating the liquid in the cylindrical part of the container is used before the start of the measurement.
  • a rotation about the longitudinal axis of the container is used to transport liquid residues from the tip into the cylinder.
  • the axis of rotation is in this case preferably perpendicular, but at least aligned obliquely to the optical axis of the detector or the optical recording system.
  • a mechanical vibration device or an ultrasonic treatment may be provided.
  • the container at least temporarily in rotation, preferably about the cylinder longitudinal axis, is added. That is, the axis of rotation is perpendicular, but at least aligned obliquely to the optical axis of the detector or the optical recording system.
  • the invention can be provided to determine the trapped in the liquid gas or air bubbles in size from the determined by their maximum cross section of the recorded image data and converted according to the circular volume formula in a gas bubble volume, which is determined by the Level volume can be subtracted.
  • the assumption is also made that those gas bubbles which adjoin both the cylinder side wall and an end wall form approximately a quarter sphere, while those gas bubbles which completely adjoin the cylinder inner wall approximately assume a hemisphere can be.
  • a sequence of n image data is recorded offset in time from one and the same container, wherein the container is surrounded by a n-th full circle about an axis perpendicular to the optical axis, in particular about the cylinder axis. longitudinal axis is rotated.
  • the invention relates to a device for determining the volume of a container at least partially filled with a liquid.
  • the device has at least one radiation source for emitting electromagnetic radiation and a detector which can be coupled to an evaluation unit, in particular a CCD or video camera for recording two-dimensional image data of the container arranged between radiation source and detector.
  • the device is designed in particular for receiving image data of the container in transmission geometry, so that the radiation transmitted through the container and the liquid contained therein can be absorbed by the detector and fed to the downstream evaluation unit for image evaluation.
  • refractive and / or diffractive beam guidance means are provided between the detector and the radiation source. These have individual imaging lenses, preferably at least one lens designed for imaging the container on the detector.
  • the downstream of the detector evaluation is for determining the filling volume, ie the Amount of liquid formed in the container. In this case, a fill level height of the liquid in the preferably cylindrical container and at least the inner cross section of the container, or an inner cross-sectional area, are determined automatically from the image data.
  • the device is characterized in particular by the fact that, to determine the inner cross-section of the container, the container is exposed to a parallel beam and at least one telecentric objective is arranged between the detector and the radiation source.
  • the telecentric optics can be provided as object-side and / or image-side objective.
  • a rotatably mounted about an axis plate for receiving the container is provided.
  • the arrangement of the container on the turntable is such that the cylinder longitudinal axis of the container and the axis of rotation of the turntable are aligned parallel to each other or even coincide.
  • the invention comprises a computer program product with program means for determining the filling volume of a container at least partially filled with a liquid, which are adapted from the image data provided by a detector, a liquid level and an inner diameter of the container after the to determine the method described above automatically and to multiply to determine the level of volume.
  • FIG. 1 is a schematic representation of a purely optical measuring device for determining the fill level volume of a container filled with liquid
  • FIG. 2 shows a schematic representation of a container in the form of a syringe or ampoule with a tip pointing downwards
  • FIG. 3 shows the syringe according to FIG. 2 with an upward pointing tip
  • FIG. 4 is an enlarged view of a container area in the area of the
  • FIG. 5 shows a schematic illustration of a cylindrical container in cross section with telecentric illumination
  • FIG. 6 shows a schematic intensity profile of a typical intensity distribution in the case of telecentric illumination according to FIG. 5,
  • FIG. 7 shows a schematic two-dimensional intensity distribution with telecentric illumination over the entire region of the liquid column
  • Figure 8 is a schematic representation of a partially filled with liquid container
  • Figure 9 is a schematic representation of a gas bubble in the middle of the liquid.
  • the measurement system 10 shown schematically in FIG. 1 is for the purely optical filling volume determination of a liquid 30 at least partially filled Container 16 is formed. It has a radiation source 12 of electromagnetic radiation 26 and a detector 20 provided for receiving and detecting transmitted electromagnetic radiation 28.
  • the detector which is typically designed as a CCD camera, is followed by an image evaluation unit 22, which can automatically determine both the fill level of the liquid 30 and the inner diameter of the container 25 from the image data determined and recorded by the detector.
  • the container 16 which can typically be designed as a syringe, ampoule or vial, that is to say as a glass tube, is arranged on a rotatably mounted turntable 24.
  • the turntable 24 allows the rotation of the container 16 about its cylindrical longitudinal axis 25 in order to be able to record a sequence of image data relating to the different orientations of the container 16 from one and the same container.
  • the container is preferably made of transparent glass. Other embodiments, as well as the use of various transparent plastics as container material are also eligible.
  • An imaging optics 18 is provided between the container 16 and the camera 20, which provides a sharp image of the container 16 made of glass on the detector surface of the camera 20.
  • a beam-shaping optical system 14 can also be arranged between the radiation source 12 and the container 16.
  • the optical measurement of the container 16 and the liquid 30 therein is static, that is, the container 16 is in an idle state relative to the camera 20th
  • the light source 12 for example, a white light source or a gas discharge lamp is used. It is also possible to use laser light sources in the entire visible, infrared and ultraviolet spectral range.
  • the wavelength of the radiation 26 used is in particular connected to the optical transmission and absorption characteristics of the container 16 and the liquid 30 therein. For example, it is advantageous if the container wall and the liquid located therein have different transmission coefficients for the radiation 26 used.
  • an ampoule or syringe 16 as shown in FIGS. 2 or 3, can be arranged for the optical measurement according to the invention.
  • the tip of the ampoule or syringe 16 points downwards, while in FIG. 3 the syringe 16 points upwards with its tip.
  • the liquid 30 located in the cylindrical syringe 16 is bounded at the bottom by a stopper 34 serving as a closure and by an air volume 32 at the top.
  • a stopper 34 serving as a closure and by an air volume 32 at the top.
  • the determination of the two liquid levels 46, 44 is carried out with an illumination of the container 16 with diffused light, so that a directional and collimated radiation source is not required for the exposure of the container 16 with electromagnetic radiation. Also, the water levels 46, 44 and the outer diameter 48 of the container 16 can be precisely determined in reflection geometry.
  • the outer diameter of the container can be determined both in diffuse but also by means of the telecentric illumination. In the case of telecentric illumination, it is also possible to utilize the advantageous effect that the width of the plug adjacent to the container inner wall corresponds exactly to the width or the outer diameter of the glass container.
  • the optical measurement of the positions of the liquid mirror 46, 44 is carried out in transmitted light, So in transmission geometry. For this purpose, a large-area diffuse backlight is used in combination with a lens, such as a 40 mm lens.
  • the camera 20 rotated through 90 degrees about the optical axis so that the longer side of the rectangular detector comes to rest parallel to the longitudinal axis of the cylindrical container 16. It is also provided to align the optical axis of the camera perpendicular to the longitudinal axis of the container 16.
  • the upper and / or lower liquid level 46, 44 as indicated in FIG. 4, can be imaged either as a straight line or slightly elliptically on the camera. Whether it is an oval or elliptical representation, is tested on the basis of the longitudinal axis of the cylinder extending intensity profile in the center of the container.
  • the position of the plug 34 is determined, which at the same time defines a lower liquid level 44.
  • the radial-finned plug 34 is preferably made of a non-transparent to the radiation 26 material.
  • the determination of the lower liquid level 44 can be carried out by a successive vertical retraction of a horizontal line.
  • a maximum gray value or intensity change in the scanning direction parallel to the cylinder longitudinal axis determines the position 44 of the lower liquid level.
  • the level height h 36 can be obtained by subtracting the positions of upper liquid level 46 and lower liquid level. stechniksLite 44 are determined.
  • the recorded image data is based on a calibration and a conversion factor in actual size and length measures.
  • the lower boundary line 42 may also be a curved representation.
  • a rectilinear lower liquid level 44 can also be calculated and substituted here.
  • the outer diameter 48 of the container 16 is determined based on the radial extent of the plug 34 in the region of the boundary line 42.
  • the determination of the radial extent of the plug 34 and thus of the container 16 can take place both by means of the diffuse illumination of the container 16, but also in the telecentric configuration described, that is to say by means of a bundle of beams propagating parallel to the optical axis.
  • a telecentric lens 18 By using a telecentric lens 18, only beams propagating parallel to the optical axis reach the detector of the camera 20. This beam propagation through the cylindrical container 16 is sketched schematically in FIG.
  • the center beam 54 propagates through the cylinder outer wall 50 and the cylinder inner wall 52 unbroken, while the beams 56 and 58 propagating with a lateral offset to the center beam 54 experience a multiple refraction or reflection at the boundary surfaces 50, 52.
  • the beam propagation of the two parallel rays 56, 58 shown at the edge as an example runs symmetrically to a horizontal center axis of the cylindrical container 16, which is not explicitly shown.
  • the telecentric transillumination of the container 16, as indicated in FIG. 5, results in an intensity distribution in the image plane shown in cross-section in FIG. pitch with individual peaks whose distance from each other is a direct measure of the wall thickness of the container.
  • the inner diameter of the container by determining the distance between two intensity maxima of the same order, which meet in Figure 5 right and left of the center beam on the detector can be determined directly. If the refractive index of the container material is known, the wall thickness and the inner diameter of the container can be determined directly from the distances of the peaks 56 and 58. To calibrate the wall thickness measurement, the inner diameter can be mechanically scanned and determined, for example, by means of an internal measuring screw.
  • edge-side beam paths 56, 58 Only two edge-side beam paths 56, 58 are shown by way of example in FIG. While the beam path 58 undergoes a total of 3 reflections, the beam path 56 has a total of 7 reflections. In addition, there are also beam paths with 5 reflections, which are not explicitly reproduced here. Needless to say, a supplementary wall thickness measurement according to the same principle can also be carried out on the left-hand side in FIG. The determined wall thicknesses can also be averaged over several measurements of the cylinder, between which it is rotated about its longitudinal axis. Furthermore, it is conceivable to compare the intensity peaks detectable on the left and right of the center beam for the direct determination of the inner diameter of the container.
  • FIG. 7 schematically shows a two-dimensional intensity pattern resulting from the telecentric transillumination. Due to the areal by transillumination of the container 16 with parallel beams, of course, irregularities in the geometry of the container wall can also be relatively small. be determined quickly and accurately. Thus, an outwardly curved curvature of a container wall 62, 64 can be seen directly in the detectable image in telecentric configuration.
  • FIG. 8 also shows a measuring configuration in which, for example, a syringe 16 is arranged with its tip pointing downwards on the turntable 24.
  • a syringe 16 is arranged with its tip pointing downwards on the turntable 24.
  • contour lines h and ho for the determination of a volume V can be assumed and measured.
  • the determined volume is still to correct the volume Vo.
  • h 0 is a freely definable height dimension, which is placed in the vicinity of the area of the syringe 16, at which the cylindrical region merges into the tip region. If there is no liquid in the region V 0 , then the volumes which can be determined in the configuration according to FIG. 8 and in the configuration according to FIG. 3 would be identical.
  • a reference measurement which is carried out according to the configuration according to FIG. 2 or according to FIG.
  • FIG. 9 shows, by way of example, an air bubble 66 located inside the liquid 30. This is located completely at the interface between the plug 34 and the liquid 30, so that a hemisphere can be assumed for the volume thereof.
  • the horizontal diameter dx 70 and / or the vertical diameter dy 68 are determined, if appropriate averaged and used to calculate the volume of the air bubble 66.
  • the inner and outer diameter and the liquid level 44, 46 it is provided according to the invention in particular to turn the turntable 24 in a total of 8 different positions with a stepper motor by 45 Grand, thus, respectively Get 8 shots for each test object.
  • error deviations can thus be reduced to a minimum.

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  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Measurement Of Levels Of Liquids Or Fluent Solid Materials (AREA)

Abstract

L’invention propose un procédé pour déterminer le volume de remplissage d’un récipient (16) fermé, rempli au moins partiellement d’un liquide (30). Le récipient est soumis à un rayonnement électromagnétique (26) et au moins une partie du rayonnement (28) transmis par le récipient est détectée avec une résolution locale dans un plan d’image et amenée à une unité d’évaluation (22). Pour déterminer le volume de remplissage, au moins la hauteur de remplissage (36) du liquide (30) dans le récipient (16) et au moins une surface transversale interne du récipient (16) sont déterminées à partir des données d’image détectées. L’invention propose en outre un dispositif pour déterminer le volume de remplissage d’un récipient fermé, rempli au moins partiellement d’un liquide ainsi qu’un programme informatique avec des moyens de programmation pour déterminer le volume de remplissage.
EP09761496A 2008-06-12 2009-06-12 Mesure non destructive du volume de remplissage d un récipient rempli de liquide Withdrawn EP2300788A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09761496A EP2300788A1 (fr) 2008-06-12 2009-06-12 Mesure non destructive du volume de remplissage d un récipient rempli de liquide

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EP08010702A EP2133668A1 (fr) 2008-06-12 2008-06-12 Mesure non destructive du volume de remplissage d'un récipient rempli de liquide
EP09761496A EP2300788A1 (fr) 2008-06-12 2009-06-12 Mesure non destructive du volume de remplissage d un récipient rempli de liquide
PCT/EP2009/004211 WO2009149933A1 (fr) 2008-06-12 2009-06-12 Mesure non destructive du volume de remplissage d’un récipient rempli de liquide

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EP09761496A Withdrawn EP2300788A1 (fr) 2008-06-12 2009-06-12 Mesure non destructive du volume de remplissage d un récipient rempli de liquide

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DE102011117310B4 (de) * 2011-10-28 2013-12-19 Torsten Matthias Vorrichtung und Verfahren zur Kontrolle eines Volumens einer Probe
DE102011117323B4 (de) * 2011-10-28 2013-12-19 Torsten Matthias Verfahren und Vorrichtung zur Kontrolle des Volumens mindestens einer Probe
EP2771697B8 (fr) * 2011-10-28 2023-08-02 Aeneas GmbH & Co. KG Dispositif et procédé de détection de substances présentes dans des prélèvements biologiques ou chimiques
ES2870855T3 (es) * 2011-10-28 2021-10-27 Aeneas Gmbh & Co Kg Procedimiento y dispositivo para el control del volumen y de la composición al menos de una muestra
WO2013060480A2 (fr) * 2011-10-28 2013-05-02 Torsten Matthias Dispositif et procédé de contrôle du volume d'un prélèvement
CN103115652B (zh) * 2013-01-24 2015-01-21 中国工程物理研究院化工材料研究所 封闭工作缸液位的测量方法及装置

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DE2840819A1 (de) * 1978-09-20 1980-04-03 Philips Patentverwaltung Verfahren zum ermitteln des innenmasses von langgestreckten hohlkoerpern, insbesondere von rohren
DE4330412A1 (de) * 1993-09-08 1995-03-09 Boehringer Mannheim Gmbh Verfahren und Vorrichtung zur Dosierung von Flüssigkeiten
US5568262A (en) 1994-05-31 1996-10-22 Lachapelle; Joseph G. Non-destructive fill volume measurement system
US5602890A (en) * 1995-09-27 1997-02-11 Thermedics Detection Inc. Container fill level and pressurization inspection using multi-dimensional images

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WO2009149933A1 (fr) 2009-12-17

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