EP2276456A1

EP2276456A1 - Antimicrobial cosmetic preparations

Info

Publication number: EP2276456A1
Application number: EP09745484A
Authority: EP
Inventors: Horst Argembeaux; Katrin Counradi; Heike FÖLSTER; Maren Meyer; Michael WÖHRMANN
Original assignee: Beiersdorf AG
Current assignee: Beiersdorf AG
Priority date: 2008-05-13
Filing date: 2009-03-18
Publication date: 2011-01-26
Also published as: DE102008001726A1; WO2009138150A1

Abstract

Disclosed are antimicrobial cosmetic preparations containing a cationic styrene/acrylate copolymer obtained by copolymerizing butyl acrylate, ethyltrimonium chloride methacrylate, and styrene, and a maximum of 20 percent by weight of surfactants.

Description

Beiersdorf AG

Hamburg

Antimicrobial cosmetic preparations

The human body is overgrown with microorganisms throughout the skin. These live, as it were, in a symbiosis with humans, their perfect, permanent removal would lead to pathological changes. This symbiosis works only if the concentration of microorganisms and their biodiversity are in an optimal balance. If this balance is disturbed, it can lead to unpleasant to pathological changes in the skin or unpleasant perceptions from subsequent processes.

Examples of such consequences are z. As bad smells, dandruff, acne.

In cosmetics and medicine, active substances are known which have an antimicrobial effect and can thus influence the balance of the skin flora. By skillfully selecting and concentrating such active ingredients in suitable matrix formulations, it is possible for a person skilled in the art to develop products which specifically combat microorganism-induced cosmetic or pathological secondary problems. A distinction is made between such agents that kill specific or all germs and those that remove germs from surfaces and bind to themselves. Germicidal agents carry the risk of intolerance reactions, as they can not destroy the cells of the microorganisms as cell toxins, in addition, can form resistances that can adversely affect the balance of the skin flora. Another negative aspect of germicidal agents is their effectiveness kinetics, the use for short-term treatments such. As a cleaning process followed by rinsing, impossible.

Anti-microbial agents are commonly referred to as antiadhesives and show no such negative effects. They bind germs without killing them and thus inactivate their action on the skin. The formation of resistance is excluded in consequence. They also have no cell-destroying effect, which eliminates the risk of such induced intolerance reactions and they act immediately.

DE 19503423 describes carbohydrates which have such an antiadhesive effect; moreover, chitin derivatives, eg. Chitosan as described in DE 102005048776, and many tionische polymers also such an anti-adhesive effect. Nevertheless, the use of such agents has not prevailed. The reason for this is considered to be an insufficient antiadhesive effect of many of these active ingredients and a frequent inactivation due to the influence of the matrix formulation. Some, such as B. Chitosan also act as deposition Aids, resulting in an accumulation of irritating Noxen such. B. surfactants on the skin and thus leads to a potential source of irritation.

Surfactants are amphiphilic substances that can dissolve organic, nonpolar substances in water. Due to their specific molecular structure with at least one hydrophilic and one hydrophobic part of the molecule, they provide for a lowering of the surface tension of the water, the wetting of the skin, the facilitation of dirt removal and dissolution, a gentle rinsing and - as desired - for foam regulation.

The hydrophilic portions of a surfactant molecule are usually polar functional groups, for example -COO ^" , -OSO ₃ ^2" , -SO ₃ ^" , while the hydrophobic portions are generally non-polar hydrocarbon residues of the hydrophilic part of the molecule, whereby four groups can be distinguished:

Anionic surfactants,

Cationic surfactants,

• amphoteric surfactants and

• nonionic surfactants.

Anionic surfactants generally have carboxylate, sulfate or sulfonate groups as functional groups. In aqueous solution, they form negatively charged organic ions in an acidic or neutral medium. Cationic surfactants are almost exclusively characterized by the presence of a quaternary ammonium group. In aqueous solution they form positively charged organic ions in an acidic or neutral environment. Amphoteric surfactants contain both anionic and cationic groups and behave accordingly in aqueous solution depending on the pH as anionic or cationic surfactants. They have a positive charge in a strongly acidic environment and a negative charge in an alkaline environment. In the neutral pH range, however, they are zwitterionic, as the following example is intended to illustrate:

RNH ₂ ⁺ CH ₂ CH ₂ COOH X ^" (at pH = 2) X ^" = any anion, eg Cl ^"

RNH ₂ ⁺ CH ₂ CH ₂ COO ^" (at pH = 7)

RNHCH ₂ CH ₂ COO-B ⁺ (at pH = 12) B ⁺ = any cation, eg Na ⁺ Typical of non-ionic surfactants are polyether chains. Nonionic surfactants do not form ions in an aqueous medium.

A. Anionic surfactants

Advantageously used anionic surfactants are

Acylamino acids (and their salts), such as

1. acylglutamates, for example sodium acylglutamate, di-TEA-palmitoylaspartate and sodium caprylic / capric glutamate,

2. acyl peptides, for example palmitoyl-hydrolyzed milk protein, sodium cocoyl-hydrolysed soy protein and sodium / potassium cocoyl-hydrolyzed collagen,

3. sarcosinates, for example myristoyl sarcosine, TEA-lauroyl sarcosinate, sodium lauroyl sarcosinate and sodium cocoyl sarcosinate,

4. taurates, for example sodium lauroyl taurate and sodium methyl cocoyl taurate,

5. Acyl lactylates, lauroyl lactylate, caproyl lactylate

6. Alaninates

Carboxylic acids and derivatives, such as

1. carboxylic acids, for example lauric acid, aluminum stearate, magnesium alkoxide and zinc undecylenate,

2. Ester carboxylic acids, for example calcium stearoyl lactylate, laureth-6-citrate and sodium PEG-4-lauramide carboxylate,

3. Ether carboxylic acids, for example sodium laureth-13-carboxylate and sodium PEG-6-cocamide carboxylate,

Phosphoric acid esters and salts such as DEA-oleth-10-phosphate and dilaureth-4-phosphate,

Sulfonic acids and salts, such as

1. Acyl-isethionates, z. B. sodium / ammonium cocoyl isethionate,

2. alkylaryl sulphonates,

3. alkylsulfonates, for example sodium, sodium C ₁₂ -14 olefinsulfonates fin-sulfonate, sodium lauryl sulfoacetate and magnesium PEG-3 cocamide sulfate,

4. 4. Sulfosuccinates, for example dioctyl sodium sulphosuccinate, disodium laureth sulphosuccinate, disodium lauryl sulphosuccinate, disodium undecylenamido MEA sulphosuccinate and PEG-5 lauryl citrate sulphosuccinate. and sulfuric acid esters, such as

1. alkyl ether sulfate, for example sodium, ammonium, magnesium, MIPA, TIPA laureth sulfate, sodium myreth sulfate and sodium C _12-13 pareth sulfate,

2. Alkyl sulfates, for example sodium, ammonium and TEA lauryl sulfate.

B. Cationic surfactants

Advantageously to use cationic surfactants

1. alkylamines,

2. alkylimidazoles,

3. Ethoxylated amines and

4. Quaternary surfactants.

5. Esterquats

Quaternary surfactants contain at least one N atom covalently bonded to 4 alkyl and / or aryl groups. This results in a positive charge regardless of the pH. Advantageous quaternary surfactants are alkyl betaine, alkyl amidopropyl betaine and alkyl amidopropyl hydroxysulfain. Cationic surfactants can furthermore preferably be selected from the group of quaternary ammonium compounds, in particular benzyltrialkylammonium chlorides or bromides, such as, for example, benzyldimethylstearylammonium chloride, alkyltrialkylammonium salts, for example cetyltrimethylammonium chloride or bromide, alkyldimethylhydroxyethylammonium chlorides or bromides, Dialkyldimethylammonium chlorides or bromides, alkylamidethyltrimethylammonium ether sulfates, alkylpyridinium salts, for example lauryl or cetylpyrimidinium chloride, imidazoline derivatives and compounds having a cationic character such as amine oxides, for example alkyldimethylamine oxides or alkylaminoethyldimethylamine oxides. Cetyltrimethylammonium salts are particularly advantageous to use.

C. Amphoteric surfactants

Advantageously used amphoteric surfactants

1. acyl / dialkylethylenediamine, for example sodium acylamphoacetate, disodium acyl amphodipropionate, disodium alkyl amphodiacetate, sodium acylamphohydroxypropyl sulfonate, disodium acyl amphodiacetate and sodium acyl amphopropionate,

2. N-alkylamino acids, for example aminopropylalkylglutamide, alkylaminopropionic acid, sodium alkylimidodipropionate and lauroamphocarboxyglycinate. D. Nonionic surfactants

Advantageously used nonionic surfactants are

1. Alcohols

2. alkanolamides, such as cocamide MEA / DEA / MIPA,

3. amine oxides, such as cocoamidopropylamine oxide,

4. Esters formed by esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan or other alcohols,

5. Ethers, for example ethoxylated / propoxylated alcohols, ethoxylated / propoxylated esters, ethoxylated / propoxylated glycerol esters, ethoxylated / propoxylated triglyceride esters, ethoxylated propoxylated lanolin, ethoxylated / propoxylated polysiloxanes, propoxylated POE ethers and alkyl polyglycosides such as lauryl glucoside, Decyl glycoside and cocoglycoside.

6. sucrose ester, ether

7. Polyglycehnester, Diglycerolester, Monoglycerinester

8. Methyl glucose esters, esters of hydroxy acids

It is also advantageous to use a combination of anionic and / or amphoteric surfactants with one or more nonionic surfactants.

Invention:

It has surprisingly been found that antimicrobial cosmetic preparations containing a cationic styrene / acrylate copolymer obtainable by copolymerization of butyl acrylate, ethyltrimonium chloride methacrylate and styrene and at most 20 wt .-% surfactants to overcome the disadvantages of the prior art. Such cationic styrene / acrylate copolymers in combination with surface-active substances such. As emulsifiers or surfactants enhance the anti-adhesive effect or at least not reduce it. Formulations with higher levels of surfactants show similar effects when the proportion of anionic surfactants is very low. Moreover, such formulations do not show any increased surfactant adsorption on the skin and are thus excellently compatible.

It is advantageous if the surface-active substances are selected from the group of anionic, cationic, amphoteric or nonionic surfactants or mixtures thereof. It is preferred if the content of anionic surface-active substances is at most 5% by weight, preferably at most 3% by weight, particularly preferably at most 2.5% by weight. It is preferred if the cationic styrene / acrylate copolymer is a polymer with the INCI name "butyl acrylate / ethyltrimonium chloride methacrylates / styrene copolymer." Polymers whose cationic charges are free from degradation or Activation protected and so are still effective even after a long time. Such protection can be provided, for example, by the cationic group of adjacent nonionic side chains. Such polymers are for. As described in US 20050003163.

A particularly advantageous deodorant effect is a butyl acrylate / ethyltrimonium chloride methacrylate / styrene copolymer, which is sold by Dow Reichhold Specialty Latex under the trade name PolySaf ™ 5600. PolySaf 5600 is offered as a - 40% aqueous suspension and can be easily incorporated into a wide variety of cosmetic formulations.

It is particularly advantageous if the cationic styrene / acrylate copolymer in active contents of 0.01 to 4 wt .-%, preferably from 0.1 to 3 wt .-%, particularly preferably from 0.5 to 2 wt .-% is present. The invention also includes the use of preparations according to any one of the preceding claims as deodorants, deodorizing products, personal care, shower or anti-acne products.

Attempts to investigate the Tensidadsorbtion show that there is no increased Tensidadsadsorption. The following describes the method and results of the surfactant adsorption tests carried out:

Aim:

Quantitative determination of the noun-fed amount of sodium laureth sulfate,

Cocamidopropyl betaines and sodium cocoamphoacetate from shower formulations on the

Skin (shower formulations with or without described cationic polymer ((PolySaf 5600;

40% aqueous dispersion) or with chitosan). The sample was taken after one-time

Application.

Execution: Number of test persons: 20

Application:

The forearm areas (area = 4.91 cm ² ) were foamed with 500 ul_ product 30s, then rinsed with 1 L of water and blotted dry with pulp. Extraction of the areas was performed with 1 ml of 1% Triton X-100 solution. The extracts were diluted 1:10 with water, filtered and then measured directly. Quantitative determination of sodium laureth sulfate (LES), cocamidopropyl betaine (CAPB) and sodium cocoamphoacetate (CAA) was performed by LC-MS (external standard calibration). The reference substances used were the raw materials TEXAPON N 70 (LES Cognis), active content 70% and REWOTERIC AM C (CAA Evonik Goldschmidt), active content 32.5%. The contents given refer to the reference substances used; To calculate the absolute surfactant contents, the results given must be corrected by the activity content deviating from 100%.

Results:

Test i

sample coding

(01) Untreated

(10) Standard shower with 6.5% sodium laureth sulfate (without chitosan)

(20) Shower formulation without chitosan with 2.1% LES, 7.2% sodium

Cocoamphoacetate (30) Shower formulation with chitosan containing 2.1% LES, 7.2% sodium

cocoamphoacetates

Result:

Significantly Increased Adsorption of Sodium Laureth Sulfate and Sodium Cocoamphoacetate from the Shower Formulation with Chitosan (30) 01 10 20 30

Cocoamphoace Cocoamphoace Cocoamphoace Cocoamphoace

Test person LES (μg / areal) tat (μg / areal) LES (μg / areal) tat (μg / areal) LES (μg / areal) tat (μg / areal) LES (μg / areal) tat (μg / areal)

1-1 0.08 0.38 11, 84 0.41 7.47 42.57 29.23 121.45

1-2 0.05 0.30 13.22 0.45 5.87 35.41 34.68 156.19

2-1 0.06 0.00 10.20 0.29 5.26 27.82 17.91 74.65

2-2 0.07 0.00 11.39 0.35 5.82 30.81 20.53 76.65

3-1 0,04 0,00 6,12 0,22 3,66 20,69 39,84 129,73

3-2 0.02 0.00 7.49 0.29 2.41 13.54 30.96 104.36

4-1 0.03 0.00 8.13 0.26 4.30 21.50 15.34 77.81

4-2 0.02 0.00 8.40 0.27 4.77 29.45 16.90 70.00

5-1 0.06 0.32 13.46 0.77 5.53 36.13 15.85 96.83

5-2 0.04 0.32 1 1.85 0.35 4.93 31.62 28.16 134.78

6-1 0.05 0.00 1 1.98 0.46 5.00 34.39 24.52 107.59

6-2 0.04 0.00 9.98 0.34 5.25 31.60 18.54 74.37

7-1 0.00 0.00 14.47 0.63 5.96 37.41 34.1 1 134.70

7-2 0.00 0.00 13.37 0.52 7.00 37.53 51.68 226.50

8-1 0.14 0.00 25.01 0.93 10.07 73.65 49.27 200.59

8-2 0.09 0.00 19.82 0.70 7.23 51.95 45.14 201.91

9-1 0.25 0.36 12.24 0.45 7.09 36.35 24.30 81.45

9-2 0,20 0,50 11,02 0,49 6,64 31,06 19,92 64,97

10-1 0.06 0.00 10.03 0.30 4.47 23.31 23.01 113.57

10-2 0.06 0.00 12.79 0.47 5.22 28.54 30.77 141.34

1 1-1 0.05 0.00 1 1.09 0.35 3.21 19.89 14.64 45.29

11-2 0.04 0.00 13.46 0.40 3.85 18.61 14.75 52.15

12-1 0.08 0.58 19.98 0.70 11.30 59.93 26.97 1 11.24

12-2 0.08 0.77 14.9 »0.52 9.40 55.78 30.61 141.83

13-1 0.05 0.19 14.16 0.49 3.87 25.26 1 1.76 41.43

13-2 0.08 0.22 13.36 0.44 4.82 26.61 14.25 65.44

14-1 0.03 0.00 5.68 0.00 2.37 11.88 8.77 32.43

14-2 0.03 0.25. _ 2,93 16,58 10,67 40,09

15-1 0.02 0.00 4.86 0.00 2.76 14.99 7.69 24.70

15-2 0.02 0.00 5.78 0.22 3.49 21.36 1 1.09 39.60

16-1 0.39 0.00 14.04 0.39 7.43 48.40 14.52 73.43

16-2 0.49 0.00 9.43 0.32 7.98 50.97 20.28 110.67

17-1 0.02 0.32 3.86 0.00 2.11 9.76 8.07 22.18

17-2 0.02 0.00 4.72 0.00 1.93 10.45 14.32 45.84

18-1 0.10 0.00 5.62 0.23 2.70 15.03 13.23 52.42

18-2 0.09 0.00 7.69 0.22 2.23 13.69 14.31 57.74

19-1 0.15 0.00 16.06 0.44 2.45 8.90 6.34 14.01

19-2 0.15 0.00 12.89 0.30 3.03 9.86 5.21 14.41

20-1 0.07 0.00 14.48 0.36 5.40 34.86 1 1.06 46.53

20-2 0.08 0.00 14.91 0.36 3.09 18.02 12.28 52.62

Mean 0.08 0.11 1 1.53 0.38 5.01 29.15 21.04 86.84

Stabw 0,10 0,19 4,48 0,20 2,28 15,15 11,70 52,19

Var% 115.8% 173.4% 38.8% 53.8% 45.6% 52.0% 55.6% 60.1%

Sodium cocoamphoacetate: 0.00 corresponds to <determination limit (0.15 μg / areal)

See Figure 1

Test 2

sample coding

(01) untreated

(10) Shower formulation with chitosan with 2.1% LES, 7.2% sodium

Cocoamphoacetate, 2.9% Cocamidopropyl Betaine (20) Shower formulation without new cat. Polymer with 2.1% LES, 10.1%

Cocamidopropyl Betaine (30) Shower formulation with new cat. Polymer (PolySaf 5600 (40% aqueous

Dispersion)) with 2.1% LES, 10.1% cocamidopropyl betaines Result:

Significantly increased adsorption of sodium laureth sulfate from the formulation with chitosan (10) compared to the shower formulations with new cat. Polymer (30) or placebo (20). Also, betaine is more strongly adsorbed in relation to the amount used and in addition sodium cocoamphoacetate (not shown in the diagram), so that the total amount of surfactant adsorbed on the skin from the formulation (10) with chitosan is many times higher than that Wording with the new kat. Polymer.

01 10 20 30

Cocoampho Cocoampho;

LES Betain cetat LES Betain cetat LES Betain LES betaine

Subject (μg / Areal) (μg / Areal) (μg / Areal) (μg / Areal) (μg / Areal) (μg / Areal) (μg / Areal) (μg / Areal) (μg / Areal) (μg / Areal) )

1 1.59 0.84 0.00 40.00 59.35 159.33 12.13 57.51 4.67 26.48

2 3.16 0.54 0.00 28.35 21.93 68.23 15.21 31.20 7.09 25.96

3 2.18 0.58 0.00 31.42 28.67 90.67 17.64 46.69 8.16 38.07

4 1, O ₅ 0.00 0.00 42.95 66.17 211.84 14.27 69.75 12.08 85.79

5 0.83 0.00 0.00 36.19 58.87 167.87 7.24 29.13 2.47 13.71

6 1.40 0.66 0.00 27.01 40.47 120.81 4.50 31.35 13.57 68.12

7 0.49 0.00 0.00 16.54 19.09 64.07 5.06 15.86 2.23 10.98

8 0.34 0.00 0.00 32.49 43.24 127.62 10.52 45.30 5.47 30.00

9 1.52 0.61 0.00 54.91 72.99 209.49 18.03 94.15 10.81 80.40

10 0.15 0.00 0.00 31.19 34.24 105.99 7.28 21.68 3.86 24.97

11 1.67 0.00 0.00 47.91 62.66 156.55 6.70 26.53 51.70 69.36

I ₂ 2.31 0.49 0.00 33.87 49.26 125.16 8.84 38.07 3.70 21.88

13 0.42 0.00 0.00 28.26 42.99 108.87 7.65 47.76 2.49 19.77

14 2.18 0.66 0.00 37.72 60.23 155.66 14.17 91.34 6.07 49.37

I ₅ 1.49 0.48 0.14 28.50 49.46 131.69 8.89 49.08 5.68 50.30

16 1.67 0.46 0.00 18.49 23.40 65.64 7.74 32.48 3.55 20.19

17 2.62 0.00 0.00 21.06 23.05 70.76 8.40 37.87 4.46 21.57

18 1.1 1 0.79 0.00 32.24 42.72 1 19.12 12.18 60.33 4.15 31.14

19 0.64 0.00 0.00 26.50 28.66 84.59 5.74 16.74 2.76 17.76

20 3.53 2.37 0.00 39.23 58.91 168.83 9.23 43.03 5.10 24.30

Mean 1.52 0.42 0.01 32.74 44.32 125.64 10.07 44.29 8.00 36.51

Stabw 0.94 0.56 0.03 9.44 16.59 45.01 4.04 21.77 10.78 22.78

Var% 61.7% 131.5% 447.2% 28.8% 37.4% 35.8% 40.1% 49.2% 134.6% 62.4%

Sodium cocoamphoacetate: 0.00 corresponds to <determination limit (0.15 μg / mL) Betaine: 0.00 corresponds to <determination limit (0.1 μg / mL)

See Figure 2

Attempts to investigate the antiadhesive effect show a very good reduction of bacterial adhesion by preparations according to the invention. Execution:

Bacteria of a LINK (overnight culture) are centrifuged off, washed with buffer, fixed in 70% EtOH for 30 min and stained with propidium iodide. The excess dye is removed by washing several times. The bacteria are incubated for 1 h with the raw materials (anti-adhesives). Subsequently, the bacterial suspensions are incubated with human corneocytes, which are obtained from the forearm of a subject, for 1 h at RT (room temperature). After this adhesion period, the bacteria-corneocyte complexes are obtained by separation of the non-adherent bacteria and the adhesion rate is determined by flow cytometry and controlled microscopically. The rate of adhesion of the control batch, in which bacteria (not pretreated) and Comeozyten are incubated, is defined as 100% relative Adhäsungsrate. All other approaches are calculated in relation to it. Values <100% indicate an inhibition of bacterial adhesion, values> 100% an increased bacterial adhesion.

The graph below shows the relative rates of adhesion after incubation with a cationic example polymer (PolySaf 5600, 40% aqueous dispersion) and surfactant mixtures with and without cationic polymer.

The example polymer shows a very good reduction in bacterial adhesion to 19% relative adhesion rate. Both surfactant formulations show a slight influence on the adhesion (85% and 95%, respectively). Surfactant formulation 1 with a higher content of anionic surfactants shows a strong influence on the effectiveness of the cationic polymer. In contrast, surfactant formulation 2, with a significantly lower content of anionic surfactants, can even increase the effectiveness of the example polymer (to 14% relative adhesion rate).

See Figure 3

Fig.: Anti-adhesive effectiveness of surfactant formulations.

The following graph shows the influence of the cationic polymer PolySaf 5600 (as a 40% aqueous dispersion) on the relative adhesion rate. The polymer alone reduces the relative adhesion rate to a value of 19%. When incorporated into a de-formulation, the effectiveness of the PolySaf 5600 polymer is at a similar level (relative adhesion rate of 22%) while the formulation itself has no effect. See Figure 4

Fig.: Anti-adhesive effectiveness of cationic polymers in deodorizing

In addition, formulations based on such combinations may contain other components, e.g. Preservatives, stabilizers, buffering agents, thickeners, perfumes, pearlescing agents, opacifiers, complexing agents, humectants, solvents, dyes, oils, extracts, vitamins, antioxidants, UV filters.

Also preferred may be the combination with other Deowirkstoffen such as triclosan, chlorhexidine or the naturally occurring compounds such as Famesol, 2-butyl octanoic acid and phenoxyethanol. Also, the combination with aluminum salts such as aluminum hydroxychloride (aluminum chlorohydrate) or aluminum / zirconium salts may be preferred.

Example formulations for a variety of applications are deodorant applications, deodorant showers, personal care products, anti-dandruff shampoo, foot bath, skin care, facial cleansing or anti-acne products.

Example recipes:

Example 15

Example 17

The liquid phase obtained by mixing together the respective components is filled with a propane-butane mixture (2.7) in a ratio of 39:61 in aerosol containers.

Example 18

The liquid phase obtained by mixing the respective components together with a propane-butane mixture (2.7) in the ratio 17:83 filled in aerosol container.

Example 19

Example 21 -23

Example 24 Example 25

Example 26

The liquid phase obtained by mixing together the respective components is filled with a propane-butane mixture (2.7) in the ratio 19:81 in aerosol containers.

Example 27:

Example 28:

Example 29 - Recipes

The pH of the shower gels is 4.8 - 5.3: The viscosity is between 2000 and 5000 mPa.

Claims

claims

1. Antimicrobial cosmetic preparations containing a cationic styrene / acrylate copolymer obtainable by copolymerization of butyl acrylate, Ethyltrimoniumchlorid- methacrylate and styrene and at most 20 wt .-% of surface-active substances.

2. Preparation according to claim 1, characterized in that the surface-active substances from the group of anionic, cationic, amphoteric or nonionic surfactants or mixtures thereof are selected.

3. Preparations according to one of the preceding claims, characterized in that the content of surface-active substances is at most 15 wt .-%.

4. Preparations according to one of the preceding claims 1 or 2, characterized in that the content of anionic surface-active substances is at most 5 wt .-%.

5. Preparations according to claim 1, 2 or 3, characterized in that the content of anionic surface-active substances is at most 4 wt .-%.

6. Preparations according to claim 1, 2, 3 or 4, characterized in that the content of anionic surface-active substances is at most 2.5 wt .-%.

7. Preparation according to one of the preceding claims, characterized in that the cationic charges of the cationic styrene / acrylate copolymer are protected by adjacent nonionic side chains from degradation or inactivation.

8. Preparation according to one of the preceding claims, characterized in that the cationic styrene / acrylate copolymer is a polymer with the INCI name "butyl acrylates / Ethylthmonium Chloride Methacrylates / Styrene Copolymer".

9. Preparations according to one of the preceding claims, characterized in that the cationic styrene / acrylate copolymer in active contents of 0.01 to

4 wt .-%, preferably from 0.1 to 3 wt .-%, particularly preferably from 0.5 to 2.0 wt .-% is present.

0. Use of preparations according to one of the preceding claims as deodorants, deodorants, personal hygiene products, shower or anti-acne products.