EP2269629A3 - Compositions et procédés pour produire des cellules présentant des antigènes - Google Patents
Compositions et procédés pour produire des cellules présentant des antigènes Download PDFInfo
- Publication number
- EP2269629A3 EP2269629A3 EP10010087.4A EP10010087A EP2269629A3 EP 2269629 A3 EP2269629 A3 EP 2269629A3 EP 10010087 A EP10010087 A EP 10010087A EP 2269629 A3 EP2269629 A3 EP 2269629A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- methods
- vivo
- presenting cells
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 210000000612 antigen-presenting cell Anatomy 0.000 title abstract 3
- 210000004443 dendritic cell Anatomy 0.000 abstract 3
- 238000000338 in vitro Methods 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 102000003812 Interleukin-15 Human genes 0.000 abstract 1
- 108090000172 Interleukin-15 Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000001476 gene delivery Methods 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000011160 research Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4648—Bacterial antigens
- A61K39/46482—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/052—Lipopolysaccharides [LPS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20357100P | 2000-05-11 | 2000-05-11 | |
EP01933309A EP1280889B1 (fr) | 2000-05-11 | 2001-05-11 | Compositions et procédés de production de cellules présentatrices d'antigènes |
EP07016833A EP1927657A3 (fr) | 2000-05-11 | 2001-05-11 | Compositions et procédés pour la production de cellules présentant un antigène |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01933309.5 Division | 2001-05-11 | ||
EP07016833.1 Division | 2007-08-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2269629A2 EP2269629A2 (fr) | 2011-01-05 |
EP2269629A3 true EP2269629A3 (fr) | 2013-09-11 |
Family
ID=22754519
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10010087.4A Withdrawn EP2269629A3 (fr) | 2000-05-11 | 2001-05-11 | Compositions et procédés pour produire des cellules présentant des antigènes |
EP01933309A Expired - Lifetime EP1280889B1 (fr) | 2000-05-11 | 2001-05-11 | Compositions et procédés de production de cellules présentatrices d'antigènes |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01933309A Expired - Lifetime EP1280889B1 (fr) | 2000-05-11 | 2001-05-11 | Compositions et procédés de production de cellules présentatrices d'antigènes |
Country Status (6)
Country | Link |
---|---|
EP (2) | EP2269629A3 (fr) |
AT (1) | ATE371722T1 (fr) |
AU (1) | AU2001259744A1 (fr) |
DE (1) | DE60130206T2 (fr) |
ES (1) | ES2288952T3 (fr) |
WO (1) | WO2001085920A2 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002036141A2 (fr) * | 2000-11-02 | 2002-05-10 | Immunex Corporation | Methode permettant d'ameliorer des reponses immunitaires induites par des lymphocytes |
AU2003295331A1 (en) * | 2002-09-19 | 2004-04-23 | Centocor, Inc. | Method of inducing maturation of dendritic cells and uses therefor |
CA2525519A1 (fr) | 2003-05-08 | 2004-12-02 | Xcyte Therapies, Inc. | Generation et isolement de lymphocytes t specifiques de l'antigene |
NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
DE102007006736B4 (de) | 2007-02-07 | 2012-01-12 | Dagmar Briechle | In-vitro Testkit zur tierversuchsfreien Bestimmung des sensibilisierenden Potentials einer Substanz |
EP2205252B1 (fr) * | 2007-09-27 | 2017-04-05 | The Board Of Trustees Of The University Of Arkansas | Inhibition de l'activation et de la potentialisation des lymphocytes t régulateurs entraînées par une cellule dendritique de réponses des lymphocytes t spécifiques d'un antigène de tumeur par l'interleukine-15 et un inhibiteur de la kinase map |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997026328A1 (fr) * | 1996-01-17 | 1997-07-24 | Imperial College Innovations Limited | Immunotherapie utilisant des lymphocytes t cytotoxiques (ctl) |
WO1999003499A1 (fr) * | 1997-07-16 | 1999-01-28 | Institut National De La Sante Et De La Recherche Medicale | Vesicule cellulaire denommee ''exosome'', leur preparation et utilisation dans la stimulation d'une reponse immunitaire |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747024A (en) | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
-
2001
- 2001-05-11 WO PCT/US2001/015300 patent/WO2001085920A2/fr active IP Right Grant
- 2001-05-11 AU AU2001259744A patent/AU2001259744A1/en not_active Abandoned
- 2001-05-11 EP EP10010087.4A patent/EP2269629A3/fr not_active Withdrawn
- 2001-05-11 ES ES01933309T patent/ES2288952T3/es not_active Expired - Lifetime
- 2001-05-11 DE DE60130206T patent/DE60130206T2/de not_active Expired - Lifetime
- 2001-05-11 EP EP01933309A patent/EP1280889B1/fr not_active Expired - Lifetime
- 2001-05-11 AT AT01933309T patent/ATE371722T1/de not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997026328A1 (fr) * | 1996-01-17 | 1997-07-24 | Imperial College Innovations Limited | Immunotherapie utilisant des lymphocytes t cytotoxiques (ctl) |
WO1999003499A1 (fr) * | 1997-07-16 | 1999-01-28 | Institut National De La Sante Et De La Recherche Medicale | Vesicule cellulaire denommee ''exosome'', leur preparation et utilisation dans la stimulation d'une reponse immunitaire |
Non-Patent Citations (3)
Title |
---|
BANCHEREAU J & STEINMAN R M: "Dendritic cells and the control of immunity", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 392, no. 6673, 19 March 1998 (1998-03-19), pages 245 - 252, XP002134557, ISSN: 0028-0836 * |
BANCHEREAU J ET AL: "IMMUNOBIOLOGY OF DENDRITIC CELLS", ANNUAL REVIEW OF IMMUNOLOGY, ANNUAL REVIEWS INC, US, vol. 18, 2000, pages 767 - 811, XP001018258, ISSN: 0732-0582 * |
ZITVOGEL L ET AL: "Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 4, no. 5, 1 May 1998 (1998-05-01), pages 594 - 600, XP002085387, ISSN: 1078-8956 * |
Also Published As
Publication number | Publication date |
---|---|
EP1280889A2 (fr) | 2003-02-05 |
AU2001259744A1 (en) | 2001-11-20 |
EP2269629A2 (fr) | 2011-01-05 |
ATE371722T1 (de) | 2007-09-15 |
ES2288952T3 (es) | 2008-02-01 |
WO2001085920A2 (fr) | 2001-11-15 |
DE60130206D1 (de) | 2007-10-11 |
EP1280889B1 (fr) | 2007-08-29 |
WO2001085920A3 (fr) | 2002-05-10 |
DE60130206T2 (de) | 2008-05-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Verdijk et al. | Polyriboinosinic polyribocytidylic acid (poly (I: C)) induces stable maturation of functionally active human dendritic cells | |
DK1604016T3 (da) | In vitro-fremgangsmåde til differentiering af monocytiske dendritiske precursorceller i umodne dendritiske celler | |
EP2722387A3 (fr) | Endoderme définitif | |
EP2341072A3 (fr) | Procédé pour l'obtention de cellules lymphocytes activées et de cellules présentatrices d'antigènes à impulsion antigénique | |
BRPI0212545A8 (pt) | método ex vivo ou in vitro para produzir uma população de célula dendrítica madura e método para produzir células t | |
EP2695608A3 (fr) | Formulations contenant un lipide | |
EP2248898A3 (fr) | Méthodes d'induction de la différenciation de cellules de mammifère non différentiées en ostéoblastes | |
EP2278022A3 (fr) | Vecteurs d'expression, systèmes de transfection et procédé d'utilisation correspondant | |
RU2008122550A (ru) | Композиции и способы индуцирования активации незрелых моноцитарных дендритных клеток | |
IL148844A0 (en) | Methods related to immunostimulatory nucleic acid-induced interferon | |
WO2005016388A3 (fr) | Systeme d'implant structural et biologique | |
EP1165830A4 (fr) | Cellules souches et reseaux derives de tissus adipeux | |
WO2003105908A3 (fr) | Methodes et compositions faisant appel a des asialodeterminants cellulaires et a des glycoconjugues pour fournir des cellules a des tissus et a des organes | |
EP2308987A3 (fr) | Transfection de cellules eucaryotes avec des polynucléotides linéaires par électroporation | |
EP2283721A3 (fr) | Lentille d'eau genetiquement mise au point | |
EP2269629A3 (fr) | Compositions et procédés pour produire des cellules présentant des antigènes | |
AU2002331356A1 (en) | Nanoparticles for dna administration to a target organ | |
DE60108661D1 (de) | Herstellung und verwendung von dendritischen zellen | |
EP2377922A3 (fr) | Endoderme exprimant PDX1 | |
EP0747473A3 (fr) | Ensemble porte-objet pour culture biologique | |
WO2000030667A3 (fr) | Compositions et methodes d'utilisation de lactadherine ou de ses variants | |
EP1927657A3 (fr) | Compositions et procédés pour la production de cellules présentant un antigène | |
Goxe et al. | Monocyte-derived dendritic cells: development of a cellular processor for clinical applications | |
EP2465526A3 (fr) | Cellules NKT élevées et leurs utilisations dans le traitement de troubles liés à l'immunité | |
CA2441535A1 (fr) | Techniques d'apport de molecules d'acides nucleiques dans des cellules et evaluation de cet apport |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20100921 |
|
AC | Divisional application: reference to earlier application |
Ref document number: 1927657 Country of ref document: EP Kind code of ref document: P Ref document number: 1280889 Country of ref document: EP Kind code of ref document: P |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 5/0784 20100101ALI20130417BHEP Ipc: C07K 14/54 20060101AFI20130417BHEP Ipc: C12N 1/38 20060101ALI20130417BHEP Ipc: A61K 35/12 20060101ALI20130417BHEP |
|
PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 14/54 20060101AFI20130802BHEP Ipc: C12N 5/0784 20100101ALI20130802BHEP Ipc: C12N 1/38 20060101ALI20130802BHEP Ipc: A61K 35/12 20060101ALI20130802BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20131203 |