EP2136836B8 - Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof - Google Patents

Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof Download PDF

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Publication number
EP2136836B8
EP2136836B8 EP08745178.7A EP08745178A EP2136836B8 EP 2136836 B8 EP2136836 B8 EP 2136836B8 EP 08745178 A EP08745178 A EP 08745178A EP 2136836 B8 EP2136836 B8 EP 2136836B8
Authority
EP
European Patent Office
Prior art keywords
fusions
mycobacterium tuberculosis
immunogenic compositions
tuberculosis polypeptides
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP08745178.7A
Other languages
German (de)
French (fr)
Other versions
EP2136836A2 (en
EP2136836B1 (en
Inventor
Steven G. Reed
Rhea N. Coler
Gregory C. IRETON
Bertholet Sylvie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Access to Advanced Health Institute
Original Assignee
Infectious Disease Research Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infectious Disease Research Institute Inc filed Critical Infectious Disease Research Institute Inc
Priority to PL08745178T priority Critical patent/PL2136836T3/en
Priority to EP16206308.5A priority patent/EP3199176B1/en
Publication of EP2136836A2 publication Critical patent/EP2136836A2/en
Application granted granted Critical
Publication of EP2136836B1 publication Critical patent/EP2136836B1/en
Publication of EP2136836B8 publication Critical patent/EP2136836B8/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
EP08745178.7A 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof Active EP2136836B8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL08745178T PL2136836T3 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof
EP16206308.5A EP3199176B1 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91016907P 2007-04-04 2007-04-04
PCT/US2008/059500 WO2008124647A2 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP16206308.5A Division EP3199176B1 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof
EP16206308.5A Division-Into EP3199176B1 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof

Publications (3)

Publication Number Publication Date
EP2136836A2 EP2136836A2 (en) 2009-12-30
EP2136836B1 EP2136836B1 (en) 2017-01-04
EP2136836B8 true EP2136836B8 (en) 2017-04-12

Family

ID=39620241

Family Applications (2)

Application Number Title Priority Date Filing Date
EP08745178.7A Active EP2136836B8 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof
EP16206308.5A Active EP3199176B1 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP16206308.5A Active EP3199176B1 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof

Country Status (11)

Country Link
US (6) US8486414B2 (en)
EP (2) EP2136836B8 (en)
JP (3) JP5378350B2 (en)
CN (2) CN101687027B (en)
BR (1) BRPI0809926B8 (en)
DK (1) DK2136836T3 (en)
ES (1) ES2621211T3 (en)
MX (2) MX2009010800A (en)
PL (1) PL2136836T3 (en)
WO (1) WO2008124647A2 (en)
ZA (1) ZA200907316B (en)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2207035B1 (en) * 2006-03-14 2013-10-16 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
BRPI0809926B8 (en) 2007-04-04 2021-05-25 Infectious Disease Res Inst composition comprising antigens from mycobacterium tuberculosis, isolated fusion polypeptide, isolated polynucleotide encoding said polypeptide, and use of said composition to stimulate a protective immune response
EP3360566B1 (en) 2009-11-20 2019-12-25 Oregon Health&Science University Methods for detecting a mycobacterium tuberculosis infection
WO2012057904A1 (en) * 2010-10-27 2012-05-03 Infectious Disease Research Institute Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity
EP2573107A1 (en) * 2011-09-21 2013-03-27 Norwegian Institute of Public Health A recombinant fusion protein
WO2013090897A1 (en) * 2011-12-15 2013-06-20 The Trustees Of The University Of Pennsylvania Using adaptive immunity to detect drug resistance
CN102586139B (en) * 2012-01-20 2013-03-20 广东本科生物工程股份有限公司 A strain of high-yielding AD/ADD and a method for efficiently producing AD/ADD
CN110339160A (en) 2012-02-07 2019-10-18 传染性疾病研究院 Improvement adjuvant formulation and its application method comprising TLR4 agonist
WO2013119763A1 (en) 2012-02-07 2013-08-15 Intuitive Biosciences, Inc. Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
US10048561B2 (en) 2013-02-21 2018-08-14 View, Inc. Control method for tintable windows
WO2014009438A2 (en) * 2012-07-10 2014-01-16 Transgene Sa Mycobacterial antigen vaccine
MX385774B (en) 2012-08-03 2025-03-18 Infectious Disease Res Inst COMPOSITIONS FOR USE IN THE TREATMENT OF AN ACTIVE MYCOBACTERIUM TUBERCULOSIS INFECTION.
CN102899334B (en) * 2012-10-29 2015-02-25 英诺特（唐山）生物技术有限公司 Mycobacterium tuberculosis recombinant protein and preparation method thereof
WO2014145923A2 (en) * 2013-03-15 2014-09-18 The Trustees Of The Univeristy Of Pennsylvania Synthetic immunogens for prophylaxis or treatment of tuberculosis
CN104237508B (en) * 2013-06-19 2015-12-02 华中农业大学 A kind of detection kit of Much's bacillus and application
CN104237509B (en) * 2013-06-19 2015-12-02 华中农业大学 A kind of detection kit of Much's bacillus and application
WO2014210018A1 (en) * 2013-06-25 2014-12-31 Aeras Global Tb Vaccine Foundation Tuberculosis compositions and methods of using the same
WO2015031778A2 (en) * 2013-08-30 2015-03-05 Globeimmune, Inc. Compositions and methods for the treatment or prevention of tuberculosis
US9504743B2 (en) 2013-09-25 2016-11-29 Sequoia Sciences, Inc Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US9149522B2 (en) 2013-09-25 2015-10-06 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US20150086592A1 (en) 2013-09-25 2015-03-26 Sequoia Sciences, Inc Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US9149521B2 (en) 2013-09-25 2015-10-06 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
JP6249712B2 (en) * 2013-10-09 2017-12-20 公益財団法人ヒューマンサイエンス振興財団 Method of operating prognostic device for patients with non-paraneoplastic acute encephalitis
CN103698531B (en) * 2013-11-25 2015-10-14 广东体必康生物科技有限公司 The purposes of Rv1860, Rv0173 and/or Rv1812c albumen in the phthisical product of preparation diagnostic activities
IL310015B2 (en) 2013-12-31 2026-02-01 Access To Advanced Health Inst Single vial vaccine formulations
US10765731B2 (en) 2014-01-09 2020-09-08 Transgene Sa Fusion of heterooligomeric mycobacterial antigens
KR101477795B1 (en) * 2014-04-23 2015-01-02 건국대학교 산학협력단 Composition comprising ADK for preventing or treating sepsis or septic shock
JP6450007B2 (en) * 2014-12-10 2019-01-09 コングク ユニバーシティ グローカル インダストリー−アカデミック コラボレーション ファウンデーション Antibacterial composition containing ADK protein as an active ingredient, or composition for preventing or treating sepsis
US10792340B2 (en) * 2015-04-03 2020-10-06 Konkuk University Glocal Industry-Academic Collaboration Foundation Antibacterial composition for combating carbapenem-resistant gram-negative bacteria comprising ADK protein as active ingredient
CN106645733A (en) * 2015-07-16 2017-05-10 广东体必康生物科技有限公司 Protein for specific detection of mycobacterium tuberculosis infection
IL263030B2 (en) 2016-05-16 2024-11-01 Access To Advanced Health Inst Pegylated liposomes and methods of use
EP4112638A1 (en) 2016-05-16 2023-01-04 Access to Advanced Health Institute Formulation containing tlr agonist and methods of use
MX2018014270A (en) * 2016-05-21 2019-02-14 Infectious Disease Res Inst Compositions and methods for treating secondary tuberculosis and nontuberculous mycobacterium infections.
KR102748354B1 (en) 2016-06-01 2024-12-31 액세스 투 어드밴스드 헬스 인스티튜트 Nanoalum particles containing sizing agent
CN109890411A (en) 2016-06-16 2019-06-14 国际艾滋病疫苗行动组织公司 Tuberculosis composition and treatment or prevention method lungy
CN109843321A (en) 2016-06-22 2019-06-04 国际艾滋病疫苗行动组织公司 Recombinant cytomegalovirus vector as a tuberculosis vaccine
ES2950436T3 (en) 2016-12-14 2023-10-10 Becton Dickinson Co Methods and compositions to obtain an assessment of tuberculosis in a subject
KR102673794B1 (en) 2017-06-15 2024-06-11 액세스 투 어드밴스드 헬스 인스티튜트 Nanostructured lipid carriers and stable emulsions and their uses
CN107817228B (en) * 2017-06-30 2022-06-14 四川农业大学 Detection method for E.coli O157:H7 enzyme-free and fluorescence-free labeling
CN111315406A (en) 2017-09-08 2020-06-19 传染病研究所 Liposome formulations including saponins and methods of use
US11638749B2 (en) 2017-10-17 2023-05-02 International Aids Vaccine Initiative, Inc. Tuberculosis antigen cassettes
WO2019126523A2 (en) * 2017-12-22 2019-06-27 Massachusetts Eye And Ear Infirmary Comprehensive microbial panel for molecular diagnosis of eye infections
JP2021522245A (en) 2018-04-26 2021-08-30 チルドレンズ ナショナル メディカル センターＣｈｉｌｄｒｅｎ’Ｓ Ｎａｔｉｏｎａｌ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ Mycobacterial antigen composition and usage
CN108411030B (en) * 2018-05-25 2021-05-14 兰州大学 Primer pair, kit containing primer pair, application of primer pair and method for detecting ecological A17 and R108 of medicago truncatula
CN108948175B (en) * 2018-07-23 2020-11-20 首都医科大学附属北京胸科医院 Tuberculosis protein interacting with human protein SMAD2 and its application
JP2021535930A (en) * 2018-09-17 2021-12-23 キュラティス インコーポレイティッド Antigenic enhancer and vaccine composition comprising a STING agonist
KR102524577B1 (en) * 2019-04-22 2023-04-21 전남대학교산학협력단 Flagellin fusion protein and uses thereof
JP7252674B2 (en) * 2019-05-02 2023-04-05 エル－ベース カンパニー リミテッド Novel oligopeptide and pharmaceutical composition for prevention or treatment of cancer containing the same as an active ingredient
BR112021023726A2 (en) 2019-05-25 2022-02-15 Infectious Disease Res Inst Composition and method for spray drying an adjuvant vaccine emulsion
EP3983011A1 (en) * 2019-06-14 2022-04-20 Statens Serum Institut Fusion proteins for tuberculosis vaccines
GB201909953D0 (en) * 2019-07-11 2019-08-28 Sec Dep For Environment Food And Rural Affairs Acting Through The Animal And Plant Health Agency Diagnostic reagents
US11679163B2 (en) 2019-09-20 2023-06-20 Hdt Bio Corp. Compositions and methods for delivery of RNA
CN111286551A (en) * 2020-01-04 2020-06-16 昆明理工大学 Primer and kit for rapidly detecting mycobacterium tuberculosis and using method thereof
JP2023518976A (en) 2020-03-23 2023-05-09 エイチディーティー バイオ コーポレーション Compositions and methods for delivering RNA
CA3173408A1 (en) 2020-12-23 2022-06-30 Access To Advanced Health Institute Solanesol vaccine adjuvants and methods of preparing same
CN113121703B (en) * 2021-03-03 2023-04-25 上海晶诺生物科技有限公司 Fusion protein with tubercle bacillus immunogenicity and application thereof
AU2022349251A1 (en) 2021-09-22 2024-04-11 Hdt Bio Corp. Sars-cov-2 rna vaccine compositions and methods of use
KR20240088845A (en) 2021-09-22 2024-06-20 에이치디티 바이오 코포레이션 Dried Nanoparticle Composition
KR20240096468A (en) 2021-09-22 2024-06-26 에이치디티 바이오 코포레이션 RNA vaccines against infectious diseases
JP2024535354A (en) 2021-09-22 2024-09-30 エイチディーティー バイオ コーポレーション Cancer treatment compositions and uses thereof
CN114150006B (en) * 2021-11-29 2023-07-25 中国农业科学院植物保护研究所 Gene cluster and recombinant bacterium capable of improving milbemycins yield and preparation method and application thereof
CN116262794B (en) * 2021-12-13 2024-09-13 江苏瑞科生物技术股份有限公司 Recombinant mycobacterium tuberculosis antigen, preparation method and application thereof
EP4583841A1 (en) 2022-09-09 2025-07-16 Access to Advanced Health Institute Immunogenic vaccine composition incorporating a saponin
CN116041454B (en) * 2022-12-07 2023-12-26 中国疾病预防控制中心传染病预防控制所 Mycobacterium tuberculosis protein antigen mixture, multi-antigen fusion protein, encoding gene and application
NL2036756B1 (en) * 2024-01-05 2024-08-29 Univ Shihezi Fluorescent pcr method for detecting listeria monocytogenes and mycobacterium tuberculosis in milk
CN118987197B (en) * 2024-10-24 2025-01-24 山东第二医科大学 A self-adjuvanted heat-stable nano multivalent tuberculosis vaccine and its preparation method and application
CN119823286B (en) * 2025-01-16 2026-02-06 中国动物卫生与流行病学中心 Recombinant protein antigen and application thereof in preparation of kit for detecting bovine gamma interferon

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4866034A (en) 1982-05-26 1989-09-12 Ribi Immunochem Research Inc. Refined detoxified endotoxin
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4761180A (en) 1986-08-27 1988-08-02 Hewlett-Packard Company Dyes containing tetramethylammonium cation for ink-jet printing inks
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5725871A (en) 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
SE466259B (en) 1990-05-31 1992-01-20 Arne Forsgren PROTEIN D - AN IGD BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE, AND THE USE OF THIS FOR ANALYSIS, VACCINES AND PURPOSE
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5756353A (en) 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
ES2105262T3 (en) 1992-05-18 1997-10-16 Minnesota Mining & Mfg PHARMACY SUPPLY DEVICE THROUGH THE MUCOSAS.
CA2138997C (en) 1992-06-25 2003-06-03 Jean-Paul Prieels Vaccine composition containing adjuvants
US5359681A (en) 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
WO1996002555A1 (en) 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
UA56132C2 (en) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Vaccine composition (variants), method for stabilizing qs21 providing resistance against hydrolysis (variants), method for manufacturing vaccine
US6592877B1 (en) 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US5856462A (en) 1996-09-10 1999-01-05 Hybridon Incorporated Oligonucleotides having modified CpG dinucleosides
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6355257B1 (en) 1997-05-08 2002-03-12 Corixa Corporation Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
EP1484405A1 (en) 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis
GB9727262D0 (en) 1997-12-24 1998-02-25 Smithkline Beecham Biolog Vaccine
US20020081579A1 (en) 1998-02-13 2002-06-27 Jane E. R. Potter Method for the isolation of novel antigens
KR100797876B1 (en) 1998-04-07 2008-01-24 코릭사 코포레이션 Fusion protein of Mycobacterium tuberculosis antigen and its use
WO1999052549A1 (en) 1998-04-09 1999-10-21 Smithkline Beecham Biologicals S.A. Adjuvant compositions
EP1104306B1 (en) 1998-08-10 2006-01-11 Antigenics Inc. Compositions of cpg and saponin adjuvants and methods of use thereof
AU779978B2 (en) * 1999-10-07 2005-02-24 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
US7472098B2 (en) 2000-02-14 2008-12-30 Ubs Financial Services, Inc. System and method for execution of trades made pursuant to stock option and purchase plans
DE60139963D1 (en) * 2000-06-20 2009-10-29 Corixa Corp FUSION PROTEINS FROM MYCOBACTERIUM TUBERCULOSIS
WO2003093307A2 (en) 2002-04-27 2003-11-13 The Secretary Of State For Environment, Food And Rural Affairs Mycobacterial antigens and uses thereof
EP1523331B1 (en) * 2002-07-13 2013-02-27 Statens Serum Institut Therapeutic tb vaccine
WO2006026404A2 (en) * 2004-08-26 2006-03-09 Sequella, Inc. Assay for detecting tuberculosis in nonhuman primates
WO2006026464A2 (en) * 2004-08-27 2006-03-09 Davidsen Kevin P Handclapping aid
CA2836319A1 (en) 2005-06-23 2006-12-28 Statens Serum Institut Tuberculosis vaccines comprising antigens expressed during the latent infection phase
KR101378872B1 (en) 2006-09-26 2014-04-11 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) Vaccine composition containing synthetic adjuvant
BRPI0809926B8 (en) 2007-04-04 2021-05-25 Infectious Disease Res Inst composition comprising antigens from mycobacterium tuberculosis, isolated fusion polypeptide, isolated polynucleotide encoding said polypeptide, and use of said composition to stimulate a protective immune response

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US20250304629A1 (en) 2025-10-02
CN101687027A (en) 2010-03-31
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EP3199176A1 (en) 2017-08-02
US20240140997A1 (en) 2024-05-02
ZA200907316B (en) 2013-03-27
US11091521B2 (en) 2021-08-17
CN101687027B (en) 2015-01-28
ES2621211T3 (en) 2017-07-03
US20130209500A1 (en) 2013-08-15
MX351247B (en) 2017-10-05
JP2016145209A (en) 2016-08-12
BRPI0809926B8 (en) 2021-05-25
MX2009010800A (en) 2010-01-29
PL2136836T3 (en) 2017-07-31
BRPI0809926A2 (en) 2014-10-07
US9822152B2 (en) 2017-11-21
US20100129391A1 (en) 2010-05-27
EP3199176B1 (en) 2020-02-19
US12344641B2 (en) 2025-07-01
BRPI0809926B1 (en) 2020-09-29
DK2136836T3 (en) 2017-04-10
JP2010524854A (en) 2010-07-22
WO2008124647A2 (en) 2008-10-16
US20220017578A1 (en) 2022-01-20
EP2136836B1 (en) 2017-01-04
US8486414B2 (en) 2013-07-16
WO2008124647A3 (en) 2009-04-02
JP5378350B2 (en) 2013-12-25
US11897922B2 (en) 2024-02-13
JP5922074B2 (en) 2016-05-24
US20180170975A1 (en) 2018-06-21
CN104815324A (en) 2015-08-05

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