EP2124968A4 - Zusammensetzungen und verfahren zur behandlung von muskelschwund - Google Patents

Zusammensetzungen und verfahren zur behandlung von muskelschwund

Info

Publication number
EP2124968A4
EP2124968A4 EP06774377.3A EP06774377A EP2124968A4 EP 2124968 A4 EP2124968 A4 EP 2124968A4 EP 06774377 A EP06774377 A EP 06774377A EP 2124968 A4 EP2124968 A4 EP 2124968A4
Authority
EP
European Patent Office
Prior art keywords
compositions
treatment
methods
muscle wasting
wasting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06774377.3A
Other languages
English (en)
French (fr)
Other versions
EP2124968A1 (de
Inventor
Roderic M K Dale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lakewood-Amedex Inc
Original Assignee
Lakewood-Amedex Inc
Lakewood Amedex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lakewood-Amedex Inc, Lakewood Amedex Inc filed Critical Lakewood-Amedex Inc
Publication of EP2124968A1 publication Critical patent/EP2124968A1/de
Publication of EP2124968A4 publication Critical patent/EP2124968A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP06774377.3A 2006-06-30 2006-06-30 Zusammensetzungen und verfahren zur behandlung von muskelschwund Withdrawn EP2124968A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2006/025657 WO2008005002A1 (en) 2006-06-30 2006-06-30 Compositions and methods for the treatment of muscle wasting

Publications (2)

Publication Number Publication Date
EP2124968A1 EP2124968A1 (de) 2009-12-02
EP2124968A4 true EP2124968A4 (de) 2013-10-23

Family

ID=37102772

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06774377.3A Withdrawn EP2124968A4 (de) 2006-06-30 2006-06-30 Zusammensetzungen und verfahren zur behandlung von muskelschwund

Country Status (4)

Country Link
EP (1) EP2124968A4 (de)
AU (1) AU2006345724B2 (de)
CA (1) CA2558160C (de)
WO (1) WO2008005002A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2351976T3 (es) 2003-04-29 2011-02-14 Avi Biopharma, Inc. Composiciones para mejorar el transporte y la eficacia antisentido de análogos de ácidos nucleicos en células.
US20050288246A1 (en) 2004-05-24 2005-12-29 Iversen Patrick L Peptide conjugated, inosine-substituted antisense oligomer compound and method
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
US8097596B2 (en) 2006-06-30 2012-01-17 Lakewood-Amedex, Inc. Compositions and methods for the treatment of muscle wasting
US20100016215A1 (en) 2007-06-29 2010-01-21 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
US9161948B2 (en) 2011-05-05 2015-10-20 Sarepta Therapeutics, Inc. Peptide oligonucleotide conjugates
EP3302489A4 (de) 2015-06-04 2019-02-06 Sarepta Therapeutics, Inc. Verfahren und verbindungen zur behandlung von krankheiten und leiden im zusammenhang mit lymphozyten
WO2018118599A1 (en) 2016-12-19 2018-06-28 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
AU2019206634A1 (en) * 2018-01-12 2020-07-23 Keros Therapeutics, Inc. Activin receptor type IIB variants and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006478A1 (en) * 2001-07-10 2003-01-23 Oligos Etc. Inc. Oligonucleotide-containing pharmacological compositions and their use
US20030129171A1 (en) * 1997-07-14 2003-07-10 Luc Grobet Double-muscling in mammals
US20050124566A1 (en) * 2001-05-18 2005-06-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
CN1718194A (zh) * 2005-06-24 2006-01-11 奥林格斯技术有限公司 治疗肌肉萎缩的寡核苷酸药物
WO2006086667A2 (en) * 2005-02-09 2006-08-17 Avi Bio Pharma, Inc. Antisense composition and method for treating muscle atrophy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6656475B1 (en) * 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129171A1 (en) * 1997-07-14 2003-07-10 Luc Grobet Double-muscling in mammals
US20050124566A1 (en) * 2001-05-18 2005-06-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
WO2003006478A1 (en) * 2001-07-10 2003-01-23 Oligos Etc. Inc. Oligonucleotide-containing pharmacological compositions and their use
WO2006086667A2 (en) * 2005-02-09 2006-08-17 Avi Bio Pharma, Inc. Antisense composition and method for treating muscle atrophy
CN1718194A (zh) * 2005-06-24 2006-01-11 奥林格斯技术有限公司 治疗肌肉萎缩的寡核苷酸药物

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ACOSTA J ET AL: "Myostatin gene silenced by RNAi show a zebrafish giant phenotype", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 119, no. 4, 10 October 2005 (2005-10-10), pages 324 - 331, XP027663478, ISSN: 0168-1656, [retrieved on 20051010] *
ALEX CLOP ET AL: "A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep", NATURE GENETICS, vol. 38, no. 7, 4 June 2006 (2006-06-04), pages 813 - 818, XP055078053, ISSN: 1061-4036, DOI: 10.1038/ng1810 *
ALEX CLOP: "Supplementary Figure 5", NATURE GENETICS, 4 June 2006 (2006-06-04), pages 1 - 3, XP055078055, Retrieved from the Internet <URL:http://www.nature.com/ng/journal/v38/n7/extref/ng1810-S5.pdf> [retrieved on 20130906] *
DUMONCEAUX ET AL: "Improvement of Muscle Mass Using shRNA Targeting Myostatin or Activin Receptor IIb", MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, vol. 13, 1 January 2006 (2006-01-01), pages S14, XP005675138, ISSN: 1525-0016 *
PANTOPOULOS K ET AL: "The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies", PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, ACADEMIC PRESS, US, vol. 48, 1 January 1994 (1994-01-01), pages 181 - 238, XP009172334, ISSN: 0079-6603 *
See also references of WO2008005002A1 *
THOMAS R. MAGEE ET AL: "Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass", THE JOURNAL OF GENE MEDICINE, vol. 8, no. 9, 29 June 2006 (2006-06-29), pages 1171 - 1181, XP055078809, ISSN: 1099-498X, DOI: 10.1002/jgm.946 *
ZADOR E ET AL: "Antisense inhibition of myoD expression in regenerating rat soleus muscle is followed by an increase in the mRNA levels of myoD, myf-5 and myogenin and by a retarded regeneration", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1590, no. 1-3, 12 June 2002 (2002-06-12), pages 52 - 63, XP004362110, ISSN: 0167-4889, DOI: 10.1016/S0167-4889(02)00198-2 *

Also Published As

Publication number Publication date
WO2008005002A1 (en) 2008-01-10
CA2558160C (en) 2017-01-03
AU2006345724B2 (en) 2013-11-21
AU2006345724A1 (en) 2008-01-10
CA2558160A1 (en) 2007-12-30
EP2124968A1 (de) 2009-12-02

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Owner name: LAKEWOOD-AMEDEX, INC

A4 Supplementary search report drawn up and despatched

Effective date: 20130920

RIC1 Information provided on ipc code assigned before grant

Ipc: C07H 21/04 20060101ALI20130916BHEP

Ipc: A61K 31/70 20060101AFI20130916BHEP

Ipc: C12N 5/00 20060101ALI20130916BHEP

Ipc: C07H 21/02 20060101ALI20130916BHEP

Ipc: C12Q 1/68 20060101ALI20130916BHEP

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Effective date: 20140423