EP2076603A4 - Plateforme de propagation virale sans sérum utilisée comme candidate de vaccin anti-viral - Google Patents

Plateforme de propagation virale sans sérum utilisée comme candidate de vaccin anti-viral

Info

Publication number
EP2076603A4
EP2076603A4 EP07853807A EP07853807A EP2076603A4 EP 2076603 A4 EP2076603 A4 EP 2076603A4 EP 07853807 A EP07853807 A EP 07853807A EP 07853807 A EP07853807 A EP 07853807A EP 2076603 A4 EP2076603 A4 EP 2076603A4
Authority
EP
European Patent Office
Prior art keywords
virus
serum
vaccine candidate
free
propagation platform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07853807A
Other languages
German (de)
English (en)
Other versions
EP2076603A2 (fr
Inventor
Inn Yuk
Wenlin Zeng
Misa Sugui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2007/066037 external-priority patent/WO2007118134A2/fr
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of EP2076603A2 publication Critical patent/EP2076603A2/fr
Publication of EP2076603A4 publication Critical patent/EP2076603A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/08—Inactivation or attenuation by serial passage of virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18551—Methods of production or purification of viral material
    • C12N2760/18552—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18651—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18651—Methods of production or purification of viral material
    • C12N2760/18652—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP07853807A 2006-10-23 2007-10-05 Plateforme de propagation virale sans sérum utilisée comme candidate de vaccin anti-viral Withdrawn EP2076603A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86255006P 2006-10-23 2006-10-23
PCT/US2007/066037 WO2007118134A2 (fr) 2006-04-06 2007-04-05 Plateforme de propagation virale sans sérum utilisée comme candidate de vaccin anti-viral
US94416207P 2007-06-15 2007-06-15
US97392107P 2007-09-20 2007-09-20
PCT/US2007/080610 WO2008051698A2 (fr) 2006-10-23 2007-10-05 Plateforme de propagation virale sans serum utilisee comme candidate de vaccin anti-viral

Publications (2)

Publication Number Publication Date
EP2076603A2 EP2076603A2 (fr) 2009-07-08
EP2076603A4 true EP2076603A4 (fr) 2011-05-11

Family

ID=40691374

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07853807A Withdrawn EP2076603A4 (fr) 2006-10-23 2007-10-05 Plateforme de propagation virale sans sérum utilisée comme candidate de vaccin anti-viral

Country Status (5)

Country Link
EP (1) EP2076603A4 (fr)
JP (1) JP2010507363A (fr)
KR (1) KR20090084859A (fr)
BR (1) BRPI0717469A2 (fr)
WO (1) WO2008051698A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101875917B (zh) * 2009-04-28 2012-07-04 北京清大天一科技有限公司 生物反应器微载体培养动物细胞生产猪瘟疫苗的方法
EP2699672B1 (fr) * 2011-04-18 2019-12-25 The Trustees of Princeton University Procédé de production de virus dans des cellules cultivées
EP3456816A4 (fr) * 2016-05-09 2019-12-11 Kyowa Hakko Bio Co., Ltd. Milieu, additif destinés à un milieu sans albumine, et procédé de culture de cellules souches pluripotentes
KR20200044973A (ko) * 2017-09-15 2020-04-29 라이프 테크놀로지스 코포레이션 세포를 배양 및 팽창시키기 위한 조성물 및 방법
WO2024075819A1 (fr) * 2022-10-07 2024-04-11 Ａｇｃ株式会社 Procédé de production de vecteur viral utilisant une cellule

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007118134A2 (fr) * 2006-04-06 2007-10-18 Medimmune, Inc. Plateforme de propagation virale sans sérum utilisée comme candidate de vaccin anti-viral

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007118134A2 (fr) * 2006-04-06 2007-10-18 Medimmune, Inc. Plateforme de propagation virale sans sérum utilisée comme candidate de vaccin anti-viral

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
B. NAGEL ET AL: "GLOSSARY FOR CHEMISTS OF TERMS USED IN BIOTECHNOLOGY (IUPAC Recommendations 1992)", PURE & APPL. CHEM., vol. 64, no. 1, 1 January 1992 (1992-01-01), Great Britain, pages 143 - 148, XP055073736 *
BARRETT P NOEL ET AL: "Vero cell platform in vaccine production: moving towards cell culture-based viral vaccines", EXPERT REVIEW OF VACCINES, UK, vol. 8, no. 5, 1 May 2009 (2009-05-01), pages 607 - 618, XP009128183, ISSN: 1744-8395, DOI: 10.1586/ERV.09.19 *
FRAZATTI-GALLINA N M ET AL: "Vero-cell rabies vaccine produced using serum-free medium", VACCINE, ELSEVIER LTD, GB, vol. 23, no. 4, 9 December 2004 (2004-12-09), pages 511 - 517, XP004629187, ISSN: 0264-410X, DOI: 10.1016/J.VACCINE.2004.06.014 *
FRAZZATI-GALLINA N M ET AL: "Higher production of rabies virus in serum-free medium cell cultures on microcarriers", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 92, no. 1, 15 November 2001 (2001-11-15), pages 67 - 72, XP027295856, ISSN: 0168-1656, [retrieved on 20011115] *
INN H YUK ET AL: "A serum-free Vero production platform for a chimeric virus vaccine candidate", CYTOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 51, no. 3, 16 November 2006 (2006-11-16), pages 183 - 192, XP019448504, ISSN: 1573-0778, DOI: 10.1007/S10616-006-9030-7 *
SÉBASTIEN QUESNEY ET AL: "Kinetics and metabolic specificities of Vero cells in bioreactor cultures with serum-free medium", CYTOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 42, no. 1, 1 May 2003 (2003-05-01), pages 1 - 11, XP019236782, ISSN: 1573-0778, DOI: 10.1023/A:1026185615650 *
TRABELSI K ET AL: "Comparison of various culture modes for the production of rabies virus by Vero cells grown on microcarriers in a 2-l bioreactor", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 36, no. 4, 2 March 2005 (2005-03-02), pages 514 - 519, XP025278458, ISSN: 0141-0229, [retrieved on 20050302], DOI: 10.1016/J.ENZMICTEC.2004.11.008 *
WU S-C ET AL: "Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development", VACCINE, ELSEVIER LTD, GB, vol. 22, no. 29-30, 28 September 2004 (2004-09-28), pages 3858 - 3864, XP004567461, ISSN: 0264-410X, DOI: 10.1016/J.VACCINE.2004.05.037 *

Also Published As

Publication number Publication date
EP2076603A2 (fr) 2009-07-08
WO2008051698A2 (fr) 2008-05-02
BRPI0717469A2 (pt) 2014-04-08
JP2010507363A (ja) 2010-03-11
KR20090084859A (ko) 2009-08-05
WO2008051698A3 (fr) 2008-07-10

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Legal Events

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Owner name: MEDIMMUNE, LLC

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A4 Supplementary search report drawn up and despatched

Effective date: 20110408

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/86 20060101ALI20110404BHEP

Ipc: C07K 14/135 20060101ALI20110404BHEP

Ipc: C12N 15/85 20060101AFI20090415BHEP

Ipc: C12N 7/02 20060101ALI20110404BHEP

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