EP2066789A4 - Structure cristalline d'une arnt synthetase - Google Patents

Structure cristalline d'une arnt synthetase

Info

Publication number
EP2066789A4
EP2066789A4 EP07870156A EP07870156A EP2066789A4 EP 2066789 A4 EP2066789 A4 EP 2066789A4 EP 07870156 A EP07870156 A EP 07870156A EP 07870156 A EP07870156 A EP 07870156A EP 2066789 A4 EP2066789 A4 EP 2066789A4
Authority
EP
European Patent Office
Prior art keywords
crystal structure
trna synthetase
trna
synthetase
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07870156A
Other languages
German (de)
English (en)
Other versions
EP2066789A2 (fr
Inventor
Michael Richard Kevin Alley
Fernando Rock
Weimin Mao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anacor Pharmaceuticals Inc
Original Assignee
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anacor Pharmaceuticals Inc filed Critical Anacor Pharmaceuticals Inc
Publication of EP2066789A2 publication Critical patent/EP2066789A2/fr
Publication of EP2066789A4 publication Critical patent/EP2066789A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
EP07870156A 2006-09-29 2007-10-01 Structure cristalline d'une arnt synthetase Withdrawn EP2066789A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84854006P 2006-09-29 2006-09-29
PCT/US2007/080128 WO2008070257A2 (fr) 2006-09-29 2007-10-01 Structure cristalline d'une arnt synthétase

Publications (2)

Publication Number Publication Date
EP2066789A2 EP2066789A2 (fr) 2009-06-10
EP2066789A4 true EP2066789A4 (fr) 2009-12-30

Family

ID=39492904

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07870156A Withdrawn EP2066789A4 (fr) 2006-09-29 2007-10-01 Structure cristalline d'une arnt synthetase

Country Status (2)

Country Link
EP (1) EP2066789A4 (fr)
WO (1) WO2008070257A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA38319A1 (fr) 2013-01-30 2016-08-31 Dow Agrosciences Llc Utilisation des benzoxaboroles à titre d'agents antimicrobiens volatils sur les viandes, les plantes, ou des parties de plantes
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
JP6605513B2 (ja) 2014-07-01 2019-11-13 第一三共株式会社 抗菌剤としての三環式ベンゾオキサボロール
NZ745681A (en) 2016-03-07 2022-05-27 Agrofresh Inc Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
JP2021505660A (ja) 2017-11-30 2021-02-18 ボラゲン，インコーポレーテッド ベンゾキサボロール化合物およびその配合物
CN108358961B (zh) * 2018-04-08 2020-10-20 安徽先和医药研究有限公司 一种易纯化苯并氧杂硼杂戊环类抗真菌药物的制备方法
BR112021003037A2 (pt) 2018-08-18 2021-05-11 Boragen, Inc. formas sólidas de benzoxaborol substituído e composições do mesmo
CN112933243B (zh) * 2021-01-25 2023-06-27 中山大学 一种异亮氨酰tRNA合成酶与雷弗霉素A的复合物晶体及其制备方法和应用
CN114644645B (zh) * 2022-03-08 2023-05-26 南京农业大学 3-吲哚取代苯硼唑类化合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001009154A2 (fr) * 1999-07-29 2001-02-08 Yale University UTILISATION DE LA STRUCTURE CRISTALLINE DE LA SYNTHETASE ARNt-ISOLEUCYLE DU STAPHYLOCOCCUS AUREUS DANS LA CONCEPTION D'ANTIBIOTIQUES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221640B1 (en) * 1997-05-14 2001-04-24 Cubist Pharmaceuticals, Inc. Enterococcal aminoacyl-trna synthetase proteins, nucleic acids and strains comprising same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001009154A2 (fr) * 1999-07-29 2001-02-08 Yale University UTILISATION DE LA STRUCTURE CRISTALLINE DE LA SYNTHETASE ARNt-ISOLEUCYLE DU STAPHYLOCOCCUS AUREUS DANS LA CONCEPTION D'ANTIBIOTIQUES

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FERNANDO L ROCK ET AL: "An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, WASHINGTON, DC, vol. 316, 22 June 2007 (2007-06-22), pages 1759 - 1761, XP007910488, ISSN: 0036-8075 *
FUKUNAGA R ET AL: "Crystal Structure of Leucyl-tRNA Synthetase from the Archaeon Pyrococcus horikoshii Reveals a Novel Editing Domain Orientation", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 346, no. 1, 11 February 2005 (2005-02-11), pages 57 - 71, XP004720636, ISSN: 0022-2836 *
FUKUNAGA RYUYA ET AL: "Crystallization of leucyl-tRNA synthetase complexed with tRNALeu from the archaeon Pyrococcus horikoshii", ACTA CRYSTALLOGRAPHICA. SECTION F: STRUCTURAL BIOLOGY ANDCRYSTALLIZATION COMMUNICATIONS ONLINE, BLACKWELL MUNKSGAARD, COPENHAGEN, DK, vol. 61, no. 1, 1 January 2005 (2005-01-01), pages 30 - 32, XP009125709, ISSN: 1744-3091 *
HSU JENNIFER L ET AL: "Functional divergence of a unique C-terminal domain of leucyl-tRNA synthetase to accommodate its splicing and aminoacylation roles", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 281, no. 32, 11 August 2006 (2006-08-11), pages 23075 - 23082, XP009125708, ISSN: 0021-9258 *
LIU YUNQING ET AL: "Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination.", BIOCHEMICAL JOURNAL,, vol. 394, no. 2, 1 March 2006 (2006-03-01), pages 399 - 407, XP009125706 *
ZHAI YUXIN ET AL: "Modulation of substrate specificity within the amino acid editing site of leucyl-tRNA synthetase", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, PA.; US, vol. 46, no. 11, 20 March 2007 (2007-03-20), pages 3331 - 3337, XP009125707, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
WO2008070257A2 (fr) 2008-06-12
WO2008070257A3 (fr) 2008-10-02
EP2066789A2 (fr) 2009-06-10
WO2008070257A9 (fr) 2008-09-04

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