EP2061589A2 - Procédé de fabrication d'un bioréacteur ou système lab-on-a-chip ainsi que bioréacteurs ou systèmes lab-on-a-chip fabriqués ainsi - Google Patents

Procédé de fabrication d'un bioréacteur ou système lab-on-a-chip ainsi que bioréacteurs ou systèmes lab-on-a-chip fabriqués ainsi

Info

Publication number
EP2061589A2
EP2061589A2 EP07801315A EP07801315A EP2061589A2 EP 2061589 A2 EP2061589 A2 EP 2061589A2 EP 07801315 A EP07801315 A EP 07801315A EP 07801315 A EP07801315 A EP 07801315A EP 2061589 A2 EP2061589 A2 EP 2061589A2
Authority
EP
European Patent Office
Prior art keywords
lab
wavelength
electromagnetic radiation
bioreactor
contact surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP07801315A
Other languages
German (de)
English (en)
Inventor
Volker Franke
Frank Sonntag
Jan Hauptmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Publication of EP2061589A2 publication Critical patent/EP2061589A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/14—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using wave energy, i.e. electromagnetic radiation, or particle radiation
    • B29C65/1429—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using wave energy, i.e. electromagnetic radiation, or particle radiation characterised by the way of heating the interface
    • B29C65/1435—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using wave energy, i.e. electromagnetic radiation, or particle radiation characterised by the way of heating the interface at least passing through one of the parts to be joined, i.e. transmission welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/14—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using wave energy, i.e. electromagnetic radiation, or particle radiation
    • B29C65/16—Laser beams
    • B29C65/1629—Laser beams characterised by the way of heating the interface
    • B29C65/1635—Laser beams characterised by the way of heating the interface at least passing through one of the parts to be joined, i.e. laser transmission welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/44—Joining a heated non plastics element to a plastics element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/02—Preparation of the material, in the area to be joined, prior to joining or welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/303—Particular design of joint configurations the joint involving an anchoring effect
    • B29C66/3032—Particular design of joint configurations the joint involving an anchoring effect making use of protrusions or cavities belonging to at least one of the parts to be joined
    • B29C66/30325—Particular design of joint configurations the joint involving an anchoring effect making use of protrusions or cavities belonging to at least one of the parts to be joined making use of cavities belonging to at least one of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/542—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining hollow covers or hollow bottoms to open ends of container bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/731—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the intensive physical properties of the material of the parts to be joined
    • B29C66/7311—Thermal properties
    • B29C66/73115—Melting point
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/731—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the intensive physical properties of the material of the parts to be joined
    • B29C66/7311—Thermal properties
    • B29C66/73115—Melting point
    • B29C66/73116—Melting point of different melting point, i.e. the melting point of one of the parts to be joined being different from the melting point of the other part
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/733—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence
    • B29C66/7336—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence at least one of the parts to be joined being opaque, transparent or translucent to visible light
    • B29C66/73361—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence at least one of the parts to be joined being opaque, transparent or translucent to visible light at least one of the parts to be joined being opaque to visible light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/733—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence
    • B29C66/7336—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence at least one of the parts to be joined being opaque, transparent or translucent to visible light
    • B29C66/73365—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence at least one of the parts to be joined being opaque, transparent or translucent to visible light at least one of the parts to be joined being transparent or translucent to visible light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/739—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/7392—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/74—Joining plastics material to non-plastics material
    • B29C66/746—Joining plastics material to non-plastics material to inorganic materials not provided for in groups B29C66/742 - B29C66/744
    • B29C66/7461—Ceramics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/92—Measuring or controlling the joining process by measuring or controlling the pressure, the force, the mechanical power or the displacement of the joining tools
    • B29C66/924—Measuring or controlling the joining process by measuring or controlling the pressure, the force, the mechanical power or the displacement of the joining tools by controlling or regulating the pressure, the force, the mechanical power or the displacement of the joining tools
    • B29C66/9241—Measuring or controlling the joining process by measuring or controlling the pressure, the force, the mechanical power or the displacement of the joining tools by controlling or regulating the pressure, the force, the mechanical power or the displacement of the joining tools by controlling or regulating the pressure, the force or the mechanical power
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/92—Measuring or controlling the joining process by measuring or controlling the pressure, the force, the mechanical power or the displacement of the joining tools
    • B29C66/929—Measuring or controlling the joining process by measuring or controlling the pressure, the force, the mechanical power or the displacement of the joining tools characterized by specific pressure, force, mechanical power or displacement values or ranges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00851—Additional features
    • B01J2219/00853—Employing electrode arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
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Definitions

  • the invention relates to a method for producing a bioreactor or lab-on-a-chip system and bioreactors or lab-on-a-chip systems produced therewith.
  • at least two different components are connected to each other, wherein the two components are first brought into contact with each other and then one of the components is thereby melted at its contact surface to the other component.
  • electromagnetic radiation is radiated through one of the components onto the contact surface.
  • both components are melted at their surfaces to be joined.
  • the molten areas of the components mix and establish a firm connection after curing.
  • the problem with welding is, on the one hand, that the components must be connected to each other as long as the surfaces have melted. This is particularly relevant when welding by means of an arc or with a flame, if the surfaces in the connected state are not accessible from the outside.
  • a major disadvantage of welding is that both bodies must be melted. Bodies whose melting points are very different can not be joined by welding if the melting temperature of the higher melting body is above the temperature at which the colder melting body is already beginning to decompose.
  • Object of the present invention is therefore to provide a method by which bodies with very different melting points, namely a ceramic and a polymer can be connected to each other, regardless of whether the surfaces to be connected are accessible from the outside or not.
  • the inventive method is based on the idea to connect two bodies by melting while they are in contact with each other.
  • one of the two bodies to be connected is irradiated from a polymer of electromagnetic radiation of a certain wavelength ⁇ while the other body absorbs electromagnetic radiation of the same wavelength ⁇ from a ceramic.
  • the two bodies to be connected are first brought into contact with each other and then the electromagnetic radiation is irradiated by the body transparent to the respective wavelengths of the electromagnetic radiation onto the boundary surface between the two bodies.
  • the electro- Magnetic radiation is absorbed by the other body, resulting in heating of the interface.
  • the melting point of the two bodies lies in very different areas.
  • the respective fusible body need not necessarily be meltable as a whole, it is sufficient if it is meltable in the area in which a connection to the other body is to be produced.
  • the absorptivity and transparency of the two bodies need only be given for those wavelengths at which the heating of the interface is to be carried out.
  • the absorption behavior or the transmittivity at other wavelengths does not matter.
  • the wavelength for establishing a specific connection between two of these bodies is then selected so that the body lying in the direction of incidence of the radiation behind the interface to be bonded absorbs the corresponding radiation, while all the bodies lying in front of the interface in the direction of incidence of the beam are exposed to the radiation are transparent.
  • the method according to the invention is particularly suitable for connecting the at least two bodies which can not be melted together. It is particularly advantageous if the surface of that body made of ceramic, which does not melt during bonding, is roughened or structured on the contact surface with the melting body of polymer.
  • the roughening can, for example, way done by means of a laser beam or by means of sandpaper. Also files or other mechanical effects such as water and / or sandblasting or milling, or even chemical etching methods are possible. It is crucial that depressions and structures in the micrometer range can be generated in the surface.
  • the use of a laser, advantageously of a pulsed laser, for structuring is particularly advantageous, since in this way a targeted structure can be realized.
  • the structures may be on the order of a few micrometers or a few millimeters.
  • grooves or holes come into question.
  • the grooves may for example have a triangular cross-section, wherein the apex of the triangle may be oriented to the surface or in the direction of the body.
  • grooves with rectangular cross sections or round cross sections, in particular circular sectors, are possible.
  • the holes may be pyramidal, with the tips of the pyramids being oriented toward the surface or into the body. In the former case, the pyramidal hole would have a small opening at the surface.
  • the depressions can also be introduced at a shallow angle to the surface.
  • the method described above can also be realized without a specific structuring of the surface of the non-fusible body.
  • the molten material flows into the pre-existing surface roughness of the infusible body.
  • This pressing can be done for example by means of any mechanical devices, such as brackets, screws or clamps, but is preferably done with a pneumatic and / or hydraulic press o- a different type of press.
  • a pressure of 1 bar is particularly well.
  • the material properties of the bodies to be joined and the gap between them but also a higher or lower pressure can be applied.
  • the heat conduction takes place because of the very small thermal conductivity of the ceramic almost exclusively in the area in which the actual connection of the two bodies to be produced and in which the electromagnetic radiation is effective.
  • the pressure can also be applied selectively, for example by a sliding or rolling welding head. This can be designed so that it brings the same time for pressing the electromagnetic radiation to the joint.
  • thermoplastic polymers According to the invention, a large number of different materials can be joined together. Particularly suitable is the method described for the connection of ceramics with thermoplastic polymers.
  • the electromagnetic radiation for melting the meltable body of polymer can be produced in different ways. Particularly advantageous is the use of a laser, advantageously a continuous laser. Its wavelength may be in the visible range and / or in the near infrared range and / or in the far infrared range. For example, a wavelength between 800 nm and 1090 nm is particularly suitable for bonding ceramic with a thermoplastic.
  • the power of the laser is selected so that the desired temperature is established during absorption in the boundary region. But it is also possible to generate the electromagnetic radiation by means of a sufficiently strong incandescent lamp.
  • At least one contact surface of the two bodies can be at least partially activated by a suitable treatment.
  • a suitable treatment all conventional measures for the surface activation of solids are suitable for this, but the activation preferably takes place chemically or energetically.
  • chemical activ For example, etching processes or surface derivatization, for example with reactive compounds, may be used as energetic activation, in particular irradiations, preferably with ultraviolet irradiation.
  • mechanical measures for roughening or structuring are also suitable for this purpose.
  • the essential advantage of the method according to the invention is that materials with very different melting points can be connected to one another.
  • fusible bodies can be connected to such bodies that decompose when heated, such as thermosets.
  • the bioreactors or lab-on-a-chip systems produced according to the invention have at least one ceramic-containing or existing processing region.
  • the processing area is closed at least on one side with a transparent window comprising a polymer or thermoplastic.
  • the transparent window is connected to the processing area by the method according to the invention.
  • the processing region can have at least one disk-shaped subdivider which can be arranged parallel next to the at least one transparent window, sealingly contacting it.
  • the divider divides the processing area into at least one compartment. There may also be at least two dividers for the formation of several compartments.
  • Another advantage is that no additives have to be used for bonding, whereby impairments of the function of the connected component can be avoided.
  • very strong compounds can be produced without a material conversion takes place. There are almost no mechanical stresses in the joining area, even with thermal cycling.
  • FIG 1 shows the principle of the method according to the invention
  • FIG. 2 shows a layer system produced by means of the method according to the invention.
  • FIG. 3 shows a number of layers of a bioreactor to be connected, which can be closed with the aid of the method according to the invention with an optically transparent window.
  • FIG. 1 shows the principle of the method according to the invention.
  • A shows an overall view
  • B shows an enlargement of the boundary area between the bodies 1 and 2.
  • a fusible body 1 made of polymer is connected to a ceramic body 2 which is not fusible at the same temperature.
  • the body 1 is arranged touching the body 2 and pressed the two bodies 1 and 2 with a pressure 3 against each other.
  • Electromagnetic radiation 4 is now radiated through the melting body 1 onto the non-melting body 2.
  • the fusible body 1 for electromagnetic radiation 4 of the given wavelength is transparent, while the non-melting body 2 is not transparent to the electromagnetic radiation of this wavelength, but absorbs it.
  • the transparency of the melting body 1 for electromagnetic radiation 4 of the irradiated wavelength need not be one hundred percent, it only has to be so great that the fusible body 1 does not melt even by the absorption of the incident radiation itself. Accordingly, the degree of absorption of the body 2 which is not meltable at the given temperature need only be so great that sufficient heat is produced at the interface between the two bodies that the melting temperature of the melting body 1 is reached.
  • the enlargement B of FIG. 1 shows an idealized representation of the boundary region ⁇ between the fusible body 1 and the non-melting body 2.
  • the non-fusible body 2 is provided with depressions 5. Viewed over the entire surface, these depressions 5 represent a roughening or structuring. The diameter of these depressions is, for example, in the micrometer or in the millimeter range.
  • FIG. 2 shows the cross section through a layer system, which was prepared by the method according to the invention.
  • a layer system can be, for example, a lab-on-a-chip system for analyzing cell growth under defined conditions or a microbiological reactor.
  • a bioreactor has several layers 2a, 2b, 2c of a Low Temperature Cofired Ceramics (LTCC). These are connected via border areas 6 with transparent polystyrene windows 1 '. Through microchannels 12 different media can be passed through the bioreactor.
  • the uppermost layer of the LTCC 2a layer system was connected to the polystyrene window 1 'in the process according to the invention. For this purpose, first the LTCC layers 2a, 2b, 2c were finished assembled and sintered.
  • LTCC Low Temperature Cofired Ceramics
  • the surface area was then structured with a pulsed Nd: YAG laser. Subsequently, the polystyrene window 1 'at the joint in the boundary region ⁇ was pressed against the uppermost LTCC layer 2a, and then the melting was carried out with a continuous laser beam 4.
  • the surface of the reactor chambers was first structured from LTCC. An average of seventeen craters per mm 2 were randomly distributed on the surface. The production of the craters was made with a pulsed laser with a pulse frequency of 10 kHz and pulse durations of about 100 ns with a mean laser power (pulsed) of 20 watts. Approx. 10 pulses were irradiated per crater.
  • the polystyrene window became 1 'connected to the body 2, as a cell reactor of LTCC ceramic by irradiation of electromagnetic radiation 4.
  • a laser with the wavelength of 1064 nm and a laser power (cw) of 45 watts at a speed of 15 mm / s on the
  • the window 1 'formed of thermoplastic polymer was pressed against the reactor chamber made of LTCC at a pressure in the joining zone of 1.4 bar (60 N to 4.2 cm 2 ).
  • a window 1 ' can also be a functional element at the same time or alone.
  • a microfluidic system with microfluidic elements e.g. Channels, which in turn may have inlet and outlet openings, between the functional element / window 1 'and body 2 are formed.
  • the partial elements of LTCC 2a, 2b and 2c were connected to each other by sintering to the reactor chamber.
  • FIG. 3 shows the various layers 2a, 2b, 2c, 2d, 2e of a five-layer LTCC multilayer system.
  • Each layer contains 4 identical subunits of the lab-on-a-chip system or bioreactor. All layers contain large circular openings 7a, 7b, 7c, 7d, which form the cell reactors when the LTCC layers 2a, 2b, 2c, 2d, 2e are stacked on top of each other.
  • meandering channels 8a, 8b, 8c, 8d are introduced, which with a tempered
  • Liquid can be flowed through in order to produce a constant temperature within the cell reactor can.
  • the overlying layer 2c has LTCC-based sensors 9a, 9b, 9c, 9d, with which, for example, impedance and temperature can be measured.
  • Through holes 10 provide an electrical connection fertilize the sensors to the overlying layers ago.
  • An impedance measurement is used, for example, to investigate changes in cell growth, eg the adsorption of cells on a surface. This makes it possible to analyze the reaction of a cell culture to various test media or growth conditions.
  • Various media can be introduced through the microchannels IIa, IIb, 11c, Hd in position 2b.
  • the meandering structure opens up the possibility of mixing two different test liquids or of carrying out a dilution.
  • the lab-on-a-chip system can be connected to the necessary supply devices and electronic measuring devices.
  • the individual layers 2a to 2e of the unsintered ceramic are cut and patterned with the aid of a pulsed laser system.
  • the layers are then stacked and sintered.
  • the bioreactor can be hermetically sealed with a window 1 'made of polystyrene.

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Abstract

La présente invention concerne un procédé de fabrication d'un bioréacteur ou système Lab-on-a-Chip ainsi que des bioréacteurs ou systèmes lab-on-a-chip (laboratoire sur puce) fabriqués ainsi. Au moins deux composants différents sont reliés ensemble. La présente invention a pour objectif d'indiquer un procédé, à l'aide duquel des corps dotés de points de fusion très différents peuvent être reliés ensemble, à savoir une céramique et un polymère, indépendamment de l'accessibilité par l'extérieur des surfaces à relier. Dans le procédé selon l'invention, un premier corps en un polymère qui est au moins partiellement transparent à un rayonnement électromagnétique d'au moins une longueur d'onde ?, et un second corps en une céramique qui absorbe le rayonnement électromagnétique d'au moins une longueur d'onde ?, sont reliés ensemble. Le premier corps est fusible au moins par zones. Dans une première étape, le premier corps et le second corps sont disposés de manière contiguë en réalisant des surfaces de contact de telle sorte que le corps soit fusible dans au moins une zone de sa surface de contact par rapport à l'autre corps. Dans une seconde étape, au moins la zone fusible de la surface de contact est amenée en fusion du fait que le rayonnement électromagnétique de longueur d'onde ? est irradié au travers du premier corps sur la zone fusible de la surface de contact.
EP07801315A 2006-08-31 2007-08-29 Procédé de fabrication d'un bioréacteur ou système lab-on-a-chip ainsi que bioréacteurs ou systèmes lab-on-a-chip fabriqués ainsi Ceased EP2061589A2 (fr)

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PCT/DE2007/001578 WO2008025351A2 (fr) 2006-08-31 2007-08-29 Procédé de fabrication d'un bioréacteur ou système lab-on-a-chip ainsi que bioréacteurs ou systèmes lab-on-a-chip fabriqués ainsi

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