EP2025764A8 - Probe for detection of mutation in abl gene and use thereof - Google Patents

Probe for detection of mutation in abl gene and use thereof Download PDF

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Publication number
EP2025764A8
EP2025764A8 EP08711556A EP08711556A EP2025764A8 EP 2025764 A8 EP2025764 A8 EP 2025764A8 EP 08711556 A EP08711556 A EP 08711556A EP 08711556 A EP08711556 A EP 08711556A EP 2025764 A8 EP2025764 A8 EP 2025764A8
Authority
EP
European Patent Office
Prior art keywords
mutation
probe
abl gene
detection
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08711556A
Other languages
German (de)
French (fr)
Other versions
EP2025764A4 (en
EP2025764A1 (en
EP2025764B1 (en
Inventor
Mitsuharu Hirai
Satoshi Majima
Shinya Kimura
Taira Maekawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arkray Inc
Original Assignee
Arkray Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arkray Inc filed Critical Arkray Inc
Publication of EP2025764A1 publication Critical patent/EP2025764A1/en
Publication of EP2025764A8 publication Critical patent/EP2025764A8/en
Publication of EP2025764A4 publication Critical patent/EP2025764A4/en
Application granted granted Critical
Publication of EP2025764B1 publication Critical patent/EP2025764B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

Detection probes are provided that are capable of detecting a sequence to be detected containing a mutation even when a sequence not to be detected containing no mutation coexists with the sequence to be detected containing a mutation, which are different only in a single base from each other. At least one oligonucleotide selected from the group consisting of SEQ ID NOs: 2∼16 is used as a probe. Even in a sample containing an abl gene in which a mutation has occurred and an abl gene in which no mutation has occurred, the use of such probes in, for example, Tm analysis allows the mutation to be detected.
EP08711556.4A 2007-02-20 2008-02-19 Probe for detection of mutation in abl gene and use thereof Active EP2025764B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007040077A JP4942508B2 (en) 2007-02-20 2007-02-20 Probe for detecting abl gene mutation and use thereof
PCT/JP2008/052732 WO2008102760A1 (en) 2007-02-20 2008-02-19 PROBE FOR DETECTION OF MUTATION IN abl GENE AND USE THEREOF

Publications (4)

Publication Number Publication Date
EP2025764A1 EP2025764A1 (en) 2009-02-18
EP2025764A8 true EP2025764A8 (en) 2009-06-17
EP2025764A4 EP2025764A4 (en) 2011-01-19
EP2025764B1 EP2025764B1 (en) 2013-04-10

Family

ID=39710037

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08711556.4A Active EP2025764B1 (en) 2007-02-20 2008-02-19 Probe for detection of mutation in abl gene and use thereof

Country Status (6)

Country Link
US (1) US9012619B2 (en)
EP (1) EP2025764B1 (en)
JP (1) JP4942508B2 (en)
KR (1) KR101070349B1 (en)
CN (1) CN101548022B (en)
WO (1) WO2008102760A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9115391B2 (en) 2008-07-02 2015-08-25 Arkray, Inc. Method of detecting a polymorphism at a polymorphism site
WO2011090154A1 (en) * 2010-01-21 2011-07-28 アークレイ株式会社 Target sequence amplification method, polymorphism detection method, and reagents for use in the methods
JP5940771B2 (en) * 2010-07-12 2016-06-29 アークレイ株式会社 Probe for detecting abl gene polymorphism and use thereof
KR101660322B1 (en) * 2011-04-28 2016-09-29 아크레이 가부시키가이샤 Probe for detecting mutation in exon12 of npm1 gene and use thereof
JP2013074888A (en) 2011-09-15 2013-04-25 Arkray Inc METHOD FOR DETECTING MUTATION AT GENE IL28B (rs8099917) AND ITPA(rs1127354)
CN107109398B (en) * 2014-12-19 2020-08-18 荣研化学株式会社 Oligonucleotide probe for detecting single nucleotide polymorphism and method for detecting single nucleotide polymorphism
CN113832215B (en) 2016-02-09 2024-02-06 荣研化学株式会社 Method for detecting target nucleic acid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69733282T2 (en) * 1996-06-04 2006-01-19 University Of Utah Research Foundation, Salt Lake City Monitoring hybridization during PCR
NZ521593A (en) 2000-03-29 2004-11-26 Lgc Ltd Hybridisation beacon and method of rapid sequence detection and discrimination
ATE431417T1 (en) 2001-06-14 2009-05-15 Univ California MUTATIONS IN BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571
JP2004097209A (en) * 2002-07-17 2004-04-02 Kawamura Inst Of Chem Res Method for analyzing polynucleotide
DE10319694A1 (en) 2003-05-02 2004-12-02 Robert Bosch Gmbh Fuel injector
CN1324146C (en) * 2005-02-01 2007-07-04 合肥中科大生物技术有限公司 Fluorescent quantitative PT-PCR detection kit for detecting BCR-ABL fusion gene (P210bcr/abl)mRNA
JPWO2007055244A1 (en) * 2005-11-08 2009-04-30 国立大学法人名古屋大学 Gene mutation detection array and detection method
JPWO2008018305A1 (en) * 2006-08-08 2009-12-24 アークレイ株式会社 Mutation detection method and kit used therefor

Also Published As

Publication number Publication date
US9012619B2 (en) 2015-04-21
EP2025764A4 (en) 2011-01-19
KR101070349B1 (en) 2011-10-05
CN101548022A (en) 2009-09-30
JP2008199965A (en) 2008-09-04
EP2025764A1 (en) 2009-02-18
EP2025764B1 (en) 2013-04-10
KR20080107403A (en) 2008-12-10
JP4942508B2 (en) 2012-05-30
CN101548022B (en) 2012-11-21
WO2008102760A1 (en) 2008-08-28
US20090176231A1 (en) 2009-07-09

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