EP2024673B1 - Dispositif de raccords aseptiques - Google Patents
Dispositif de raccords aseptiques Download PDFInfo
- Publication number
- EP2024673B1 EP2024673B1 EP20070777082 EP07777082A EP2024673B1 EP 2024673 B1 EP2024673 B1 EP 2024673B1 EP 20070777082 EP20070777082 EP 20070777082 EP 07777082 A EP07777082 A EP 07777082A EP 2024673 B1 EP2024673 B1 EP 2024673B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- coupling device
- aseptic coupling
- front portion
- aseptic
- collar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L37/00—Couplings of the quick-acting type
- F16L37/08—Couplings of the quick-acting type in which the connection between abutting or axially overlapping ends is maintained by locking members
- F16L37/084—Couplings of the quick-acting type in which the connection between abutting or axially overlapping ends is maintained by locking members combined with automatic locking
- F16L37/098—Couplings of the quick-acting type in which the connection between abutting or axially overlapping ends is maintained by locking members combined with automatic locking by means of flexible hooks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/16—Tube connectors; Tube couplings having provision for disinfection or sterilisation
- A61M39/18—Methods or apparatus for making the connection under sterile conditions, i.e. sterile docking
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L37/00—Couplings of the quick-acting type
- F16L37/28—Couplings of the quick-acting type with fluid cut-off means
- F16L37/30—Couplings of the quick-acting type with fluid cut-off means with fluid cut-off means in each of two pipe-end fittings
- F16L37/32—Couplings of the quick-acting type with fluid cut-off means with fluid cut-off means in each of two pipe-end fittings at least one of two lift valves being opened automatically when the coupling is applied
- F16L37/34—Couplings of the quick-acting type with fluid cut-off means with fluid cut-off means in each of two pipe-end fittings at least one of two lift valves being opened automatically when the coupling is applied at least one of the lift valves being of the sleeve type, i.e. a sleeve is telescoped over an inner cylindrical wall
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1027—Quick-acting type connectors
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L2201/00—Special arrangements for pipe couplings
- F16L2201/40—Special arrangements for pipe couplings for special environments
- F16L2201/44—Special arrangements for pipe couplings for special environments sterile
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87917—Flow path with serial valves and/or closures
- Y10T137/87925—Separable flow path section, valve or closure in each
- Y10T137/87941—Each valve and/or closure operated by coupling motion
- Y10T137/87949—Linear motion of flow path sections operates both
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87917—Flow path with serial valves and/or closures
- Y10T137/87925—Separable flow path section, valve or closure in each
- Y10T137/87965—Valve- or closure-operated by coupling motion
Definitions
- Aseptic coupling devices can be used to connect two or more sterilized pathways.
- aseptic coupling devices can be used to couple a fluid pathway from a first piece of processing equipment to a fluid pathway from a second piece of processing equipment to establish a sterile pathway for fluid transfer between the first and second pieces of equipment.
- Typical aseptic coupling device require a "dry-to-dry” or “dry connection” that is created through the use of one or more pathway clamping devices placed upstream of the aseptic coupling devices so that the aseptic coupling devices are kept free of fluid while the connection between the aseptic coupling devices is made, the clamping devices are removed to allow fluid to flow through the aseptic coupling devices.
- WO96/21120 A describes a high flow low spill quick coupling valve assembly used to connect pressurized large diameter fluid lines.
- the coupling device includes a female coupling and a male coupling; the male coupling includes means for the connection to a fluid conduit connector and includes a valve member defining open and closed position; the female coupling also includes a valve member defining open and closed position; a clip assembly is disposed proximate the front end of the female coupling for releasably locking the male coupling in the female coupling, so that the female coupling fluid passageway is in fluid communication with the male coupling fluid passageway.
- the male coupling can be coupled to the female coupling in a position such that their respective valve members do not allow fluid flow through the two couplings.
- the subject matter of the invention is an aseptic coupling device as defined by the appended claims.
- the aseptic coupling device includes a first state in which fluid does not flow through the aseptic coupling device.
- the aseptic coupling device includes a second state in which fluid does flow through the aseptic coupling device, and a third state in which fluid does not flow through at least a portion of the aseptic coupling device.
- the aseptic coupling device can be moved from the first, second, and third states to control the flow of fluid through the aseptic coupling device.
- the term "aseptic” means freedom, to a specified degree, from microorganisms. In one example embodiment, the degree of freedom from microorganisms is measured to a concentration of 1 x 10 6 colony forming units (CFU).
- CFU colony forming units
- the term "sterile” is synonymous with the term “aseptic.”
- the term "fluid” means any substance that can be made to flow including, but is not limited to, liquids, gases, granular or powdered solids, mixtures or emulsions of two or more fluids, suspensions of solids within liquids or gases, etc.
- the sterility of various components can be achieved using one or more sterilization techniques, including Gamma, E-beam, ethylene oxide (EtO), and/or Autoclave technologies.
- sterilization techniques including Gamma, E-beam, ethylene oxide (EtO), and/or Autoclave technologies.
- System 100 includes a first piece of processing equipment 110 and a second piece of processing equipment 120.
- equipment 110, 120 are bioreactors including biomaterial.
- equipment 110, 120 can be other apparatuses that require a sterile connection therebetween such as, for example, a reactor and a media bag or other receptacle.
- Equipment 110 includes a fluid pathway 112 extending therefrom that is terminated by a first aseptic coupling device 114.
- equipment 120 includes a fluid pathway 122 extending therefrom that is terminated by a first aseptic coupling device 124.
- the environment within pathways 112, 122 and aseptic coupling devices 114, 124 is sterile.
- Aseptic coupling device 114 can be connected to aseptic coupling device 124.
- aseptic coupling devices 114, 124 are genderless. In other embodiments, aseptic coupling devices 114, 124 are male and female connectors, respectively.
- Aseptic coupling device 114 includes a first portion 210 and a second portion 250.
- First portion 210 includes a front portion 214 with a face 212 configured to be connected to a mating aseptic coupling device, such as aseptic coupling device 124, as described below.
- First portion 210 also includes a main body 216 with barbs 218, 220 formed thereon.
- a fluid path 222 is formed through front portion 214 and main body 216 of first portion 210.
- valve member 240 Positioned within main body 216 is a valve member 240 including a sealing portion 242 that seals against an interior surface 244 of main body 216.
- a spring 246 moves valve member 240 axially so that a barb 241 formed on valve member 240 contacts a notch 245 formed in interior surface 244 to define the closed position shown in Figure 4 .
- Another sealing portion 249 of valve member 240 seals against a member 248 positioned within main body 216.
- Second portion 250 of aseptic coupling device 114 includes a front portion 254 and a main body 255.
- a collar portion 252 is positioned about front portion 254 and can be slid axially with respect to front portion 254, as described below.
- a barb portion 256 of second portion 250 is configured to be connected to a fluid pathway (e.g., fluid pathway 112) such as a fluid line or piece of processing equipment.
- a fluid path 258 is formed through front portion 254 and main body 255.
- a sealing portion 260 that is positioned to seal against internal surface 244 of main body 216 of first portion 210 when second portion 250 is connected thereto, as described below.
- a valve member 262 positioned with main body 255 is moved by a spring 264 into contact with seat portion 266 formed by main body 255.
- aseptic coupling device 114 is shown in a shipped state.
- first portion 210 is connected to second portion 250.
- Main body 216 of first portion 210 is received within front portion 254 and main body 255 of second portion 250.
- ends 226 (see Figure 3 ) of barbs 218 formed on main body 216 of first portion 210 engage a front lip 310 formed by main body 255 of second portion 250 to connect first portion 210 to second portion 250.
- fluid path 222 of first portion 210 and fluid path 258 of second portion 250 are sealed by valve members 240, 262, respectively, so that fluid path 222 is not in communication with fluid path 258.
- barb portion 256 can be connected to a fluid pathway prior to shipment and the entire assembly sterilized. In this manner, the sterility of fluid paths 222, 258 is maintained while aseptic coupling device 114 is in the shipped state.
- an outer wrap such as a plastic or other polymer is applied to aseptic coupling device 114 when aseptic coupling device 114 is in the shipped state.
- the outer wrap can be used, for example, to maintain aseptic coupling device 114 in the shipped state prior to removal of the plastic.
- shrink wrap is formed on the outer exposed surfaces of first and second portions 210, 250 of aseptic coupling device 114. The shrink wrap is removed before aseptic coupling device 114 can be moved from the shipped state to a flow state, as described below.
- Aseptic coupling device 114 can be connected to a mating aseptic coupling device (e.g., aseptic coupling device 124) while in the shipped state to form a sterile connection.
- aseptic coupling device 114 includes an apparatus 290 (see Figure 4 ) connected to front surface 212 that is used to create a sterile connection with a mating aseptic coupling device.
- Such a sterile connection is made by removing any shrink wrap and dust capping from aseptic coupling device 114 and aligning aseptic coupling device 114 with the mating aseptic coupling device.
- an adhesive of apparatus 290 connects the coupling devices.
- Tabs 292 of aseptic coupling device 114 and the mating aseptic coupling device are thereby aligned.
- the exposed tabs 292 are pulled to cause a membrane of apparatus 290 to roll together out of aseptic coupling device 114 and the mating aseptic coupling device.
- the membranes can be removed complete and discarded, thereby creating the sterile connection.
- a sanitary clamp can be used to clamp front surfaces 212 of aseptic coupling device 114 and the mating aseptic coupling device together to maintain the connection.
- a Disposable Aseptic Connector manufactured by BioQuate Incorporated of Clearwater, Florida, and/or disclosed in U.S. Patent No. 6,679,529 to Johnson et al.
- a KLEENPACK connector manufactured by Pall Corporation of East Hills, New York, and/or disclosed in U.S. Patent No. 6,341,802 to Matkovich can be used.
- other aseptic connectors can be used.
- first portion 210 can be moved axially with respect to second portion to position aseptic coupling device 114 into the flow state.
- front lip 310 of main body 255 of second portion 250 rides over a ramped portion 222 (see Figure 3 ) of barbs 218 until front lip 310 slips beyond barbs 218 to engage ends 224 to lock second portion 250 to first portion 210 in the flow state.
- a front surface 502 of member 248 forces valve member 262 against spring 264 in an axial direction towards barb portion 256 of second portion 250 so that valve member 240 is forced by a surface 504 of main body 255 against spring 246 in an opposite axial direction towards front portion 212 of first portion 210.
- fluid communication is created between flow paths 222, 258 of first and second portions 210, 250 so that a flow path A extends through aseptic coupling device 114 to allow fluid to flow therethrough.
- aseptic coupling device 114 As aseptic coupling device 114 is moved from the shipped state to the flow state, the sterility of fluid pathways 222, 258 through aseptic coupling device 114 is maintained.
- aseptic coupling device 114 can be moved from the flow state to a disconnected state to stop the flow of liquid through aseptic coupling device 114 to disconnect first portion 210 from second portion 250.
- collar portion 252 is slid or retracted axially from a locked position, shown in Figure 18 .
- Collar portion 252 moves along a groove 420 formed in front portion 254 toward barb portion 256 to an unlocked position, shown in Figure 25 .
- a tab 508 of collar portion 252 engages a bead 510 formed in front portion 254 to define the locked position. As collar portion 252 is moved axially, tab 508 rides over bead 510 formed on front portion 254 and engages another bead 512 on front portion 254 to define the unlocked position.
- buttons 410 include portions 412 (see Figures 21 and 22 ) that extend through a groove 434 formed between seat portions 432.
- seat portions 432 clear buttons 410. Buttons 410 can then be depressed radially so that portions 412 contact and deform lip 310 of main body 255. As shown in Figure 27 , lip 310 of main body 255 is generally formed in an oval shape.
- lip 310 As portions 412 deform lip 310 by depressing buttons 410 in opposite directions Y and Z, lip 310 is moved into a more circular shape that increases the diameter of lip 310 adjacent to barbs 218.
- buttons 410 When buttons 410 are fully pressed as shown in Figure 28 , lip 310 clears ends 224 of buttons 218 to allow first portion 210 to slide axially out of second portion 250. As first portion 210 slides out of second portion 250, deformed lip 310 clears buttons 218 and 220 until first portion 210 reaches a disconnected state, as shown in Figure 4 .
- valve member 262 is moved by spring 264 back to the position shown in Figure 4 . In this manner, fluid pathway 258 is closed, thereby stopping the flow of fluid through second portion 250 of aseptic coupling device 114 in the disconnected state.
- aseptic coupling device 124 is a typical aseptic coupling device that does not necessarily include valve member 240 or second portion 250. In alternative embodiments, aseptic coupling device 124 can be similar in construction to aseptic coupling device 114.
- aseptic coupling device 114 is connected to aseptic coupling device 124. Next, aseptic coupling device 114 is moved from the shipped state to the flow state to allow fluid flow therethrough. Subsequently aseptic coupling device 114 is moved to the disconnected state to stop the flow of fluid therethrough.
- the aseptic coupling devices are made of a polymeric material.
- the aseptic coupling devices are made of polycarbonate and the seals used therein are made of a silicone rubber. Other materials can be used.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Mechanical Engineering (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Quick-Acting Or Multi-Walled Pipe Joints (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Claims (6)
- Dispositif de raccord aseptique, comprenant :une portion avant (214) définissant une surface avant (212) configurée pour créer une connexion stérile avec un dispositif de raccord aseptique conjugué (124), la portion avant comportant un organe de soupape avant (240) définissant des positions ouverte et fermée ;une portion arrière (250) comportant un organe de soupape arrière (262) définissant des positions ouverte et fermée ;un organe de bouton (410) qui, lorsqu'il est actionné, permet le mouvement de la portion arrière par rapport à la portion avant ;un organe de collier (252) ayant une portion positionnée sous l'organe de bouton (410) pour limiter le mouvement de l'organe de bouton lorsque l'organe de collier est dans une position verrouillée, et pour permettre le mouvement de l'organe de bouton lorsque l'organe de collier est dans une position déverrouillée ;la portion avant (214) étant accouplée à la portion arrière (250) dans une première position de telle sorte que l'organe de soupape avant (240) et l'organe de soupape arrière (262) ne permettent pas l'écoulement de fluide à travers la portion avant et la portion arrière ;la portion avant étant déplaçable axialement par rapport à la portion arrière jusque dans une deuxième position pour permettre un écoulement de fluide à travers la portion avant et la portion arrière ; etlorsque l'organe de collier (252) est déplacé dans la position déverrouillée, et que l'organe de bouton est actionné, la portion arrière (250) étant déplaçable axialement par rapport à la portion avant de telle sorte que la portion avant soit déconnectée de la portion arrière, et que l'organe de soupape arrière ne permette pas l'écoulement de fluide à travers la portion arrière.
- Dispositif selon la revendication 1, caractérisé en ce qu'il comporte un appareil (290) relié à la surface avant (212) de la portion avant (214) configurée pour créer une connexion stérile avec un dispositif d'accouplement aseptique conjugué.
- Dispositif selon la revendication 1, dans lequel l'organe de collier (252) définit une portion de siège (432) telle que lorsque l'organe de collier est dans la position verrouillée, la portion de siège soit positionnée par rapport à l'organe de bouton de manière à limiter le mouvement de l'organe de bouton et dans lequel, lorsque l'organe de collier est déplacé axialement dans la position déverrouillée, la portion de siège soit déplacée par rapport à l'organe de bouton pour permettre le mouvement de l'organe de bouton.
- Dispositif selon la revendication 1, dans lequel l'organe de bouton est configuré pour se déplacer radialement par rapport au mouvement axial de l'organe de collier.
- Dispositif selon la revendication 1, dans lequel l'organe de collier (252) a une portion de siège (432) qui dépasse l'organe de bouton (410) lorsque l'organe de collier (252) est glissé axialement jusque dans une position rétractée.
- Dispositif selon la revendication 1, dans lequel, lorsque la portion avant (214) est déconnectée de la portion arrière (250), l'organe de soupape avant (240) ne permet pas l'écoulement à travers la portion avant.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74725906P | 2006-05-15 | 2006-05-15 | |
PCT/US2007/011690 WO2007133793A2 (fr) | 2006-05-15 | 2007-05-15 | Dispositif de raccords aseptiques |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2024673A2 EP2024673A2 (fr) | 2009-02-18 |
EP2024673B1 true EP2024673B1 (fr) | 2013-05-15 |
Family
ID=38573420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20070777082 Active EP2024673B1 (fr) | 2006-05-15 | 2007-05-15 | Dispositif de raccords aseptiques |
Country Status (3)
Country | Link |
---|---|
US (1) | US7631660B2 (fr) |
EP (1) | EP2024673B1 (fr) |
WO (1) | WO2007133793A2 (fr) |
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US20130204215A1 (en) * | 2011-05-11 | 2013-08-08 | Bioflo, Llc | Valve for Regulating the Flow of A Liquid |
US20120286187A1 (en) * | 2011-05-11 | 2012-11-15 | Spolski Kevin J | Valve for Regulating the Flow of A Liquid |
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US11739872B2 (en) * | 2021-06-17 | 2023-08-29 | Colder Products Company | Aseptic fluid couplings |
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US11796109B2 (en) | 2021-12-28 | 2023-10-24 | Cytiva Us Llc | Connector with rotatable tube |
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-
2007
- 2007-05-15 WO PCT/US2007/011690 patent/WO2007133793A2/fr active Application Filing
- 2007-05-15 EP EP20070777082 patent/EP2024673B1/fr active Active
- 2007-05-15 US US11/748,819 patent/US7631660B2/en active Active
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US20080067807A1 (en) | 2008-03-20 |
WO2007133793A2 (fr) | 2007-11-22 |
EP2024673A2 (fr) | 2009-02-18 |
US7631660B2 (en) | 2009-12-15 |
WO2007133793A3 (fr) | 2008-01-17 |
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