EP2012118A4 - IgG PURIFICATION SEPARATOR, AND IgG MONOMER PURIFICATION METHOD USING THE SAME - Google Patents

IgG PURIFICATION SEPARATOR, AND IgG MONOMER PURIFICATION METHOD USING THE SAME

Info

Publication number
EP2012118A4
EP2012118A4 EP07742314A EP07742314A EP2012118A4 EP 2012118 A4 EP2012118 A4 EP 2012118A4 EP 07742314 A EP07742314 A EP 07742314A EP 07742314 A EP07742314 A EP 07742314A EP 2012118 A4 EP2012118 A4 EP 2012118A4
Authority
EP
European Patent Office
Prior art keywords
igg
purification
monomer
same
separator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07742314A
Other languages
German (de)
French (fr)
Other versions
EP2012118A1 (en
Inventor
Koji Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tosoh Corp
Original Assignee
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tosoh Corp filed Critical Tosoh Corp
Publication of EP2012118A1 publication Critical patent/EP2012118A1/en
Publication of EP2012118A4 publication Critical patent/EP2012118A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/261—Synthetic macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B01J20/28019—Spherical, ellipsoidal or cylindrical
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28042—Shaped bodies; Monolithic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/327—Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

To provide a separating agent for IgG purification, whereby IgG can be separated and purified efficiently at a high purity, and a method for purifying an IgG using it. A separating agent for IgG purification, characterized in that a polyacrylic acid and/or a polymethacrylic acid is immobilized on a carrier, and a method for purifying an IgG monomer, characterized in that a mixture containing an IgG monomer and an impurity containing polymeric IgG is contacted to the separating agent and eluted.
EP07742314A 2006-04-25 2007-04-24 IgG PURIFICATION SEPARATOR, AND IgG MONOMER PURIFICATION METHOD USING THE SAME Withdrawn EP2012118A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006120626 2006-04-25
PCT/JP2007/058879 WO2007123242A1 (en) 2006-04-25 2007-04-24 SEPARATOR FOR IgG PURIFICATION, AND METHOD FOR PURIFICATION OF IgG MONOMER USING THE SAME

Publications (2)

Publication Number Publication Date
EP2012118A1 EP2012118A1 (en) 2009-01-07
EP2012118A4 true EP2012118A4 (en) 2009-12-16

Family

ID=38625139

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07742314A Withdrawn EP2012118A4 (en) 2006-04-25 2007-04-24 IgG PURIFICATION SEPARATOR, AND IgG MONOMER PURIFICATION METHOD USING THE SAME

Country Status (4)

Country Link
US (1) US8088833B2 (en)
EP (1) EP2012118A4 (en)
JP (1) JPWO2007123242A1 (en)
WO (1) WO2007123242A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110098933A1 (en) * 2009-10-26 2011-04-28 Nellcor Puritan Bennett Ireland Systems And Methods For Processing Oximetry Signals Using Least Median Squares Techniques
KR20120132529A (en) * 2010-04-14 2012-12-05 에프. 호프만-라 로슈 아게 Immunoglobulin Aggregate Removal
JP6340317B2 (en) 2012-10-18 2018-06-06 Jnc株式会社 Cation exchange chromatography carrier for antibody purification and method for separating antibody monomer and polymer produced in the manufacturing process of antibody drug
JP6332267B2 (en) * 2013-03-29 2018-05-30 東ソー株式会社 Cation exchanger for liquid chromatography, its production method and its use
JP6621414B2 (en) * 2014-01-30 2019-12-18 フレゼニウス・ヘモケア・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータＦＲＥＳＥＮＩＵＳ ＨＥＭＯＣＡＲＥ ＩＴＡＬＩＡ Ｓ．ｒ．ｌ． Filtration device
US20190039046A1 (en) * 2016-02-25 2019-02-07 Hitachi, Ltd. Adsorbent material and purification method
JP6898535B1 (en) * 2020-06-16 2021-07-07 ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 Virus purification method using apatite column

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6468272A (en) * 1987-09-08 1989-03-14 Kanegafuchi Chemical Ind Adsorbent and removing apparatus
EP0306617A2 (en) * 1987-09-08 1989-03-15 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Use of Adsorbent and of apparatus for removing autoantibodies
EP0337144A1 (en) * 1988-03-31 1989-10-18 MERCK PATENT GmbH Separation materials
WO1999062936A1 (en) * 1998-06-01 1999-12-09 Genentech, Inc. Separation of protein monomers from aggregates by use of ion-exchange chromatography

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59206045A (en) 1983-05-11 1984-11-21 Asahi Chem Ind Co Ltd Adsorbent for lipoprotein of low specific weight
US5258503A (en) * 1987-09-08 1993-11-02 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Autoantibody adsorbent and apparatus for removing autoantibodies using the same
JP2726662B2 (en) * 1987-09-08 1998-03-11 鐘淵化学工業株式会社 Adsorbent and removal device using the same
JPH0622633B2 (en) * 1987-10-30 1994-03-30 鐘淵化学工業株式会社 Adsorbent and removal device using the same
PT1678208E (en) 2003-10-27 2013-07-10 Wyeth Llc Removal of high molecular weight aggregates using hydroxyapatite chromatography
JP2006120626A (en) 2004-09-24 2006-05-11 Toshiba Corp Hydrogen production apparatus and fuel cell system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6468272A (en) * 1987-09-08 1989-03-14 Kanegafuchi Chemical Ind Adsorbent and removing apparatus
EP0306617A2 (en) * 1987-09-08 1989-03-15 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Use of Adsorbent and of apparatus for removing autoantibodies
EP0337144A1 (en) * 1988-03-31 1989-10-18 MERCK PATENT GmbH Separation materials
WO1999062936A1 (en) * 1998-06-01 1999-12-09 Genentech, Inc. Separation of protein monomers from aggregates by use of ion-exchange chromatography

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2007123242A1 *

Also Published As

Publication number Publication date
WO2007123242A1 (en) 2007-11-01
US8088833B2 (en) 2012-01-03
EP2012118A1 (en) 2009-01-07
US20090234033A1 (en) 2009-09-17
JPWO2007123242A1 (en) 2009-09-10

Similar Documents

Publication Publication Date Title
EP2012118A4 (en) IgG PURIFICATION SEPARATOR, AND IgG MONOMER PURIFICATION METHOD USING THE SAME
EP2360183A4 (en) ANTIBODY PURIFICATION METHOD
EA200501894A1 (en) REMOVAL OF USED GAS POLLUTANTS IN MEMBRANE ION TRANSPORT SYSTEMS
AU2003208106A1 (en) Silicon purifying method, slag for purifying silicon, and purified silicon
EP1670882A4 (en) PURIFICATION OF BIODIESEL USING ADSORBENT MATERIALS
MY154353A (en) Purfication of alcohols prior to their use in the presence of an acid catalyst
NO20044738L (en) Process for desulfurization of natural gas
WO2007127126A3 (en) Silicon refining process
AU2003214132A1 (en) (meth)acrylic acid crystal and method for the production and purification of aqueous (meth)acrylic acid
ATE263122T1 (en) WATER AND WASTEWATER TREATMENT PROCESSES FOR REMOVING CONTAMINANTS
MY120051A (en) Process for purification of (meth)acrylic acid
WO2005007262A3 (en) Method of removing mercury from exhaust gases
WO2006116494A3 (en) Gas induction bustle for use with a flare or exhaust stack
MY128271A (en) Purification method for (meth) acrylic acid
AU4126501A (en) Removal of sulfur compounds from wastewater
ATE338016T1 (en) METHOD FOR PURIFYING HEXAFLUORINE-1,3-BUTADIENE
EP1765490A4 (en) PROCESS FOR REMOVING SULFUR COMPOUNDS FROM HYDROCARBON STREAMS AND ADSORBENT USED THEREIN
WO2007019515A3 (en) Method for enabling the provision of purified carbon dioxide
MY146782A (en) Method for the adsorptive purification of alkyl methacrylates
ZA200702090B (en) Method for the extractive purification of (meth)acrylic acid using a separating agent
EA200700139A1 (en) The method of separation and purification of cesium-131 FROM BARIUM CARBONATE
WO2003074289A3 (en) System for handling folded sheet material
FR2801306B1 (en) PROCESS FOR THE PURIFICATION OF (METH) ACRYLIC MONOMERS BY DISTILLATION
AR033529A1 (en) ELIMINATION OF COMPOUNDS CONTAINING PHOSPHORES OF AN OLEFINE FEEDING LOAD
AUPR536501A0 (en) Method for removing oil, fat and grease from water

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20081119

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

DAX Request for extension of the european patent (deleted)
RBV Designated contracting states (corrected)

Designated state(s): DE FR GB

A4 Supplementary search report drawn up and despatched

Effective date: 20091113

17Q First examination report despatched

Effective date: 20100309

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20140821