EP1997471B2 - Apparatus for the automatic preparation of a drug and respective method of preparation - Google Patents

Apparatus for the automatic preparation of a drug and respective method of preparation Download PDF

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Publication number
EP1997471B2
EP1997471B2 EP08157120.0A EP08157120A EP1997471B2 EP 1997471 B2 EP1997471 B2 EP 1997471B2 EP 08157120 A EP08157120 A EP 08157120A EP 1997471 B2 EP1997471 B2 EP 1997471B2
Authority
EP
European Patent Office
Prior art keywords
container
drug
intake
control unit
components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP08157120.0A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1997471B1 (en
EP1997471A1 (en
Inventor
Luigino De Marco
Renzo Lazzarini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISITEC Srl
Original Assignee
ISITEC Srl
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Filing date
Publication date
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Publication of EP1997471B1 publication Critical patent/EP1997471B1/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/84—Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B01F35/7131—Breaking or perforating packages, containers or vials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/714—Feed mechanisms for feeding predetermined amounts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/75425—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers
    • B01F35/754251—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers reciprocating in the mixing receptacle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions

Definitions

  • the present invention concerns an apparatus for the automatic preparation of a drug and the relative method of preparation.
  • the present invention is used for the preparation and dosage of liquid homogeneous solutions or dispersions of chemical products, of synthetic or natural origin, in order to prepare solutions for clinical use in the human and veterinary field or for industrial use.
  • a first difficulty is connected to the fact that the prescription of a drug to a patient in chemotherapy occurs after his clinical state has been evaluated and the prescribed doses must be confirmed by a medical examination with every cycle. Consequently, the unit responsible for the preparation of the drug with the particular dosage must prepare solutions, which are always personalized and different each time, of the drug with the correct dosage. This has to be done very quickly, and often in great quantities, and so as to allow the nursing staff then to administer the therapies during working hours, often in a day hospital.
  • Another difficulty is connected to the variety of molecules used and the need to control the delivery of the preparations, according to how they will be used within the stability period that is characteristic of each preparation.
  • the number of solutions prepared a year can be in the order of several tens of thousands, with some dozens of different molecules, of which a large part in everyday use.
  • Another difficulty is the need to guarantee absolutely sterile conditions in every step of the preparation cycle.
  • the drugs, or their components, are supplied in containers with doses that vary between about 50% and 150% of the average individual daily dose.
  • doses that vary between about 50% and 150% of the average individual daily dose.
  • the complexity of the therapeutic protocols may even entail the use of five different active principles, distributed over several days.
  • the operation to prepare the drug consists in taking a solution containing the drug from a container located in an extractor hood, using a sterile syringe, and controlling visually, on the graduated scale of the syringe, the volume of the solution picked up.
  • the accuracy of the assessment depends on the optical aberrations due to the parallax error in the alignment between the operator's eye and the graduated scale of the syringe. This mistake can be accentuated, if the interference of the glass of the extractor hood is taken into account.
  • the solution taken is further diluted and infused through an injection point into a sac or container made of deformable plastic material.
  • the dosage must be extremely accurate, according to the measuring instruments used, such as sterile syringes and connection sets between the syringe and the containers. Care must also be taken to keep the products sterile by means of methodical disinfection standards. For example, the work place is protected by adequate techniques to prevent the production of spray during the dilution, intake and preparation of the drug.
  • extractor hoods and individual protection devices such as gloves, work uniform and mask, allows to protect the operator and the work spaces but, at the same time, it limits spaces available for maneuver and makes the dosing operations not very easy, especially if we consider that these operations are repeated by the operator many times in the course of the working day.
  • the repetitiveness of the operation and the familiarity acquired by the operator in handling the components of the drug also lead to a drop in attention of the operator, which increases the probability of mistakes.
  • the manual operation could be mistaken due to an exchange of the solutions used or to a mistake in the dosage. In fact, the solutions are mostly colorless or have similar colors and packaging. If a mistake is made, it would be impossible to detect it before the drug is administered.
  • the international application WO-A-99/63547 discloses an apparatus for the preparation of radioactive solutions in which a computer controlled syringe pump is used to transfer the solution between reagent vials and to dispense the reagents.
  • Purpose of the present invention is to achieve an apparatus and perfect a relative method that allows to prepare a drug automatically, starting from several components, in an accurate and safe way, both for the patient and for the operator, which is totally sterile, quick and with repeatable results in an accurate manner.
  • the Applicant has devised, tested and embodied the present invention to overcome the shortcomings of the state of the art and to obtain these and other purposes and advantages.
  • an apparatus for the automatic preparation of a drug consisting of at least two components comprises a first container for a first component, a second container for a second component and a third container to receive the drug thus prepared.
  • the apparatus also comprises an intermediate container for the preparation of the drug, connected both to the third container and also, by means of valve means selectively openable and closable, to the first and second containers; an intake/injection device, able to be activated in intake mode in order to take in dosed quantities of the first and second component inside the intermediate container, and able to be activated in injection mode in order to transfer the prepared drug from the intermediate container to the third container; and an electronic control unit suitable to manage automatically and in a coordinated manner the selective activation of the valve means and the intake/injection device.
  • the electronic unit comprises, or is associated with, memorization means able to memorize data relating to predetermined doses of the drug.
  • the apparatus according to the present invention is provided with sensor means able to detect the values of said dosed quantities and to transmit them to the electronic control unit. In this way, from a comparison between the memorized data and the values detected, it is possible to control the correctness of the quantities of the components actually taken in, thus preventing any toxic effect for the patient.
  • the whole preparation operation is automated and does not involve the operator directly, except for the preparation of the containers that feed the components and except in the startup and control of the preparation procedure managed by the electronic control unit.
  • the present invention thus allows to prepare a drug automatically, starting from several components, in an accurate and safe way, both for the patient and for the operator, which is quick and with repeatable results in an accurate manner.
  • the exact quantity of the component taken in is controlled by calibrating the intake/injection device, the containers and the relative connection circuits.
  • the calibration values are inserted into the electronic control unit by the operator responsible for starting each operation to prepare the drug or, preferably, memorized once only in the control unit.
  • any change in the intake/injection device, the containers and the relative connection circuits is detected by said sensor means and signaled to the control unit which, by means of suitable alarm means, for example, acoustic and/or visual, obliges the operator to insert or recall from the memory the corresponding calibration values.
  • suitable alarm means for example, acoustic and/or visual
  • the accuracy of intake and dosage that is thus determined also allows to reduce waste in the components of the drug, allowing a considerable saving in costs.
  • An advantageous variant of the present invention provides to use a dosing syringe, of the sterile type, as an intake/injection device.
  • the apparatus By using sterile containers, syringes and relative connection circuits, the apparatus in its entirety is rendered sterile and prevents contaminations of the drug prepared.
  • the apparatus can also be used as an injector-doser in the course of parenteral therapy according to a program controlled by the electronic control unit, by connecting the sterile syringe to an infusion line of suitable length.
  • an apparatus 10 is used for the preparation of chemotherapy drugs formed by two or more components and used in oncological therapies.
  • the apparatus 10 comprises two containers 12 and 14, a first container 12 that contains a drug in solution, at a concentration such that it must be suitably diluted so as to be administered to the patient, and a second container 14 that contains a diluent for the drug in solution to be diluted.
  • the drug suitably prepared is sent, as shown hereafter, to a medical sac 16.
  • the containers 12 and 14 are of the sterile closing type, standard for medical applications, as is the medical sac 16.
  • the containers 12 and 14 and the medical sac 16 are put in communication with corresponding circuits 15, 17 and 19, of the sterile type, also standard for medical applications, which in turn converge into a hydraulic connection element 18, for example formed by a two-way Luer-Lock ramp.
  • a container 27 Downstream of the connection element 18 a container 27 is provided, selectively connected with the containers 12, 14 and 16, inside which, as will be shown hereafter, the drug is mixed and prepared.
  • connection element 18 Connected to the connection element 18 there are two taps 34 and 36, for example two-way or three-way, which are associated respectively with the circuits 15 and 17, in order to regulate the quantity of the stream of drug in solution and of diluent entering the connection element 18.
  • the circuits 15 and 17 can consist of needles or ventilated needles which perforate the containers 12 and 14 and which are attached, screwed or inserted into the respective taps 34 and 36.
  • the perforation of the containers 12 and 14 is guided by a slide or cradle or hopper on the bottom of which there are packings, either rigid or elastic, in such a number as to regulate the penetration of the points of the needles on the inner side of the containers 12 and 14, allowing maximum recoup of the content thereof.
  • the taps 34 and 36 are driven by relative independent motors 35 and 37, to operate in coordination with each other so as to determine all the possible combinations of quantities of drug in solution and diluent.
  • the motors 35 and 37 move shaped guides, not shown in the drawings, to house the external wings of the taps 34 and 36.
  • the exact dosage quantities of the drug in solution and of diluent are selectively taken in by a dosing syringe 20, whose hollow cylinder 26 defines inside it the container 27. Inside the cylinder 26 the drug in solution and the diluent are mixed, and from here the prepared drug is injected, through the element 18, into the medical sac 16.
  • the hollow cylinder 26 of the dosing syringe 20 has a Luer-Lock tip 21, inserted into the connection element 18, and a piston 22 inserted slidingly inside it.
  • the piston 22 and the cylinder 26 are able to slide one with respect to the other, along the common longitudinal axis X, to perform the known intake and injection of the syringe 20.
  • the piston 22 is provided with a piston-thrust portion 24, which is constrained to suitable retaining fins 32.
  • a suitable electric motor 28, shown schematically in fig. 1 is able to act by means of a transmission mechanism 29, on the fins 32, in order to drive the piston-thrust 24 and thus move the piston 22 in alternate mode, along its longitudinal axis X. If the piston 22 is moved in the direction of the arrow F in fig. 1 , the syringe 20 operates in intake mode, whereas if the piston 22 is moved in the direction of the arrow G in fig. 1 , the syringe 20 operates in injection mode.
  • the transmission mechanism 29 can consist of a worm screw, a screw pin, metal or polymer telescopic extensions, as required.
  • the base 23 of the cylinder 26 is constrained to other fins 30, mounted on the motor 28.
  • connection between the fins 30 and 32 and the base 23 and the piston-thrust 24 may be made by means of a screw, an elastic element, an attachment tooth or by means of vacuum.
  • the preparation of the drug according to the present invention is made according to updated dosages of the drugs to be administered to each patient.
  • the doses are memorized in a database 42 as drug preparation data, together with the chemical-physical characteristics of the components and possible other necessary data.
  • the containers 12 and 14 are prepared, block 52 in fig. 2 .
  • the medical sac 16 is prepared, into which the drug, prepared and ready to be administered, is introduced.
  • a step of opening at least one of the two taps 34 and 36, block 54 in fig. 2 to allow the passage of a determinate dosed quantity of drug in solution and/or diluent.
  • the method according to the invention provides an intake step by the syringe 20, block 55 in fig. 2 , which is simultaneous with the step of mixing the drug in solution and the diluent in the cylinder 26 of the syringe 20, so as to prepare the final drug.
  • the apparatus 10 In order to coordinate the opening and closing of the taps 34 and 36 with the movement of the piston 22 during the intake and injection steps, and to guarantee the correct dosage of the drug, the apparatus 10 is provided with a control unit 40, which is electronically connected also to the clinical database 42 which contains the dosages.
  • the control unit 40 commands the two motors 35 and 37 of the taps 34 and 36, in order to selectively control the opening and closing thereof, simultaneously or in sequence, according to the dosage provided for the preparation of a determinate drug to be administered.
  • control unit 40 is also able to command the activation of the electric motor that drives the piston-thrust 24, so as to determine the relative steps of intake and injection.
  • the entity of the travel of the piston 22 and the opening of the taps 34 and 36 determines the quantity of drug in solution and of diluent taken in, and is controlled by suitable electro-mechanical and/or electronic sensors 39, 41 and 43, shown schematically in the drawings.
  • the sensors 39, 41 and 43 detect signals relating to the dosed quantities and send them to the control unit 40, and also the sequence with which the components are taken in through the taps 34 and 36.
  • the signals are used for a safety check, block 57 in fig. 2 , by the control unit 40, which calculates the exact composition of the various components in the drug, and verifies if the doses are correct by comparing them with the pre-set ones in the database 42. If the doses are not correct, then the drug prepared in container 16 is expelled, block 58 in fig. 2 , and eliminated, with the restoration of a new container 16, block 53 in fig. 2 . On the contrary, if the doses are correct, the drug prepared is injected, block 59.
  • the quantity and speed of transfer of the drug in solution and diluent through the circuits 15, 17 and 19 depends on the speed of movement of the piston 22, commanded by the electric motor 28 which in turn is commanded by the unit 40.
  • the speed in particular, is adjustable according to the doses of drug prescribed, and also according to the nature of the components to be taken in, for example lyophilized drug or in solution, and the viscosity of the solutions prepared or injected, to prevent the formation of instantaneous over-pressure or back flows into the containers 12, 14 and 16.
  • the force applied by the motor to move the piston 22 is such as to allow operations in depression and to empty the containers 12 and 14 also without an air valve, with a considerable reduction of waste.
  • the depression operation allows to reduce the possibility of leakages in the subsequent operation of the feed container.
  • One advantage of the invention is that, all in all, the operating parts of the apparatus 10, that is, the motor that drives the syringe 20, the syringe 20 itself, the taps 34 and 36 with the relative motors 35 and 37 and part of the circuits 15, 17 and 19, have a limited overall bulk, such that they can easily be housed on the work surface of the chemical or microbiological hoods, or hoods for chemotherapy, and the isolators for advanced aseptic processing.
  • the containers 12, 14 and 16 used are provided with recognition labels, read optically or electromagnetically, for example a bar code, so that each operation to insert data relating to the components used in the control unit 40 can be validated by means of automatic reading, thus considerably reducing possibilities of mistakes that are found when said data is introduced manually by means of a keyboard.
  • the control unit 40 commands a bar code to be printed, which certifies the correct sequence and conformity of preparation and which contains the references of the final destination, the sequence of operations performed and the operators who intervened.
  • an RFID tag can be used, which also gives the advantage of traceability.
  • the apparatus 10 can be aligned with other identical apparatuses for a battery functioning on the work surface of the hoods, or on a surface suspended by a frame outside the hoods.
  • the modular nature of the apparatus 10 allows to associate several lines to prepare the drug in a battery under the same hood or insulator.
  • the connections and electric feeds and the electric control boards for the functioning of the apparatuses 10 can be disposed towards the outside of the work surface of the hoods and can converge independently, by means of an electric circuit, in the sole control unit 40. In this way, the simultaneous functioning of the individual lines is possible even in the event of an interruption or malfunction of an apparatus.
  • the motor 28 that commands the movement of the piston 22 is of the pneumatic type and that this movement is transmitted directly or by mechanical transmission and that it is controlled electro-mechanically.
  • motors 35 and 37 instead of shaped guides, may be provided with grippers or hooks or clamps, in order to drive the external wings of the taps 34 and 36.
  • the motor 28 may be conformed so as to collect the possible leaks from the circuits 15 and 17, and may be made of material resistant to corrosion from chemical substances used in the operation to decontaminate the work spaces and/or the chemical neutralization operation.
  • a transparent shell may be mounted on the motor 28, which surrounds the syringe 20 and the taps 34 and 36, to reveal and/or confine any sprays that develop.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP08157120.0A 2007-05-30 2008-05-28 Apparatus for the automatic preparation of a drug and respective method of preparation Active EP1997471B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000093A ITUD20070093A1 (it) 2007-05-30 2007-05-30 Apparecchiatura per la preparazione automatica di un farmaco e relativo procedimento per la preparazione

Publications (3)

Publication Number Publication Date
EP1997471A1 EP1997471A1 (en) 2008-12-03
EP1997471B1 EP1997471B1 (en) 2012-03-14
EP1997471B2 true EP1997471B2 (en) 2015-02-25

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EP08157120.0A Active EP1997471B2 (en) 2007-05-30 2008-05-28 Apparatus for the automatic preparation of a drug and respective method of preparation

Country Status (4)

Country Link
EP (1) EP1997471B2 (es)
AT (1) ATE549008T1 (es)
ES (1) ES2384193T5 (es)
IT (1) ITUD20070093A1 (es)

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CN102430363B (zh) * 2011-09-20 2014-03-26 中国科学院深圳先进技术研究院 自动化配药设备及方法
EP2793978B1 (en) * 2011-12-22 2023-03-08 ICU Medical, Inc. Fluid transfer devices and methods of use
KR102124393B1 (ko) 2013-03-15 2020-06-23 백스터 코포레이션 잉글우드 예비혼합 용액을 이용한 제제를 배합하기 위한 시스템 및 방법
ES2805051T3 (es) 2013-11-25 2021-02-10 Icu Medical Inc Procedimientos y sistema para llenar bolsas I.V. con líquido terapéutico
JP2017524456A (ja) * 2014-07-14 2017-08-31 アイシーユー・メディカル・インコーポレーテッド 流体移送デバイスおよび使用の方法
ITUB20150371A1 (it) * 2015-05-05 2016-11-05 Masmec S P A Sistema per la preparazione ed il dosaggio di farmaci chemioterapici
CN108025271A (zh) * 2015-09-22 2018-05-11 费森尤斯卡比德国有限公司 配制药物制剂的方法和装置
CA3233913A1 (en) 2015-12-04 2017-06-08 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
USD851745S1 (en) 2016-07-19 2019-06-18 Icu Medical, Inc. Medical fluid transfer system
AU2017302557B2 (en) 2016-07-25 2022-10-13 Icu Medical, Inc. Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems
CN111065366A (zh) * 2017-08-23 2020-04-24 费森尤斯卡比德国有限公司 用于生产医疗制剂的设备的阀单元
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
NL2031054B1 (en) * 2021-11-01 2023-05-31 The Compounding Company B V Compounding system
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Also Published As

Publication number Publication date
ATE549008T1 (de) 2012-03-15
EP1997471B1 (en) 2012-03-14
ES2384193T5 (es) 2015-06-05
EP1997471A1 (en) 2008-12-03
ES2384193T3 (es) 2012-07-02
ITUD20070093A1 (it) 2008-11-30

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