EP1992338A3 - Pharmaceutical compositions for the oral administration of heparin or derivatives thereof - Google Patents

Pharmaceutical compositions for the oral administration of heparin or derivatives thereof Download PDF

Info

Publication number
EP1992338A3
EP1992338A3 EP08160486A EP08160486A EP1992338A3 EP 1992338 A3 EP1992338 A3 EP 1992338A3 EP 08160486 A EP08160486 A EP 08160486A EP 08160486 A EP08160486 A EP 08160486A EP 1992338 A3 EP1992338 A3 EP 1992338A3
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical compositions
oral administration
heparin
derivatives
parnaparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08160486A
Other languages
German (de)
French (fr)
Other versions
EP1992338B1 (en
EP1992338A2 (en
Inventor
Mauro Ajani
Luigi Moro
Roberto Villa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cosmo Technologies Ltd
Original Assignee
Cosmo Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cosmo Technologies Ltd filed Critical Cosmo Technologies Ltd
Publication of EP1992338A2 publication Critical patent/EP1992338A2/en
Publication of EP1992338A3 publication Critical patent/EP1992338A3/en
Application granted granted Critical
Publication of EP1992338B1 publication Critical patent/EP1992338B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Pharmaceutical compositions suitable for the oral administration of parnaparin and/or its salts, particularly controlled-release oral pharmaceutical compositions for the treatment of inflammatory bowel diseases and related conditions, are disclosed.
EP08160486A 2001-12-11 2002-12-03 Pharmaceutical compositions for the oral administration of heparin or derivatives thereof Expired - Lifetime EP1992338B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI002599A ITMI20012599A1 (en) 2001-12-11 2001-12-11 PHARMACEUTICAL COMPOSITIONS FOR THE ORAL ADMINISTRATION OF HEPARINE OR DERIVATIVES, USEFUL FOR THERAPY OF INFLAMMATORY DISEASES OF THE INT
EP02791763A EP1455761B1 (en) 2001-12-11 2002-12-03 Pharmaceutical compositions for the oral administration of heparin or derivatives thereof

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP02791763.2 Division 2002-12-03
EP02791763A Division EP1455761B1 (en) 2001-12-11 2002-12-03 Pharmaceutical compositions for the oral administration of heparin or derivatives thereof

Publications (3)

Publication Number Publication Date
EP1992338A2 EP1992338A2 (en) 2008-11-19
EP1992338A3 true EP1992338A3 (en) 2009-08-12
EP1992338B1 EP1992338B1 (en) 2012-06-27

Family

ID=11448679

Family Applications (2)

Application Number Title Priority Date Filing Date
EP08160486A Expired - Lifetime EP1992338B1 (en) 2001-12-11 2002-12-03 Pharmaceutical compositions for the oral administration of heparin or derivatives thereof
EP02791763A Expired - Lifetime EP1455761B1 (en) 2001-12-11 2002-12-03 Pharmaceutical compositions for the oral administration of heparin or derivatives thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP02791763A Expired - Lifetime EP1455761B1 (en) 2001-12-11 2002-12-03 Pharmaceutical compositions for the oral administration of heparin or derivatives thereof

Country Status (18)

Country Link
US (1) US8642082B2 (en)
EP (2) EP1992338B1 (en)
JP (1) JP4634713B2 (en)
KR (2) KR100984801B1 (en)
CN (2) CN100490823C (en)
AT (1) ATE410148T1 (en)
AU (1) AU2002358082A1 (en)
CA (1) CA2465832C (en)
CY (1) CY1108625T1 (en)
DE (1) DE60229287D1 (en)
DK (2) DK1992338T5 (en)
ES (2) ES2312652T3 (en)
HK (1) HK1072181A1 (en)
IT (1) ITMI20012599A1 (en)
MX (1) MXPA04005710A (en)
PT (2) PT1455761E (en)
SI (1) SI1455761T1 (en)
WO (1) WO2003049721A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
DK1183014T3 (en) 1999-06-14 2004-02-09 Cosmo Spa Flavored controlled release oral pharmaceutical compositions
EP2060253A1 (en) 2007-11-14 2009-05-20 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
US8257744B2 (en) * 2000-07-07 2012-09-04 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
SE0201922D0 (en) 2002-06-20 2002-06-20 Ltp Lipid Technologies Provide Anticoagulant Composition
EP1792621B1 (en) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Orally administrable heparin derivatives
RU2009113557A (en) * 2006-09-12 2010-10-20 Космо Текнолоджиз Лтд (Ie) PHARMACEUTICAL COMPOSITIONS FOR ORAL OR RECTAL INTRODUCTION OF PROTEIN SUBSTANCES
KR100837558B1 (en) 2007-04-30 2008-06-12 (주)아모레퍼시픽 Emulsion composition containing double-stabilized ceramide nano capsule, method for manufacturing the same, and cosmetic composition containing the same
EP2213282A1 (en) 2009-01-30 2010-08-04 Laboratorios Farmaceuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
US8802156B2 (en) 2007-11-14 2014-08-12 Laboratorios Farmacéuticos Rovi, S.A. Pharmaceutical forms for the release of active compounds
KR101291813B1 (en) 2011-04-27 2013-08-02 임승택 Dextrin-ceramide complex with increased hydrophilicity and preparing method thereof
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
KR20200037574A (en) 2018-10-01 2020-04-09 (주)우리비앤비 Cosmetic composition for preventing hair loss comprising heparin
EP3791884A1 (en) * 2019-09-16 2021-03-17 Oskar Bunz Combination of heparin and magnesium salt for the treatment of viral infections
CN110585164A (en) * 2019-10-08 2019-12-20 苏州弘森药业股份有限公司 Method for preparing esomeprazole magnesium sodium bicarbonate capsule

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000048589A1 (en) * 1999-02-22 2000-08-24 Emisphere Holdings, Inc. Solid oral dosage form containing heparin or a heparinoid in combination with a carrier
WO2000076481A1 (en) * 1999-06-14 2000-12-21 Cosmo S.P.A. Mesalazine controlled release oral pharmaceutical compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6054313A (en) 1983-09-01 1985-03-28 Terumo Corp Heparin composition absorbable through intestine
JP2893191B2 (en) * 1988-11-08 1999-05-17 武田薬品工業株式会社 Controlled release matrix agent
IE61651B1 (en) 1990-07-04 1994-11-16 Zambon Spa Programmed release oral solid pharmaceutical dosage form
US5665379A (en) * 1990-09-28 1997-09-09 Pharmacia & Upjohn Aktiebolag Lipid particle forming matrix, preparation and use thereof
DE69425453T2 (en) 1993-04-23 2001-04-12 Novartis Ag Drug delivery device with controlled release
US5665370A (en) * 1995-02-22 1997-09-09 Temple University Of The Commonwealth System Of Higher Education Compositions containing cockroach aggregation pheromones, their production and uses
FR2763848B1 (en) * 1997-05-28 2000-01-28 Rhone Poulenc Rorer Sa USE OF LOW MOLECULAR WEIGHT HEPARINS FOR THE PREVENTION AND TREATMENT OF CENTRAL NERVOUS TRAUMA
IT1298575B1 (en) * 1998-02-06 2000-01-12 Vectorpharma Int PHARMACEUTICAL COMPOSITIONS IN THE FORM OF NANOPARTICLES INCLUDING LIPID SUBSTANCES AND ANTIPHILIC SUBSTANCES AND RELATED PROCESS OF
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
MXPA02004741A (en) 1999-11-12 2003-12-11 Emisphere Tech Inc Liquid heparin formulation.
EP1390383B1 (en) * 2001-05-11 2012-02-29 Isis Pharmaceuticals, Inc. Antisense permeation enhancers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000048589A1 (en) * 1999-02-22 2000-08-24 Emisphere Holdings, Inc. Solid oral dosage form containing heparin or a heparinoid in combination with a carrier
WO2000076481A1 (en) * 1999-06-14 2000-12-21 Cosmo S.P.A. Mesalazine controlled release oral pharmaceutical compositions

Also Published As

Publication number Publication date
AU2002358082A1 (en) 2003-06-23
JP2005511718A (en) 2005-04-28
DK1992338T5 (en) 2013-04-08
EP1455761B1 (en) 2008-10-08
PT1992338E (en) 2012-07-30
CN100490823C (en) 2009-05-27
ES2312652T3 (en) 2009-03-01
CY1108625T1 (en) 2014-04-09
CN1258360C (en) 2006-06-07
EP1455761A1 (en) 2004-09-15
CN1599600A (en) 2005-03-23
SI1455761T1 (en) 2009-02-28
KR20040063989A (en) 2004-07-15
JP4634713B2 (en) 2011-02-16
EP1992338B1 (en) 2012-06-27
MXPA04005710A (en) 2004-12-06
DE60229287D1 (en) 2008-11-20
EP1992338A2 (en) 2008-11-19
KR100984801B1 (en) 2010-10-04
DK1992338T3 (en) 2013-03-25
CN1839877A (en) 2006-10-04
US8642082B2 (en) 2014-02-04
ATE410148T1 (en) 2008-10-15
KR20090065556A (en) 2009-06-22
WO2003049721A1 (en) 2003-06-19
ES2386922T3 (en) 2012-09-06
PT1455761E (en) 2008-12-17
DK1455761T3 (en) 2009-01-12
CA2465832C (en) 2011-06-28
HK1072181A1 (en) 2005-08-19
KR101062687B1 (en) 2011-09-06
ITMI20012599A1 (en) 2003-06-11
CA2465832A1 (en) 2003-06-19
US20050020539A1 (en) 2005-01-27

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