EP1952817A4 - Aloe vera extract, process for production of aloe vera extract, and ameliorating agent for hyperglycemia - Google Patents

Aloe vera extract, process for production of aloe vera extract, and ameliorating agent for hyperglycemia

Info

Publication number
EP1952817A4
EP1952817A4 EP06823482A EP06823482A EP1952817A4 EP 1952817 A4 EP1952817 A4 EP 1952817A4 EP 06823482 A EP06823482 A EP 06823482A EP 06823482 A EP06823482 A EP 06823482A EP 1952817 A4 EP1952817 A4 EP 1952817A4
Authority
EP
European Patent Office
Prior art keywords
aloe vera
vera extract
hyperglycemia
production
ameliorating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06823482A
Other languages
German (de)
French (fr)
Other versions
EP1952817B1 (en
EP1952817A1 (en
Inventor
Miyuki Tanaka
Muneo Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morinaga Milk Industry Co Ltd
Original Assignee
Morinaga Milk Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morinaga Milk Industry Co Ltd filed Critical Morinaga Milk Industry Co Ltd
Priority to EP10157399.6A priority Critical patent/EP2206509B1/en
Publication of EP1952817A1 publication Critical patent/EP1952817A1/en
Publication of EP1952817A4 publication Critical patent/EP1952817A4/en
Application granted granted Critical
Publication of EP1952817B1 publication Critical patent/EP1952817B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
EP06823482.2A 2005-11-25 2006-11-20 Aloe vera extract, method of producing aloe vera extract, and hyperglycemia improving agent Active EP1952817B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10157399.6A EP2206509B1 (en) 2005-11-25 2006-11-20 Method of producing aloe vera extract

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005340245 2005-11-25
PCT/JP2006/323095 WO2007060911A1 (en) 2005-11-25 2006-11-20 Aloe vera extract, process for production of aloe vera extract, and ameliorating agent for hyperglycemia

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP10157399.6A Division EP2206509B1 (en) 2005-11-25 2006-11-20 Method of producing aloe vera extract
EP10157399.6 Division-Into 2010-03-23

Publications (3)

Publication Number Publication Date
EP1952817A1 EP1952817A1 (en) 2008-08-06
EP1952817A4 true EP1952817A4 (en) 2009-09-23
EP1952817B1 EP1952817B1 (en) 2013-05-22

Family

ID=38067138

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06823482.2A Active EP1952817B1 (en) 2005-11-25 2006-11-20 Aloe vera extract, method of producing aloe vera extract, and hyperglycemia improving agent
EP10157399.6A Active EP2206509B1 (en) 2005-11-25 2006-11-20 Method of producing aloe vera extract

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10157399.6A Active EP2206509B1 (en) 2005-11-25 2006-11-20 Method of producing aloe vera extract

Country Status (10)

Country Link
US (3) US20090004307A1 (en)
EP (2) EP1952817B1 (en)
JP (1) JP4095115B2 (en)
KR (1) KR100897492B1 (en)
CN (2) CN103494998B (en)
AU (1) AU2006317258B2 (en)
CA (1) CA2602066C (en)
ES (2) ES2425149T3 (en)
RU (1) RU2356572C1 (en)
WO (1) WO2007060911A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005094838A1 (en) * 2004-03-31 2005-10-13 Morinaga Milk Industry Co., Ltd. Drugs, foods and drinks for ameliorating hyperglycemia
ES2719098T3 (en) * 2008-11-19 2019-07-08 Morinaga Milk Industry Co Ltd Compositions comprising a lofenol
JP4580041B2 (en) * 2008-11-19 2010-11-10 森永乳業株式会社 Antioxidant
MX2012008982A (en) 2010-02-03 2012-08-23 Morinaga Milk Industry Co Ltd Method for manufacturing aloe powder.
DE102012222365A1 (en) 2012-12-05 2014-06-05 Aesculap Ag Composition for use in the prophylaxis of post-surgical adhesions
WO2015015815A1 (en) * 2013-07-30 2015-02-05 森永乳業株式会社 Fibroblast activator
WO2015015816A1 (en) * 2013-07-30 2015-02-05 森永乳業株式会社 Fibroblast activator
KR101520934B1 (en) * 2013-12-30 2015-05-18 건국대학교 산학협력단 Method of Preparing Aloe vera Extract Having Enhanced Antioxidant Activity
WO2015141787A1 (en) * 2014-03-20 2015-09-24 森永乳業株式会社 Method for manufacturing aloe extract, and aloe extract
CN106999503A (en) * 2014-11-28 2017-08-01 森永乳业株式会社 The prevention of the symptom caused by disorder balanced as sex hormone or improver
JP6285050B2 (en) * 2014-11-28 2018-02-28 森永乳業株式会社 Matrix metalloprotease production inhibitor
JP2019043863A (en) * 2017-08-30 2019-03-22 森永乳業株式会社 UCP expression promoter
JP7239489B2 (en) 2017-12-19 2023-03-14 森永乳業株式会社 Method for producing aloe powder
JP7245637B2 (en) * 2018-11-30 2023-03-24 森永乳業株式会社 Method for producing aloe extract
EP4129434A4 (en) * 2020-03-24 2024-04-24 Morinaga Milk Industry Co., Ltd. Supercritical fluid exraction device and method for manufacturing target product using same
WO2022045354A1 (en) * 2020-08-31 2022-03-03 森永乳業株式会社 Method for producing phytosterol starting material
WO2023054477A1 (en) * 2021-09-28 2023-04-06 森永乳業株式会社 Method for producing aloe extract

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011144A1 (en) * 1997-09-02 1999-03-11 The Ricex Company, Inc. A method for treating hypercholesterolemia, hyperlipidemia, and atherosclerosis

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942656B2 (en) 1980-07-07 1984-10-16 森下製薬株式会社 antilipidemic agent
US4851224A (en) 1986-06-05 1989-07-25 Carrington Laboratories, Inc. Process for preparation of aloe products
US4801582A (en) 1984-04-05 1989-01-31 Toyo Yakushoku Kogyo Co., Ltd. Method and composition for treating hypoglycemia using aloe polysaccharides
JPS60214741A (en) 1984-04-05 1985-10-28 Toyo Yakushiyoku Kogyo Kk Hypoglycemic agent
JP3685833B2 (en) 1995-02-06 2005-08-24 日本メナード化粧品株式会社 Immunosuppression improving agent
JP2844520B2 (en) 1995-03-20 1999-01-06 カーリントン ラボラトリーズ インコーポレーテッド Aloe juice production method
US5929051A (en) * 1998-05-13 1999-07-27 Carrington Laboratories, Inc. Aloe pectins
DE19916034C1 (en) 1999-04-09 2000-08-03 Cognis Deutschland Gmbh Isolation of phytosterols following methyl esterification of rape seed or soya fatty acids comprises crystallization from 25 - 75 wt. % methanol, useful as hypocholesterolemic agents in drugs and foods
JP4499209B2 (en) 1999-05-10 2010-07-07 日本メナード化粧品株式会社 Obesity prevention and improvement agent
JP2002068997A (en) 2000-08-23 2002-03-08 Air Green Co Ltd Aloe-vera stock solution and concentrate thereof
JP2002205955A (en) 2001-01-05 2002-07-23 Daily Foods Kk Colorless, transparent and additive-free 100% aloe vera pressed juice free from aloin
JP4186176B2 (en) 2001-03-27 2008-11-26 デイリーフーズ株式会社 Aloe vera press
JP2002371003A (en) 2001-06-15 2002-12-26 Kikkoman Corp Inhibitor against blood sugar level increase
JP2003095941A (en) 2001-09-26 2003-04-03 Ito En Ltd Sugar digestion enzyme inhibitor, hyperglycemia inhibitor, therapeutic or prophylactic agent for obesity, therapeutic or prophylactic agent for diabetes, and healthy food and drink
JP2003113394A (en) 2001-10-04 2003-04-18 Unitika Ltd Extract of konjak and food and drink including the same
JP2003277269A (en) 2002-03-20 2003-10-02 Univ Nihon Carcinogensis preventing agent
JP2003286185A (en) 2002-03-29 2003-10-07 Daily Foods Kk Squeezed liquid of aloe vera and hypoglycemic agent containing the squeezed liquid as effective ingredient
JP4846990B2 (en) * 2003-08-06 2011-12-28 株式会社テラ・ブレインズ Adiponectin secretion promoter
MY138963A (en) * 2003-08-27 2009-08-28 Malaysian Palm Oil Board One-stage and two-stage supercritical fluid extractions of carotenes concentrate, vitamin e concentrate and other minor components concentrates
WO2005094838A1 (en) * 2004-03-31 2005-10-13 Morinaga Milk Industry Co., Ltd. Drugs, foods and drinks for ameliorating hyperglycemia
MY146635A (en) * 2004-09-01 2012-09-14 Malaysian Palm Oil Board Specialty palm oil products and other specialty vegetable oil products
RU2327463C2 (en) * 2004-09-29 2008-06-27 Моринага Милк Индастри Ко., Лтд. Medicinal agent and food substance or beverage for improved hyperglycemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011144A1 (en) * 1997-09-02 1999-03-11 The Ricex Company, Inc. A method for treating hypercholesterolemia, hyperlipidemia, and atherosclerosis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAN A ET AL: "Effect of Aloe vera Leaf Gel and Pulp Extracts on the Liver in Type-II Diabetic Rat Models", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 27, no. 5, 1 May 2004 (2004-05-01), pages 694 - 698, XP002990130, ISSN: 0918-6158 *
RAJASEKARAN S ET AL: "Hypoglycemic Effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats", JOURNAL OF MEDICINAL FOOD, MARY ANN LIEBERT, LARCHMONT, NY, US, vol. 7, no. 1, 1 January 2004 (2004-01-01), pages 61 - 66, XP003011589, ISSN: 1096-620X *
See also references of WO2007060911A1 *
YONGCHAIYUDHA S ET AL: "Antidiabetic activity of Aloe vera L.juice. I. Clinical trial in new cases of diabetes mellitus", PHYTOMEDICINE, GUSTAV FISCHER VERLAG, STUTTGART, vol. 3, no. 3, 1 January 1996 (1996-01-01), pages 241 - 243, XP003011590, ISSN: 0944-7113 *

Also Published As

Publication number Publication date
CN101128211A (en) 2008-02-20
CN103494998B (en) 2015-08-12
US8709512B2 (en) 2014-04-29
JP4095115B2 (en) 2008-06-04
EP2206509A1 (en) 2010-07-14
AU2006317258A1 (en) 2007-05-31
EP1952817B1 (en) 2013-05-22
AU2006317258B2 (en) 2008-12-18
US20090004307A1 (en) 2009-01-01
CA2602066C (en) 2014-02-11
CA2602066A1 (en) 2007-05-31
US20110104314A1 (en) 2011-05-05
KR20070096010A (en) 2007-10-01
RU2356572C1 (en) 2009-05-27
ES2576845T3 (en) 2016-07-11
ES2425149T3 (en) 2013-10-11
EP2206509B1 (en) 2016-03-23
KR100897492B1 (en) 2009-05-15
WO2007060911A1 (en) 2007-05-31
JPWO2007060911A1 (en) 2009-05-07
US20130079314A1 (en) 2013-03-28
CN101128211B (en) 2014-08-13
CN103494998A (en) 2014-01-08
US8877265B2 (en) 2014-11-04
EP1952817A1 (en) 2008-08-06

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