EP1951040B1 - Cornseed treated with aqueous rodenticide formulation - Google Patents

Abstract

The invention relates to novel aqueous rodenticide formulations, cereal grains treated with said formulations, and methods for controlling rodents based on said formulations.

Description

The present invention encompasses novel cereal grains stained with aqueous rhodenticidal formulations, methods of making a delivery formulation, and methods of controlling rodents based on these formulations.

Aqueous rhodenticidal formulations which can be used to pickle cereal grains to produce appropriate bait formulations are, because of their ease of handling, an attractive alternative to powder formulations for the person skilled in the art, since baits treated with these formulations run the risk of abrasion or undesired displacement of the active ingredient from the bait into the environment. The patent GB 728 537 discloses, for example, melon grains pickled with an aqueous formulation of wheat flour and rhodenticide.

The requirements for seed dressing formulations containing Rhodentizide are also high: they should be applied when applied to the bait, e.g. may consist of cereal grains, on the one hand cause the best possible adhesion of the drug to the bait due to the toxicity of the drug. On the other hand, possible dust formation in the use or processing of the pickled product should be minimal.

The object of the present invention was thus to provide Rhodentizid formulations which cause the best possible adhesion of the active ingredient to the grain during the pickling of cereal grains, and / or in which a dust formation in the use or processing of the pickled product is minimal.

1. (a) mindestens ein Rhodentizid;
2. (b) mindestens ein Polyol aus der Gruppe Glycol, Polyethylenglycol, Glycerin, Propylenglykol oder Dipropylenglykol;
3. (c) Polyethylenwachs oder Latexcopolymer auf Basis Styrol/Butadien; und
4. (d) Monosaccharid und/oder Disaccharid, wobei der Gehalt 10,0 Gew.-% bis 50,0 Gew.- % beträgt,

umfasst.The object has been achieved by providing a cereal grains treated and dried with an aqueous rhodentizide formulation, wherein the formulation

1. (a) at least one Rhodentizid;
2. (B) at least one polyol from the group glycol, polyethylene glycol, glycerol, propylene glycol or dipropylene glycol;
3. (c) polyethylene wax or latex copolymer based on styrene / butadiene; and
4. (d) monosaccharide and / or disaccharide, the content being from 10.0% by weight to 50.0% by weight,

includes.

An advantage of these formulations of the invention is also that these formulations can in principle do without any solvent, which is desirable due to odor or safety considerations.

Optionally, of course, odorless and tasteless solvents can be used. By way of example but not limiting here butyrolactone or Caprolactone. Suitable amounts are 0-10% by weight, preferably 1 to 7% by weight, more preferably 2 to 6% by weight.

The content of monosaccharide and / or disaccharide and / or oligosaccharide is preferably 10.0 to 35.0% by weight, more preferably 15.0 to 25.0% by weight.

The content of Rhodentizid is 0.01% by weight to 30% by weight, preferably 0.01 to 1% by weight, particularly preferably 0.02-0.2% by weight.

The content of polyol is 1 wt .-% to 50%, preferably 1 to 20 wt .-%

The content of adhesive is 1 wt .-% to 30 wt .-%, preferably 1 to 10 wt .-%, particularly preferably 1 to 5 wt .-%.

• Pflanzliche Rhodentizide wie Scillirosid oder Strychnin;
• Coumarin Rhodentizide wie Brodifacoum,; Bromadiolone, Coumachlor, Coumafuryl, Coumatetralyl, Difenacoum, Difethialone, Flocoumafen, Warfarin;
• Indandion Rhodentizide wie, Chlorophacinon, Diphacinon, Pindon;Anorganische Rhodentizide wie Arsenoxid, Kaliumarsenit, Natriumarsenit, Thalliumarsenit;
• Organophosphat Rhodentizide wie Phosacetim;
• Pyrimidinamine Rhodentizide wie Crimidine; Thioharnstoff Rhodentizide wie Antu;Harnstoff Rhodentizide wie Pyrinuron;verschiedene Rhodentizide wie Bromethalin, Chloralose, Fluoroacetamid, Flupropadin, Natrium oder Kaliumsalze der Blausäure, Norbormide sowie Natriumfluoroacetat;

vorzugsweise die oben erwähnten Coumarin Rhodentizide; besonders bevorzugt Flocumafen und Difenacum; ganz besonders bevorzugt Flocumafen.Suitable Rhodentizide are

• Herbal rhodenticides such as scilliroside or strychnine;
• Coumarin rhodenticides like Brodifacoum; Bromadiolone, coumachlor, coumafuryl, coumatetralyl, difenacoum, difethialone, flocoumafen, warfarin;
• Indandion rhodenticides such as, chlorophacinone, diphacinone, pindone; inorganic rhodenticides such as arsenic oxide, potassium arsenite, sodium arsenite, thallium arsenite;
• Organophosphate rhodenticides such as phosacetim;
• Pyrimidinamine rhodenticides such as crimidine; Thiourea rhodenticides such as antu; urea rhodenticides such as pyrinuron; various rhodenticides such as bromothalin, chloralose, fluoroacetamide, flupropadine, sodium or potassium salts of hydrocyanic acid, norbormides and sodium fluoroacetate;

preferably the coumarin rhodenticides mentioned above; especially flocumafen and difenacum; most preferably flocumafen.

In the context of the present invention, the use of disaccharides is very particularly preferred.

Suitable monosaccharides are glucose, fructose, galactose, preferably fructose.

Suitable disaccharides are sucrose, maltose, lactose, preferably sucrose (eg in pure form or as molasses, beet sugar)

Adhesives are styrene / butadiene based latex copolymers (available, for example, as Semkote E-125, Uniqema) and polyethylene wax (e.g., commercially available as Poligen® WE 7 BASF).

Furthermore, the formulations according to the invention may optionally contain further adjuvants, such as e.g. Surfactants (such as wetting agents, adhesives and dispersants), anti-foaming agents, thickeners, bactericides and dyes.

Examples of surfactants are alkali metal salts, alkaline earth metal salts, ammonium salts of ligninsulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, dibutylnaphthalenesulfonic acid, alkylarylsulfonates, alkyl sulfates, alkylsulfonates, fatty alcohol sulfates, fatty acids and sulfated fatty alcohol glycol ethers, furthermore condensate products of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensation products of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenol ether, ethoxylated isooctylphenol, octylphenol, nonylphenol, alkylphenol polyglycol ether, Tributylphenylpolyglykolether, Tristerylphenylpolyglykolether, Alkylarylpolyetheralkohole, alcohol and Fettalkoholethylenoxid condensates, ethoxylated castor oil, Polyoxyethylenalkylether, ethoxylated polyoxypropylene, Laurylalkoholpolyglykoletheracetal, sorbitol esters, Ligninsulfitablaugen and methylcellulose.

Examples of thickeners (ie compounds which impart a pseudoplastic flow behavior to the formulation, ie high viscosity at rest and low viscosity in the agitated state) are, for example, polysaccharides or organic layer minerals such as xanthan gum (Kelzan® from Kelco), Rhodopol® 23 (US Pat. Rhone Poulenc) or Veegum® (RT Vanderbilt) or Attaclay® (Engelhardt).

Examples of antifoam agents are silicone emulsions (such as, for example, Silikon® SRE, Wacker or Rhodorsil® from Rhodia), long-chain alcohols, fatty acids, fluoroorganic compounds and mixtures thereof.

Suitable bactericides which may be present in the formulations according to the invention are all bactericides which are customary for the formulation of agrochemical active compounds such as, for example, bactericides based on diclorophene and benzyl alcohol hemiformal. Examples of bactericides are Proxel® from the company ICI or Acticide® RS from Thor Chemie and Kation® MK from Rohm & Haas.

Suitable dyes are all customary for such purposes dyes. Both water-insoluble pigments and water-soluble dyes are useful in this case. Examples which may be mentioned under the names rhodamine B, C.I. Pigment Red 112 and C.I. Solvent Red 1 known dyes, as well as pigment blue 15: 4, pigment blue 15: 3, pigment blue 15: 2, pigment blue 15: 1, pigment blue 80, pigment yellow 1, pigment yellow 13, pigment red 112, pigment red 48 : 2, pigment red 48: 1, pigment red 57: 1, pigment red 53: 1, pigment orange 43, pigment orange 34, pigment orange 5, pigment green 36, pigment green 7, pigment white 6, pigment brown 25, basic violet 10, basic violet 49, acid red 51, acid red 52, acid red 14, acid blue 9, acid yellow 23, basic red 10, basic red 108 and their color preparations (dyes) such as Disperse Blue 69-0007; BASF available compounds.

The present invention furthermore also comprises a process for the preparation of a bait formulation, which comprises treating cereal grains with a formulation according to the invention.

The term cereal grains includes all types of seeds that are present as a whole grain, i. that are not crushed, chopped or split.

The treatment / pickling can be carried out by methods known to those skilled in the art (eg by spraying or immersing / incubating the cereal grains in or with the formulation according to the invention optionally in a corresponding device such as a conti or batch stirrer). In this case, the formulation can be diluted with up to 7.5 g of water / kg cereal grains. Optionally, the treated grains can be dried.

Suitable cereal grains are barley, wheat, rice, maize, oats, rye, spelled, greens, millet, rape and sunflowers, preferably wheat.
In a further embodiment, the present invention comprises methods for controlling rodents, characterized in that one interprets the baits described above in places that are frequented by the aforementioned animals.

The term rodents is to be understood in addition to rats and mice and bismates, preferably rats and mice, particularly preferably rats.

Here, e.g. the pickled cereal grains are placed in suitable traps and placed in exposed locations, e.g. Rodents' passageways, holes where the rodents live or where they are placed by their faeces.

Preferably, the traps should be such that the rat perceives the grains in any case. From time to time, control of the amount of the poisonous food provides information about the effect and the population of the animals.

Examples Example 1 Preparation of the aqueous formulation A) Formulation 1

Storm® mastermix (40 g of a commercial Flocumafen formulation, Storm® 0.5% master mix, containing 5g / kg flocumafen) together with 150 g of beet sugar, 100 g of glycerol, 50 g of the adhesive Poligen WE 7 (polyethylene wax) 648 g of water and under Stirring solved better: mixed ?. Subsequently, 10 g of Disperse Blue were added and homogenized. 100 g of the pre-swollen xanthan gum (2% by weight xanthan gum in water) and 2 g of the bactericide (Acticide MBS) were added. The resulting mixture was homogenized.

B) Formulation 2

Storm® mastermix (40g of a commercial flocumafen formulation, Storm® 0.5% Mastermix containing 5g / kg flocumafen) was co-packaged with 200g of beet sugar, 100g of polyethylene glycol E400 Lutrol E 400; BASF, 100g of the Semkote E 125 adhesive (Synthetic latex based on styrene / butadiene) 408 g of water and mixed with stirring. Subsequently, 50 g Disperse Blue 69-0007 was added and homogenized. 100 g of the pre-swollen xanthan gum (2% by weight xanthan gum in water) and 2 g of the bactericide (Acticide MBS) were metered into this mixture and the resulting mixture was homogenized.

Example 2 - Staining with Formulations 1 and 2

Starting Materials:

• > 2.5 g of water
• 1000 g of wheat
• 2.5-25 g Formulation A, or Formulation B

production:

The wheat was presented in a commercial Conti or batch stirrer (Batch Concept ML 2000 / manufacturer Satec). Subsequently, and under mild conditions (about 690 rpm, the formulation A, or

B metered by means of a peristaltic pump or other dosing unit-After a further 30 sec, the pickled grains are placed in suitable containers
spent and stored dry until packed.

Claims (11)

1. A cereal grain treated with an aqueous rodenticide formulation and dried, the formulation comprising

   (a) at least one rodenticide;

   (b) at least one polyol selected from the group consisting of glycol, polyethylene glycol, glycerol, propylene glycol and dipropylene glycol;

   (c) polyethylene wax or latex copolymer, based on styrene/butadiene, as adhesive; and

   (d) monosaccharide and/or disaccharide, where the content is 10.0 wt% to 50.0 wt%.
2. The cereal grain according to claim 1, wherein the rodenticide content is from 0.01 % by weight to 30% by weight.
3. The cereal grain according to claim 1 or 2, wherein the polyol content is from 1% by weight to 50% by weight.
4. The cereal grain according to any of claims 1 to 3, wherein the adhesive content is from 2% by weight to 30% by weight.
5. The cereal grain according to any of claims 1 to 4, wherein flocumafen is employed as rodenticide.
6. The cereal grain according to any of claims 1 to 4, wherein glycerol is employed as polyol.
7. The cereal grain according to any of claims 1 to 6, wherein a disaccharide is employed as component d).
8. The cereal grain according to any of claims 1 to 7, comprising barley, wheat, rice, maize, oats, rye, spelt, Grünkern, millet/sorghum, rapeseed or a sunflower seed.
9. A process for preparing a bait formulation, wherein cereal grains are treated with a formulation according to any of claims 1 to 7 and the grains are dried.
10. The process according to claim 9, comprising barley, wheat, rice, maize, oats, rye, spelt, Grünkern, millet/sorghum, rapeseed or a sunflower seed.
11. A method of controlling rodents, wherein a bait comprising cereal grains according to any of claims 1 to 8 is placed at locations which are frequented by the rodents.