EP1926123A3 - Mass spectrometer and method of mass spectrometry - Google Patents

Mass spectrometer and method of mass spectrometry Download PDF

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Publication number
EP1926123A3
EP1926123A3 EP07008983A EP07008983A EP1926123A3 EP 1926123 A3 EP1926123 A3 EP 1926123A3 EP 07008983 A EP07008983 A EP 07008983A EP 07008983 A EP07008983 A EP 07008983A EP 1926123 A3 EP1926123 A3 EP 1926123A3
Authority
EP
European Patent Office
Prior art keywords
mass
rod structure
voltage
quadrupole rod
potential
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07008983A
Other languages
German (de)
French (fr)
Other versions
EP1926123A2 (en
EP1926123B1 (en
Inventor
Yuichiro Hashimoto
Hideki Hasegawa
Izumi Waki
Masuyuki Sugiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi Ltd
Original Assignee
Hitachi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Ltd filed Critical Hitachi Ltd
Publication of EP1926123A2 publication Critical patent/EP1926123A2/en
Publication of EP1926123A3 publication Critical patent/EP1926123A3/en
Application granted granted Critical
Publication of EP1926123B1 publication Critical patent/EP1926123B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods
    • H01J49/429—Scanning an electric parameter, e.g. voltage amplitude or frequency

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A linear trap (7) having high ejection efficiency and low ejection energy is realized. In a mass spectrometer in which ions generated by an ion source (1) are introduced to a quadrupole rod structure (10a to 10d) applied with RF voltage (40) and ejected from the quadrupole rod structure so as to be detected by a detection mechanism (8; 25), a mass dependent potential is formed in the axial direction of the quadrupole rod structure and ions are ejected mass selectively from the vicinity of a minimum point of the potential, the mass dependent potential being formed by applying electrostatic voltage (41) and RF voltage (40) to an insertion electrode (13a to 13d) inserted in the quadrupole rods (10a to 10d).
Figure imgaf001
EP07008983.4A 2006-11-22 2007-05-03 Mass spectrometer and method of mass spectrometry Not-in-force EP1926123B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006314986A JP4918846B2 (en) 2006-11-22 2006-11-22 Mass spectrometer and mass spectrometry method

Publications (3)

Publication Number Publication Date
EP1926123A2 EP1926123A2 (en) 2008-05-28
EP1926123A3 true EP1926123A3 (en) 2010-08-25
EP1926123B1 EP1926123B1 (en) 2013-04-10

Family

ID=39159123

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07008983.4A Not-in-force EP1926123B1 (en) 2006-11-22 2007-05-03 Mass spectrometer and method of mass spectrometry

Country Status (4)

Country Link
US (1) US7820961B2 (en)
EP (1) EP1926123B1 (en)
JP (1) JP4918846B2 (en)
CN (1) CN101188183B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0608470D0 (en) * 2006-04-28 2006-06-07 Micromass Ltd Mass spectrometer
CA2725544C (en) * 2008-05-30 2017-12-19 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University A radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers
JP5542055B2 (en) * 2008-08-29 2014-07-09 株式会社日立ハイテクノロジーズ Mass spectrometer
US7884333B2 (en) * 2008-09-25 2011-02-08 Jefferson Science Associates, Llc Particle beam and crabbing and deflecting structure
WO2010044247A1 (en) * 2008-10-14 2010-04-22 株式会社日立ハイテクノロジーズ Mass spectrometer and mass spectrometry method
JP5303286B2 (en) * 2009-01-21 2013-10-02 株式会社日立ハイテクノロジーズ Mass spectrometer
US8138472B2 (en) * 2009-04-29 2012-03-20 Academia Sinica Molecular ion accelerator
EP2609615B1 (en) * 2010-08-25 2018-10-03 DH Technologies Development Pte. Ltd. Methods and systems for providing a substantially quadrupole field with significant hexapole and octapole components
WO2012081122A1 (en) * 2010-12-17 2012-06-21 株式会社島津製作所 Ion guide and mass spectrometer
JP5771456B2 (en) * 2011-06-24 2015-09-02 株式会社日立ハイテクノロジーズ Mass spectrometry method
DE102011115195B4 (en) * 2011-09-28 2016-03-10 Bruker Daltonik Gmbh Mass spectrometric ion storage for extremely different mass ranges
US9653278B2 (en) 2011-12-28 2017-05-16 DH Technologies Development Ptd. Ltd. Dynamic multipole Kingdon ion trap
CN104160474A (en) * 2012-02-01 2014-11-19 Dh科技发展私人贸易有限公司 Method and apparatus for improved sensitivity in a mass spectrometer
US8933397B1 (en) 2012-02-02 2015-01-13 University of Northern Iowa Research Foundati Ion trap mass analyzer apparatus, methods, and systems utilizing one or more multiple potential ion guide (MPIG) electrodes
CN104303259B (en) * 2012-05-18 2016-12-14 Dh科技发展私人贸易有限公司 HDR detector correcting algorithm
CN102820202A (en) * 2012-08-24 2012-12-12 上海斯善质谱仪器有限公司 Device and method capable of adjusting ion distribution in quadrupole field
US9240309B2 (en) 2012-09-18 2016-01-19 Dh Technologies Development Pte. Ltd. Systems and methods for acquiring data for mass spectrometry images
US8969794B2 (en) 2013-03-15 2015-03-03 1St Detect Corporation Mass dependent automatic gain control for mass spectrometer
CA2912998A1 (en) * 2013-05-30 2014-12-04 Dh Technologies Development Pte. Ltd. Inline ion reaction device cell and method of operation
US9105454B2 (en) * 2013-11-06 2015-08-11 Agilent Technologies, Inc. Plasma-based electron capture dissociation (ECD) apparatus and related systems and methods
DE112015006208B4 (en) * 2015-02-23 2022-05-25 Hitachi High-Tech Corporation ION GUIDE AND MASS SPECTROMETER USING THEM
US9818595B2 (en) * 2015-05-11 2017-11-14 Thermo Finnigan Llc Systems and methods for ion isolation using a dual waveform
WO2016203328A1 (en) * 2015-06-18 2016-12-22 Dh Technologies Development Pte. Ltd. Probability-based library search algorithm (prols)
GB201802917D0 (en) 2018-02-22 2018-04-11 Micromass Ltd Charge detection mass spectrometry
JP7267865B2 (en) * 2019-07-19 2023-05-02 株式会社日立ハイテク Analysis device and analysis method
US11842891B2 (en) 2020-04-09 2023-12-12 Waters Technologies Corporation Ion detector

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783824A (en) * 1995-04-03 1998-07-21 Hitachi, Ltd. Ion trapping mass spectrometry apparatus
US20050127290A1 (en) * 2003-12-16 2005-06-16 Hitachi High-Technologies Corporation Mass Spectrometer
US20060169892A1 (en) * 2005-01-28 2006-08-03 Hitachi High-Technologies Corporation Mass spectrometer

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179278A (en) * 1991-08-23 1993-01-12 Mds Health Group Limited Multipole inlet system for ion traps
US5420425A (en) * 1994-05-27 1995-05-30 Finnigan Corporation Ion trap mass spectrometer system and method
JP3509267B2 (en) * 1995-04-03 2004-03-22 株式会社日立製作所 Ion trap mass spectrometry method and apparatus
JP3495512B2 (en) * 1996-07-02 2004-02-09 株式会社日立製作所 Ion trap mass spectrometer
WO1997007530A1 (en) * 1995-08-11 1997-02-27 Mds Health Group Limited Spectrometer with axial field
US6177668B1 (en) * 1996-06-06 2001-01-23 Mds Inc. Axial ejection in a multipole mass spectrometer
US6545268B1 (en) * 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
US6403955B1 (en) * 2000-04-26 2002-06-11 Thermo Finnigan Llc Linear quadrupole mass spectrometer
DE60309700T2 (en) * 2002-05-30 2007-09-13 MDS Inc., doing business as MDS Sciex, Concord METHOD AND DEVICE FOR REDUCING ARTEFACT IN MASS SPECTROMETERS
JP3752470B2 (en) * 2002-05-30 2006-03-08 株式会社日立ハイテクノロジーズ Mass spectrometer
US7019289B2 (en) * 2003-01-31 2006-03-28 Yang Wang Ion trap mass spectrometry
WO2005029533A1 (en) * 2003-09-25 2005-03-31 Mds Inc., Doing Business As Mds Sciex Method and apparatus for providing two-dimensional substantially quadrupole fields having selected hexapole components
JP4275545B2 (en) * 2004-02-17 2009-06-10 株式会社日立ハイテクノロジーズ Mass spectrometer
EP1743357B8 (en) * 2004-05-05 2016-02-24 DH Technologies Development Pte. Ltd. Method and apparatus for mass selective axial ejection
JP4659395B2 (en) * 2004-06-08 2011-03-30 株式会社日立ハイテクノロジーズ Mass spectrometer and mass spectrometry method
GB0416288D0 (en) 2004-07-21 2004-08-25 Micromass Ltd Mass spectrometer
CA2621758C (en) * 2005-01-17 2014-12-23 Micromass Uk Limited Mass spectrometer
US7067802B1 (en) * 2005-02-11 2006-06-27 Thermo Finnigan Llc Generation of combination of RF and axial DC electric fields in an RF-only multipole
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
GB0524042D0 (en) * 2005-11-25 2006-01-04 Micromass Ltd Mass spectrometer
US7582864B2 (en) * 2005-12-22 2009-09-01 Leco Corporation Linear ion trap with an imbalanced radio frequency field
US7569811B2 (en) * 2006-01-13 2009-08-04 Ionics Mass Spectrometry Group Inc. Concentrating mass spectrometer ion guide, spectrometer and method
GB0608470D0 (en) * 2006-04-28 2006-06-07 Micromass Ltd Mass spectrometer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783824A (en) * 1995-04-03 1998-07-21 Hitachi, Ltd. Ion trapping mass spectrometry apparatus
US20050127290A1 (en) * 2003-12-16 2005-06-16 Hitachi High-Technologies Corporation Mass Spectrometer
US20060169892A1 (en) * 2005-01-28 2006-08-03 Hitachi High-Technologies Corporation Mass spectrometer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HASHIMOTO Y ET AL: "Mass Selective Ejection by Axial Resonant Excitation from a Linear Ion Trap", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC, US LNKD- DOI:10.1016/J.JASMS.2006.01.011, vol. 17, no. 5, 1 May 2006 (2006-05-01), pages 685 - 690, XP025114278, ISSN: 1044-0305, [retrieved on 20060501] *
LOBODA A ET AL: "NOVEL LINAC II ELECTRODE GEOMETRY FOR CREATING AN AXIAL FIELD IN A MULTIPOLE ION GUIDE", EUROPEAN JOURNAL OF MASS SPECTROMETRY, IM PUBLICATIONS, US, vol. 6, 1 January 2000 (2000-01-01), pages 531 - 536, XP009038347, ISSN: 1469-0667 *

Also Published As

Publication number Publication date
JP2008130401A (en) 2008-06-05
US7820961B2 (en) 2010-10-26
US20080116372A1 (en) 2008-05-22
CN101188183A (en) 2008-05-28
JP4918846B2 (en) 2012-04-18
CN101188183B (en) 2010-09-29
EP1926123A2 (en) 2008-05-28
EP1926123B1 (en) 2013-04-10

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