EP1922073A4 - Neue gekappte pyrazinoylguanidin-natrium-kanalblocker - Google Patents
Neue gekappte pyrazinoylguanidin-natrium-kanalblockerInfo
- Publication number
- EP1922073A4 EP1922073A4 EP06751598A EP06751598A EP1922073A4 EP 1922073 A4 EP1922073 A4 EP 1922073A4 EP 06751598 A EP06751598 A EP 06751598A EP 06751598 A EP06751598 A EP 06751598A EP 1922073 A4 EP1922073 A4 EP 1922073A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- sodium channel
- channel blockers
- pyrazinoylguanidine sodium
- capped pyrazinoylguanidine
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P11/12—Mucolytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Otolaryngology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200631660T SI1922073T1 (sl) | 2005-08-03 | 2006-04-27 | Novi zaščiteni pirazinoilgvanidinski blokatorji natrijevega kanala |
PL06751598T PL1922073T3 (pl) | 2005-08-03 | 2006-04-27 | Nowe zabezpieczone pirazynoiloguanidynowe blokery kanału sodowego |
CY20131100870T CY1114638T1 (el) | 2005-08-03 | 2013-10-08 | Νεοι παρεμποδιστες διαυλων νατριου καλυμμενης πυραζινοϋλογουανιδινης |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/195,758 US7807834B2 (en) | 2005-08-03 | 2005-08-03 | Capped pyrazinoylguanidine sodium channel blockers |
PCT/US2006/015957 WO2007018640A1 (en) | 2005-08-03 | 2006-04-27 | New capped pyrazinoylguanidine sodium channel blockers |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1922073A1 EP1922073A1 (de) | 2008-05-21 |
EP1922073A4 true EP1922073A4 (de) | 2010-07-07 |
EP1922073B1 EP1922073B1 (de) | 2013-07-10 |
Family
ID=37718396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06751598.1A Active EP1922073B1 (de) | 2005-08-03 | 2006-04-27 | Neue geschützte pyrazinoylguanidin-natrium-kanalblocker |
Country Status (18)
Country | Link |
---|---|
US (3) | US7807834B2 (de) |
EP (1) | EP1922073B1 (de) |
JP (2) | JP5225085B2 (de) |
KR (1) | KR20080043773A (de) |
AU (1) | AU2006276978B2 (de) |
BR (1) | BRPI0614389A2 (de) |
CA (1) | CA2617269A1 (de) |
CY (1) | CY1114638T1 (de) |
DK (1) | DK1922073T3 (de) |
ES (1) | ES2430288T3 (de) |
HK (1) | HK1112853A1 (de) |
IL (1) | IL188941A0 (de) |
NO (1) | NO20081111L (de) |
PL (1) | PL1922073T3 (de) |
PT (1) | PT1922073E (de) |
RS (1) | RS52998B (de) |
SI (1) | SI1922073T1 (de) |
WO (1) | WO2007018640A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
JP2007502829A (ja) * | 2003-08-18 | 2007-02-15 | パリオン・サイエンシィズ・インコーポレーテッド | 環状ピラジノイルグアニジンナトリウムチャネルブロッカー |
ES2432529T3 (es) * | 2003-08-18 | 2013-12-04 | Parion Sciences, Inc. | Bloqueadores del canal de sodio de pirazinoilguanidina rematada |
US7745442B2 (en) * | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
CA2575680A1 (en) | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Cyclic amide & ester pyrazinoylguanidine sodium channel blockers |
KR20070059063A (ko) * | 2004-08-18 | 2007-06-11 | 마이클 알 존슨. | 지방족 아미드 및 에스테르 피라지노일구아니딘 나트륨채널 차단제 |
US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
US8324218B2 (en) * | 2006-06-09 | 2012-12-04 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity |
JP5254961B2 (ja) * | 2006-06-09 | 2013-08-07 | パリオン・サイエンシィズ・インコーポレーテッド | ベータアゴニスト活性を有するフェニル置換ピラジノイルグアニジンナトリウムチャネル遮断薬 |
WO2008031048A2 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
WO2008031028A2 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
WO2008124491A1 (en) * | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use taste modulators |
WO2008124496A1 (en) * | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders |
EP2211956A4 (de) | 2007-10-10 | 2014-07-09 | Parion Sciences Inc | Abgabe von osmolyten mit einer nasenkanüle |
EP2257296B1 (de) | 2008-02-26 | 2014-05-07 | Parion Sciences, Inc. | Polyaromatische natriumkanalblocker |
US20100074881A1 (en) * | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
US8367829B2 (en) | 2010-05-10 | 2013-02-05 | Gilead Sciences, Inc. | Bi-functional pyrazolopyridine compounds |
EP2569285A1 (de) | 2010-05-10 | 2013-03-20 | Gilead Sciences, Inc. | Bifunktionelle chinolinderivate |
US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
WO2012170677A1 (en) | 2011-06-07 | 2012-12-13 | Parion Sciences, Inc. | Methods of treatment |
DK2723176T3 (en) | 2011-06-27 | 2017-07-31 | Parion Sciences Inc | CHEMICAL AND METABOLIC STABLE DIPEPTIDE WITH POTENT SODIUM CHANNEL BLOCK ACTIVITY |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
CN104170419B (zh) * | 2012-03-23 | 2018-11-02 | 日本电气株式会社 | 订户服务器、监视服务器、移动终端、与之相关的方法和计算机可读介质 |
MY171122A (en) | 2012-05-29 | 2019-09-26 | Parion Sciences Inc | Dendrimer like amino amides processing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
MX2015007797A (es) | 2012-12-17 | 2015-10-05 | Parion Sciences Inc | Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida. |
CA2896686A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
GEP20186903B (en) | 2012-12-17 | 2018-10-25 | Saiensis Ink Perion | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
EP3022197B1 (de) | 2013-07-15 | 2017-09-06 | Boehringer Ingelheim International GmbH | Neue tetra- und pentasubtituierte benzimidazolium verbindungen |
EP3022196B1 (de) | 2013-07-15 | 2017-09-06 | Boehringer Ingelheim International GmbH | Neue benzimidazolium verbindungen |
MX368243B (es) | 2013-08-23 | 2019-09-25 | Parion Sciences Inc | Agentes mucolíticos de ditiol. |
US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
CN107614480B (zh) | 2015-01-30 | 2020-09-15 | 帕里昂科学公司 | 新型单硫醇粘液溶解剂 |
CA2984424A1 (en) | 2015-04-30 | 2016-11-03 | Parion Sciences, Inc. | Novel prodrugs of dithiol mucolytic agents |
GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003070182A2 (en) * | 2002-02-19 | 2003-08-28 | Johnson Michael R | Sodium channel blockers |
WO2004073629A2 (en) * | 2003-02-19 | 2004-09-02 | Parion Sciences, Inc. | Hetero substitued sodium channel blockers |
WO2005018644A1 (en) * | 2003-08-18 | 2005-03-03 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
WO2005044180A2 (en) * | 2003-08-20 | 2005-05-19 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
WO2006022935A1 (en) * | 2004-08-18 | 2006-03-02 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894376A (en) * | 1988-02-26 | 1990-01-16 | Trustees Of The University Of Pennsylvania | Methods of treating diseases characterized by hyperexcitability of neurons |
US6858614B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
EP1670475A4 (de) * | 2003-08-18 | 2009-04-15 | Parion Sciences Inc | Alaphatische pyrazinoylguanidin-natrium-kanalblocker |
US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
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-
2005
- 2005-08-03 US US11/195,758 patent/US7807834B2/en not_active Expired - Fee Related
-
2006
- 2006-04-27 JP JP2008524957A patent/JP5225085B2/ja not_active Expired - Fee Related
- 2006-04-27 ES ES06751598T patent/ES2430288T3/es active Active
- 2006-04-27 PT PT67515981T patent/PT1922073E/pt unknown
- 2006-04-27 BR BRPI0614389-0A patent/BRPI0614389A2/pt not_active IP Right Cessation
- 2006-04-27 PL PL06751598T patent/PL1922073T3/pl unknown
- 2006-04-27 RS RS20130441A patent/RS52998B/en unknown
- 2006-04-27 CA CA002617269A patent/CA2617269A1/en not_active Abandoned
- 2006-04-27 DK DK06751598.1T patent/DK1922073T3/da active
- 2006-04-27 EP EP06751598.1A patent/EP1922073B1/de active Active
- 2006-04-27 WO PCT/US2006/015957 patent/WO2007018640A1/en active Application Filing
- 2006-04-27 SI SI200631660T patent/SI1922073T1/sl unknown
- 2006-04-27 KR KR1020087002867A patent/KR20080043773A/ko not_active Application Discontinuation
- 2006-04-27 AU AU2006276978A patent/AU2006276978B2/en not_active Ceased
-
2008
- 2008-01-22 IL IL188941A patent/IL188941A0/en unknown
- 2008-03-03 NO NO20081111A patent/NO20081111L/no not_active Application Discontinuation
- 2008-07-23 HK HK08108161.8A patent/HK1112853A1/xx not_active IP Right Cessation
-
2010
- 2010-09-07 US US12/876,615 patent/US8211895B2/en active Active
-
2012
- 2012-05-09 US US13/467,618 patent/US8507497B2/en not_active Expired - Fee Related
- 2012-07-30 JP JP2012168186A patent/JP2012211188A/ja active Pending
-
2013
- 2013-10-08 CY CY20131100870T patent/CY1114638T1/el unknown
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WO2003070182A2 (en) * | 2002-02-19 | 2003-08-28 | Johnson Michael R | Sodium channel blockers |
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See also references of WO2007018640A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007018640A1 (en) | 2007-02-15 |
AU2006276978A1 (en) | 2007-02-15 |
KR20080043773A (ko) | 2008-05-19 |
RS52998B (en) | 2014-02-28 |
JP5225085B2 (ja) | 2013-07-03 |
BRPI0614389A2 (pt) | 2011-03-22 |
US20070032509A1 (en) | 2007-02-08 |
NO20081111L (no) | 2008-04-01 |
PT1922073E (pt) | 2013-10-16 |
EP1922073A1 (de) | 2008-05-21 |
HK1112853A1 (en) | 2008-09-19 |
AU2006276978B2 (en) | 2011-12-01 |
EP1922073B1 (de) | 2013-07-10 |
SI1922073T1 (sl) | 2013-11-29 |
US20120220606A1 (en) | 2012-08-30 |
US20110003832A1 (en) | 2011-01-06 |
PL1922073T3 (pl) | 2013-12-31 |
US7807834B2 (en) | 2010-10-05 |
IL188941A0 (en) | 2008-04-13 |
CY1114638T1 (el) | 2016-10-05 |
DK1922073T3 (da) | 2013-10-14 |
ES2430288T3 (es) | 2013-11-19 |
US8211895B2 (en) | 2012-07-03 |
US8507497B2 (en) | 2013-08-13 |
CA2617269A1 (en) | 2007-02-15 |
JP2012211188A (ja) | 2012-11-01 |
JP2009503067A (ja) | 2009-01-29 |
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