EP1899471A4 - Oxydation d'alcanes par des hydroxylases modifiees - Google Patents

Oxydation d'alcanes par des hydroxylases modifiees

Info

Publication number
EP1899471A4
EP1899471A4 EP06748800A EP06748800A EP1899471A4 EP 1899471 A4 EP1899471 A4 EP 1899471A4 EP 06748800 A EP06748800 A EP 06748800A EP 06748800 A EP06748800 A EP 06748800A EP 1899471 A4 EP1899471 A4 EP 1899471A4
Authority
EP
European Patent Office
Prior art keywords
alkane oxidation
hydroxylases
modified
modified hydroxylases
alkane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06748800A
Other languages
German (de)
English (en)
Other versions
EP1899471A2 (fr
Inventor
Frances Arnold
Peter Meinhold
Matthew W Peters
Rudi Fasan
Mike M Y Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of EP1899471A2 publication Critical patent/EP1899471A2/fr
Publication of EP1899471A4 publication Critical patent/EP1899471A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP06748800A 2005-03-28 2006-03-28 Oxydation d'alcanes par des hydroxylases modifiees Withdrawn EP1899471A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66590305P 2005-03-28 2005-03-28
US69887205P 2005-07-13 2005-07-13
US70078105P 2005-07-20 2005-07-20
PCT/US2006/011273 WO2006105082A2 (fr) 2005-03-28 2006-03-28 Oxydation d'alcanes par des hydroxylases modifiees

Publications (2)

Publication Number Publication Date
EP1899471A2 EP1899471A2 (fr) 2008-03-19
EP1899471A4 true EP1899471A4 (fr) 2009-11-25

Family

ID=37054005

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06748800A Withdrawn EP1899471A4 (fr) 2005-03-28 2006-03-28 Oxydation d'alcanes par des hydroxylases modifiees

Country Status (2)

Country Link
EP (1) EP1899471A4 (fr)
WO (1) WO2006105082A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524664B2 (en) 2003-06-17 2009-04-28 California Institute Of Technology Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
US8715988B2 (en) * 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
US8252559B2 (en) 2006-08-04 2012-08-28 The California Institute Of Technology Methods and systems for selective fluorination of organic molecules
WO2008016709A2 (fr) 2006-08-04 2008-02-07 California Institute Of Technology Procédés et systèmes de fluoration sélective des molécules organiques
US8802401B2 (en) 2007-06-18 2014-08-12 The California Institute Of Technology Methods and compositions for preparation of selectively protected carbohydrates
GB0719620D0 (en) * 2007-10-08 2007-11-14 Isis Innovation Mutant Enzymes
US8383346B2 (en) * 2008-06-13 2013-02-26 Codexis, Inc. Combined automated parallel synthesis of polynucleotide variants
US20090312196A1 (en) * 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
EP2426198A1 (fr) * 2010-09-03 2012-03-07 B.R.A.I.N. Biotechnology Research And Information Network AG Variantes de cytochrome P450 monooxygénase
WO2013016207A2 (fr) 2011-07-22 2013-01-31 California Institute Of Technology Variantes d'enzymes fongiques cel6 stables

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005017105A2 (fr) * 2003-06-17 2005-02-24 California University Of Technology Hydroxylation d'alcane regio- et enantio-selective avec du cytochrome p450 modifie

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9914373D0 (en) * 1999-06-18 1999-08-18 Isis Innovation Process for oxidising aromatic compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005017105A2 (fr) * 2003-06-17 2005-02-24 California University Of Technology Hydroxylation d'alcane regio- et enantio-selective avec du cytochrome p450 modifie

Also Published As

Publication number Publication date
EP1899471A2 (fr) 2008-03-19
WO2006105082A3 (fr) 2008-12-18
WO2006105082A2 (fr) 2006-10-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK YU

DAX Request for extension of the european patent (deleted)
R17D Deferred search report published (corrected)

Effective date: 20081218

RIC1 Information provided on ipc code assigned before grant

Ipc: C07H 21/04 20060101ALI20090223BHEP

Ipc: C12N 9/02 20060101AFI20090223BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20091022

17Q First examination report despatched

Effective date: 20100119

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Effective date: 20121002