EP1858509A4 - Nouveaux inhibiteurs de cathepsine c et leur utilisation - Google Patents

Nouveaux inhibiteurs de cathepsine c et leur utilisation

Info

Publication number
EP1858509A4
EP1858509A4 EP06736473A EP06736473A EP1858509A4 EP 1858509 A4 EP1858509 A4 EP 1858509A4 EP 06736473 A EP06736473 A EP 06736473A EP 06736473 A EP06736473 A EP 06736473A EP 1858509 A4 EP1858509 A4 EP 1858509A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
novel cathepsin
cathepsin
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06736473A
Other languages
German (de)
English (en)
Other versions
EP1858509A1 (fr
Inventor
David T Fosbenner
Ronggang Liu
Michael L Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of EP1858509A1 publication Critical patent/EP1858509A1/fr
Publication of EP1858509A4 publication Critical patent/EP1858509A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP06736473A 2005-03-02 2006-03-01 Nouveaux inhibiteurs de cathepsine c et leur utilisation Withdrawn EP1858509A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65789705P 2005-03-02 2005-03-02
PCT/US2006/007162 WO2006094003A1 (fr) 2005-03-02 2006-03-01 Nouveaux inhibiteurs de cathepsine c et leur utilisation

Publications (2)

Publication Number Publication Date
EP1858509A1 EP1858509A1 (fr) 2007-11-28
EP1858509A4 true EP1858509A4 (fr) 2009-03-18

Family

ID=36941504

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06736473A Withdrawn EP1858509A4 (fr) 2005-03-02 2006-03-01 Nouveaux inhibiteurs de cathepsine c et leur utilisation

Country Status (3)

Country Link
EP (1) EP1858509A4 (fr)
JP (1) JP2008531706A (fr)
WO (1) WO2006094003A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200922556A (en) * 2007-08-20 2009-06-01 Glaxo Group Ltd Novel cathepsin C inhibitors and their use
US8481547B2 (en) * 2009-12-18 2013-07-09 Janssen Pharmaceutica Nv Substituted benzothiazole and benzoxazole derivatives useful as inhibitors of DPP-1
US8552032B2 (en) * 2009-12-18 2013-10-08 Janssen Pharmaceutica Nv Bicyclic derivatives useful as inhibitors of DPP-1
WO2012119941A1 (fr) 2011-03-04 2012-09-13 Prozymex A/S Composés de peptidylnitrile à titre d'inhibiteurs de peptidases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106289A1 (fr) * 2003-05-30 2004-12-09 Prozymex A/S Inhibiteurs de protease
WO2004110988A1 (fr) * 2003-06-18 2004-12-23 Prozymex A/S Inhibiteurs de la protease
WO2005000800A1 (fr) * 2003-06-30 2005-01-06 Merck Frosst Canada Ltd. Inhibiteurs de la cathepsine cysteine protease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2212080A1 (de) * 1971-03-15 1972-10-12 Eli Lilly and Co., Indianapolis, Ind. (V.StA.) 3-Nitropyrazolderivate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106289A1 (fr) * 2003-05-30 2004-12-09 Prozymex A/S Inhibiteurs de protease
WO2004110988A1 (fr) * 2003-06-18 2004-12-23 Prozymex A/S Inhibiteurs de la protease
WO2005000800A1 (fr) * 2003-06-30 2005-01-06 Merck Frosst Canada Ltd. Inhibiteurs de la cathepsine cysteine protease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEATON D N ET AL: "Novel and potent cyclic cyanamide-based cathepsin K inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 7, 1 April 2005 (2005-04-01), pages 1815 - 1819, XP025313507, ISSN: 0960-894X, [retrieved on 20050401] *
KIM S H ET AL: "Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 18, no. 14, 15 July 2008 (2008-07-15), pages 3988 - 3991, XP022852880, ISSN: 0960-894X, [retrieved on 20080610] *
RYDZEWSKI ROBERT M ET AL: "Peptidic 1-cyanopyrrolidines: Synthesis and SAR of a series of potent, selective cathepsin inhibitors", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 10, no. 10, October 2002 (2002-10-01), pages 3277 - 3284, XP002512387, ISSN: 0968-0896 *
See also references of WO2006094003A1 *

Also Published As

Publication number Publication date
WO2006094003A1 (fr) 2006-09-08
EP1858509A1 (fr) 2007-11-28
JP2008531706A (ja) 2008-08-14

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20070928

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

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RAX Requested extension states of the european patent have changed

Extension state: HR

Payment date: 20070928

A4 Supplementary search report drawn up and despatched

Effective date: 20090217

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 11/00 20060101ALI20090209BHEP

Ipc: C07D 231/04 20060101ALI20090209BHEP

Ipc: A61K 31/415 20060101AFI20060912BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20090519