EP1855523A4 - Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor - Google Patents

Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor

Info

Publication number
EP1855523A4
EP1855523A4 EP06717647A EP06717647A EP1855523A4 EP 1855523 A4 EP1855523 A4 EP 1855523A4 EP 06717647 A EP06717647 A EP 06717647A EP 06717647 A EP06717647 A EP 06717647A EP 1855523 A4 EP1855523 A4 EP 1855523A4
Authority
EP
European Patent Office
Prior art keywords
hyperleptinemia
insulin
androgen receptor
mice lacking
leptin resistance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06717647A
Other languages
German (de)
French (fr)
Other versions
EP1855523A2 (en
Inventor
Chawnshang Chang
Hung-Yun Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Publication of EP1855523A2 publication Critical patent/EP1855523A2/en
Publication of EP1855523A4 publication Critical patent/EP1855523A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP06717647A 2005-01-07 2006-01-06 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor Withdrawn EP1855523A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64212905P 2005-01-07 2005-01-07
PCT/US2006/000474 WO2006074378A2 (en) 2005-01-07 2006-01-06 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor

Publications (2)

Publication Number Publication Date
EP1855523A2 EP1855523A2 (en) 2007-11-21
EP1855523A4 true EP1855523A4 (en) 2010-06-23

Family

ID=36648219

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06717647A Withdrawn EP1855523A4 (en) 2005-01-07 2006-01-06 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor

Country Status (4)

Country Link
EP (1) EP1855523A4 (en)
AU (1) AU2006203870A1 (en)
CA (1) CA2596783A1 (en)
WO (1) WO2006074378A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003012394A2 (en) * 2001-07-27 2003-02-13 University Of Rochester Androgen receptor knock-out transgenic animals
WO2003100028A2 (en) * 2002-05-28 2003-12-04 University Of Rochester Tr2, tr4, tr2/tr4 double knockouts and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005513460A (en) * 2001-12-19 2005-05-12 エクセリクシス・インコーポレイテッド Regulation of insulin receptor signaling by targeting FACL

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003012394A2 (en) * 2001-07-27 2003-02-13 University Of Rochester Androgen receptor knock-out transgenic animals
WO2003100028A2 (en) * 2002-05-28 2003-12-04 University Of Rochester Tr2, tr4, tr2/tr4 double knockouts and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALEVIZAKI M ET AL: "The androgen receptor gene CAG polymorphism is associated with the severity of coronary artery disease in men.", CLINICAL ENDOCRINOLOGY DEC 2003 LNKD- PUBMED:14974917, vol. 59, no. 6, December 2003 (2003-12-01), pages 749 - 755, XP002581156, ISSN: 0300-0664 *
FAN WUQIANG ET AL: "Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion", DIABETES, vol. 54, no. 4, April 2005 (2005-04-01), pages 1000 - 1008, XP002581155, ISSN: 0012-1797 *
MAYES J S ET AL: "Direct effects of sex steroid hormones on adipose tissues and obesity.", OBESITY REVIEWS : AN OFFICIAL JOURNAL OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF OBESITY NOV 2004 LNKD- PUBMED:15458395, vol. 5, no. 4, November 2004 (2004-11-01), pages 197 - 216, XP002581154, ISSN: 1467-7881 *
SATO TAKASHI ET AL: "Late onset of obesity in male androgen receptor-deficient (AR KO) mice.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 3 JAN 2003 LNKD- PUBMED:12480537, vol. 300, no. 1, 3 January 2003 (2003-01-03), pages 167 - 171, XP002581152, ISSN: 0006-291X *
ZITZMANN M ET AL: "The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men.", DIABETOLOGIA JAN 2003 LNKD- PUBMED:12637980, vol. 46, no. 1, January 2003 (2003-01-01), pages 31 - 39, XP002581153, ISSN: 0012-186X *

Also Published As

Publication number Publication date
CA2596783A1 (en) 2006-07-13
WO2006074378A2 (en) 2006-07-13
EP1855523A2 (en) 2007-11-21
WO2006074378A3 (en) 2007-03-08
AU2006203870A1 (en) 2006-07-13

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Legal Events

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