WO2006074378A3 - Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor - Google Patents

Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor Download PDF

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Publication number
WO2006074378A3
WO2006074378A3 PCT/US2006/000474 US2006000474W WO2006074378A3 WO 2006074378 A3 WO2006074378 A3 WO 2006074378A3 US 2006000474 W US2006000474 W US 2006000474W WO 2006074378 A3 WO2006074378 A3 WO 2006074378A3
Authority
WO
WIPO (PCT)
Prior art keywords
hyperleptinemia
insulin
androgen receptor
mice lacking
leptin resistance
Prior art date
Application number
PCT/US2006/000474
Other languages
French (fr)
Other versions
WO2006074378A2 (en
Inventor
Chawnshang Chang
Hung-Yun Lin
Original Assignee
Univ Rochester
Chawnshang Chang
Hung-Yun Lin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rochester, Chawnshang Chang, Hung-Yun Lin filed Critical Univ Rochester
Priority to CA002596783A priority Critical patent/CA2596783A1/en
Priority to EP06717647A priority patent/EP1855523A4/en
Priority to AU2006203870A priority patent/AU2006203870A1/en
Publication of WO2006074378A2 publication Critical patent/WO2006074378A2/en
Publication of WO2006074378A3 publication Critical patent/WO2006074378A3/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Animal Husbandry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are compositions and methods for related to diabetes and coronary heart disease.
PCT/US2006/000474 2005-01-07 2006-01-06 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor WO2006074378A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002596783A CA2596783A1 (en) 2005-01-07 2006-01-06 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor
EP06717647A EP1855523A4 (en) 2005-01-07 2006-01-06 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor
AU2006203870A AU2006203870A1 (en) 2005-01-07 2006-01-06 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64212905P 2005-01-07 2005-01-07
US60/642,129 2005-01-07

Publications (2)

Publication Number Publication Date
WO2006074378A2 WO2006074378A2 (en) 2006-07-13
WO2006074378A3 true WO2006074378A3 (en) 2007-03-08

Family

ID=36648219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/000474 WO2006074378A2 (en) 2005-01-07 2006-01-06 Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor

Country Status (4)

Country Link
EP (1) EP1855523A4 (en)
AU (1) AU2006203870A1 (en)
CA (1) CA2596783A1 (en)
WO (1) WO2006074378A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138832A1 (en) * 2001-12-19 2003-07-24 Kadyk Lisa C. Modulating insulin receptor signaling through targeting FACL

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003012394A2 (en) * 2001-07-27 2003-02-13 University Of Rochester Androgen receptor knock-out transgenic animals
US20060212953A1 (en) * 2002-05-28 2006-09-21 Chawnshang Chang Tr2, tr4, tr2/tr4 double knockouts and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138832A1 (en) * 2001-12-19 2003-07-24 Kadyk Lisa C. Modulating insulin receptor signaling through targeting FACL

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LIN H.Y. ET AL., DIABETES, vol. 54, June 2005 (2005-06-01), pages 1717 - 1725, XP008121193 *
PROCHAZKA M. AND LEITER E., HORM. METAB. RES., vol. 23, no. 4, April 1991 (1991-04-01), pages 149 - 154, XP008121248 *
See also references of EP1855523A4 *
WU F.C.W. AND VON ECKARDSTEIN A., ENDOCRINE REV., vol. 24, no. 2, 2003, pages 183 - 217, XP008121249 *
YEH S. ET AL., PNAS, vol. 99, no. 21, 15 October 2002 (2002-10-15), pages 13498 - 13503, XP002323412 *

Also Published As

Publication number Publication date
EP1855523A4 (en) 2010-06-23
CA2596783A1 (en) 2006-07-13
EP1855523A2 (en) 2007-11-21
AU2006203870A1 (en) 2006-07-13
WO2006074378A2 (en) 2006-07-13

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