EP1844924A3 - Method for regulating the amount of active ingredients in tablets during production in a rotary tabletting machine - Google Patents

Method for regulating the amount of active ingredients in tablets during production in a rotary tabletting machine Download PDF

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Publication number
EP1844924A3
EP1844924A3 EP07005438A EP07005438A EP1844924A3 EP 1844924 A3 EP1844924 A3 EP 1844924A3 EP 07005438 A EP07005438 A EP 07005438A EP 07005438 A EP07005438 A EP 07005438A EP 1844924 A3 EP1844924 A3 EP 1844924A3
Authority
EP
European Patent Office
Prior art keywords
amount
active ingredient
pressure roller
during production
regulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07005438A
Other languages
German (de)
French (fr)
Other versions
EP1844924A2 (en
EP1844924B1 (en
Inventor
Ingo Schmidt
Ines Andersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fette GmbH
Original Assignee
Fette GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fette GmbH filed Critical Fette GmbH
Publication of EP1844924A2 publication Critical patent/EP1844924A2/en
Publication of EP1844924A3 publication Critical patent/EP1844924A3/en
Application granted granted Critical
Publication of EP1844924B1 publication Critical patent/EP1844924B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/005—Control arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

Verfahren zur Regelung der Wirkstoffmenge von Tabletten während der Produktion in einer Rundläufertablettenpresse, welche eine Matrizenscheibe mit Matrizenbohrungen, den Matrizenbohrungen zugeordnete Ober- und Unterstempel, eine Befüllstation, eine Dosierkurve für die Unterstempel in der Befüllstation, mindestens eine Druckstation mit mindestens einer oberen und einer unteren Druckrolle, wobei mindestens die untere Druckrolle mittels einer Druckrollenverstellvorrichtung bezüglich der anderen Druckrolle verstellbar ist, eine Dosierkurvenverstellvorrichtung zur Höhenverstellung der Dosierkurve, eine Preßkraft-Meßvorrichtung an der Druckstation, einen Steuer- und Bedienrechner und eine Wirkstoffmeßvorrichtung aufweist, gekennzeichnet durch folgende Verfahrensschritte:
während der Tablettenproduktion wird die Wirkstoffmenge von Tabletten gemessen und Werte für die Wirkstoffmenge werden im Steuer- und Bedienrechner mit einem vorgegebenen Wirkstoff-Sollwert verglichen und
nach Maßgabe der Abweichung der gemessenen Wirkstoffmenge vom Wirkstoff-Sollwert wird die Dosierkurve verstellt.

Figure imgaf001
A method of controlling the amount of active ingredient of tablets during production in a rotary tablet press comprising a die plate with die bores, top and bottom punches associated with the die bores, a filling station, a metering curve for the bottom punches in the filling station, at least one printing station having at least one top and one bottom Pressure roller, wherein at least the lower pressure roller is adjustable by means of Druckrollenverstellvorrichtung with respect to the other pressure roller, a Dosierkurvenverstellvorrichtung for height adjustment of the metering curve, a Preßkraft measuring device at the printing station, a control and operating computer and a Wirkstoffmeßvorrichtung, characterized by the following method steps:
during tablet production, the amount of active ingredient is measured by tablets and values for the amount of active ingredient are compared in the control and operating computer with a predetermined drug target value and
according to the deviation of the measured amount of active ingredient from the active ingredient setpoint, the metering curve is adjusted.
Figure imgaf001
EP07005438.2A 2006-04-12 2007-03-16 Method for regulating the amount of active ingredients in tablets during production in a rotary tabletting machine Not-in-force EP1844924B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006017196A DE102006017196B4 (en) 2006-04-12 2006-04-12 Method of controlling the amount of active ingredient of tablets during production in a rotary tablet press

Publications (3)

Publication Number Publication Date
EP1844924A2 EP1844924A2 (en) 2007-10-17
EP1844924A3 true EP1844924A3 (en) 2008-09-03
EP1844924B1 EP1844924B1 (en) 2014-07-02

Family

ID=38134103

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07005438.2A Not-in-force EP1844924B1 (en) 2006-04-12 2007-03-16 Method for regulating the amount of active ingredients in tablets during production in a rotary tabletting machine

Country Status (3)

Country Link
US (1) US7471992B2 (en)
EP (1) EP1844924B1 (en)
DE (1) DE102006017196B4 (en)

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US7799273B2 (en) * 2004-05-06 2010-09-21 Smp Logic Systems Llc Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes
US7444197B2 (en) 2004-05-06 2008-10-28 Smp Logic Systems Llc Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes
PT1889198E (en) 2005-04-28 2015-03-06 Proteus Digital Health Inc Pharma-informatics system
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
DE102008049015B4 (en) 2008-09-25 2013-10-31 Fette Compacting Gmbh Method for monitoring the quality of powdery pressed material and a rotary press for carrying out the method
DE102009016406B4 (en) * 2009-04-04 2010-12-16 Fette Gmbh Printing station in a rotary press
WO2010129288A2 (en) 2009-04-28 2010-11-11 Proteus Biomedical, Inc. Highly reliable ingestible event markers and methods for using the same
DK2427166T3 (en) 2009-05-07 2014-01-27 Gea Pharma Systems Ltd Tablet Preparation Module and Method for Continuous Tablet Preparation
UA109424C2 (en) * 2009-12-02 2015-08-25 PHARMACEUTICAL PRODUCT, PHARMACEUTICAL TABLE WITH ELECTRONIC MARKER AND METHOD OF MANUFACTURING PHARMACEUTICAL TABLETS
DE102010005780B4 (en) 2010-01-27 2013-07-11 Fette Compacting Gmbh Rotary tablet press and method for pressing tablets in a rotary tablet press
RU2012143791A (en) 2010-04-07 2014-05-20 Проутьюс Диджитал Хэлс, Инк. MINIATURE INGESTED DEVICE
WO2012071280A2 (en) 2010-11-22 2012-05-31 Proteus Biomedical, Inc. Ingestible device with pharmaceutical product
DE102011050290B4 (en) * 2011-05-11 2013-11-07 Ima Kilian Gmbh & Co.Kg Rotary tablet press with tablet drain, tablet expiration therefor, weighing device therefor and method for producing tablets on a tablet press
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
CN102294837A (en) * 2011-08-04 2011-12-28 安徽中人科技有限责任公司 Medicine pressing machine for preparing small-diameter granular implanting agent by powdery materials
CN103085310A (en) * 2011-11-07 2013-05-08 四川汇利实业有限公司 High-efficiency tablet press with feed chute
JP2016508529A (en) 2013-01-29 2016-03-22 プロテウス デジタル ヘルス， インコーポレイテッド Highly expandable polymer film and composition containing the same
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
CN104015395B (en) * 2014-06-03 2015-09-30 唐伟 A kind of equipment being converted into sheet, ring-type and other special-shaped finished products for powder
EP2965897B1 (en) 2014-07-10 2018-10-03 I.M.A. INDUSTRIA MACCHINE AUTOMATICHE S.p.A. Tablet press machine and method for producing and weighing tablet
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
RU2711058C1 (en) 2016-07-22 2020-01-14 Протеус Диджитал Хелс, Инк. Electromagnetic probing and detection of swallowed event markers
TWI735689B (en) 2016-10-26 2021-08-11 日商大塚製藥股份有限公司 Methods for manufacturing capsules with ingestible event markers
IT201900019649A1 (en) * 2019-10-23 2021-04-23 Ima Spa Tablet press machine and compression method.
EP3900923B1 (en) * 2020-04-22 2023-11-01 PrivMed X AB Method for the automatic production of individualized tablets and tablet press for the automated production of individualized tablets
CN117281737B (en) * 2023-11-22 2024-02-02 山西旺龙药业集团有限公司 Filling device and method for producing norfloxacin capsules

Citations (6)

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DE2502098A1 (en) * 1974-01-31 1975-08-14 Kilian & Co Gmbh Tablet weight monitoring and control system - for a high speed rotary tabletting press
US3910737A (en) * 1973-11-30 1975-10-07 Yasuo Shimada Apparatus for automatically molding tablets including size and weight correction
JPS61111799A (en) * 1984-11-02 1986-05-29 Hata Tekkosho:Kk Rotary type powder compression molding machine
DE4315680A1 (en) * 1993-05-05 1994-11-10 Korsch Maschfab Method for quality assurance in the production of tablets using presses
US6325609B1 (en) * 1998-07-29 2001-12-04 Kikusui Seisakusyo Ltd. Compression molding machine for powder material
EP1568480A2 (en) * 2004-02-20 2005-08-31 Fette GmbH Method and device for quality control in the preparation of tablets

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US5585113A (en) * 1994-09-09 1996-12-17 Korsch Pressen Gmbh Process for quality control in the production of tablets by pressing
US5745356A (en) * 1996-06-25 1998-04-28 Exide Electronics Corporation Independent load sharing of AC power systems connected in parallel
US6499984B1 (en) * 2000-05-22 2002-12-31 Warner-Lambert Company Continuous production of pharmaceutical granulation
US6917124B2 (en) * 2000-10-27 2005-07-12 Liebert Corporation Uninterruptible power supply
US20050073783A1 (en) * 2003-10-02 2005-04-07 Phoenixtec Power Co., Ltd. Parallel redundant power system and the control method for the same
US20050200038A1 (en) * 2004-03-12 2005-09-15 Courtoy Nv Method for controlling a rotary tablet press and such a press
ATE366921T1 (en) * 2004-05-27 2007-08-15 Uhlmann Visiotec Gmbh TABLET PRESS WITH INTEGRATED NIR MEASURING DEVICE

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910737A (en) * 1973-11-30 1975-10-07 Yasuo Shimada Apparatus for automatically molding tablets including size and weight correction
DE2502098A1 (en) * 1974-01-31 1975-08-14 Kilian & Co Gmbh Tablet weight monitoring and control system - for a high speed rotary tabletting press
JPS61111799A (en) * 1984-11-02 1986-05-29 Hata Tekkosho:Kk Rotary type powder compression molding machine
DE4315680A1 (en) * 1993-05-05 1994-11-10 Korsch Maschfab Method for quality assurance in the production of tablets using presses
US6325609B1 (en) * 1998-07-29 2001-12-04 Kikusui Seisakusyo Ltd. Compression molding machine for powder material
EP1568480A2 (en) * 2004-02-20 2005-08-31 Fette GmbH Method and device for quality control in the preparation of tablets

Also Published As

Publication number Publication date
EP1844924A2 (en) 2007-10-17
DE102006017196B4 (en) 2008-09-11
US7471992B2 (en) 2008-12-30
US20070241127A1 (en) 2007-10-18
DE102006017196A1 (en) 2007-10-25
EP1844924B1 (en) 2014-07-02

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