EP1844012A2 - Novel process for the preparation of substituted indoles - Google Patents
Novel process for the preparation of substituted indolesInfo
- Publication number
- EP1844012A2 EP1844012A2 EP06700281A EP06700281A EP1844012A2 EP 1844012 A2 EP1844012 A2 EP 1844012A2 EP 06700281 A EP06700281 A EP 06700281A EP 06700281 A EP06700281 A EP 06700281A EP 1844012 A2 EP1844012 A2 EP 1844012A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- formula
- compound
- process according
- methyl
- vii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0500604.4A GB0500604D0 (en) | 2005-01-13 | 2005-01-13 | Novel process |
PCT/GB2006/000060 WO2006075139A2 (en) | 2005-01-13 | 2006-01-09 | Novel process for the preparation of substituted indoles |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1844012A2 true EP1844012A2 (en) | 2007-10-17 |
Family
ID=34203986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06700281A Withdrawn EP1844012A2 (en) | 2005-01-13 | 2006-01-09 | Novel process for the preparation of substituted indoles |
Country Status (15)
Country | Link |
---|---|
US (1) | US7781598B2 (en) |
EP (1) | EP1844012A2 (en) |
JP (1) | JP2008526936A (en) |
KR (1) | KR20070104350A (en) |
CN (1) | CN101102999B (en) |
AU (1) | AU2006205697B2 (en) |
BR (1) | BRPI0606639A2 (en) |
CA (1) | CA2594391A1 (en) |
GB (1) | GB0500604D0 (en) |
IL (1) | IL183965A0 (en) |
MX (1) | MX2007008348A (en) |
NO (1) | NO20074047L (en) |
NZ (1) | NZ556147A (en) |
WO (1) | WO2006075139A2 (en) |
ZA (1) | ZA200705216B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (en) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
SE0301569D0 (en) * | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
SE0302232D0 (en) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
SE0303180D0 (en) * | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
JP2009538289A (en) * | 2006-05-26 | 2009-11-05 | アストラゼネカ・アクチエボラーグ | Biaryl or heteroaryl substituted indoles |
AU2010270050B9 (en) | 2009-07-06 | 2013-06-27 | Astrazeneca Ab | Intermediates and processes for the preparation of 4- (acetylamino) ) -3- [ (4-chloro-phenyl) thio] -2-methyl-1H-indole-1-acetic acid |
BR112014014558A8 (en) | 2011-12-16 | 2017-07-04 | Atopix Therapeutics Ltd | pharmaceutical composition, use of a crth2 antagonist and a proton pump inhibitor, and kit for the treatment of eosinophilic esophagitis |
CN103288707B (en) * | 2013-05-28 | 2015-12-23 | 浙江大学 | A kind of preparation method of 3-benzene sulfydryl indole derivative |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE790679A (en) | 1971-11-03 | 1973-04-27 | Ici Ltd | INDOLE DERIVATIVES |
JPH0615542B2 (en) | 1986-07-22 | 1994-03-02 | 吉富製薬株式会社 | Pyrazolopyridine compound |
US5095031A (en) | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
WO1993005020A1 (en) | 1991-09-06 | 1993-03-18 | Merck & Co., Inc. | Indoles as inhibitors of hiv reverse transcriptase |
FR2692574B1 (en) | 1992-06-23 | 1995-06-23 | Sanofi Elf | 4-HYDROXY BENZENETHIO DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF AMINOALKOXYBENZENESULFONYL DERIVATIVES. |
HUT74614A (en) | 1993-02-24 | 1997-01-28 | Merck & Co Inc | Nindol derivates suitable for treatment of infection by hiv and pharmaceutical compositions containing them |
US5486525A (en) | 1993-12-16 | 1996-01-23 | Abbott Laboratories | Platelet activating factor antagonists: imidazopyridine indoles |
US5567711A (en) | 1995-04-19 | 1996-10-22 | Abbott Laboratories | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists |
TW472045B (en) | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
AR017256A1 (en) | 1997-08-21 | 2001-09-05 | American Home Prod | INDOL SUBSTITUTED COMPOUNDS, METHOD FOR SOLID PHASE SYNTHESIS OF THE SAME, COMBINATION SETS TO BE EMPLOYED IN THAT METHOD, USE OF COMPOUNDS TO PREPARE A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM |
ES2198033T3 (en) | 1997-12-19 | 2004-01-16 | Eli Lilly And Company | HYDOGLUCEMIC IMIDAZOLINE COMPOUNDS. |
US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
AU5886500A (en) | 1999-06-23 | 2001-01-09 | Sepracor, Inc. | Indolyl-benzimidazole antibacterials, and methods of use thereof |
WO2001032621A1 (en) | 1999-10-29 | 2001-05-10 | Wakunaga Pharmaceutical Co., Ltd. | Novel indole derivatives and drugs containing the same as the active ingredient |
CN1615873A (en) | 1999-12-24 | 2005-05-18 | 阿文蒂斯药物有限公司 | Azaindoles compound |
WO2001092224A1 (en) | 2000-05-31 | 2001-12-06 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
EP1414442A1 (en) * | 2001-08-07 | 2004-05-06 | Smithkline Beecham Plc | 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders |
TWI317634B (en) | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
AU2003218962B2 (en) | 2002-02-01 | 2008-09-25 | F. Hoffmann-La Roche Ag | Substituted indoles as alpha-1 agonists |
SE0200411D0 (en) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200356D0 (en) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
EP1505061A4 (en) | 2002-05-16 | 2007-08-22 | Shionogi & Co | Compound exhibiting pgd 2 receptor antagonism |
SE0201635D0 (en) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (en) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
SE0202463D0 (en) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
KR20050084890A (en) * | 2002-10-30 | 2005-08-29 | 머크 프로스트 캐나다 앤드 캄파니 | Pyridopyrrolizine and pyridoindolizine derivatives |
TWI284124B (en) * | 2002-12-03 | 2007-07-21 | Hoffmann La Roche | Aminoalkoxyindoles |
SE0301569D0 (en) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
SE0302232D0 (en) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
JP2007508363A (en) | 2003-10-14 | 2007-04-05 | オキサジェン リミテッド | Compound having CRTH2 antagonist activity |
SE0303180D0 (en) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
GB2422831A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
JP2009538289A (en) | 2006-05-26 | 2009-11-05 | アストラゼネカ・アクチエボラーグ | Biaryl or heteroaryl substituted indoles |
US20090318526A1 (en) | 2006-06-08 | 2009-12-24 | Uno Jacob Weber | Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia |
JP5237938B2 (en) | 2006-06-28 | 2013-07-17 | サノフイ | Novel CXCR2 inhibitor |
-
2005
- 2005-01-13 GB GBGB0500604.4A patent/GB0500604D0/en not_active Ceased
-
2006
- 2006-01-09 JP JP2007550831A patent/JP2008526936A/en active Pending
- 2006-01-09 MX MX2007008348A patent/MX2007008348A/en active IP Right Grant
- 2006-01-09 KR KR1020077015946A patent/KR20070104350A/en not_active Application Discontinuation
- 2006-01-09 BR BRPI0606639-9A patent/BRPI0606639A2/en not_active IP Right Cessation
- 2006-01-09 CN CN2006800023115A patent/CN101102999B/en not_active Expired - Fee Related
- 2006-01-09 NZ NZ556147A patent/NZ556147A/en not_active IP Right Cessation
- 2006-01-09 EP EP06700281A patent/EP1844012A2/en not_active Withdrawn
- 2006-01-09 CA CA002594391A patent/CA2594391A1/en not_active Abandoned
- 2006-01-09 WO PCT/GB2006/000060 patent/WO2006075139A2/en active Application Filing
- 2006-01-09 AU AU2006205697A patent/AU2006205697B2/en not_active Ceased
- 2006-01-09 US US11/813,816 patent/US7781598B2/en not_active Expired - Fee Related
-
2007
- 2007-06-14 IL IL183965A patent/IL183965A0/en unknown
- 2007-06-29 ZA ZA200705216A patent/ZA200705216B/en unknown
- 2007-08-06 NO NO20074047A patent/NO20074047L/en not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO2006075139A2 * |
Also Published As
Publication number | Publication date |
---|---|
AU2006205697B2 (en) | 2009-01-22 |
BRPI0606639A2 (en) | 2009-07-07 |
JP2008526936A (en) | 2008-07-24 |
NO20074047L (en) | 2007-08-06 |
WO2006075139A3 (en) | 2006-10-19 |
CA2594391A1 (en) | 2006-07-20 |
CN101102999B (en) | 2010-12-29 |
NZ556147A (en) | 2010-01-29 |
GB0500604D0 (en) | 2005-02-16 |
KR20070104350A (en) | 2007-10-25 |
US7781598B2 (en) | 2010-08-24 |
CN101102999A (en) | 2008-01-09 |
MX2007008348A (en) | 2007-08-03 |
IL183965A0 (en) | 2007-10-31 |
AU2006205697A1 (en) | 2006-07-20 |
US20080051586A1 (en) | 2008-02-28 |
WO2006075139A2 (en) | 2006-07-20 |
ZA200705216B (en) | 2008-09-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7781598B2 (en) | Process for the preparation of substituted indoles | |
WO2011124704A1 (en) | Process for preparing an intermediate for silodosin | |
EP2118058B1 (en) | Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole | |
AU735516B2 (en) | Process for preparing 4-substituted-1H-indole-3-glyoxamides | |
US6541635B1 (en) | Method for producing angiotensin converting enzyme inhibitor | |
KR20030017484A (en) | Novel method for systhesis of n-[(s)-1-carboxybutyl]-(s)-alanine esters and use in synthesis of perindopril | |
EP2349998B1 (en) | A novel process for the preparation of eletriptan | |
US5869694A (en) | Process for preparing 4-hydroxy-2-pyrrolidone | |
AU750368B2 (en) | Process for preparing 4-substituted-1H-indole-3-glyoxamides | |
HU225459B1 (en) | Process for preparing substituted imidazopyridine compound | |
RU2429235C2 (en) | Method of producing substituted benzofuran-5,6-dicarbonitriles | |
HU199414B (en) | Process for producing substituted indolinone derivatives | |
US4595755A (en) | 5-halo-1,2,3-(1,2-dihydropyrrolo)-4-quinolones | |
JP2677115B2 (en) | Imine compound and method for producing the same | |
SK13592001A3 (en) | Synthesis of 3-amino-3-aryl propanoates | |
JPH10195064A (en) | Production of 5-amino-1,2,4-thiadiazoleacetic acid derivative (syn-isomer) | |
JP4286921B2 (en) | 3-carboxy-1-phenyl-2-pyrrolidinone derivatives and production method | |
KR100377578B1 (en) | Process for the preparation of ondansetron and pharmaceutically acceptable salts thereof | |
JPH11152282A (en) | New carboxylic acid derivative and its production | |
CN114105961A (en) | Preparation method of IDO1 inhibitor (LY-3381916) | |
US6423849B1 (en) | Process of preparing 5-(2-substituted-4-nitrophenyl)-oxazole, novel oxazole compound, and process of preparing the same | |
JP2536756B2 (en) | 5-alkoxyanthranilic acid ester | |
JPH10310568A (en) | N-alkoxycarbonyl-l-asparagine | |
JP2000143624A (en) | 3-carboxy-1-phenyl-2-pyrrolidinone derivative and its production | |
JPS62201866A (en) | Production of indoleacetic acid derivative |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20070813 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: HR |
|
RAX | Requested extension states of the european patent have changed |
Extension state: HR Payment date: 20070813 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1107813 Country of ref document: HK |
|
17Q | First examination report despatched |
Effective date: 20110318 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1107813 Country of ref document: HK |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20140715 |