WO2006075139A2 - Novel process for the preparation of substituted indoles - Google Patents
Novel process for the preparation of substituted indoles Download PDFInfo
- Publication number
- WO2006075139A2 WO2006075139A2 PCT/GB2006/000060 GB2006000060W WO2006075139A2 WO 2006075139 A2 WO2006075139 A2 WO 2006075139A2 GB 2006000060 W GB2006000060 W GB 2006000060W WO 2006075139 A2 WO2006075139 A2 WO 2006075139A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- compound
- process according
- methyl
- vii
- Prior art date
Links
- SHTVHNWTKBEJOB-UHFFFAOYSA-N Cc([nH]c1cccc([N+]([O-])=O)c11)c1Sc(cc1)ccc1Cl Chemical compound Cc([nH]c1cccc([N+]([O-])=O)c11)c1Sc(cc1)ccc1Cl SHTVHNWTKBEJOB-UHFFFAOYSA-N 0.000 description 2
- 0 C*C(C[n]1c2cccc([N+]([O-])=O)c2c(Sc(cc2)ccc2Cl)c1C)=O Chemical compound C*C(C[n]1c2cccc([N+]([O-])=O)c2c(Sc(cc2)ccc2Cl)c1C)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002594391A CA2594391A1 (en) | 2005-01-13 | 2006-01-09 | Process for the preparation of substituted indoles |
NZ556147A NZ556147A (en) | 2005-01-13 | 2006-01-09 | Novel process for the preparation of substituted indoles |
MX2007008348A MX2007008348A (en) | 2005-01-13 | 2006-01-09 | Novel process for the preparation of substituted indoles. |
JP2007550831A JP2008526936A (en) | 2005-01-13 | 2006-01-09 | New method for producing substituted indoles |
CN2006800023115A CN101102999B (en) | 2005-01-13 | 2006-01-09 | Novel process for the preparation of substituted indoles |
BRPI0606639-9A BRPI0606639A2 (en) | 2005-01-13 | 2006-01-09 | new process for the preparation of substituted indoles |
US11/813,816 US7781598B2 (en) | 2005-01-13 | 2006-01-09 | Process for the preparation of substituted indoles |
AU2006205697A AU2006205697B2 (en) | 2005-01-13 | 2006-01-09 | Novel process for the preparation of substituted indoles |
EP06700281A EP1844012A2 (en) | 2005-01-13 | 2006-01-09 | Novel process for the preparation of substituted indoles |
IL183965A IL183965A0 (en) | 2005-01-13 | 2007-06-14 | Novel process for the preparation of substituted indoles |
NO20074047A NO20074047L (en) | 2005-01-13 | 2007-08-06 | New process for the production of substituted indoles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0500604.4A GB0500604D0 (en) | 2005-01-13 | 2005-01-13 | Novel process |
GB0500604.4 | 2005-01-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006075139A2 true WO2006075139A2 (en) | 2006-07-20 |
WO2006075139A3 WO2006075139A3 (en) | 2006-10-19 |
Family
ID=34203986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2006/000060 WO2006075139A2 (en) | 2005-01-13 | 2006-01-09 | Novel process for the preparation of substituted indoles |
Country Status (15)
Country | Link |
---|---|
US (1) | US7781598B2 (en) |
EP (1) | EP1844012A2 (en) |
JP (1) | JP2008526936A (en) |
KR (1) | KR20070104350A (en) |
CN (1) | CN101102999B (en) |
AU (1) | AU2006205697B2 (en) |
BR (1) | BRPI0606639A2 (en) |
CA (1) | CA2594391A1 (en) |
GB (1) | GB0500604D0 (en) |
IL (1) | IL183965A0 (en) |
MX (1) | MX2007008348A (en) |
NO (1) | NO20074047L (en) |
NZ (1) | NZ556147A (en) |
WO (1) | WO2006075139A2 (en) |
ZA (1) | ZA200705216B (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7687535B2 (en) | 2003-05-27 | 2010-03-30 | Astrazeneca Ab | Substituted 3-sulfur indoles |
US7709521B2 (en) | 2003-08-18 | 2010-05-04 | Astrazeneca Ab | Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases |
US7723373B2 (en) | 2002-07-17 | 2010-05-25 | Astrazeneca Ab | Indole-3-sulphur derivatives |
US7741360B2 (en) | 2006-05-26 | 2010-06-22 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
US7754735B2 (en) | 2002-05-30 | 2010-07-13 | Astrazeneca Ab | Substituted indoles |
US7781598B2 (en) | 2005-01-13 | 2010-08-24 | Astrazeneca Ab | Process for the preparation of substituted indoles |
WO2011004182A1 (en) | 2009-07-06 | 2011-01-13 | Astrazeneca Ab | Intermediates and processes for the preparation of 4- (acetylamino) ) -3- [ (4-chloro-phenyl) thio] -2-methyl-1h-indole-1-acetic acid |
WO2013088109A1 (en) | 2011-12-16 | 2013-06-20 | Oxagen Limited | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0303180D0 (en) * | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
CN103288707B (en) * | 2013-05-28 | 2015-12-23 | 浙江大学 | A kind of preparation method of 3-benzene sulfydryl indole derivative |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004106302A1 (en) * | 2003-05-27 | 2004-12-09 | Astrazeneca Ab | Novel substituted 3-sulfur indoles |
Family Cites Families (37)
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BE790679A (en) | 1971-11-03 | 1973-04-27 | Ici Ltd | INDOLE DERIVATIVES |
JPH0615542B2 (en) | 1986-07-22 | 1994-03-02 | 吉富製薬株式会社 | Pyrazolopyridine compound |
US5095031A (en) * | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
WO1993005020A1 (en) | 1991-09-06 | 1993-03-18 | Merck & Co., Inc. | Indoles as inhibitors of hiv reverse transcriptase |
FR2692574B1 (en) | 1992-06-23 | 1995-06-23 | Sanofi Elf | 4-HYDROXY BENZENETHIO DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF AMINOALKOXYBENZENESULFONYL DERIVATIVES. |
BR9405737A (en) | 1993-02-24 | 1995-12-05 | Merck & Co Inc | Compound process of inhibiting HIV transcriptase, process for preventing HIV infection or treating HIV infection, pharmaceutical composition useful for inhibiting HIV transcriptase, and useful for preventing or treating HIV infection or for the treatment of AIDS or ARC |
US5486525A (en) * | 1993-12-16 | 1996-01-23 | Abbott Laboratories | Platelet activating factor antagonists: imidazopyridine indoles |
US5567711A (en) * | 1995-04-19 | 1996-10-22 | Abbott Laboratories | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists |
TW472045B (en) | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
WO1999009007A1 (en) | 1997-08-21 | 1999-02-25 | American Home Products Corporation | Solid phase synthesis of 2,3-disubstituted indole compounds |
WO1999032482A1 (en) | 1997-12-19 | 1999-07-01 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
AU5886500A (en) | 1999-06-23 | 2001-01-09 | Sepracor, Inc. | Indolyl-benzimidazole antibacterials, and methods of use thereof |
AU7962200A (en) | 1999-10-29 | 2001-05-14 | Wakunaga Pharmaceutical Co., Ltd | Novel indole derivatives and drugs containing the same as the active ingredient |
CA2699568C (en) | 1999-12-24 | 2013-03-12 | Aventis Pharma Limited | Azaindoles |
CN1431999A (en) | 2000-05-31 | 2003-07-23 | 阿斯特拉曾尼卡有限公司 | Indole derivatives with vascular damagine activity |
US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
EP1414442A1 (en) * | 2001-08-07 | 2004-05-06 | Smithkline Beecham Plc | 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders |
TWI317634B (en) * | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
RU2337909C2 (en) | 2002-02-01 | 2008-11-10 | Ф.Хоффманн-Ля Рош Аг | Substituted indoles and pharmaceutical composition, possessing agonistic activity with respect to alfa- 1a/l adrenorecerptor |
SE0200356D0 (en) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200411D0 (en) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
US7534897B2 (en) | 2002-05-16 | 2009-05-19 | Shionogi & Co., Ltd. | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism |
SE0201635D0 (en) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) * | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (en) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
SE0202463D0 (en) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
CA2503767C (en) * | 2002-10-30 | 2009-09-22 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Pyridopyrrolizine and pyridoindolizine derivatives |
PL377464A1 (en) * | 2002-12-03 | 2006-02-06 | F. Hoffmann-La Roche Ag | Aminoalkoxyindoles as 5-ht6-receptor ligands for the treatment of cns-disorders |
SE0302232D0 (en) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
US20070232681A1 (en) | 2003-10-14 | 2007-10-04 | Oxagen Limited | Compounds Having Crth2 Antagonist Activity |
SE0303180D0 (en) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
GB2422831A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
JP2009538289A (en) * | 2006-05-26 | 2009-11-05 | アストラゼネカ・アクチエボラーグ | Biaryl or heteroaryl substituted indoles |
RU2008152763A (en) | 2006-06-08 | 2010-07-20 | Ньюроки А/С (Dk) | APPLICATION OF CANNABINOID RECEPTOR AGONISTS AS MEDICINES HYPOTHERMIC INDUCING FOR TREATMENT OF ISCHEMIA |
KR20090023645A (en) | 2006-06-28 | 2009-03-05 | 사노피-아벤티스 | New cxcr2 inhibitors |
-
2005
- 2005-01-13 GB GBGB0500604.4A patent/GB0500604D0/en not_active Ceased
-
2006
- 2006-01-09 EP EP06700281A patent/EP1844012A2/en not_active Withdrawn
- 2006-01-09 MX MX2007008348A patent/MX2007008348A/en active IP Right Grant
- 2006-01-09 KR KR1020077015946A patent/KR20070104350A/en not_active Application Discontinuation
- 2006-01-09 WO PCT/GB2006/000060 patent/WO2006075139A2/en active Application Filing
- 2006-01-09 CN CN2006800023115A patent/CN101102999B/en not_active Expired - Fee Related
- 2006-01-09 US US11/813,816 patent/US7781598B2/en not_active Expired - Fee Related
- 2006-01-09 AU AU2006205697A patent/AU2006205697B2/en not_active Ceased
- 2006-01-09 CA CA002594391A patent/CA2594391A1/en not_active Abandoned
- 2006-01-09 JP JP2007550831A patent/JP2008526936A/en active Pending
- 2006-01-09 BR BRPI0606639-9A patent/BRPI0606639A2/en not_active IP Right Cessation
- 2006-01-09 NZ NZ556147A patent/NZ556147A/en not_active IP Right Cessation
-
2007
- 2007-06-14 IL IL183965A patent/IL183965A0/en unknown
- 2007-06-29 ZA ZA200705216A patent/ZA200705216B/en unknown
- 2007-08-06 NO NO20074047A patent/NO20074047L/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004106302A1 (en) * | 2003-05-27 | 2004-12-09 | Astrazeneca Ab | Novel substituted 3-sulfur indoles |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7754735B2 (en) | 2002-05-30 | 2010-07-13 | Astrazeneca Ab | Substituted indoles |
US8093278B2 (en) | 2002-05-30 | 2012-01-10 | Astrazeneca Ab | Substituted indoles |
US7723373B2 (en) | 2002-07-17 | 2010-05-25 | Astrazeneca Ab | Indole-3-sulphur derivatives |
US7687535B2 (en) | 2003-05-27 | 2010-03-30 | Astrazeneca Ab | Substituted 3-sulfur indoles |
EP2281815A1 (en) * | 2003-05-27 | 2011-02-09 | AstraZeneca AB | 4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid ethyl ester intermediate compound |
US7709521B2 (en) | 2003-08-18 | 2010-05-04 | Astrazeneca Ab | Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases |
US7781598B2 (en) | 2005-01-13 | 2010-08-24 | Astrazeneca Ab | Process for the preparation of substituted indoles |
US7741360B2 (en) | 2006-05-26 | 2010-06-22 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
WO2011004182A1 (en) | 2009-07-06 | 2011-01-13 | Astrazeneca Ab | Intermediates and processes for the preparation of 4- (acetylamino) ) -3- [ (4-chloro-phenyl) thio] -2-methyl-1h-indole-1-acetic acid |
US8227622B2 (en) | 2009-07-06 | 2012-07-24 | Astrazeneca Ab | Pharmaceutical process and intermediates 714 |
AU2010270050B9 (en) * | 2009-07-06 | 2013-06-27 | Astrazeneca Ab | Intermediates and processes for the preparation of 4- (acetylamino) ) -3- [ (4-chloro-phenyl) thio] -2-methyl-1H-indole-1-acetic acid |
WO2013088109A1 (en) | 2011-12-16 | 2013-06-20 | Oxagen Limited | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
Also Published As
Publication number | Publication date |
---|---|
CN101102999B (en) | 2010-12-29 |
BRPI0606639A2 (en) | 2009-07-07 |
JP2008526936A (en) | 2008-07-24 |
CA2594391A1 (en) | 2006-07-20 |
CN101102999A (en) | 2008-01-09 |
NZ556147A (en) | 2010-01-29 |
AU2006205697B2 (en) | 2009-01-22 |
US20080051586A1 (en) | 2008-02-28 |
AU2006205697A1 (en) | 2006-07-20 |
WO2006075139A3 (en) | 2006-10-19 |
ZA200705216B (en) | 2008-09-25 |
IL183965A0 (en) | 2007-10-31 |
US7781598B2 (en) | 2010-08-24 |
KR20070104350A (en) | 2007-10-25 |
NO20074047L (en) | 2007-08-06 |
GB0500604D0 (en) | 2005-02-16 |
MX2007008348A (en) | 2007-08-03 |
EP1844012A2 (en) | 2007-10-17 |
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